Senior Scientist, Mass Spectrometry

Posted on March 26,

Ribometrix is committed to delivering on the promise of addressing human disease through novel scientific insight into the structure of RNA. Unlike traditional drug discovery methodologies that target the product of RNA (proteins), we believe small molecule therapeutics can be designed to interact with RNA to deliver a meaningful therapeutic benefit to patients living with disease.

We are a team of individuals driven by the spirit of innovation, collaboration, empowerment, and integrity who are committed to the goal of helping patients with our novel therapeutic approach.

If you are looking for an opportunity to pioneer new science, collaborate with great people, and ultimately help those in need, then Ribometrix may be the place for you.

We are seeking a highly motivated Senior Scientist to join our Lead Discovery group and spearhead our mass spectrometry (MS)-based applications. This person will be part of a team that is responsible for discovering and characterizing RNA-small molecule interactors and will have a key role in identifying and progressing RNA-targeted therapeutics. The position provides opportunities to collaborate extensively with other members of the Lead Discovery, Chemistry, and RNA Biology teams and to contribute to both the science and strategy of treating disease by targeting RNA. An ideal candidate will have prior experience as a member of a team involved in drug discovery and working with validated processes and procedures. 

Responsibilities include but are not limited to:

  • Establish, maintain, and troubleshoot MS-based platforms.
  • Develop and implement MS assays to support drug discovery screening and compound profiling activities.
  • Provide leadership to expand a MS-based strategy for identification and characterization of RNA/small molecule binders.
  • Perform complex data analysis and interpretation to generate conclusions and next steps that drive the science forward.
  • Implement high-throughput sample processing methods to facilitate timely data generation.
  • Support multiple tasks and maintain attention to detail in a fast-paced environment.
  • Train others on the theoretical and practical aspects of MS-based techniques and to perform MS assays.
  • Work collaboratively and lead by example to promote our Ribometrix Core Values: Integrity, Collaboration, Innovation, Empowerment, Resilience, and Fun.


  • BS in Chemistry (or related field) with 18+ years experience, MS in Chemistry (or related field) with 15+ years experience, or PhD in Chemistry (or related field) with 6+ years experience.
  • Extensive knowledge and experience in liquid chromatography and mass spectrometry (LC-MS, ESI-MS) and its application to early, target-based drug discovery is required.
  • Experience with chromatographic separation techniques, especially SEC, and Agilent MassHunter software are preferred.
  • Strong initiative, problem solving skills, desire to learn, attention to detail, and ability to effectively organize and prioritize are required.
  • Ability to work independently and as part of a diverse and dynamic team is required.
  • Excellent interpersonal skills, proactive communication skills, and strong written and verbal communication and presentation skills are required.
  • A can-do attitude complemented with a willingness to help where needed is required.
  • Experience using Microsoft Office tools is required.
  • Experience working in drug discovery, especially in an industry setting, is preferred.
  • Previous experience in a startup/entrepreneurial environment is preferred.

Ribometrix is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. Reasonable accommodations may be made to enable qualified individuals with disabilities to perform the essential functions of this position. 

Recruiting Agencies, Please Note:
Ribometrix will not accept unsolicited assistance from recruiting/search agencies for this employment opportunity. Please, no phone calls or emails. All resumes submitted by recruiting or search agencies to any employee at Ribometrix via email, the Internet or in any form and/or method without a valid written search/recruitment agreement in place for this position will be deemed the sole property of Ribometrix. No fee will be paid in the event the candidate is hired by Ribometrix as a result of the referral or through other means.