Position Overview
The Scientist / Senior Scientist (Infectious Diseases), Vaccines & Immunotherapeutics will develop mRNA immunotherapies across multiple therapeutic programs. This role is important in NATi’s development of immunotherapy candidates from discovery/pre-clinical to IND-enabling stages. The successful candidate will have prior experience and proven track record in the academic or biotech laboratory settings.
Key Responsibilities
- Support and execute the Vaccines R&D strategy in a creative, innovative manner.
- Develop and optimise laboratory methods for characterisation of the different RNA therapeutic modalities (e.g., mRNA, circRNA, saRNA, gRNA), focusing on protein translation and stability.
- Design and conduct in vitro assays to assess vaccine-specific responses and identify and quantify cellular targets and efficacy readouts for infectious diseases.
- Stay current with immunology, vaccinology literature and emerging platforms and provide scientific expertise in the areas of cellular and humoral immune responses to vaccines.
- Independently write protocols, procedures and develop and maintain SOPs to ensure reproducibility, compliance, and readiness for IND submission, contribute to CMC documentation.
- Prepare technical reports, presentations, and documentation to support internal decision-making and external regulatory submissions. Communicate results orally or written, internally or externally.
- Train and mentor junior lab personnel.
- Collaborate with scientists across multiple functions.
- Maintain accurate records using LIMS/ELN systems to support data integrity and reproducibility.
- Support tech transfer activities to external CDMOs, including preparation of reports, training, and troubleshooting support.
Qualifications & Experience
- PhD in Immunology or a related field with minimum of 8+ years of experience. Industry experience preferred.
- Detailed knowledge in immunology and cellular biology, mechanisms underlying autoimmune, allergy and inflammatory diseases with deep expertise in T-cell function and with emphasis on cytokine signalling, tolerance mechanisms, and immunopathology.
- Proven proficiency in immunophenotyping, particularly extensive hands-on experience with multi-color flow cytometry including panel design, staining fluency, compensation, and data analysis/interpretation.
- Strong record of accomplishment in advancing immunology-focused therapeutics and leading translational/biomarker initiatives.
- Proven ability to develop, validate and troubleshoot assays.
- Ability to work independently and collaboratively in a cross-functional, fast-paced multidisciplinary environment to effectively deliver results within reasonably established timelines.
- Knowledge and experience with in vivo models.
- Expertise developing mRNA-LNP therapeutics is highly desirable.
- Ability to work well with CROs.
- This position is based in Singapore. Successful candidates must be willing to relocate to Singapore.
Global Recruitment & Notes
NATi is conducting a global search for top-tier talent in RNA therapeutics and welcomes applications from leading pharmaceutical scientists and biotech innovators worldwide. Roles provide competitive compensation aligned with global industry standards, attractive benefits, and long-term career growth opportunities within Singapore’s biomedical innovation ecosystem. The eligibility criteria are not exhaustive; A*STAR may include additional selection criteria under its prevailing recruitment policies. Only shortlisted candidates will be notified.
