Call for PhD Candidate to Work on RNA Splicing and Neurodevelopmental disorders – DIM-C-BRAINS Fellowship OpportunityDecember 2nd, 2025 INSERM U1204 / SABNP / Université Paris-Saclay, Évry, France We are seeking a motivated Master student/graduate interested in applying for a DIM C-BRAINS PhD fellowship to join our laboratory at Université Évry Paris-Saclay, France. Our research group focuses on the characterization of molecular interactions involved in spliceosome assembly, which enable precise splice site recognition and regulate alternative splicing (Tari et al., EMBO Reports, PMID: 31271494). In parallel, we are exploring small molecules that target splicing factors, offering promising therapeutic avenues (Kobayashi et al., FEBS Journal, PMID: 34520118). Recent studies highlight that mutations impacting the RNA splicing machinery are recurrent in Neurodevelopmental Disorders, including autism spectrum disorders (ASD), intellectual disabilities (ID), attention-deficit/hyperactivity disorder (ADHD), and developmental language disorders. The successful candidate will work on the characterization of novel partners of the essential splicing factor U2AF2 that have been recently identified in the lab (Pankivskyi et al, under revision), investigating their role in splicing regulation and their implications in NDDs. We welcome strong candidates and are committed to supporting the development of a competitive DIMM C-BRAINS application. Application: https://dim-cbrains.fr/en/phd-program/dim-cbrains |