Postdoc Position to Study the Structural Biology of RNA Triple Helices
Posted on May 25

The Brown Laboratory at the University of Notre Dame is interested in understanding the biological, biochemical, and structural roles of RNA triple helices, structures that were deduced to form over 60 years ago yet only 3 examples in the human transcriptome have been validated by 3D structures. Using the MALAT1 triple helix as a model system, we are interested in several key questions. How do proteins and small molecules bind specifically to an RNA triple helix? Is there an undiscovered class of triple-stranded RNA binding proteins? What are the structural parameters of an ideal RNA triple helix? What is the folding pathway of an RNA triple helix? What other RNA triple helices exist in mammalian cells? Can we establish the “triplexome”? To investigate these questions, we are currently using a variety of approaches, including X-ray crystallography, cryo-EM, cell-based assays, molecular biology, classical biochemistry, and high-throughput methods. Priority will be given to candidates with experience in structural biology.

To apply, please submit the following:
Cover letter stating

  • Hands-on experience in structural and biochemical approaches (list methods used)
  • Long-term career goals
  • Date of availability to begin postdoc research
  • Name and contact information of three references

Curriculum vitae listing

  • Education/Research Experience
  • Publications
  • Awards/Honors
  • Presentations

Please submit application materials or inquiries to [email protected].

Jessica A. Brown, PhD
Clare Boothe Luce Assistant Professor
Department of Chemistry & Biochemistry
University of Notre Dame
Notre Dame, IN 46556
[email protected]