Position Title: Postdoctoral Fellow – RNA Structural Biology
Department: Biophysics
Institution: Medical College of Wisconsin
Location: Milwaukee, WI
Job Type: Full-Time

Position Summary

The Wang Lab in the Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Postdoctoral Fellow to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques—including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy—to explore RNA structure–function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.

This position offers an exciting opportunity for candidates passionate about cutting-edge RNA biology and structural biology, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment.

Key Responsibilities

• Design and execute experiments to investigate the structure and dynamics of noncoding RNAs using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
• Conduct biochemical assays to study RNA–protein and RNA–small molecule interactions
• Perform in vitro transcription, RNA purification, labeling, and structural probing
• Analyze experimental data, interpret results, and contribute to manuscript preparation
• Present research findings at lab meetings, institutional seminars, and scientific conferences
• Mentor graduate students and contribute to training and scientific development within the lab
• Assist with the development of grant proposals and collaborative research initiatives

Required Qualifications

• Ph.D. in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular Biology, or a related discipline (or expected within 6 months of the start date)
• Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM)
• Strong background in RNA biology or nucleic acid biochemistry
• Proven ability to work independently, manage time effectively, and troubleshoot experiments
• Excellent written and verbal communication skills

Preferred Qualifications

• Experience with RNA preparation and purification
• Familiarity with RNA structural probing methods (e.g., SHAPE, DMS mapping, RNase digestion)
• Experience in protein expression, purification, and RNA–protein complex reconstitution
• Exposure to small-molecule screening or RNA-targeted drug discovery
• Strong publication record in peer-reviewed journals

Application Instructions

Interested applicants should submit the following materials to Dr. Yaqiang Wang ([email protected] ):

• Cover letter outlining research interests and career goals
• Curriculum vitae (CV)
• Contact information for three professional references

Review of applications will begin immediately and continue until the position is filled.

About MCW and Milwaukee

The Department of Biophysics at the Medical College of Wisconsin has a rich tradition of innovation and excellence in structural biology and biomedical imaging, with particular strengths in EPR (electron paramagnetic resonance), NMR (nuclear magnetic resonance), and MRI (magnetic resonance imaging). The department offers access to state-of-the-art facilities for NMR (solution and solid-state), EPR, MRI, X-ray crystallography, cryo-EM, mass spectrometry, high-performance computing, and biomolecular analysis.

MCW is Wisconsin’s largest private research institution and the third-largest private medical school in the U.S. The institution fosters a collaborative environment that integrates basic science, clinical research, and education to advance biomedical knowledge and human health.

Milwaukee, located 90 miles north of Chicago along the western shore of Lake Michigan, is a vibrant city known for its cultural diversity, rich history, and natural beauty. Named one of National Geographic’s “Best of the World” destinations in 2023, Milwaukee offers a unique mix of urban energy and outdoor recreation. The city features renowned museums, a thriving music and culinary scene, historic neighborhoods, professional sports, and a wide range of festivals. Affordable housing, excellent schools, and a strong sense of community contribute to an outstanding quality of life. Learn more at www.visitmilwaukee.org.