Apply Here: https://careers.a-star.edu.sg/job/Scientist%2C-Bioconjugation-&-Targeted-RNA-Delivery/1669-en_GB/
Position Overview
We seek a highly motivated, results-driven, bench-level scientist with strong expertise in bioconjugation and targeted delivery to support the development of ligand-oligonucleotide conjugates (LOCs) for extrahepatic RNA delivery. This role is focused on hands-on experimental work and project leadership, contributing directly to the design, synthesis, and characterization of LOCs that efficiently target tissues such as skeletal/cardiac muscles, adipose tissues, and ocular compartments with high selectivity. The successful candidate will lead individual projects and collaborate cross-functionally to identify and optimize LOCs with high tissue/cell selectivity and functional delivery.
Key Responsibilities
- Design and execute conjugation strategies to generate LOCs with optimized delivery profiles.
- Perform hands-on synthesis, purification, and analytical characterization of LOCs using diverse conjugation chemistries and linker designs.
- Collaborate closely with oligonucleotide chemists, biologists, and pharmacologists to evaluate LOCs in vitro and in vivo.
- Support CRO coordination and reagent sourcing for ligand libraries and conjugation reagents.
- Ensure reproducibility and analytical rigor across experimental workflows
- Maintain high-quality documentation of experimental procedures, results, and data interpretation.
- Contribute to innovation and IP generation through novel conjugation approaches and delivery strategies.
- Present findings in internal meetings and contribute to technical reports, publications, and patent filings.
Qualifications & Experience
- A doctorate degree in Chemistry, Chemical Biology, Organic/Medicinal Chemistry, or a related field.
- A minimum of 2-6 years of relevant industry experience in bioconjugation chemistry applied to LOCs, ADCs, PDCs, or targeted delivery systems
- Hands-on experience establishing conjugation chemistries (e.g., Click, lysine-/cysteine-based coupling, enzymatic ligation, stimuli-sensitive linkers) workflows for development of LOCs.
- Hands-on experience with multiscale purification methods (e.g., preparative RP-HPLC, affinity, ion-exchange, hydrophobic interaction, and size exclusion chromatography, tangential flow filtration) and the associated instruments.
- Deep understanding of analytical techniques (e.g., LC-MS, LC-HRMS, CE-SDS, DSC, HIC, NMR) coupled with hands-on experience developing analytical workflows for robust characterization of LOCs.
- Experience coordinating with CROs and cross-functional program leadership.
- Demonstrated innovation through IP, publications, IND filings, or other public disclosures.
- Excellent organizational, interpersonal, and verbal/written communication skills.
- This position is based in Singapore. Successful candidates must be willing to relocate to Singapore.
Global Recruitment & Notes
NATi is conducting a global search for top-tier talent in RNA therapeutics. We welcome applications from leading pharmaceuticals scientists and biotech innovators worldwide.
This role provides a highly competitive compensation package aligned with global industry standards, including attractive benefits and long-term career growth opportunities within Singapore’s thriving biomedical innovation ecosystem. Join us in shaping the future of RNA-based medicines and establishing Singapore as a world-class hub for nucleic acid therapeutics.
