Scientist/Sr Scientist RNA Structural Biology at Arrakis Therapeutics

Posted on August 29,

Do you have the passion to join a group whose mission is to pioneer the discovery of a
new class of medicines to treat diseases unaddressed by today’s therapies? Does it
excite you to be a part of a company with a platform that can address any disease area
with high unmet medical need? If yes, you may be a great fit to join Arrakis on our path
to bring powerful new RNA-targeted small molecule (rSM) medicines to millions of

Your Impact at Arrakis

The mission of Arrakis Therapeutics is to extend small molecule medicines into new
realms of biology by discovering and developing compounds that selectively target
RNA. By targeting distinct RNA structure:function relationships, Arrakis aims to generate
drug candidates with novel mechanisms of action for molecular targets that are
challenging to drug with other approaches, opening up vast new realms of human
biology for medicine.
We’re looking for a highly motivated RNA structural biologist with a passion for
leveraging an integrative structural biology approach to investigate RNA and RNAligand
complexes. You will design and conduct innovative experiments, communicate
effectively in meetings and collaborate with other cross functional teams providing RNA
structural biology expertise to advance early drug discovery efforts. Demonstrated
experience in X-ray crystallography, cryo-EM or atomic force microscopy is required, as
well as a strong background in other biochemical and biophysical techniques for the
characterization of RNA.

Job Responsibilities

• Design and prepare RNA constructs for investigation of RNA and RNA-ligand
complexes by X-ray crystallography, atomic force microscopy and other structural
biology techniques
• Perform structural study experiments, analyze, interpret, and effectively
communicate results to project teams
• Contribute to multiple projects in parallel in collaboration with cross-functional
teams to inform development of RNA-targeting small molecules
• Interface with CROs, academic collaborators and RNA Biochemistry team
• Maintain scientific and technical expertise through familiarity with scientific
literature and attending conferences
• Contribute to Arrakis’ scientific publications and patent applications
• PhD in Biochemistry, Biophysics, Molecular Biology or related scientific field,
industry experience is a plus; Master’s with 6+ years of industry experience; or
Bachelor’s with 8+ years of industry experience
• Expertise in biochemical/biophysical characterization and structure determination
of RNA by X-ray crystallography, cryo-EM or atomic force microscopy
• Extensive experience in RNA construct design, production and characterization
• Familiarity with other biophysical methods (e.g., SAXS, MS, SPR, etc.)
• Familiarity with biomolecular structure modeling and RNA-ligand interactions
• Proven track record of scientific innovation, as demonstrated by peer reviewed
publications and/or patents
• Proactive and efficient to enable high-quality results while fostering a positive
work environment
• Exhibits passion and excitement over work. Has a can-do attitude without losing
• Adjusts quickly to changing priorities and conditions and copes effectively with
complexity and change.