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Postdoctoral Researcher in Structural Biology -- Medical College of Wisconsin (MCW)
Posted on July 7th, 2025
Position Title: Postdoctoral Fellow – RNA Structural Biology
Department: Biophysics
Institution: Medical College of Wisconsin
Location: Milwaukee, WI
Job Type: Full-Time
Position Summary
The Wang Lab in the Department of Biophysics at the Medical College of Wisconsin is seeking a highly motivated Postdoctoral Fellow to join our research team focused on the structural and functional analysis of oncogenic noncoding RNAs. We utilize a multidisciplinary approach that integrates biochemical, biophysical, and structural biology techniques—including NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy—to explore RNA structure–function relationships and identify opportunities for RNA-targeted therapeutic intervention in cancer and related diseases.
This position offers an exciting opportunity for candidates passionate about cutting-edge RNA biology and structural biology, with the potential to develop novel experimental approaches and lead research projects in a collaborative and well-resourced environment.
Key Responsibilities
- Design and execute experiments to investigate the structure and dynamics of noncoding RNAs using biophysical and structural techniques (e.g., NMR, X-ray crystallography, cryo-EM)
- Conduct biochemical assays to study RNA–protein and RNA–small molecule interactions
- Perform in vitro transcription, RNA purification, labeling, and structural probing
- Analyze experimental data, interpret results, and contribute to manuscript preparation
- Present research findings at lab meetings, institutional seminars, and scientific conferences
- Mentor graduate students and contribute to training and scientific development within the lab
- Assist with the development of grant proposals and collaborative research initiatives
Required Qualifications
- Ph.D. in Biochemistry, Biophysics, Structural Biology, Chemistry, Molecular Biology, or a related discipline (or expected within 6 months of the start date)
- Hands-on experience in at least one structural biology technique (e.g., NMR spectroscopy, X-ray crystallography, cryo-EM)
- Strong background in RNA biology or nucleic acid biochemistry
- Proven ability to work independently, manage time effectively, and troubleshoot experiments
- Excellent written and verbal communication skills
Preferred Qualifications
- Experience with RNA preparation and purification
- Familiarity with RNA structural probing methods (e.g., SHAPE, DMS mapping, RNase digestion)
- Experience in protein expression, purification, and RNA–protein complex reconstitution
- Exposure to small-molecule screening or RNA-targeted drug discovery
- Strong publication record in peer-reviewed journals
Application Instructions
Interested applicants should submit the following materials to Dr. Yaqiang Wang ([email protected] ):
- Cover letter outlining research interests and career goals
- Curriculum vitae (CV)
- Contact information for three professional references
Review of applications will begin immediately and continue until the position is filled.
About MCW and Milwaukee
The Department of Biophysics at the Medical College of Wisconsin has a rich tradition of innovation and excellence in structural biology and biomedical imaging, with particular strengths in EPR (electron paramagnetic resonance), NMR (nuclear magnetic resonance), and MRI (magnetic resonance imaging). The department offers access to state-of-the-art facilities for NMR (solution and solid-state), EPR, MRI, X-ray crystallography, cryo-EM, mass spectrometry, high-performance computing, and biomolecular analysis.
MCW is Wisconsin’s largest private research institution and the third-largest private medical school in the U.S. The institution fosters a collaborative environment that integrates basic science, clinical research, and education to advance biomedical knowledge and human health.
Milwaukee, located 90 miles north of Chicago along the western shore of Lake Michigan, is a vibrant city known for its cultural diversity, rich history, and natural beauty. Named one of National Geographic’s “Best of the World” destinations in 2023, Milwaukee offers a unique mix of urban energy and outdoor recreation. The city features renowned museums, a thriving music and culinary scene, historic neighborhoods, professional sports, and a wide range of festivals. Affordable housing, excellent schools, and a strong sense of community contribute to an outstanding quality of life. Learn more at www.visitmilwaukee.org.
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A postdoc position in the Torben Heick Jensen lab., Aarhus University, Denmark
Posted on July 1st, 2025
Mammalian Nuclear RNA Production and Turnover Systems
A postdoc position is available in the laboratory of Torben Heick Jensen at the Department of Molecular Biology and Genetics, Aarhus University, Denmark. We are looking for applicants with interests in the biogenesis and turnover of nuclear RNA and its relationship to gene expression regulation in mammalian cells. Applied methods range from cell biological over biochemical to molecular biology and bioinformatics approaches. Collaboration with structural biologists is possible.
Applicants should hold a PhD in Molecular Biology, Biochemistry, Cell Biology, Genomics, Bioinformatics or related fields. Applicants should be self-driven, motivated and capable of planning and conducting independent research while being willing to collaborate in an international and interdisciplinary team. Good communication skills in written and spoken English are essential, and applicants should have a strong publication record with clear contributions as first author.
In the Jensen team, projects are carried out independently or in interdisciplinary collaboration with leading structural- and/or mass spectrometry-biologists. The team consists of a dynamic mix of experimental and computational biologists aiming to examine the factors and complexes governing the production and turnover of eukaryotic transcriptomes.
Tax deduction benefits are available for non-Danish individuals. Apply using this link before August 15th 2025: https://mbg.au.dk/aktuelt/ledige-stillinger/job/a-postdoc-position-in-the-torben-heick-jensen-lab-aarhus-university-denmark-mammalian-nuclear-rna-production-and-turnover-systems. The position is available from 1st October 2025 or as soon as possible thereafter.
For further information contact: Professor Torben Heick Jensen. Tel.: +45 6020 2705, e-mail [email protected].
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Post-Doctoral Positions To Study Mechanisms Of Translation And Translation-Associated Quality Control Processes
Posted on June 18th, 2025
Two postdoctoral research positions are available in the laboratory of Tatyana Pestova and Christopher Hellen at the State University of New York Downstate Health Sciences University in Brooklyn, NY. Our NIH-funded research uses state-of-art biochemical and molecular biology approaches to characterize molecular mechanisms of (1) canonical and non-canonical modes of translation initiation in mammals, including IRES-mediated initiation, (2) physiologically important specific cases of translational regulation, (3) translation elongation, termination and ribosome recycling, and (4) events downstream of termination, with a major focus on quality control processes, including mRNA surveillance and ribosome-associated quality control.
Required qualifications include a Ph.D. in Molecular Biology/Molecular Biochemistry, and practical experience in RNA and/or protein biochemistry, including the expression and purification of native/recombinant proteins and the functional analysis of proteins and RNA-protein complexes. Experience in investigating aspects of eukaryotic translation and associated quality control processes will be highly appreciated. Our research involves active collaborations with leading cryoEM laboratories, and experience in structural biology would therefore be helpful. Candidates should be highly motivated, be able to work independently and show excellent critical thinking, scholarly ability and communication skills.
These positions carry a salary of $62,000 - $72,000 (depending on experience) plus benefits, including health insurance. Review of applications will begin immediately until the positions are filled. To apply, please send a cover letter discussing your interest in a position and mentioning the expected availability date, your curriculum vitae (with a summary of research experience, including techniques and methods used, and a list of publications) and contact information for three references to:
[email protected]
or
[email protected]
As an Equal Opportunity / Affirmative Action employer, the Research Foundation for SUNY will not discriminate in its employment practices due to an applicant's race, color, religion, sex, national origin and veteran or disability status. Personnel are chosen on the basis of ability without regard to Race, Color, Religion, Sex, Age, National Origin, Disability or Marital Status in Accordance with Federal and State Law.
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Call for Postdoctoral Candidate to Work on RNA Splicing – Marie Skłodowska-Curie Fellowship Opportunity
Posted on June 17th, 2025
Université Paris-Saclay, Évry, France
We are seeking a motivated PhD graduate interested in applying for a Marie Skłodowska-Curie Postdoctoral Fellowship (MSCA-PF) to join our laboratory at Université d'Évry, Université Paris-Saclay, France.
Our research group focuses on the characterization of molecular interactions involved in spliceosome assembly, which enable precise splice site recognition and regulate alternative splicing (Tari et al., EMBO Reports, PMID: 31271494).
In parallel, we are exploring small molecules that target splicing factors, offering promising therapeutic avenues for cancer treatment (Kobayashi et al., FEBS Journal, PMID: 34520118).
The selected candidate will work on the characterization of novel interactions recently identified in the lab, investigating their role in splicing regulation and their implications in cancer biology.
We welcome strong candidates and are committed to supporting the development of a competitive MSCA-PF application.
Application deadline for MSCA-PF: 10 September 2025
Location: Université Évry Paris-Saclay, Evry, France.
Contact: Alexandre Maucuer: [email protected]
Lab website: http://sabnp.univ-evry.fr/
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Postdoctoral position on the link between mRNA decay and transcriptional modulation near Frankfurt, Germany
Posted on June 2nd, 2025
The Stainier lab is seeking a highly motivated Postdoctoral Researcher with expertise in RNA biology to investigate a form of genetic compensation that we termed transcriptional adaptation. Briefly, transcriptional adaptation occurs upon mutant mRNA decay, for example due to a premature termination codon. The decay fragments would in turn modulate the expression of related/adapting genes, leading to varying degrees of phenotypic rescue, in some cases. We have observed this phenomenon in zebrafish, mouse, C. elegans, and more recently humans. This is a novel and quickly developing field of research where many open questions remain to be addressed including 1) the nature, possible modification, and localization/trafficking of the decay fragments, and 2) the regulation of related/adapting genes by the decay fragments. For more detailed information please see our recent publications: (https://www.nature.com/articles/s41586-019-1064-z; https://www.nature.com/articles/nature14580; https://elifesciences.org/articles/50014; https://www.embopress.org/doi/full/10.1038/s44319-025-00427-3; https://www.nature.com/articles/s41586-024-08539-x)
REQUIRED QUALIFICATIONS:
A Ph.D. in biology, biochemistry, genetics or a similar subject with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge of RNA and/or protein biochemistry and molecular biology is a plus.
ABOUT THE EMPLOYER:
The Max Planck Institute for Heart and Lung Research in Bad Nauheim is an interdisciplinary research institution with international flair. Our researchers have the opportunity to work on various model systems by making use of the latest cutting-edge technologies. Researchers are supported by state-of-the-art core facilities which offer services in next generation sequencing, proteomics, bioinformatics, cytometry, microscopy, and small animal imaging.
The Max Planck Society strives for gender and diversity equality; we welcome applications from all backgrounds. Furthermore, the Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
HOW TO APPLY:
For further information, please contact Prof. Didier Stainier ([email protected]).
To apply, please submit the names and contact information for 2-3 references, a CV, and a short statement (2 pages max.) of your research experience and interests to [email protected]
https://www.mpi-hlr.de/46552/developmental-genetics
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