Postdoctoral Position available at Yale School of Medicine – Engineering translation enhancers for therapeutic mRNAs

Posted on December 8,

A postdoctoral position is available in the laboratory of Carson Thoreen in the Department of Cellular and Molecular Physiology at Yale School of Medicine. We are a multi-disciplinary lab that studies complex systems for controlling gene expression. Our lab previously discovered how the mTOR signaling pathway controls the translation of the ATF4 transcription factor, a master regulator of amino acid metabolism (Park et al. Cell Reports, 2017), and terminal oligopyrimidine (TOP) mRNAs, a conserved mRNA family that encode hundreds of essential proteins (Thoreen et al, Nature, 2012; Philippe et al., PNAS, 2020). A position is currently available for creative and motivated candidates to engineer novel RNA-encoded elements for controlling the translation and stability of therapeutic mRNAs. This position is a jointly funded collaboration with the lab of Prof. Wendy Gilbert (Department of Molecular Biophysics and Biochemistry). The successful applicant will benefit from having two supportive mentors with complementary expertise in the translational control field. Some familiarity with transcriptome-scale methodology, RNA biochemistry, and basic bioinformatics are desired. Applicants should email a current CV and cover letter describing research interests to [email protected]. Lab website: