Postdoctoral Position: RNA break repair & tRNA splicing

Posted on September 18,

An opportunity is available to join the laboratory of Dr. Stewart Shuman at Memorial Sloan Kettering Cancer Center (MSKCC) in New York City.

Topic: Purposeful site-specific breakage of RNAs underlies important biological pathways that either require RNA repair (e.g., tRNA splicing) – or are ameliorated by RNA repair (e.g., tRNA restriction by ribotoxins). We are studying the mechanisms, structures, specificities, and evolution of the agents of RNA repair: enzymes that heal and seal broken RNA ends. Our approach integrates protein/RNA biochemistry, crystallography, and genetics. We apply them to gain insight into the biology of known RNA repair pathways and to discover and characterize new RNA repair enzymes, several of which have achieved wide use in the RNA community (e.g. T4 RNA ligase 2; E. coli RtcB).

Interested individuals with a doctoral degree and experience in nucleic acid biochemistry and/or crystallography can email a CV, a statement of research experience and interests, and the names of three references to [email protected]

Information about postdoctoral life at MSKCC can be found at