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Computational Engineering of Nucleic Acid Nanostructures (EU funded position) at Sixfold Bioscience, London (UK)

About Sixfold Bioscience

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of Cell and Gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.

The opportunity

As an RNA nanotechnologist you’ll have the opportunity to radically improve how we deliver Cell and Gene therapeutics. You’ll learn how to use computational methods to build advanced functionalities into our drug delivery systems to improve both safety and efficacy. You’ll be working in-sync with intra- and extra-cellular systems to ‘hack’ biology for more effective RNA based therapeutics.

We know this is a big challenge, which is why you’ll be working in close collaboration with our multidisciplinary team of chemists, biologists and computational scientists. You’ll become familiar with areas of science you might not be typically exposed to. As we work towards our common goal you’ll see how teams function as part of a rapidly growing startup.

Your work will make invaluable contributions to the scientific and strategic direction of the company, which is why we will give you all the support to help achieve your goals. Oh, and being funded by a prestigious Horizon 2020 Innovation Associate grant from the European Commission means you’ll gain access to additional financial support to develop your skills and build your network!

During the first year, you’ll

  • Apply computational techniques to adapt and optimize Sixfold’s proprietary oligonucleotide delivery systems for therapeutic cargo.
  • Utilise your computational background for the modelling and simulation of RNA.
  • Work in collaboration with our chemistry and computational teams to improve the speed and accuracy of RNA software.
  • [Optional] Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).

Who you are

You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who is:

  • Awarded or soon-to-be-awarded with a PhD degree in either Biophysics, RNA Nanotechnology, DNA nanotechnology, Computational (Bio)Chemistry or equivalent scientific discipline.
  • Familiar with RNA nanotechnology software, such as: Murlet, RNAbuild, Revolvr, Ligate, Trace, Nupack, RiboSketch, Hyperfold, MPGAfold, KNetFold, NanoTiler, RNA2D3D and StructureLab.

Perks

  • €58-62,000 gross annual salary.
  • 12 month full-time position.
  • €4,000 relocation package (e.g. removals, travel costs, family travel costs, visa costs).
  • €5,500 for training and conferences.
  • Participation at a European Commission kick-off meeting in Brussels

Other perks

  • Possibility of full time employment following the 1 year Horizon 2020 Innovation Associate program, including employee stock options.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Team-wide social events.
  • 25 days paid vacation (not including bank holidays)

Application process

The application process consists of the following:

  1. September 1st at 11:59pm: Applications close.
  2. September 2nd: Shortlisted candidates notified.
  3. September 2-5th: Skills-based challenge for Shortlisted candidates (remote).
  4. September 6th: Candidates invited to interview.
  5. September 9-11th: Interviews (via Skype).
  6. October 15th: Start date.

Eligibility

  • Awarded or soon-to-be-awarded with a PhD
  • To have resided or carried out your main activity in the UK for no more than 12 months in the previous 3 years.
  • Be able to relocate to London.

Further Information

Should you have any questions, please email careers@nullsixfold.bio

Apply here: http://bit.ly/H2020-RNA

Visit our website: https://www.sixfold.bio/

Postdoctoral Position Available, Newly Established Group of Dr Lovorka Stojic, London

A postdoctoral position is available in a newly established group of Dr Lovorka Stojic at the Barts Cancer Institute in London to work on the role of long noncoding RNAs (lncRNAs) in genome stability and cancer.

The project is aimed at identifying mechanisms by which specific lncRNAs safeguard genome integrity and determine the contribution of lncRNA dysregulation to genome instability in cancer. Using cutting-edge quantitative proteomics, genomics and imaging, we aim to functionally dissect a subset of lncRNA genes, in order to identify lncRNA molecular interactors and examine their functional relevance in pathways governing genome stability.

This project is based on our prevoius work, mainly: Stojic et al., NAR, 2018; Stojic et al., bioRxiv, 2019.

For more information about the lab, please visit stojiclab.com.

Skils required: PhD in biology or related life science field. Significant laboratory experience in cell and molecular biology is essential. Experience in the field of RNA biology, genomics and bioinformatics is strongly desired.

Interested candidates should send their CV, cover letter and the names of three referees to

lovorka.stojic@nullcruk.cam.ac.uk

Deadline: 31st September 2019.

Earliest start date: 1st November 2019.

Duration: 3 years

About the Institute please visit www.bartscancer.london and www.bci.qmul.ac.uk

 

Research Technician / Research Associate Position Available, University of Delaware

Research Technician / Research Associate position available to study RNA-protein interactions and mechanism, University of Delaware

The Mugridge Lab (mugridgelab.org) in the Department of Chemistry & Biochemistry at the University of Delaware is seeking a full-time Research Associate I to join our team. We are a new lab at UD focused on a mechanistic understanding of enzymes that control RNA function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development.

Under the general direction of the Principal Investigator, the Research Associate I will carry out cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein interactions, and contribute to lab maintenance and organization. This is an exciting opportunity for a motivated BS or MS level scientist to help build a new lab, generate data for publication, and take on diverse techniques and roles.

MAJOR RESPONSIBILITIES:

  • Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.
  • Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.
  • Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.
  • Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).
  • Maintain a detailed laboratory notebook.
  • Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.
  • Help ensure general lab safety standards.
  • Perform miscellaneous job-related duties as assigned.

QUALIFICATIONS:

  • Bachelor’s degree and two years of job-related experience or equivalent combination of education and experience. Degree in Biochemistry, Chemistry, Molecular Biology, Bioengineering, or related field preferred.
  • Experience in a biochemical research laboratory.
  • Experience with molecular cloning and protein expression and purification methods. Experience with AKTA FPLC is a plus.
  • Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.
  • Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.
  • Ability to work both independently and as part of a team.
  • Enthusiasm to learn new techniques and take on new roles.
  • Excellent communication and organizational skills.

Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references.

APPLY HERE: https://careers.udel.edu/cw/en-us/job/494198/research-associate-i-chemistry-biochemistry

Postdoctoral Fellow Position Available, RNA Modification and Function, University of Delaware

Postdoctoral Fellow position available to develop new tools to study RNA modification and function, University of Delaware

The Mugridge lab (mugridgelab.org) in the Department of Chemistry & Biochemistry at the University of Delaware is seeking a postdoctoral fellow to join our team. We are a new lab focused on a mechanistic understanding of enzymes that control RNA function and impact human disease. In particular, we are interested in understanding how diverse chemical modifications on RNA, which affect RNA structure, processing, translation, and stability, regulate gene expression. We are looking for an enthusiastic, self-motivated postdoc to engage in a project developing new tools to study RNA modification biology and RNA-modifying enzymes.

The ideal candidate will have a PhD in chemistry, biochemistry, synthetic biology, or a related field, and have experience with protein engineering, in vitro aptamer selection, or chemical biology approaches. Candidates with experience in structural biology or molecular biology with interests in protein-nucleic acid interactions and/or RNA modification biology are also encouraged to apply. The successful applicant will have a strong scientific record, excellent communication skills, ability to work independently and as part of team, and willingness to help mentor junior scientists. This is an exciting opportunity to develop new tools to study RNA biology, apply these tools to study RNA function and/or RNA-modifying enzymes, and contribute to growing and steering the scientific directions of a new lab.

Applications should consist one page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references.

APPLY HERE: https://careers.udel.edu/cw/en-us/job/494158/post-doctoral-fellow-chemistry-biochemistry

Two Post-Doc Positions Available, The Ke Lab, Jackson Laboratory

The Ke Lab at The Jackson Laboratory with two Post-doc postings online:

1) Computational Biology Postdoc:

https://careers-jax.icims.com/jobs/25557/postdoctoral-associate—ke-lab/job

2) RNA Biology Postdoc:

https://careers-jax.icims.com/jobs/25230/postdoctoral-associate—ke-lab/job

The Laboratory of Dr. Shengdong Ke has two postdoctoral associate openings (one in RNA biology, and the other in computational biology) at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in the fundamental mechanism of m6A RNA genomics; and regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation, Genes & Development 2015, 29:2037-53.)

Requirements for Computational Biology Postdoc:

The successful candidate will develop and apply computational methods for genomic data analyses, have novel opportunities at the intersection of algorithms, data interpretation, and experimental design in close collaboration with the experimental team in the lab.  A good publication record and excellent communication skills are essential. A PhD. in a quantitative area is required: computational biology, computer science, statistics, physics and/or applied math.  Programming in Python, Perl, R or C++ is desired, as well as experience in genomic dataset analysis and integration.

Requirements for RNA Biology Postdoc:

Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, cancer biology or computational biology. Biochemistry and/or computational background and interest is a plus.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA is a world leader in mammalian genetics.  JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health. JAX is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

Research/Laboratory Manager, Research Group of Steven Brenner, University of California, Berkeley

About Berkeley

The University of California, Berkeley, is one of the world’s most iconic teaching and research institutions. Since 1868, Berkeley has fueled a perpetual renaissance, generating unparalleled intellectual, economic and social value in California, the United States and the world. Berkeley’s culture of openness, freedom and acceptance—academic and artistic, political and cultural—make it a very special place for students, faculty and staff.

Berkeley is committed to hiring and developing staff who want to work in a high performing culture that supports the outstanding work of our faculty and students. In deciding whether to apply for a staff position at Berkeley, candidates are strongly encouraged to consider the alignment of the Berkeley Workplace Culture with their potential for success at http://jobs.berkeley.edu/why-berkeley.html.

Application Review Date

The First Review Date for this job is: July 30, 2019

Position will remain open until filled.

Departmental Overview

The Brenner research group is an interdisciplinary research group, at the University of California, Berkeley. Our research has implications for diseases from cancer to Crohn’s Disease, and the future of personalized medicine for all people. We have a dozen members ranging from undergraduates to senior researchers and the research group provides a dynamic, occasionally demanding, flexible, and supportive work environment. We are associated with the Department of Plant and Microbial Biology, the Department of Molecular and Cell Biology, the Department of Bioengineering, the Center for Computational Biology, and the Institute for Quantitative Bioscience at the University of California Berkeley. We are also affiliated with Lawrence Berkeley National Lab and the University of California, San Francisco. We have collaborations with researchers worldwide.

Responsibilities

The Brenner computational genomics research group is seeking a Research / Laboratory Manager. The Research / Laboratory Manager will play a key role in facilitating effective laboratory operations and research efforts for a cutting-edge genomics, computational biology, and bioinformatics research group.

*   Day-to-day management and requisition of laboratory materials and supplies, organization and maintenance of chemical and lab equipment inventories, and upkeep of the common laboratory including space safety procedures/protocols including for collaborative programs.

*   Routine information management, interfacing with department and service structures, outreach and website production, calendar maintenance, travel coordination, management of correspondence, and meeting schedules and retreats, including for collaborative programs.

*   Learn and employ standard laboratory and program management tasks including procurement and reimbursement, personnel appointments, and budget and grant preparation, management, review and reporting including for collaborative programs.

*   Production of weekly reports and recording of information in standardized forms.

*   Supervision of one or more undergraduate assistant(s) to perform routine tasks.

*   Depending on skills, preparation of reagents and buffers; equipment maintenance; scientific software development and graphics; editing of research papers and grant proposals.

Required Qualifications

*   Excellent facility with all components of the Microsoft Office family and Adobe Creative Suite.

*   Able to work effectively with and respond to collaborators and other lab members and meet their needs.

*   Excellent organizational skills and attention to detail.

*   Ability to prioritize tasks and work independently.

*   Demonstrated fluent and facile command of written and spoken English.

*   Overtime may be required for this position; limited travel might be required.

Preferred Qualifications

*   Previous experience using and maintaining standard molecular biology equipment such as PCR machines, microplate readers, and chemical inventories.

*   Previous experience with scientific data analysis and/or visualization, software development, script writing and web site development.

*   Authorship of published scientific papers, and scientific poster presentation experience.

Salary & Benefits

For information on the comprehensive benefits package offered by the University visit:

http://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

How to Apply

Please submit your cover letter and resume as a single attachment through the UC Berkeley job site: https://jobsprod.is.berkeley.edu/psp/jobsprod/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_CE.GBL?Page=HRS_CE_JOB_DTL&Action=A&JobOpeningId=27300&SiteId=1&PostingSeq=1

Equal Employment Opportunity

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see: http://www.eeoc.gov/employers/upload/poster_screen_reader_optimized.pdf

For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct

Research/Laboratory Supervisor Position Available, University of California, Berkeley

About Berkeley
The University of California, Berkeley, is one of the world’s most iconic teaching and research institutions. Since 1868, Berkeley has fueled a perpetual renaissance, generating unparalleled intellectual, economic and social value in California, the United States and the world. Berkeley’s culture of openness, freedom and acceptance—academic and artistic, political and cultural—make it a very special place for students, faculty and staff.

Berkeley is committed to hiring and developing staff who want to work in a high performing culture that supports the outstanding work of our faculty and students. In deciding whether to apply for a staff position at Berkeley, candidates are strongly encouraged to consider the alignment of the Berkeley Workplace Culture with their potential for success at http://jobs.berkeley.edu/why-berkeley.html.

Application Review Date
The First Review Date for this job is: July 30, 2019
Position will remain open until filled.

Departmental Overview
The Brenner research group is an interdisciplinary research group, at the University of California, Berkeley. Our research has implications for diseases from cancer to Crohn’s Disease, and the future of personalized medicine for all people. We have a dozen members ranging from undergraduates to senior researchers and the research group provides a dynamic, occasionally demanding, flexible, and supportive work environment. We are associated with the Department of Plant and Microbial Biology, the Department of Molecular and Cell Biology, the Department of Bioengineering, the Center for Computational Biology, and the Institute for Quantitative Bioscience at the University of California Berkeley. We are also affiliated with Lawrence Berkeley National Lab and the University of California, San Francisco. We have collaborations with researchers worldwide.

Responsibilities:
The Research / Laboratory Supervisor has a leading role in facilitating effective laboratory operations and research efforts for a cutting-edge genomics and computational biology research group, and facilitating its campus, national, and international collaborations and interactions. Involves supervising and coaching other research group staff. Involves supporting laboratory research, which includes routine and non-routine operations, data/information management and interpretation, development and performance of laboratory management procedures, leading engagement of organizational structures for over a dozen units at multiple institutions, literature management, and preparation of reports and support of scientific papers and proposals.

* Supervises and schedules the activities of laboratory including support staff and researchers; may plan and direct work of entry to intermediate level research associates.
* Prioritizes laboratory obligations and delegates appropriately. Sophisticated information management of laboratory management data and reporting, including weekly summary reports and periodic reports to institutional units and funders
* Supervises staff and trainee management activities including recruitment, personnel appointments, performance evaluations and handling disciplinary issues.
* Ensures regulatory compliance relative to safety and security in research programs; develops and provides for staff training in equipment use and safety protocols and secure and sensitive data management.
* Oversees or performs laboratory research and project inventory planning and purchasing, and reimbursement. Management and requisition of laboratory and project materials and supplies, organization and maintenance of chemical and lab supplies and equipment inventories.
* Employ routine and non-routine laboratory management and budget planning and accounting oversight and grant management and reporting.
* Ensures that data collections and equipment are maintained properly. Upkeep of the laboratory.
* Consults and coordinates with academic supervisors, professional researchers, trainees, and staff (both in host laboratory and in collaborative groups, on campus, at other institutions, and internationally) on the nature and objectives of the research project and grant and collaboration goals, including coordinating meetings, symposia, and retreats.
* Interfaces with department, program, and service structures. Facilitates research collaborations within campus and with other institutions.
* Performs state-of-the-art, complex research projects proposal design and logistics supervision in collaboration with academic supervisors. Identifies funding opportunities, and pursues. Depending upon skills, prepare laboratory materials. Supervise and coordinate vetting of project proposals.
* Coaches and mentors laboratory support staff and entry to intermediate associates.
* Contribute towards providing editorial support, graphic design, and administrative management and content for articles for publication in scientific journals, for poster and oral presentations at conferences or symposiums, grant proposals, and reports.
* Depending on skills, engage in scientific software development and visualization.
* Oversee outreach and website production, calendar maintenance, travel coordination, management of correspondence, and meeting schedules within group, campus, and with other institutions.

Required Qualifications
* Solid leadership skills associated with planning work assignments, establishing priorities and scheduling space.
* Solid interpersonal skills to develop and maintain effective working relationships with students, trainees faculty and staff.
* Knowledge of data/knowledge/information acquisition, management, and analysis techniques.
* Advanced knowledge research management to collaborate effectively with faculty and function as a resource to research associates.
* Solid interpersonal communication skills to effectively supervise staff.
* Knowledge of necessary lab, and data safety and security procedures and requirements.
* Excellent facility with all components of the Microsoft Office family and Adobe Creative Suite.
* Able to work effectively with and respond to other lab members and meet their needs.
* Able to provide surge effort/hours as needed for projects with deadlines.
* Excellent organizational skills and attention to detail.
* Ability to work with quantitative information, including complex budget development and deployment and accounting oversight.
* Ability to prioritize tasks and work independently
* Demonstrated fluent and facile command of written and spoken English.

Education/Training:
* Bachelor’s degree preferably in a biological science, computer science, mathematics or equivalent work experience (such as leading laboratory operations). Advanced degree or comparable training preferred.

Preferred Qualifications
* Previous experience with scientific data analysis and/or visualization, software development, script writing and web site development.
* Previous experience using and maintaining standard molecular biology equipment such as PCR machines, microplate readers, and chemical inventories.
* Authorship of published scientific papers, and scientific poster presentation experience.

Salary & Benefits
For information on the comprehensive benefits package offered by the University visit:
http://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

How to Apply
Please submit your cover letter and resume as a single attachment through the UC Berkeley job site: https://jobsprod.is.berkeley.edu/psp/jobsprod/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_CE.GBL?Page=HRS_CE_JOB_DTL&Action=A&JobOpeningId=27301&SiteId=1&PostingSeq=1

Equal Employment Opportunity
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
http://www.eeoc.gov/employers/upload/poster_screen_reader_optimized.pdf

For the complete University of California nondiscrimination and affirmative action policy see:
http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct