Postdoctoral Position Available in Ailong Ke’s Laboratory at Yale University
Posted on May 28th, 2025
Location: New Haven, USA
Overview: A postdoctoral position is open in Ailong Ke’s Laboratory at Yale University. We utilize advanced biochemical and biophysical methodologies to explore molecular mechanisms in RNA-guided processes such as CRISPR-Cas and develop innovative genome editing applications. Detailed research information is available on our laboratory and departmental websites.
Possible areas of study:
- Structural Biology
- Projects: Mechanistic investigation of RNA-guided processes and novel bacterial immunity, studied in vitro and in situ.
- Ideal Candidate: Should have a strong background in nucleic acid biochemistry, cryo-EM or cryo-ET. Experience in microbial engineering is considered a plus.
- Resources: The lab provides routine access to Krios and FIB-milling instruments.
- Genome Editing
- Projects: Developing novel genome editing tools and enhancing in vivo delivery methods.
- Ideal Candidate: Should have a solid foundation in nucleic acid biochemistry, various deep sequencing techniques, and mammalian cell culture. Experience in mRNA synthesis and delivery or mouse work is considered a plus.
- Protein and RNA Engineering
- Projects: Developing or improving novel genome editing tools using AI or high-throughput approaches.
- Ideal Candidate: Should have expertise in AI, directed evolution, or deep mutational scanning.
Qualifications:
- Candidates must have published at least one first-author paper in a reputable journal.
- A Ph.D. or M.D. degree is required before the start date.
Application: Please send your CV, list of publications, and three recommendation letters to ailong.ke@yale.edu for consideration.
Representative Publications:
- Nat Chem Biol. 2024 Dec;20(12):1617-1628.
- Molecular Cell, 2024; 84(3): 463-475
- Science, 2022; 377(6612): 1278-1285
- Science, 2022; 376(6600): 1476-1481
- Nature, 2021; 598(7881): 515-520
- Molecular Cell, 2019; 74(5): 936-950
- Science, 2018; 361(6397)
- Nature, 2017; 550(7674): 137-141
- Cell, 2017; 170(1): 48-60
- Nature, 2016; 530(7591): 499-503
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Fully Funded Ph.D. Position in RNA Biology – Québec City, Canada
Posted on May 27th, 2025
A fully funded Ph.D. position is available in the laboratory of Dr. Dmitry Kretov at the Centre de recherche du CHU de Québec – Université Laval in Québec City, Canada, starting in Fall 2025.
Our young lab, launched in January 2025, investigates how RNA-binding proteins (RBPs) and microRNAs regulate gene expression during early embryonic development and cancer progression. This position is part of an NSERC-funded project titled "Development of an in vivo high-throughput screening platform to decipher post-transcriptional regulatory networks," which builds on our newly developed method, RBPscan, a quantitative tool for measuring RNA–protein interactions in vivo (Kretov et al., bioRxiv, 2025).
The selected Ph.D. candidate will apply and further develop this technique to decipher the binding specificities of RBPs involved in the assembly of RNA granules, using diverse biological models such as early zebrafish embryos, cancer cell lines, and induced pluripotent stem cells (iPSCs).
As a newly established lab, we offer close mentorship, a collaborative research culture, and a strong commitment to scientific and professional development. Our group is part of the dynamic Oncology Axis, based in a brand-new, state-of-the-art research center located in the beautiful and historic city of Québec, Canada.
We are looking for a highly motivated candidate with a Master’s degree in molecular biology, biochemistry, or a related field. Prior experience with wet-lab molecular biology techniques is required. The ideal candidate should be enthusiastic about learning new experimental approaches and exploring the frontiers of post-transcriptional gene regulation.
To apply, please send the following documents to dmitry.kretov@crchudequebec.ulaval.ca:
- Your curriculum vitae (CV).
- A motivation letter outlining your interest in the position.
- Contact information for at least three references.
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Postdoctoral Position in RNA Editing at Boston University
Posted on May 24th, 2025
A postdoctoral position is available in Prof. Ruslan Afasizhev's laboratory in the Department of Molecular and Cell Biology at Boston University Medical Campus. Our NIH-funded research program investigates the mechanisms of mitochondrial RNA editing and RNA processing in trypanosomes. Ongoing projects include mitochondrial transcription, mRNA editing, polyadenylation, translation, and small RNA biogenesis. We collaborate extensively in proteomics, bioinformatics, and cryo-electron microscopy. We have recently determined the first structures of RNA editing complexes, providing exciting opportunities for cutting-edge research.
Qualifications: A strong background in molecular biology and biochemistry, and a record of impactful peer-reviewed publications in RNA-related fields. Preferred experience with RNA-Seq, bioinformatics, protein purification, mass spectrometry, or interactomics.
Environment: Boston University Medical Campus, located in Boston's vibrant South End, provides an outstanding collaborative environment, extensive networking opportunities within a dynamic biomedical community in the Greater Boston Area, and excellent cultural and recreational resources.
Compensation: Starting postdoctoral salary of $70,000 plus comprehensive benefits.
Application: Interested candidates should send a letter of intent and CV to ruslana@bu.edu.
Relevant publications:
PNAS, 2018 (PMID 30333188)
Nature Communications, 2019 (PMID 30635574)
Trends in Parasitology, 2020 (PMID 32191849)
Nucleic Acids Research, 2020 (PMID 32614436)
Science, 2023 (PMID 37410820)
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Fully Funded PhD Student Position in Reproductive Biology
Posted on May 21st, 2025
We are offering a fully funded PhD student position focused on the regulation of male fertility through an interdisciplinary approach. Our current research centers on understanding the molecular and cellular mechanisms involved in the final maturation (capacitation) of sperm within the female reproductive tract, using a bovine model. Traditionally, sperm cells have been considered transcriptionally and translationally inactive. However, our recent studies challenge this dogma. We have shown that sperm contains full-length mRNA, which is actively translated during the capacitation process. Despite this discovery, the molecular mechanisms governing mRNA translation in sperm remain unknown.
The goal of this graduate student position is to reconceptualize translational quiescence in sperm by exploring the molecular basis of translational regulation. The ideal candidate should have a strong background in biochemistry and RNA biology, along with experience in advanced cellular and molecular biological techniques. Knowledge of reproductive biology would be an asset. The selected student will have the unique opportunity to develop expertise in various methodologies, including RNA extraction from sperm, reverse transcription polymerase chain reaction (RT-PCR), immunoblotting, mass spectrometry-based protein identification, polysome profiling, and ribosome profiling. This research will be conducted in collaboration with the Thakor lab at the University of Lethbridge, Artificial Insemination centers, and human fertility clinics. The successful candidate will have exemplary opportunities for professional skills development and career awareness.
The University of Calgary (UCalgary) is Canada's entrepreneurial university, situated in the country's most enterprising city. It is a leading research institution, consistently ranked among the top universities of its age. Founded in 1966, UCalgary is home to 36,000 students who benefit from an innovative learning environment enriched by research opportunities, hands-on experiences, and entrepreneurial thinking. For more information, please visit ucalgary.ca.
Please send a letter of motivation, current curriculum vitae, and contact information for at least three references to jthundat@ucalgary.ca and thakor.lab@uleth.ca. We thank all interested candidates; however, we will contact selected candidates only.
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