Scientist / Senior Scientist, RNA – Protein Biology, Translational Research

Posted on January 26,

Sardona Therapeutics is a venture-backed biotech startup developing a new class of small molecule therapies that target RNA-binding proteins. Our founders and advisors are world-leaders in the field of RNA/protein biology and small molecule drug development – and are demonstrated company builders. We are using this knowledge and experience to translate extraordinary science into life-changing treatments for patients that need it most. Join us as we scale new peaks in cancer therapy!

This role is an opportunity to join San Francisco-based Sardona Therapeutics as a founding scientist, bringing your scientific talent and passion to build and grow the company. We love people who are excited about what they do, have a demonstrated ability to solve challenging problems and thrive in high-energy teams.

Job Description:

-       Perform experiments using standard biochemistry, cellular and molecular biology techniques including mammalian cell culture, RT-qPCR, westernblot, immunoprecipitation, flow cytometry.
-       Execute gene loss- and gain-of-function studies to support target validation and characterization efforts (cDNA overexpression, RNAi, CRISPR, shRNA) utilizing mammalian cell culture and primary cells.
-       Participate in the discovery and development of novel RNA-protein targeted therapeutics and apply RNA-research techniques incl. RNA (CLIP)-seq, RNA- and protein pulldown and cell-based reporter assays.
-       Support xenograft studies to enable in vivo drug discovery.
-       Collaborate with an interdisciplinary team and manage CROs to facilitate the success of projects.
-       Maintain detailed records of experimental protocols and data in laboratory notebooks.
-       Present/summarize work verbally and in written form effectively.

Your Profile

-       PhD in cell/molecular biology, biochemistry, cell biology or related discipline plus 0-4 years of postdoctoral research experience in industry or academia.
-       Hands-on experience with gene modulation techniques in cell-based studies and demonstrated experience with RNA and protein analysis techniques to investigate target engagement and MOA.
-       Experience in designing, developing, performing and analyzing in vitro and cell-based assays.
-       Familiarity with in vivo cancer xenograft models, or willingness to learn, is a plus.
-       Proficiency in utilizing software such as GraphPad Prism, Microsoft Office, Adobe Illustrator/Photoshop and FloJo for data analysis and figure preparation.
-       Excellent communication skills with the ability to work in a multidisciplinary team, mentor junior associates and colleagues and to manage CROs.
-       Proactive, high attention to detail, excellent organizational and record keeping skills.

What we offer:

-       We strive to support the next generation of groundbreaking minds and entrepreneurial talents. As a founding scientist, you have the unique opportunity to make significant contributions to Sardona's drug pipeline.
-       Equity incentives and comprehensive benefits package. We are looking for candidates who bring a strong sense of ownership to drive Sardona’s projects forward and you deserve to be compensated accordingly.
-       Flexible work hours and work from home are possible.
-       We are a JLABs company. Attend monthly workshops to learn from world-leaders in biotech.
-       State of the art lab space in the MBC BioLabs Dogpatch site (953 Indiana Street, San Francisco); an entrepreneurial hub full of the best scientists and operators the Bay Area has to offer. Our lab is a very short walk from the 22nd St Caltrain Station and a number of wonderful restaurants and cafés.

Excited to join Sardona? We’d love to hear from you. Send your resume and cover letter to [email protected]