Postdoc Position –Alternative Splicing Evolution, Brain Development, and CiliopathiesFebruary 23, 2023 The Laboratory of Dr. Chaolin Zhang in Department of Systems Biology, Columbia University Irving Medical Center (CUIMC) has multiple postdoctoral openings to conduct research on mammalian RNA regulatory networks as funded by NIH and other funding sources. This posting is to search for candidates to work on a project the role of linage alternative exons in the context neurodevelopment, including cilia function & ciliopathies. Taking a multidisciplinary approach that tightly integrates biochemistry, molecular biology, genome engineering and high-throughput data analysis and integrative modeling, the Zhang Laboratory studies how RNA and proteins interact to form regulatory networks in the nervous system at the mechanistic and systems levels, how these networks contribute to intrinsic neuronal functional properties, and how such properties are implicated in health and disease. We are working to translate fundamental discoveries to RNA-based precision medicine for devastating disorders with unmet medical needs. The Zhang lab consists of a group of inspired and creative scientists from diverse background. Recent lab members have successfully transitioned into prominent academic and pharmaceutical industry positions. More information about the Zhang laboratory can be found at http://zhanglab.c2b2.columbia.edu. The candidates will lead an exciting project that aims to understand the function of lineage-specific alternative exons, especially in a group of cilia genes, in neurodevelopment and genetic diseases. The candidates will use an array of molecular and cell biology approaches, such as cloning, transient/stable expression, RT-PCR/qPCR, westernblots, IP/co-IP, RNASeq, clow cytometry, CRISPR/gene editing, stem cell differentiation, molecular biology, and other cutting-edge methods. Studies will be performed in both cell (including ESC/iPSC) and mouse models. The candidates will work in a dynamic and interdisciplinary environment at Columbia University Medical Center. Strong mentorship will be provided to help them achieve their career goals. Selected recent publications:
Required/desired qualifications: A Ph.D. or equivalent degree in a Molecular Biology, Cell Biology, Neurobiology, or related fields This position requires independence, effective communication, critical thinking, creativity, multi-tasking, organization, and the ability to work in a collaborative research environment. The ideal candidate will have previous experience with cilia biology in cell culture and animal models, strong background in molecular & cell biology, and familiarity with neurobiology. Applicants should send a curriculum vitae and names and contacts of three references to: Dr. Chaolin Zhang Columbia University is an Equal Opportunity and Affirmative Action Employer. Hiring is contingent upon eligibility to work in the United States. Women and minorities are encouraged to apply. |