Postdoctoral Position on RNA Biology

Posted on May 5,

Johns Hopkins University
Jiou Wang Laboratory

Highly motivated postdoctoral candidates are invited to lead several new projects to address fundamental questions in Nucleic Acid Biology. Current directions in the lab include but are not limited to novel functions of DNA/RNA of unconventional structures, RNA granules, and general RNA-binding protein homeostasis. Candidates with a strong background in biochemical, molecular, and/or computational analyses of nucleic acids are encouraged to apply. Our representative publications are the following:

1. Liu H, Lu YN, Paul T, Periz G, Banco MT, Ferré-D'Amaré AR, Rothstein JD, Hayes LR, Myong S, Wang J. (2021) A Helicase Unwinds Hexanucleotide Repeat RNA G-quadruplexes and Facilitates Repeat-Associated Non-ATG Translation. J. Am. Chem. Soc. doi:10.1021/jacs.1c00131. (PMID: 33855846)

2. Simko E, Liu H, Zhang T, Velasquez A, Teli S, Haeusler AR, Wang J. (2020) G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 achitectual IncRNA. Nucleic Acids Res. doi:10.1093/nar?gkaa475. (PMID: 32496517)

3. Alexander E, Niaki A, Zhang T, Sarkar J, Liu Y, Nirujogi R, Pandey A, Myong S, Wang J. (2018) Ubiquilin 2 Modulates ALS/FTD-linked FUS-RNA Complex Dynamics and Stress Granule Formation. Proc. Natl. Acad. Sci. USA doi.org/10.1073/pnas.18119977115. (PMID: 30442662)

4. Zhang T, Wu Y, Mullane P, Ji Y, Liu H, He L, Arora A, Hwang H, Alessi A, Niaki A, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim J, Shorter J, Ong S, Leung A, Wang J. (2018) FUS Regulates Activity of MicroRNA-mediated Gene Silencing. Molecular Cell 69:787-801. (PMID: 29499134)

5. Haeusler AR, Donnelly C, Periz G, Simko E, Shaw P, Kim M, Maragakis N, Troncoso J, Pandey A, Sattler R, Rothstein J, and Wang J. (2014) C9orf72 Nucleotide Repeat Structures Initiate Molecular Cascade of Disease. Nature 507:195-200. (PMID: 24598541)

The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research. Our lab is affiliated with the Department of Biochemistry and Molecular Biology of the Bloomberg School of Public Health and the Department of Neuroscience of the School of Medicine. The Baltimore/Washington D.C. area also offers rich professional and living opportunities.

Candidates should have a doctoral degree and strong research background. Please send a statement of research experience and career goals, a copy of Curriculum Vitae, and contact information of at least one reference to Dr. Jiou Wang at [email protected].

A complete listing of PubMed-accessible publications can be accessed at the following URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Jiou+Wang.

More information available at: http://www.jhu-bmb-phd.org/faculty/jiou-wang. The Johns Hopkins University is an Equal Opportunity Employer.