RNA Collaborative seminars are held virtually every other Wednesday, from 4:00-5:00 pm EDT (8:00 -9:00 pm GMT) and are recorded and made freely available for viewing on the RNA Collaborative YouTube Channel.
If you have difficulty viewing an archived seminar or would like more information, please contact Stacey O’Neil at [email protected].
Previous Seminars
“HEXIM1 Directs a Cell Type-Specific Transcriptional Program”
Laurie Steiner, MD
Lindsey Distinguished Professor for Pediatric Research, Department of Pediatrics – Neonatology; Member, UR Center for RNA Biology, University of Rochester
“Mechanistic insights into complete transgene insertion by R2 retrotransposon proteins”
Connor Horton
Graduate student, Kathleen Collins Lab, University of California, Berkeley
“rRNA modifications create specialized cancer ribosomes that rewire cancer cell metabolism”
Adrianna Dabrowska, PhD
Postdoctoral Scholar, Davide Ruggero Lab, UCSF
Moderators:
Eric J. Wagner, PhD
Professor, Department of Biochemistry & Biophysics; Associate Director, UR Center for RNA Biology, University of Rochester Medical Center
and
Carolyn Sangokoya, MD, PhD
Assistant Professor, UCSF Department of Pathology; Broad Center of Regenerative Medicine and Stem Cell Research; Bay Area RNA Club; Founder and Executive Director, UCSF Women Physician-Scientists Supergroup
“Mechanism of mRNA decay inhibition by a bacterial pathogen effector”
Dr. Eugene Valkov
Stadtman Investigator, RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute
“Selective decay of interferon mRNAs controls antiviral immunity and innate memory”
Rachel Braun
BMB Graduate Student, University of Pennsylvania Perelman School of Medicine
Moderators:
Pedro Batista, PhD
Stadtman Investigator, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute
and
Jim Hoxie, MD
Penn Institute for RNA Innovation
“Temporal control of CRISPR-Cas9 activity using bio-orthogonal chemistry”
Dr. Maksim Royzen
Department of Chemistry & The RNA Institute, University at Albany
“The emergence of antibiotics resistance and the function of small regulatory RNAs in bacteria”
Prof. Eric Massé
Université de Sherbrooke
Moderators:
Dr. Alan Chen
Department of Chemistry & The RNA Institute, University at Albany
and
Prof. Michelle Scott
Université de Sherbrooke
“3′-end stabilization increases cellular half-life and improves potency of mRNA therapeutics”
Alicia Bicknell, PhD
Former Scientific Director of RNA Biology, Moderna Therapeutics
“Application of RNA activation for the treatment of sickle cell disease”
Bríd Ryan, PhD
Chief Scientific Officer, MiNA Therapeutics
Moderators:
Frank Slack, PhD
Shields Warren Mallinckrodt Professor of Medical Research
Director, HMS Initiative for RNA Medicine
Director, Cancer Research Institute
Departments of Medicine and Pathology
BIDMC Cancer Center/Harvard Medical School
Moderators:
Dr Selene Fernandez Valverde
Senior Lecturer RNA New Research Talent Program, UNSW RNA Institute
and
Julia Alterman
Assistant Professor, RNA Therapeutics Institute, UMass Chan Medical School
“Gene Silencing by cityRNAs”
Kotaro Nakanishi, PhD
Professor, Department of Chemistry and Biochemistry, The Ohio State University
“Getting the message across: a structural mechanism for selecting diverse mRNAs for subcellular localisation”
Simon Bullock, PhD
MRC Laboratory of Molecular Biology, Cambridge, UK
Moderators:
Rene Arvola
Postdoctoral Scholar, Singh and Amacher Lab, Department of Molecular Genetics, The Ohio State University
and
Susanne Bornelöv, PhD
Department of Biochemistry, University of Cambridge, UK
UNC RNA Discovery Center & Singapore NUS RNA Supergroup
“How Do Small Molecules Bind RNA?”
Yinglong Miao, PhD
Associate Professor, Pharmacology & Computational Medicine Program
“Investigating changes in alternative splicing during influenza A virus infection”
Jessica HO, PhD
Assistant Professor, Signature Research Programme in Emerging Infectious Diseases, Duke-NUS Medical School
Moderators:
Chad Pecot, MD
Director, Professor, Division of Oncology – UNC-Chapel Hill
Yale Center for RNA Science and Medicine & Harvard Medical School Initiative for RNA Medicine (HIRM)
mRNA stabilization by chemical modifications in drug-resistant glioblastoma
Siggy Nachtergaele, Ph.D.
Assistant Professor, Molecular, Cellular & Developmental Biology
Circular RNA: Engineering, Manufacturing, Medicine
Alex Wesselhoeft, PhD
Director of RNA Therapeutics, Gene & Cell Therapy Institute, MGB, HMS Instructor, Division of Engineering in Medicine, BWH
Moderators:
Karla M Neugebauer, PhD
R. Selden Rose Professor of Molecular Biophysics and Biochemistry and Professor of Cell Biology
and
Frank Slack, PhD
“The tight regulation of RNA-DNA hybrids at short telomeres promotes repair and delays senescence onset”
Adjunct Director, Institute of Molecular Biology (IMB), Mainz
Professor at the Faculty of Biology, Johannes Gutenberg University of Mainz, Germany
“Capture me if you can: identification of long noncoding RNAs in vertebrate genomes”
Barbara Uszczyńska-Ratajczak, PhD
Group Leader, Computational Biology of Noncoding RNA, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland
Moderators:
Aaquib Mohd, PhD student
Rene Ketting Lab, IMB Mainz
and
Zbigniew Warkocki, PhD
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland
University of Rochester Center for RNA Biology & University of Michigan Center for RNA Biomedicine
“Discovery and Therapeutic Applications of RNA “Stitching””
Doug Anderson, PhD
Assistant Professor of Medicine, Cardiovascular Research Institute (CVRI)
Member, University of Rochester Center for RNA Biology: From Genome to Therapeutics
“High-Throughput Identification of Small Molecule Inhibitors Targeting OncoMiR-181a for Cancer Therapy”
Grace McIntyre, PhD Student
Analisa DiFeo laboratory – Department of Pathology, University of Michigan
Center for RNA Biomedicine
“Real-time Monitoring of Ligand Recognition by a Riboswitch during Transcription”
Adrien Chauvier, PhD. Research Lab Specialist
Nils Walter laboratory – Department of Chemistry, University of Michigan|
RNA Center for Biomedicine
Moderators:
Eric J. Wagner, Ph.D.
Professor, Department of Biochemistry and Biophysics
Associate Director, Center for RNA Biology
Wilmot Cancer Institute
University of Rochester School of Medicine and Dentistry
and
Nils G. Walter
Francis S Collins Collegiate Professor of Chemistry, Biophysics, and Biological Chemistry
Director, Single Molecule Analysis in Real-Time (SMART) Center
Co-Director, Center for RNA Biomedicine (https://rna.umich.edu)
Associate Director, U-M PREP NIH Postbac Program
Department of Chemistry, University of Michigan
European Molecular Biology Laboratory (EMBL) & RNA Initiative at the Italian Institute of Technology
Speaker 1: Eva Kowalinski, Group Leader, EMBL-Grenoble “SL RNA recognition by the unusual trypanosomatid cap-binding complex”
Speaker 2: Valeria Famà, PhD Student, Center for Genomic Science of IIT@SEMM, Istituto Italiano di Tecnologia (IIT), Milan, Italy, “Subcellular dynamics of RNA metabolism: the hidden life of RNAs”
Moderators:
Sora Matsumoto, EMBL-Heidelberg
Chiara Finocchiaro, Center for Genomic Science of IIT@SEMM
Speaker 1: Jens Hör, PhD, Group Leader, Helmholtz Institute for RNA based Infection Research, Junior Professor, University of Würzburg “Insights into the role of RNA in bacterial immunity and phage replication”
Speaker 2: Jie Ren, PhD, Beijing Institute of Genomics, Chinese Academy of Sciences “Nascent RNA at the crossroad of transcription and replication”
Moderators:
Neva Caliskan; HIRI
Chao-Po Lin, Shanghai RNA Club
Speaker Dennis Halterman, “Molecular warfare between plants and microbes at the RNA level”
Speaker Mark Lea, “The role of mRNA modifications in ribosomal decoding: a molecular dynamics study”
Speaker Jessica Willi, “Back to the future: how ancient ribosomes could unlock efficient biotech”
Moderators:
Speaker Thomas Gonatopoulos-Pournatzis, PhD, “Genome-Scale Exon Deletion Screens Reveal Exons Critical for Cell Fitness and Gene Expression“
Speaker Emmanouil “Manolis” Maragkakis, PhD, “Regulation of RNA stability and translation in stress response and senescence“
Moderators:
Speaker Julie Claycomb, “Proximity Labeling Identifies Putative Germ Granule and Small RNA Factors in C. elegans“
Speaker Hosna Jabbari, “From RNA Structure to Function“
Moderators:
Speaker Shenglong Zhang, “Empowering Mass Spectrometry for De Novo Unbiased Sequencing of RNA Modifications“
Speaker Sweta Vangaveti, “Elucidating the influence of RNA modifications and Magnesium ions on tRNAPhe conformational dynamics using Molecular Dynamics Simulations“
Moderators:
Speaker Edward Kreider, “ In vivo expression of pathogen-specific antibodies from mRNA“
Speaker Jilian Melamed, “ olerogenic mRNA-LNP vaccines for autoimmune disease“
Moderators:
Speaker Wen Tang, “Mechanisms of piRNA Production and Degradation”
Speaker Gina Nostramo, “FitRNAs for duty: Free introns of tRNAs as complementarity-dependent regulators of gene expression”
Moderators:
Speaker Wei Jiangbo, PhD, “FTO-LINE1 RNA axis in mESCs and mouse development”
Speaker Guo Huili, PhD, “ ROS-induced translational regulation—through spatiotemporal differences in codon recognition—is a key driver of brown adipogenesis“
Moderators:
Speaker Anna Baud, PhD, “IGF2BPs directly regulate non-canonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats”
Speaker Monika Piwecka, PhD, “ Interrogation of RNA-Bound Proteome with XRNAX Illuminates Molecular Alterations in the Mouse Brain Affected with Dysmyelination“
Moderators:
Dawid Bielewicz
Speaker Carine Tisné, PhD, “Structural basis of human mitochondrial tRNA maturation”
Speaker Sébastien Campagne, PhD, “Pending“
Moderators:
Speaker Upasna Sharma, “Sperm Small RNA-mediated Intergenerational Depigenetic Inheritance”
Speaker Daniel Kim, PhD, “Non-Invasive Insights into Health and Disease via Extracellular RNA“
Moderators:
Harry Noller, Director
Speaker Pending, “Pending”
Speaker Pending, “Pending“
Moderators:
Pending
Speaker Miona Corovic, “m6A sites in the coding region trigger translation-dependent mRNA decay”
Speaker Ann-Sophie Seistrup“Investigating the Distinctions of Worm-Specific Argonautes in the Germline of Caenorhabiditis elegans“
Moderators:
Joao Marques
Speaker Yi Yang, PhD, “Imaging RNA dynamics with bright and stable fluorescent RNAs”
Speaker Qiang Liu, PhD, “Pending“
Moderators:
Speaker Jörg Vogel, “The promise and challenge of programmable RNA antibiotics”
Speaker Pending, “Title Pending“
Moderators:
Pending
Speaker Mariangela Morlando, PhD , “A novel role of non-coding RNAs as crucial tethering molecules in regulating gene expression”
Speaker Francesco Di Palma, PhD, “The ribosome stalling mechanism induced by the human XBP1u arrest peptide at atomistic level”
Moderators:
Speaker Weirui Ma, “Multivalent 28S rRNA Is the Organizer of the Nucleolus’s Multi-layered Architecture”
Speaker Di Chen, “Reading the m6A-encoded regulation in the differentiation of embryonic stem cells“
Moderators:
Xin Li
Speaker Ana Tufegdžić Vidaković, “Ubiquitin-mediated control of RNA polymerase II at the onset of the transcription cycle”
Speaker Kostas Tzelepis, PhD, “Therapeutic targeting of RNA and its modifications“
Moderators:
Speaker Matthew Simon, PhD, “Insights into regulated gene expression from RNA and protein chemistry”
Speaker Jun Lu, PhD, “ Cell surface RNAs in neutrophils “
Moderators:
Speaker Zachary Robinson, “DDX1 unwinds and retains NEAT1 lncRNA inside nuclear bodies”
Speaker Indu Negi, PhD, “ Unravelling the dynamics of ykkC-I riboswitch: Insights into bacterial metabolism and metal ion-induced allostery through MD simulations“
Moderators:
Speaker Alain Laederach, “pre-mRNA structure change in controlling alternative splicing”
Speaker Mauro Calabrese, “Ectopically expressed Airn lncRNA recruits Polycomb to chromatin without inducing gene silencing“
Moderators:
Speaker Andrei Korostelev, PhD, “Molecular mechanism of angiogenin activation”
Speaker Julia Alterman, PhD, “Delivering siRNA to the skin: an investigation of novel chemistry and routes of administration“
Moderators:
Speaker Olivier Duss, “Tracking assembly and function of single active RNPs in real-time”
Speaker Lucía Álvarez, “The molecular dissection of TRIM25‘s RNA-binding mechanism provides key insights into its antiviral activity“
Moderators:
Speaker Karli Lipinski, “Regulation of 3ʹ splice site selection by yeast splicing factor Fyv6”
Speaker Lauren Mazurkiewicz, “Effects of diphthamide modification on translational fidelity and the yeast proteome”
Speaker: Saeed Roschdi, “Conformational variability of poly (UG) RNA: Complex folds from simple sequences”
Moderators:
Prof. Aaron Hoskins
Speaker Amanda Larracuente, PhD, “Satellite DNAs and Small RNAs in Drosophila”
Speaker John Lueck, PhD, “Development of Therapeutic Anticodon Edited (ACE)-tRNA Technologies for Nonsense Associated Diseases”
Moderators:
Speaker John Prensner, MD, PhD, “ Functions of non-canonical open reading frames in cancer“
Speaker Michelle Hastings, PhD, “Title Pending“
Moderators:
Speaker Dr. Xiaolin Wang, “A mammalian conserved circular RNA CircLARP1B regulates hepatocellular carcinoma metastasis and lipid metabolism”
Speaker Dr. Shouhong Guang, “ Germ granule compartments coordinate specialized small RNA production in C. elegans“
Moderators:
Speaker Jakub Dolata, Postdoctoral Research, “microRNA biogenesis: co-transcriptional regulation and RNA modifications”
Speaker Zbigniew Warkock, PhD Postdoc, “LINE-1 mRNA 3’ end dynamics shape its biology and retrotransposition potential“
Moderators:
Speaker Gillian Rrexroad, “Rethinking the Role of GTP Hydrolysis in Ribosomal Translocation”
Speaker Jeremy Sanford, PhD, “ CURE-ing the exon-identity crisis“
Moderators:
TBA
Speaker TBA, “Title TBA”
Speaker TBA, “Title TBA”
Moderators:
TBA
Speaker Arun Richard Chandrasekaran, PhD, “Dynamic control of nucleic acid nanostructures using RNA and RNA degrading enzymes”
Speaker Hannah Shorrock, PhD, “Alternative splicing dysregulation in CAG expansion Spinocerebellar Ataxias”
Moderators:
Speaker Carmelo Nucera, MD, PhD, “Identification of a new lincRNA in the thyroid gland”
Speaker Amanda Whipple, PhD, “Regulation of imprinted gene expression in the brain“
Moderators:
Speaker Anuja Kibe, PhD, “The translational landscape of HIV-1 infected cells reveals novel gene regulatory principles”
Speaker Patrick Bohn, “Native long read RNA structure probing to reveal RNA interaction sites”
Speaker Sahil Sharma, PhD, “Endogenous RNA targeting by RNA-guided nuclease Cas9 in its native host”
Moderators:
Speaker Anthony Khong, Ph.D, “Stress granules promote chemoresistance by enhancing p21 levels and triggering cell cycle exit”
Speaker Pek Jun Wei , PhD, “Stable intronic sequences RNA: an expanding universe“
Moderators:
Speaker Natasha Caplen, Ph.D., “hnRNPs, RNA biosynthesis, and disease: Insights from a fusion-driven cancer”
Speaker Sarah Dremel, Ph.D., “Consequences of circular RNA escape during herpesvirus host shut off“
Moderators:
Speaker Shuai Liu, PhD, “Lipid-based nanoparticles for organ selective mRNA delivery”
Speaker Aiming Ren, PhD, “Structure-based investigations of the working mechanisms underlying some specific non-coding RNA molecules“
Moderators:
Xin Li, PhD
Speaker Haissi Cui, PhD, “Mammalian aminoacyl-tRNA Synthetases in mRNA translation and beyond”
Speaker Marc Fabian, PhD, “Exploring how biomolecular condensates can regulate mRNA decay”
Moderators:
Speaker Sara Corvigno, PhD, “Enhanced vesicles for nucleotide delivery for cancer therapy”
Speaker Paola Amero, PhD, “Aptamer chimera for therapeutic delivery“
Moderators:
Speaker Erin Sternburg, PhD, “RGG motifs govern nuclear localization, RNA-binding, and stress granule recruitment of the neurodegeneration-linked RNA-binding protein FUS”
Speaker Nadezda Podvalnaya, “piRNA processing by a trimeric Schlafen-domain nuclease“
Moderators:
)
Speaker Damiano Mangoni, PhD, “L1 ncRNAs at striatal circuits promote transition from flexible to inflexible behavior”
Speaker Laura Broglia, PhD, “A circular-linear cooperative RNA network regulates cardiomyocyte differentiation by Sam68“
Moderators:
Speaker Fei-Long Meng, PhD, “Mesoscale DNA Feature in Antibody-Coding Sequence Facilitates Somatic Hypermutation”
Speaker Hua-Bing Li, PhD, “RNA Modification in Immunity“
Moderators:
Speaker Daniel Dominguez, PhD, “Title TBA”
Speaker Owen Fenton, PhD, “Development and Evaluatoin of Non-Viral RNA Delivery Platforms“
Moderators:
Chad Pecot, MD
Speaker Mélanie Ethève Quelquejeu, “RNA-cofactor conjugates as bisubstrates for the study of RNA methyltransferases”
Speaker Zeynep Baharogl, “ Epitranscriptomic adaptation to antibiotics: queuosine tRNA modification in Vibrio cholerae“
Moderators:
Speaker Gloria Brar, PhD, “Genomic expression cassettes drive unexpected RNAs and off-target effects”
Speaker Rhiju Das, PhD, “ Progress in RNA 3D modeling?“
Moderators:
Speaker Elizabeth Trofimenkoff, “On the mathematical modeling of eIF5B-mediated non-canonical translation initiation as a chemotherapeutic target”
Speaker Darren Gemmill, “Nucleolin Interacts with ZIKV RNA Terminal Regions and Modulates Virion Assembly“
Moderators:
Laura Keffer-Wilkes
Speaker Stefania Nicoli, PhD, “The hidden life of mRNAs: a non-coding role as sensors of cell environment”
Speaker Carson Thoreen, PhD, “Functions of mRNA 5′ terminal sequences“
Moderators:
Speaker Dmitri Ermolenko, “To what extent do mRNA stem-loops pause the translating ribosome?”
Speaker Joseph Wedekind, “The preQ1 riboswitch family uses multiple knotty strategies to control translation“
Moderators:
Speaker Simone Heber, “Tropomyosin 1-I/C co-ordinates kinesin-1 and dynein motors during oskar mRNA transport”
Speaker Jonas Tholen, “The structural basis of intron branch site recognition by the human spliceosome“
Moderators:
Speaker Chengming Zhu, “USTC complex and UAD-2 regulate piRNA transcription in C. elegans”
Speaker Liang Chen, “ Exportin 4 in the nuclear export of exonic circRNAs“
Moderators:
Rachel Niederer, Ph.D., “Regulation of ribosome activity and structure by a key neurotransmitter in sensory neurons”
Jay Querido, Ph.D., “The Structural Basis of Translational Initiation and its Regulation by the RNA Helicase eIF4A“
Moderators:
Speaker Upasna Sharma, “Sperm Small RNA-mediated Intergenerational Depigenetic Inheritance”
Speaker Daniel Kim, PhD, “Non-Invasive Insights into Health and Disease via Extracellular RNA“
Moderators:
Harry Noller, Director
Lijun Zhou, Ph.D., “Exploring the ‘RNA World’ with non-natural nucleic acid”
Robert Wang, “Long-read strategies to study the human transcriptome”
Moderators:
Paolo Forni, “Single cell transcriptome of the vomeronasal organ of mice, new findings, new questions”
Kaalak Reddy, “Functional consequences of disease-associated inosine misincorporation into RNA”
Moderators:
Ryan Flynn, “glycoRNAs: bridging the gap between glycobiology and RNA biology”
Sylvie Rouskin, “Viral RNA structures as regulators of gene expression and therapeutic targets”
Moderators:
Redmond Smyth, “Probing the structure and function of viral RNAs”
Bhupesh Prusty, “Regulation of miRNA processing by other miRNAs through sequence specific RNA:RNA interactions”
Moderators:
Daniel G. Tenen, “Weird nuclear noncoding RNAs regulating DNA methylation, mRNA transcription, and DNA replication”
Yue WAN, “Mapping RNA structures in single cells”
Moderators:
Pedro Batista, Ph.D., “Re-wiring of RNA methylation by oncometabolites in kidney cancer”
Joana Vidigal, Ph.D., “AGO2 unchained: in vivo roles in the miRNA pathway and beyond”
Moderators:
Ildar Gainetdinov, Ph.D., “Why do animals need two Argonaute families with different catalytic properties?”
Karina Jouravleva, Ph.D., “Structural basis for accurate and efficient microRNA biogenesis by Dicer”
Moderators:
“ZAPping out the virus”
Anuja Kibe, Helmholtz Institute of RNA-based Infection Research (HIRI)
“How to use Cytoplasmic Stress Granules to Better Treat Cancer”
Gabriel Faber, Bar Ilan University
“Blocking the evolutionary escape of viruses”
Fabian Rohden, University of Manitoba
Moderators:
Michelle Scott, “From ribosome biogenesis to gene expression regulation: small nucleolar RNAs (snoRNAs) target a wide transcriptome”
Peter Unrau, “RNA Mango aptamer tools: RNA imaging, sensors and RNA-protein complex pulldowns”
Moderators:
Elaine Stur, “Spatially resolved transcriptomics of high-grade serous ovarian carcinoma”
Menlanie Winkle, “Anti-miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response”
Moderators:
Julian Koenig, “FUBP1 is a new core component of 3′ splice site recognition that facilitates the splicing of long introns”
Kathi Zarnack, “High-throughput mutagenesis identifies mutations and RNA-binding proteins controlling CD19 splicing and CART-19 therapy resistance”
Moderators:
Roberto Giambruno, “RNA-host protein interaction analyses reveal additional proteins involved in SARS-CoV-2 RNA biology”
Caterina Gasperini, “Dissecting the role of Piwil2 (Mili) in neural stem cell fate”
Moderators:
Rujuan Liu, “Catalyzing tRNA, mRNA or others? The multifaceted role of tRNA modifying enzymes”
Hui Yang, “Structural insights into substrate targeting and inhibition of CRISPR-Cas systems”
Moderators:
Christine Roden, “SARS-CoV-2 nucleocapsid protein-RNA interactions encode viral functions”
Aki Braceros, “Counterbalanced interactions between DNA regulatory elements control long-distance epigenetic silencing by the Airn lncRNA”
Moderators:
Marc Graille, “TRMT112, a master regulator of RNA methyltransferases modifying factors involved in mRNA translation”
Andrey Klymchenko, “Fluorescent nanoparticles for amplified detection and imaging of RNA in solution and cells”
Moderators:
Julia Salzman, “Developmentally regulated RNA isoforms expression programs revealed by scRNA-seq”
Mark Ansel, “Dissecting post-transcriptional circuits in immune responses”
Moderators:
Kathryn Lilley, Ph.D., “The spatial organisation of the cell”
Alex Borodavka, Ph.D., “Putting the spotlight on the molecular choreography of viral RNAs”
Moderators:
Luke Saville, “NERD-seq: A novel approach of Nanopore direct RNA sequencing that expands representation of non-coding RNAs”
Athan Zovoilis, “Dissecting the role of SINE non-coding RNAs in brain health and disease”
Moderators:
Josien van Wolfswinkel, Ph.D., “The role of PIWI proteins and piRNAs in the eternal life of planarian stem cells”
Stephanie Halene M.D.,Ph.D., “U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies”
Moderators:
Mainak Bose, PhD (Ephrussi group), “Liquid or solid – Do material properties of RNP granules matter in vivo?”
Pravin Jagtap, PhD (Hennig group), “Molecular insights into the remodelling of roX lncRNA during Drosophila dosage compensation”
Moderators:
Peng Yao, PhD, “Hyperactive translation programs during cardiac remodeling”
Eric J. Wagner, PhD, “Unexpected interactions with the integrator complex”
Moderators:
Ge Shan, Ph.D., “CircRNA subclasses and functions”
Xiaoyuan Song, “The role of long noncoding RNAs in brain aging”
Moderators:
Kristin Koutmou, Ph.D., “Consequences of uridine modifications on translation”
Peter Todd, M.D., Ph.D., “Repeat associated Non-AUG initiated Translation in neurodegenerative disease”
Moderators:
Justin Mabin, Ph.D., “Human spliceosomal snRNA sequence variants generate variant spliceosomes”
Bo Peng, Ph.D., “Characterization of RNA binding protein regulation in neural stem cell quiescence exit”
Brian Carrick, Ph.D., “Unraveling the multiple key roles of a single RBP in development”
Moderators:
Annalisa Di Ruscio, M.D., Ph.D. “A RNA-guided approach to epigenetic therapy”
Ioannis Vlachos, Ph.D. “Efficient integration of spatial transcriptomics and single cell sequencing technologies for in depth tissue interrogation”
Moderators:
Kathryn Hamilton, PhD “IMP-licating RNA binding proteins in intestinal tissue regeneration”
Peter Choi, PhD “Consequences of RNA-binding protein mutations in cancer”
Moderators:
Gabriele Fuchs, PhD “RACK1 as a regulator of Protein biosynthesis”
Cara Pager, PhD “RNA Shapes Zika virus gene expression”
Moderators:
Jeremy Sanford, PhD “Post-transcriptional control of oncogenic gene expression by IGF2BP3”
Michael Stone, PhD “Multiplexed single-molecule analysis of human telomerase catalysis”
Moderators:
Chase Beisel, PhD “CRISPR-Cas systems and the dilemma(s) of adaptive immunity”
Antoine-Emmanuel Saliba, PhD “Uncovering host-pathogen interaction modalities using single-cell RNA-seq and RNA metabolic labeling”
Moderators:
Polly CHEN “Crosstalk between RNA editing and RNA splicing”
Yvonne TAY “Widespread 3’UTR splicing promotes oncogene expression and tumorigenesis”
Moderators:
Astrid Haase, MD, PhD “A small RNA perspective on genomic conflict”
John (Jay) Schneekloth, Jr, PhD “Targeting RNA with small molecules: tools and tactics”
Moderators:
Jenna Lentini (PhD student) “DALRD3 targets specific arginine-tRNAs for 3-methylcytosine modification”
David Mathews, MD, PhD “Using conservation to determine RNA secondary structure”
Moderators:
Dorothee Dormann, PhD “Regulation of neurodegeneration-linked RNA-binding proteins by nuclear import receptors and post-translational modifications”
René Ketting, PhD “Small RNAs and epigenetic inheritance”
Moderators:
Éric Lécuyer, PhD (IRCM, Montreal Clinical Research Institute), “Insights into the subcellular travels of cellular RNAs and RNA binding proteins”
Moderators:
Sherif Abou Elela
Paola Amero, Ph.D. “Conversion of RNA Aptamer into Modified DNA Aptamers Provides for Prolonged Stability and Enhanced Antitumor Activity”
Santosh Kumar Dasari, Ph.D. “New directions in targeting cancer epigenetics”
Moderators:
Stefano Gustincich, PhD, “SINEUPs: a new functional class of antisense long non-coding RNAs”
Moderators:
Sethu Pitchiaya, Ph.D. “Dynamic multivalent interactions drive mammalian RNA regulation”
Chase Weidmann, Ph.D. “Characterizing cellular RNA-protein interaction networks with chemical probes”
Moderators:
Wendy V. Gilbert, PhD “Revealing new functions for ancient RNA modifying enzymes in health and disease”
Antonio Giraldez, PhD “Mechanisms of posttranscriptional regulation during the maternal to zygotic transition”
Moderators:
Lena Anastasakou, Ph.D. “An evolutionarily conserved structure-to-function axis governs the functional mechanism of the regulatory lncRNA MEG3”
François Dossin, Ph.D. “Mechanistic dissection of SPEN function during X chromosome inactivation.”
Moderators:
Jean-Louis Mergny, Ph.D. “Quadruplexes are everywhere”
Alexandre David, Ph.D. “RNA Epigenetics steers colorectal cancer cell fate”
Moderators:
Gonçalo Bernades, Ph.D. “A small-molecule targeted RNA degradation approach: empowering RNA methylation analysis”
Lori Passmore Ph.D. “Mechanistic insight into the mRNA poly(A) tail machinery”
Moderators:
Jinbiao Ma, Ph.D., “Structural insights into molecular mechanism for N6-adenosine methylation by MT-A70 family methyltransferase METTL4”
Qiangfeng Zhang, Ph.D., “A fight against SARS-CoV-2 powered by RNA structure systems biology and machine intelligence”
Moderators:
Jinzhong Lin, Ph.D.
Stephen Floor, Ph.D. (UCSF), “RNA chaperones remodel gene expression”
Le Cong, PhD (Stanford), “Data-inspired genome technology for RNA-guided recombineering and lineage recording”
Moderators:
Li Li, Ph.D., “Efficient chemical RNA copying with 2-aminoimidazole activated nucleotides”
Wenwen Fang, Ph.D., “Sensing RNA: from microRNA biogenesis to innate immunity”
Moderators:
Luc Roberts, Ph.D., “Grad School to Biotech: A start up perspective”
Kristi Turton & Riya Roy, “RNA Innovation: The power of academic and industry collaborations”
Moderators:
Melissa J. Moore, Ph.D., Moderna Therapeutics, “A timely confluence: The backstory of Moderna’s COVID-19 vaccine“
Moderators:
Nils Walter, Ph.D., Co-Director, U-M Center for RNA Biomedicine
Neva Caliskan, Ph.D., “Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch”
Mathias Munschauer, Ph.D., “The SARS-CoV-2 RNA–protein interactome in infected human cells”
Moderators:
Nicholas Guydosh, PhD “Ribosome collisions and sites of quality control revealed by ribosome profiling”
Katherine McJunkin, PhD “CRISPR screening to identify biologically important microRNA targets”
Moderators:
Sandra Wolin, MD, PhD
Ina Huppertz, Ph.D. “RNA regulates Glycolysis and Embryonic Stem Cell Differentiation via Enolase 1”
Olivier Duss, Ph.D. “Co-transcriptional RNP complex assembly in real-time: How transient protein-RNA interactions guide nascent ribosomal RNA folding”
Moderators:
Matthias Hentze, MD
Daniel Kim, PhD “RAS signaling regulates the noncoding transcriptome”
Susan Carpenter, PhD “How do noncoding RNAs contribute to inflammation?”
Moderators:
Harry Noller, PhD
Suneet Agarwal, M.D., Ph.D. “Targeting telomerase RNA in degenerative diseases”
Carmelo Nucera. M.D., Ph.D. “Role of coding and non-coding genes in aggressive thyroid cancer”
Moderators:
Frank Slack, PhD
Paul Boutz, Ph.D. “Tumors taking the short cut: CDK12 and CDK13 in early transcription termination and nuclear RNA surveillance”
Clara Kielkopf, Ph.D. “Targeting U2AF: A vulnerable rheostat of pre-mRNA splicing”
Moderators:
Kathy Fange Liu, Ph.D. “RNA species dance to the beat of modifications”
Yoseph Barash, Ph.D. “Splicing quantification from RNASeq – How to get the signal out of the noise?“
Moderators:
Sue Hammoud, Ph.D. “Same Same Different: Single cell RNAseq identifies conserved and divergent features of mammalian spermatogenesis”
Justin Colacino, Ph.D. “Single cell transcriptomic profiling to understand breast stem cell heterogeneity in development and cancer disparities“
Moderators:
Mats Ljungman, Ph.D
Siyuan (Steven) Wang, Ph.D. “Image-based spatial genomics and transcriptomics”
Junjie Guo, Ph.D. “RNA decay deficits cause neurodegeneration in ALS/FTD”
Moderators:
Karla Neugebauer
Shuo Gu, Ph.D. “A tale of tails: How 3’ uridylation alters miRNA function”
Voula Mili, Ph.D. “Local co-translational interactions control protein function”
Moderators:
Sandra L. Wolin, MD, PhD
Tim Yu, MD, PhD. “Prospects for hyper-individualized RNA medicines”
Shobha Vasudevan, Ph.D. “A specialized post-transcriptional program in chemoresistant, quiescent cancer cells”
Moderators:
Frank Slack, Ph.D.
Mitch O’Connell, Ph.D. “Programmable RNA-targeting by CRISPR-Cas enzymes”
Xin Li, Ph.D. “Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs”
Moderators:
Lynne Maquat, Ph.D.
Dr. Simone Anfossi, Ph.D. “ncRNAs: ‘inside out’ cancer regulomers”
Dr. Cristian Rodriguez-Aguayo, Ph.D. “Therapeutic Targeting of ncRNAs in Cancer”
Moderators:
George Calin
Athma Pai, Ph.D. “How efficiently do cells create mRNA? Balancing speed and accuracy in gene regulation”
Jonathan Watts, Ph.D. “Fighting an RNA virus with an RNA drug”
Moderators:
Phil Zamore
Francois Bachand, Ph.D. “Nutrient-dependent control of RNA polymerase II elongation rate regulates gene expression programs by alternative polyadenylation”
Andrew McMillan, Ph.D. “Spliceosome Structure: Can the Blind Men Now Describe the Elephant?”
Moderators:
Sherif Abou Elela
Morgan Sammons, Ph.D. “Regulatory paradigms controlling a core stress response”
Alan Chen, Ph.D. “Simulating RNA folding pathways in 3D using sparse experimental constraints”
Moderators:
Marlene Belfort, Ph.D.
Peter Freddolino, Ph.D. “It’s not the gene, it’s the neighborhood: Effects of large scale chromosomal structure on bacterial transcription”
Stephanie Moon, Ph.D. “A link between translation quality control and mRNA targeting to stress granules”
Moderators:
Nils Walter, Ph.D.
Sarah Slavoff, Ph.D. “Regulation of RNA decapping and phase separation by a human polypeptide”
Nadya Dimitova, Ph.D. “Long Noncoding RNAs in Cancer: What, Where and How?”
Moderators:
Karla Neugebauer, Ph.D.
