Sr. Associate Scientist/Scientist, Production: Process Development

Posted on May 25,

Orna is a Cambridge-based biotechnology startup on a mission to create therapies for diseases inaccessible to existing approaches. Built on novel circular RNA technology developed at MIT, Orna is leading the next wave of RNA therapeutics with our best-in-class expression and delivery platform. We are seeking an exceptional scientist to join our RNA production and early process development team as a Sr Associate Scientist/Scientist. The successful candidate will work with cross-functional teams to advance our oRNA™ platform through rigorous process development. This candidate is a well-organized, team-oriented scientist with in-depth knowledge and hands-on experience in in vitro transcription reactions, nucleic acid purification and/or analytical method development for the characterization of long RNAs. They possess exceptional written and oral communication capabilities, demonstrate excellent collaboration and interpersonal skills, and are adept at problem solving in a fast-paced environment.


  • Develop and execute detailed data-driven process development plans using scientifically sound methodology, including design-of-experiments approaches
  • Work with the oRNA production team to integrate and implement validated processes/procedures into existing workflows
  • Contribute to or lead evaluation of scalable methodologies and approaches to produce and purify oRNA and tech transfer to the CMC team
  • Generate, interpret, and present process development data to cross-functional R&D teams and may contribute to our overall IP efforts
  • Contribute to oRNA productions to enable advancement of therapeutic programs and platform projects
  • Contribute to a positive and exciting work environment; contribute to a strong entrepreneurial and creative culture


  • Ph.D. in molecular biology, chemical engineering or related field with 0-3 years relevant industry experience, BS/MS with ≥ 6 years relevant industry experience
  • In-depth knowledge of RNA biology and experience in process development of RNA synthesis in a biopharmaceutical context required
  • Experience with nucleic acid production using in vitro transcription required
  • Proven track record of productively working with cross-functional teams
  • Hands-on experience with diverse chromatographic methodologies for nucleic acid separation is highly desired
  • Strong communication and collaborative instinct with good time and resource management skills
  • Highly organized and can collaborate on execution of multiple parallel initiatives
  • Detail oriented, organized, self-motivated, and excited to take on new challenges!