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Cancer Postdoctoral Fellowship Position, National Cancer Institute

The Protein-Nucleic Acid Interaction Section in Structural Biophysics Laboratory, National Cancer Institute, invites applications for a Cancer Postdoctoral Fellowship position.  Applicants should have training/expertise in RNA biology and biochemistry.  The postdoctoral fellow recruited for the position will work on exciting RNA biotechnology and cancer immunotherapy projects and have opportunities to train and learn multiple techniques for the research projects.  We seek an enthusiastic, creative and dedicated scientist to join our team.

The position is open until a qualified candidate is identified.  NIH offers a competitive stipend and comprehensive health insurance.  The appointment will be one year initially and renewable up to a total of 5 years based on performance.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation.  To apply, please send a cover letter and a curriculum vitae.  In addition, please arrange three reference letters to be sent to wangyunx@nullmail.nih.gov on behalf of applicants.

DHHS, NIH, and NCI are Equal Opportunity Employers

Faculty Positions Available, Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative

The newly founded Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative, solicits applications for faculty positions at the assistant professor level, but appointment at a more senior level is possible for applicants with suitable experience. The faculty position will be tenure track or tenured with a university year appointment starting September 1, 2019 or January 1, 2020.

Candidates must have the following qualifications:

  • A PhD, MD, or other terminal degree
  • Evidence of superlative scientific accomplishment and scholarly promise
  • Depending on field, evidence of teaching excellence

Primary school and departmental affiliation(s) will be determined by the applicant’s qualifications and preferences, and by relevance of the applicant’s research program to departmental initiatives and themes. We welcome applications from outstanding scientists in any area of RNA research complementary to existing expertise at Michigan, with particular emphasis on RNA drug targeting or as medicine, structural biology of RNA nanomachines, RNA structural in vivo profiling, RNA protein interaction profiling, and in vivo analysis of long non-coding RNA function. For further information about the Center for RNA Biomedicine’s current research areas, please visit https://www.umichrna.org.

All applications must be submitted online at https://rna.lsa.umich.edu/facRecruiting/application.php. You will be asked to upload the following materials: a cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, and a statement of teaching interests and philosophy. Candidates for appointment as an assistant professor should provide names and contact information for at least three references, as instructed in the on-line application form. To ensure full consideration, all materials should be received by January 15, 2019.

Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.

For more information, contact us directly at mjerant@nullumich.edu or 734-615-8213

Learn more about the Biosciences Initiative at University of Michigan: biosciences.umich.edu

RNA Biochemist position(s), Sixfold Bioscience, London

Job summary

Utilise RNA in innovative ways to cure disease.

At Sixfold we’re building a better way to deliver cures. We see the huge potential of gene therapies being limited to how effectively they can be systemically delivered in people. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic.

We’re seeking a highly motivated and independent researcher to join our team. Specifically, we are looking for skilled scientists that are passionate about utilising nucleic acids in innovative and transformative ways to cure disease. As a rapidly growing start-up, your work will make invaluable contributions to the scientific and strategic direction of the company.

Requirements

  • PhD with specialisation in RNA Biochemistry/Biophysics, Molecular Biology, Chemical Engineering, Nanotechnology or equivalent scientific discipline.

Extra credit

  • Hands-on experience in RNA synthesis, purification, characterisation formulation, and stability testing.
  • mRNA translational control and RNA processing.
  • Expertise in analytical techniques including HPLC, LC-MS GC-MS.
  • Cell biology expertise in mammalian cell culture and cell visualisation using techniques such as confocal microscopy and flow cytometry.

Who you are

  • Use creativity and scientific intuition for designing and undertaking experiments.
  • Can work in a highly collaborative research environment.
  • Drive innovative research through the internalisation of new techniques and technology, as well as forming internal and external collaborations.
  • Have a desire to work in a dynamic and fast-paced environment.

What you’ll do

  • Lead the development and optimisation of RNA for therapeutic use.
  • Design and execute robust laboratory experiments, interpret data, communicate findings, and maintain high-quality records.
  • Support and contribute to publishing and grant writing efforts.

Perks

  • Highly competitive salary based on experience.
  • Equity based remuneration.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • Inclusive company culture.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Opportunities for personal, professional and scientific development.
  • Team-wide social events.

About us
Who we are Located in London, Sixfold is a YCombinator and venture-backed startup. Founded by researchers from the University of Cambridge and the Francis Crick Institute, we’re dedicated to expanding the potential of gene therapies, so that ultimately we can cure more diseases in more people. It’s why we started Sixfold — to make a difference. We work at the cutting edge of science by fostering collaborations with the world’s best institutions and the sharpest minds. If you want to help cure the incurable, you belong with us.

It’s important to mention that although disease affects us all, our industry still displays a huge lack of diversity — this needs to change. Our founding team is comprised of different nationalities and is 2/3rds female founders. Our goal is to create a company culture that promotes ideas and the inclusion of scientist and engineers from all backgrounds.

Find out more

 

  

 

Postdoctoral Fellow Position Available, Department of Biomedicine in the group of Professor Ruth Brenk

At the Faculty of Medicine, Department of Biomedicine in the group of Professor Ruth Brenk (http://www.uib.no/en/rg/brenk ) a full-time (100 %) position as Postdoctoral Fellow is available for a period of 3 years. The position is part of the project “Exploration of the TPP riboswitch as a new target for antibiotics” financed by The Research Council of Norway under the Joint Programming Initiative on Antimicrobial Resistance(JPIAMR) initiative.

The main focus of the project will be hit discovery and optimization for the TPP riboswitch which is a target for new antibiotics (https://www.jpiamr.eu/wp-content/uploads/2018/11/Summary_Explore.pdf). The role of this postdoc will be high-throughput screening (HTS) assay development, hit validation (using binding assays and X-ray crystallography) and structure-based ligand design.

More information can be found here: https://www.jobbnorge.no/ledige-stillinger/stilling/161277/postdoctoral-fellow-3-years-for-hit-discovery-for-riboswitches

Ph.D. Studentships, Dept of Molecular Genetics, University of Groningen (the Netherlands)

Applications are invited for two 4-year Ph.D. studentships, starting April 2019, in the newly established research group of Dr. Danny Incarnato (embedded in the department of Molecular Genetics, headed by Prof. Dr. Oscar Kuipers) at the University of Groningen (the Netherlands), to study in vivo RNA folding dynamics.

What

The successful applicants will work on a multidisciplinary project aimed at understanding the mechanistic aspects underlying in vivo RNA structure formation. Particularly, they will:

–        study the role of different factors, such as macromolecular crowding, RNA binding proteins (RBPs) and RNA post-transcriptional modifications (PTMs), in regulating RNA folding (and their crosstalk)

–        develop novel approaches for the accurate interrogation on a transcriptome-wide scale of RNA structures and PTMs

–        integrate the wet-lab work with a substantial component of bioinformatics analyses (developing novel analysis tools where needed)

Ph.D. candidates will receive excellent training through cutting-edge research projects, advanced courses and training opportunities, complemented by workshops on generic research, transferable skills and teaching. Ph.D. candidates are committed to conduct independent and original scientific research, to report on this research in international publications and presentations, and to present the results of the research in a Ph.D. dissertation, to be completed within 4 years. Moreover, Ph.D. candidates are expected to contribute 10% of their overall workload to teaching.

Who

The ideal candidates must be highly motivated, hard-working, ambitious, creative, really enthusiastic about RNA and interested in doing both wet-lab and bioinformatics. They must hold a Diploma or Master’s degree in the field of life sciences (molecular biology, biochemistry, or related disciplines) and have at least 6 months of lab experience (ideally with a focus on RNA biology and/or Next-Generation Sequencing). Strong communication skills and the ability to work efficiently, independently as well as in a team, are required. An excellent written and oral fluency in English is essential. Prior knowledge of UNIX/Linux computing environments and of a programming language (Perl, Python, Ruby, C++) is not required but is a plus.

How

Our lab uses both prokaryotic and eukaryotic cellular models and exploits (or develops where needed) cutting-edge Next-Generation Sequencing approaches (Incarnato et al., 2017 [PMID: 28934475]; Incarnato et al., 2017 [PMID: 28180324]; Incarnato et al., 2014 [PMID: 25323333]) and bioinformatics analysis tools (Incarnato et al., 2018 [PMID: 29893890]; Incarnato et al., 2016 [PMID: 26487736]; Incarnato et al., 2013 [PMID: 23863844]), complemented by traditional molecular genetics and biochemistry techniques.

Where

Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 30,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.

The “RNA Folding Dynamics” lab is hosted in the prestigious Groningen Biomolecular Sciences and Biotechnology Institute (GBB), located in the Zernike Campus, at the northern edge of the city of Groningen.

The GBB is one of the larger institutes of the Faculty of Science and Engineering (FSE) and provides an excellent environment for top-notch research in the field of biomolecular sciences. Twelve vibrant research groups with strong roots in biophysics, biochemistry & molecular biology, cell biology, chemistry, computational biology, microbiology or genetics are organized in two focal areas: ‘Molecular Mechanisms of Biological Processes’ and ‘Physiology and Systems Biology’.

When

The preferred starting date is April 1st, 2019.

Conditions of employment

The University of Groningen offers a salary of € 2,325 gross per month in the first year to a maximum of € 2,972 gross per month in the final year (salary scale Dutch Universities), based on a full-time position (1.0 FTE) excluding an 8% holiday allowance and an 8.3% end of the year bonus.

The position offered is for four years. Each successful candidate will first be offered a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the contract period is to be expected. A Ph.D. training programme is part of the agreement and the successful candidate will be enrolled in the Graduate School Science and Engineering of the Faculty.

How to apply

Applications should consist of:

–        a cover letter with background and motivation to apply for this position

–        a curriculum vitae, including details of bachelor and master degrees, labwork experience and a publication list, if applicable

–        detailed (1-2 pages) description of previous research experience, such as the bachelor/master research projects

–        contact details of 2 academic references who can provide information on candidate’s suitability for the position

Interviews are scheduled to take place in February 2019, in Groningen.

Please refer to the official job announcement of the University of Groningen with further details on the appointment and remuneration and apply online at:

https://www.rug.nl/about-us/work-with-us/job-opportunities/overview?details=00347-02S0006PLP

Deadline

Applications for this position can be sent until January 30 23:59 h / before January 31, 2019 (Dutch local time) by means of the online application form (click on “Apply” below on the advertisement on the University website).

Information

Question regarding the open positions and the objectives of the research can be obtained by contacting: Dr. Danny Incarnato (E-mail: dincarnato@nullincarnatolab.com; Skype: incarnatolab).

Additional information on the university, faculty, institute, research groups and the city:

–        University of Groningen: https://www.rug.nl/

–        Groningen Biomolecular Science and Biotechnology Institute (GBB): https://www.rug.nl/research/gbb/

–        RNA Folding Dynamics research group: http://www.incarnatolab.com

–        The conditions of employment: https://www.rug.nl/about-us/work-with-us/

–           The city of Groningen: http://www.rug.nl/about-us/who-are-we/discover-groningen/

Seeking an Experienced RNA Computational Biologist with a strong RNA biology background

Panorama Medicine is seeking an experienced RNA Computational Biologist with a strong RNA biology background to analyze large-scale RNA data at their Philadelphia office.

Responsibilities:

  • Analyze large-scale RNA-seq data.
  • Discover underlying mechanisms of observed data results.
  • Closely work with molecular biologist for target validation.

Minimum Qualifications:

  • All applicants must have a PhD in genetics, biology, bioinformatics, or closely related fields. Post-doctoral experience is preferred.
  • Excellent understanding of RNA biology. Exposure to rare disease research and a strong record of publication is preferred.
  • Good programming and scripting abilities in languages, such as R, Python. Familiar with Linux/Unix systems.
  • Familiar with public genomics databases, such as TCGA, GTEx, LINCS, ENCODE, OMIM, etc.
  • Strong knowledge of statistics and machine learning algorithms.
  • Strong writing skills for scientific reports. Experience in grant application is preferred.
  • Excellent problem-solving, teamwork, organization, and communication skills.
  • US citizen or permanent resident only.

About Panorama Medicine:

Panorama Medicine is a VC-backed startup founded by a multidisciplinary team of world-renowned computational and experimental RNA biologists. Our mission is to use genomics and computing to accelerate drug discovery. Panorama is young and fast-growing, offering rewarding career development opportunities.

Benefits:

Panorama strives to build a Google-like work environment, creative, fun, hardworking, and highly productive. We offer a strong compensation package that includes competitive salary, generous stock options, and a comprehensive health benefits package. Flexible time off, productivity perks, paid parental leave, company sponsored learning and development opportunities.

Panorama is an Equal Opportunity Employer and Prohibits Discrimination and Harassment of Any Kind.

Interested applicants should send a cover letter and a CV to hr@nullpanoramamedicine.com.