Postdoctoral Researcher Positions in the Biochemistry and Biophysics of pre-mRNA Splicing and Single-Molecule Microscopy Instrumentation Development at UW-Madison

Posted on August 19,

We are recruiting two highly motivated postdoctoral scientists to pursue research in biochemical and biophysical characterization of pre-mRNA splicing factors and the spliceosome. We are specifically seeking scientists interested in two collaborative research projects:

  1. The Brow and Hoskins labs at University of Wisconsin-Madison (https://ipib.wisc.edu/labs/) have a position available for a postdoctoral researcher with experience in protein and/or RNA biochemistry to study allosteric signaling during spliceosome activation using single-molecule microscopy, UV-crosslinking, and related techniques. Prior experience in single-molecule analysis or in vitro pre-mRNA splicing/RNA biochemistry is preferred. Demonstrated accomplishment in biochemical research is required. The successful candidate will use state of the art approaches to characterize mutant spliceosomes with defects in activation and suppressors thereof.
    (See: pubmed.ncbi.nlm.nih.gov/30898770/, pubmed.ncbi.nlm.nih.gov/27244240/)
     
  2. The Goldsmith and Hoskins labs at University of Wisconsin-Madison (https://www2.chem.wisc.edu/faculty/physical) have a position available for a postdoctoral research scientist with experience in biophysics, microscopy, or microfluidics to develop a pipeline and instrumentation for high-throughput analysis of RNA/protein interactions. This project is part of a collaborative effort at UW-Madison in the area of RNA biology and additionally involves collaboration with teams from the Butcher and Grant labs in structural biology and biochemistry. Prior experience microscopy, microfluidics, instrumentation development, or computational methods for analysis of large microscopy data sets is preferred. Demonstrated accomplishment in biophysics, optics, physical chemistry, or computational biology research is required. The successful candidate will use state of the art methods to automate and analyze the biochemical details of splicing factor/RNA interactions across thousands of binding sites in vitro.
    (See: https://pubmed.ncbi.nlm.nih.gov/32267232/, Research Forward).

Qualified applicants should have a PhD in Biochemistry or Biophysics or related field and extensive experience in working with RNA, nucleic acids, computational biology, or single molecule biophysical methods. Top candidates will show strong interest in being part of vibrant research teams and communities, mentoring of junior scientists, and in promoting inclusion and diversity in science. These funded positions may start as early as Fall 2021. Interested applicants should email Dr. Aaron Hoskins ([email protected]) a CV and letter of introduction including the completion (or expected completion) date of their PhD studies, proposed start date, a list of publications, names of three references who may be contacted for letters, and a brief description of future research interests. Please indicate in which position(s) you are interested.