Postdoctoral Position to study basic mechanisms of RNA splicing at University Paris-Saclay, France

Posted on December 26,

The SABNP laboratory is seeking for a postdoc candidate to work in the field of RNA splicing in the team led byAlexandre Maucuer. The team is involved in the deciphering of critical molecular interactions for splicing (PMID: 31271494).

Recent data have highlighted the complexity of 3′ splice site recognition mechanisms by identifying novel regulators for the basal spliceosome machinery. In addition, post-translational modifications such as phosphorylation of splicing factors contribute to the diversity and regulation of their functions. Finally, interestingly splicing factors mutations associated with cancer are prominent among factors involved in 3' splice site recognition (PMID: 31271494, PMID: 34520118).

In this context, to dissect interactions among these splicing factors, we use a variety of techniques including protein-protein interactions in vitro and in vivo, structural NMR-based analyses, HCS fluorescence microscopy, RNAseq and other large dataset analyses.

The postdoctoral fellow will study recently identified interactions for key splicing factors and their regulation by phosphorylation. The candidate should have a good background in biochemistry, cell biology and molecular biology techniques.

Qualification: Ph.D. in Biology, Biochemistry, Computer Science, or related disciplines.

The successful candidate will be highly motivated, able to multi-task efficiently, work independently and be committed to research.

Eligibility: Candidates of any nationality are welcome. Candidates should not have been working in France for more than 12 months in the last three years. See https://apogeebio.genopole.eu/application-file/ for the detailed eligibility rules.

Laboratory: The SABNP laboratory, located at the Genopole biocluster, is part of the prestigious university Paris-Saclay. The lab focuses its research on the structure and function of RNA: Protein complexes and aims to develop applications in medicine and biotechnology.

Net salary: up to €3000 net monthly salary for 24 months. This internship will be funded by the ApogeeBio 2024 program (Genopole/European commission).

Contact: To apply, please provide a CV to alexandre.maucuer_at_inserm.fr with a statement of research interests and contact information for three references.

Deadline: 9th February 2024

Start date: ideally between 1st June 2024 and 1st October 2024.