RNA biology at the Host-Virus Interface

Posted on November 29,

What role do RNA modifications play in the lifecycle of pandemic and oncogenic viruses? How is
the transcriptional and translational output of the cell reconfigured during infection and what is
physiological consequence of this? Why do DNA viruses activate the RNA sensing innate immune
system? These are just some of the questions that we are interested in.
Postdoc positions are available in the Karijolich laboratory at the Vanderbilt University School of
Medicine. The laboratory is within the Departments of Pathology, Microbiology, and Immunology
(PMI), and Biochemistry. We are also affiliated with the Vanderbilt-Ingram Cancer Center (VICC),
Vanderbilt Center for Immunobiology (VCI), and the Vanderbilt Institute for Infection, Immunology,
and Inflammation (VI4). Vanderbilt University is located in the heart of Nashville, Tennessee.
Internationally known as “Music City”, Nashville is a thriving city located on the Cumberland River
with great restaurants, museums, art, and of course Music.
Our studies leverage a range of DNA and RNA viruses including Kaposi’s sarcoma-associated
herpesvirus, Epstein-Barr virus, Vaccinia virus, and Influenza. Ongoing projects are directed
towards double-stranded RNA induced antiviral immunity, transcriptional and post-transcriptional
regulation of gene expression, RNA modification and structure, and in vivo antiviral and antitumor
mechanisms. Our work is multidisciplinary and combines Virology, Immunology, RNA
biochemistry, genome-wide CRISPR/Cas9 screens, and high-throughput sequencing and
proteomic approaches. The laboratory is well funded with grants from the National Institutes of
Health, American Cancer Society, and Pew Charitable Trusts Foundation.
Postdoctoral candidates must have or plan to have a Ph.D. and should possess expertise in
molecular and cellular biology. While not necessary, applicants with experience processing and
analyzing high-throughput sequencing data are strongly encouraged to apply. To apply, send CV,
brief statement of research experience/interests and contact information for professional
references. Please submit applications to: [email protected]

John Karijolich, Ph.D.
Associate Professor
Department of Pathology, Microbiology, & Immunology, and Biochemistry.
Vanderbilt University School of Medicine