Postdoctoral fellowship: SnoRNA-guided RNA Modifications in Cardiovascular Disease
Posted on October 2,

The Holley Lab at Duke University ( studies the role of non-coding RNAs and RNA modifications in cardiovascular health and disease. We are interested in discovering novel molecular mechanisms that depend on snoRNA-guided modifications. Our team has recently shown that snoRNA-guided 2’-O-methylation (Nm) can regulate mRNA transcript abundance and translation in the heart:

We are now seeking a post-doctoral associate to determine how snoRNA-guided RNA methylation impacts cardiac development and heart failure. Approaches will include genetic models (mice and cell lines), mapping and quantification of RNA modifications, and integrated transcriptomics/proteomics. Bring your creativity because we are inventing new techniques and approaches for studying Nm modifications. This project has active NIH funding.

PhD, MD, or doctoral equivalent. Experience in cellular and molecular biology. Enthusiasm and positive attitude. Ability to work both independently and as a team. Interest and experience in RNA biology or cardiovascular research.

Successful candidates will have strong written and verbal communication skills. Experience working with genetic mouse models of disease would be helpful but not required. Applicants with expertise (or interest) in bioinformatics are especially encouraged to apply.

How to Apply
Applicants should send their CV, a summary letter of research experience and career goals, and contact information for 2-3 references to Christopher Holley, MD, PhD: [email protected]