Posted on June 10,

Ionis Pharmaceuticals, Inc., one of the 2020 Best Places to Work in San Diego, is in the North San Diego County city of Carlsbad.  For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing standards of care with our novel antisense technology. Ionis currently has three marketed medicines – Spinraza, the standard of care for all forms of spinal muscular atrophy; Tegsedi, the first approved RNA-targeted therapy for polyneuropathy caused by hereditary ATTR (transthyretin) amyloidosis; and Waylivra, the only approved treatment for familial chylomicronemia syndrome (FCS). Ionis has a premier late-stage pipeline highlighted by our industry-leading neurological and cardiometabolic franchises. Scientific innovation began and continues at Ionis with the understanding that sick people depend on the success of the company.  This belief drives Ionis’ vision of becoming one of the most successful biotechnology companies. 

As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. Ionis’ medicines span multiple therapeutic areas, routes of administration and diverse patient populations, and Ionis innovation is driving meaningful progress for many of the most challenging health issues.

Ionis is building upon our innovative research and drug development excellence to provide greater value to patients.  Based on the breadth and remarkable progress of our pipeline, Ionis is projecting to have a vast number of new transformational products on the market in the coming years. Ionis is well positioned financially to deliver on our strategic goals.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.


We are currently seeking an RNA biology enthusiast for the position of RNA Modeling Scientist in our Functional Genomics group. A successful candidate will be a strategic member of a fast-paced and interactive research team contributing to the discovery of novel therapeutics.


  • Apply computational methods to model the kinetics, molecular recognition, and structure of nucleic acids
  • Analyze and incorporate signal data from next-generation sequencing assays, including ChIP, CLIP, structure probing etc. to understand biochemical properties of DNA, RNA and oligonucleotides
  • Stay abreast of the latest RNA biology and transcriptomics datasets
  • Organize and document analysis strategies
  • Collaborate with computational and experimental scientists in a multidisciplinary team environment to accomplish research goals

Education and Experience:

  • Ph.D. in Computational Biochemistry or related field or Ph.D. in Biology with strong mathematics, statistics, or computational background
  • Strong skills in analysis of transcriptomics datasets
  • Background or strong interest in RNA biology preferred
  • Experience in modeling biochemical properties of nucleic acids, such as synthesis and decay rates, splicing, structure modeling and hybridization of oligonucleotides desired
  • Experience with application of computational models to accelerate genomic analysis desired
  • Excellent communication and organizational skills
  • Strong track record of innovative research demonstrated in publications and oral presentations
  • Proficiency with Linux/Unix systems and in programming with C, C++, Python, R or an equivalent high-level language desired

Excellent salary and benefits package offered. 

Please visit our website, www.ionispharma.com for more information about Ionis and to apply for this position; reference requisition #IONIS02595

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.