Postdoctoral positions to study small RNAs and alternative polyadenylation

Posted on December 15,

The Eric Lai lab at Sloan Kettering Institute, NYC (https://www.mskcc.org/research/ski/labs/eric-lai) has multiple postdoctoral positions available to join our efforts in RNA mechanisms and biology. Our group uses integrated approaches to study several areas in post-transcriptional regulation, but we have particular interest in alternative mRNA processing (splicing and 3' UTRs) and small RNA biogenesis and function.

The ideal candidate will be able to combine their background in RNA biology with our extensive unpublished tools and resources, in Drosophila and mammalian systems. We welcome applicants with experience in molecular genetic methods or computational genomics. We have an interactive, multidisciplinary, and collaborative team engaged in diverse topics in regulatory biology, and the Sloan Kettering Institute provides a vibrant research community committed to inclusivity and diversity.

Positions are currently available and funded by a new 4-yr NIH-R01 grant, and include nearby subsidized housing and benefits. Please provide CV, motivation letter and references to Eric Lai, [email protected]

 

Recent papers on splicing and APA

Joseph, B., C. Scala, S. Kondo and E. C. Lai (2021). Molecular and genetic dissection of recursive splicing. Life Science Alliance 5: e202101063, doi: 10.26508/lsa.202101063.

Kan, L., S. Ott, B. Joseph, E.S. Park., C. Dai, R. E. Kleiner, A. Claridge-Chang, and E. C. Lai (2021). A neural m6A/YTHDF pathway is required for learning and memory in Drosophila. Nature Communications 12(1):1458. doi: 10.1038/s41467-021-21537-1.

Joseph, B. and E. C. Lai (2021). The Exon Junction Complex and intron removal prevents resplicing of mRNA. PLoS Genetics 17(5):e1009563. doi: 10.1371/journal.pgen.1009563.

Lee, S., B. Zhang, L. Wei, R. Goering, S. Majumdar, J. M. Taliaferro, and E. C. Lai (2021). ELAV/Hu RNA binding proteins determine multiple neural alternative splicing programs. PLoS Genetics, 17(4):e1009439.

Wei, L., S. Lee, S. Majumdar, B. Zhang, P. Sanfilippo, B. Joseph, P. Miura, M. Soller and E. C. Lai (2020). Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3' UTR Landscape in Drosophila. Molecular Cell 80: 140-155.

Garaulet, D.L., B. Zhang, L. Wei, E. Li, and E. C. Lai (2020). A post-transcriptional regulatory circuit specifies the virgin behavioral state. Developmental Cell 54: 410-423.

  

Recent papers on miRNA/siRNA biogenesis and function

Vedanayagam J., C.-J. Lin and E. C. Lai (2021). Rapid evolutionary dynamics of an expanding family of meiotic drive factors and their hpRNA suppressors. Nature Ecology and Evolution https://doi.org/10.1038/s41559-021-01592-z.

Bejarano, F., C.-H. Chang, K. Sun, J.W. Hagen, W.-M. Deng, and E. C. Lai (2021). A comprehensive in vivo screen for anti-apoptotic miRNAs indicates broad capacities for oncogenic synergy. Developmental Biology 475:10-20.

Garaulet, D.L., A. Moro and E. C. Lai (2021). A double negative gene regulatory circuit mediates the virgin behavioral state. Cell Reports 36: 109335. PMID: 34233178.

Shang, R., S. Baek, K. Kim, B. Kim, V. N. Kim, and E. C. Lai (2020). Genomic clustering aids nuclear processing of suboptimal pri-miRNA loci. Molecular Cell 78: 303-316.