Postdoc Opportunity – RNA biology - Sheets Lab UW Madison

Posted on May 12,

The laboratory of Dr. Michael Sheets has an opening for a highly motivated postdoctoral fellow. The Sheets lab focuses on post-transcriptional mechanisms that control cell-fate decisions during vertebrate development. Toward this end, a major research area focuses on the mechanisms by which the conserved Bicaudal-C (Bicc1) protein controls cell-fate decisions that drive vertebrate embryogenesis in the aquatic frog, Xenopus laevis (Park et al Development 2016, Dowdle et al 2019 and Maerker et al 2021 [https://www.biorxiv.org/content/10.1101/2020.01.29.924456v1.full]. Bicc1 is an RNA binding protein that represses the translation of specific target mRNAs to control cell differentiation. The Sheets lab has identified multiple Bicc1-mRNA targets as well as specific Bicc1-RNA binding sites. A major biochemical aim is to define the Bicc1-RNA interactions that drive Bicc1’s mRNA selective repression. We are also defining the protein-protein interactions and mechanisms of Bicc1-mediated translational repression and exploring the roles of Bicc1 mRNA targets’ encoded proteins in vertebrate embryogenesis. In a second research area, the lab is defining the molecular mechanisms underlying Bicc1’s roles in maintaining cell identity and tissue function in adult vertebrate organisms, specifically humans. Toward this end, we are generating human iPSC models with a particular focus on kidney and neuronal cell differentiation as defects in Bicc1 have been causally linked to human diseases such as polycystic kidney disease and major depressive disorder, MDD. The Sheets lab and the Department of Biomolecular Chemistry are highly interactive, intellectually stimulating environments located within the cutting-edge, collaborative DeLuca Biochemistry Research Complex that is situated at the heart of basic biological research on the UW Madison campus. Competitive candidates for this postdoctoral position will have a PhD in a relevant scientific discipline. Previous experience in RNA molecular biology and/or human iPS cell culture is desirable. To apply, please send a cover letter, CV, and contact information for 3 references to Dr. Michael Sheets at [email protected].