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An ANR-funded postdoctoral position is available in UMR7156 – GMGM (University of Strasbourg, CNRS) for a research project on structural, molecular and biochemical aspects of two highly conserved mitochondrial ribosome assembly factors, involved in critical steps of mitoribosome maturation and associated with severe mitochondrial diseases in human.
Mitochondria inherited from their bacterial ancestors a set of essential proteins required for translation, but also acquired new, mitochondria-specific protein factors to accomplish the assembly of the highly divergent and complex mitochondrial ribosome. Our laboratory studies two such proteins, that turned out to be essential mitoribosome assembly factors with surprising biochemical and structural characteristics and still poorly understood molecular mechanisms. Their phylogenetic distribution suggests that they play critical roles in ribosome biogenesis in the majority of mitochondrial, chloroplast and even bacterial systems and represent promising drug targets in infection- but also cancer-related pathologies. Therefore, it is necessary to reach detailed structural and functional understanding of their activity in the context of ribosome maturation and beyond.
The position, which may start any time in the first half of 2020, is a standard 3-year postdoctoral contract with a net salary of ~2,400 €. A successful candidate is expected to be a highly motivated and autonomous researcher, fluent in English, have a strong background and experience in structural biology and/or biochemistry. Experience in mitochondrial or ribosome biology is not required but may be an asset.
Applications (an informal motivation letter and CV) will be sent directly to Dr Alexandre SMIRNOV and considered until the position is filled.
A Postdoctoral Researcher and a Research Technician to study spliced leader trans-splicing, University of Aberdeen
The laboratory of Berndt Müller and Jonathan Pettitt at the Institute of Medical Sciences of the University of Aberdeen has open positions for a Postdoctoral Researcher with a strong interest in RNA biology and for a Research Technician. These positions are supported by a BBSRC-funded project grant that aims to understand the molecular machinery critical for an essential, nematode-specific pre-mRNA maturation step termed spliced leader trans-splicing.
The project combines state-of-the-art nematode molecular genetics and RNA biochemistry, including genome editing, proteomics and RNA sequencing technologies to (1) determine the molecular composition of RNA-protein complexes critical for spliced leader trans-splicing; and (2) define the roles of newly identified protein factors. We have partnered with Prof Michael Sattler (Technical University of Munich), a leading expert in the structural biology of RNA-protein complexes, for the detailed analysis of molecular interactions and structures. This comprehensive, multifaceted approach will provide crucial insights into nematode gene expression, with clear implications for the development of new treatments for parasitic nematode infections.
Lab website: https://www.aberdeenwormlab.org/
University staff websites:
The POSTDOCTORAL RESEARCHER will work in collaboration with the Research Technician to employ CRISPR-Cas9 genome engineering to generate transgenic animals that express fluorescently tagged trans-splicing factors for the analysis of protein expression and localisation, and the characterisation of RNA and protein complexes by immunoprecipitation followed by RNA-Seq analysis and proteomics, respectively. The role of identified factors will be determined by analysing the effect of their loss-of-function on spliced leader trans-splicing in vivo. Their detailed molecular functions will be determined using protein-protein and RNA-protein interaction assays, including UV cross-linking “CRAC” technologies, which will also allow us to measure the dynamics of these interactions in vivo. Molecular structures will be solved in collaboration with the group of our project partner Professor Michael Sattler (Technical University of Munich), which has an established, world-leading track record in biomolecular structure determination and with whom the successful candidate will work closely.
Candidates for the POSTDOCTORAL RESEARCHER position must have a PhD in a relevant discipline such as Molecular Biology, Biochemistry or Genetics, with experience of working with Caenorhabditis elegans or another genetically-tractable system, and a strong interest in RNA biology.
The ideal candidate would have extensive experience in molecular biology techniques, RNA analysis and the investigation of RNA-protein and protein-protein interactions. Experience with high-throughput sequencing, proteomics, confocal fluorescence microscopy or genome editing would be an advantage.
Targeted start date for this position is January 1, 2020. Salary will be at the appropriate point on the Grade 6 University of Aberdeen salary scale (£33,797 – £36,914 per annum). The position will be available for a period of 36 months.
For more details about the POSTDOCTORAL RESEARCHER position and to apply go to:
The RESEARCH TECHNICIAN will work closely with the Postdoctoral Researcher and support other members of the laboratory working on related projects. This post also involves the management, organisation and operation of an expanding research laboratory and support of associated undergraduate and postgraduate research projects.
We are looking for a skilled, experienced and ambitious individual with good technical abilities in microbiology and molecular biology and experience in working with C. elegans or other genetically tractable model organisms. A good BSc in Molecular Biology, Genetics, Microbiology or related area is desirable. Training will be given for specialised techniques.
Targeted start date for this position is January 1, 2020. Salary will be on Grade 5 of the University of Aberdeen salary scale (£28,332 per annum). The position will be available for a period of 36 months.
For more details about the RESEARCH TECHNICIAN position and to apply go to:
Informal enquiries about both positions are very much encouraged and may be made to Dr Berndt Müller (firstname.lastname@example.org).
The Kleiner Lab at Princeton University is looking for a postdoctoral candidate with strong bioinformatic/computational biology ability. In particular, candidates with expertise in the analysis of CLIP data, RNAseq, RNA modification sequencing, and proteomic datasets are encouraged to apply. Those with strong experimental skills in nucleic acid chemistry, biochemistry, and cell biology, are also desired. We are a multi-disciplinary chemical biology lab that studies epitranscriptomic RNA modifications. A PhD in Chemistry, Biology or a related field is required. The start date for the position is negotiable. Please send applications containing your CV, cover letter, and a list of 3 references to email@example.com.
The postdoctoral positions are available in the Quantitative RNA Biology group headed by associate professor Marc Friedlander, part of MBW and located at the SciLifeLab. The group is part of a larger vibrant international collaborative environment and seeks to address fundamental questions in RNA biology, by applying quantitative approaches such as single-cell RNA sequencing, single-cell proteomics, various high-throughput screening methods and advanced computational biology.
Recent collaborations include paleotranscriptomic profiling of mammoth non-coding RNAs and study of the impact of space flight on the human transcriptome (NASA Twin study). The main focus of the group is to study microRNA functions in mammalian single cells, investigating the impact of microRNAs on target gene expression variation, covariation and on overall gene expression networks. This research direction is funded by an ERC Starting Grant (miRCell 758397).
The postdoctoral researchers will develop beyond-state-of-the-art methods to profile the variation of microRNA expression, interactions between microRNAs and their targets, and the impact of microRNAs on the transcriptome and proteome, in single cells. The post docs will interact with experimental and computational researchers from the group, and will participate in limited co-supervision of PhD students.
Lab website: www.friedlanderlab.org
Recent pre-print on gene covariance: www.biorxiv.org/content/10.1101/771402v1
Recent pre-print on single-cell proteomics: www.biorxiv.org/content/10.1101/749473v3
Science for Life Laboratory (SciLifeLab) is a collaboration between four universities in Stockholm and Uppsala: Stockholm University, the Karolinska Institute, the Royal Institute of Technology, and Uppsala University. The SciLifeLab is a national center for large-scale biosciences with a focus on high-throughput health and environmental research. The center combines advanced technical know-how and cutting-edge equipment with a broad knowledge in translational medicine and molecular biosciences. In particular, SciLifeLab has in the recent years become an international hub for research in single-cell and spatial transcriptomics.
Stockholm University is a leading European university offering a multicultural environment in one of the world’s most dynamic capital cities. With more than 60,000 students and 5,000 staff, the University facilitates individual and societal development by providing top quality education that is tightly linked to its internationally recognized research programs. The MBW department conducts experimental basic research in molecular cell biology, integrative biology and infection and immune biology.
Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.
In the appointment process, special attention will be given to research skills. We are looking for candidates that have extensive wet-lab experience with transcriptomic or proteomic methods, preferably in a single-cell context. Specific experience with single-molecule FISH, microfluidics, oligo-assisted proteomics, PEA or PLA constitutes an additional advantage. Familiarity with the microRNA field is not necessary, however the candidates must be highly motivated, creatively thinking and have a record of high-quality scientific publications. Excellent English language skills, both written and spoken, are a requisite.
Terms of Employment
This is a full-time position available immediately. The starting date is negotiable. The position is initially funded for two years, with a possibility of extension. The position constitutes full employment including all social benefits. Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.
Further information can be provided by associate professor Marc Friedlander, firstname.lastname@example.org
Applications should be submitted using the Stockholm University web-based application system at: www.su.se/english/about/working-at-su/jobs
Click on the position “Postdoctoral Fellows to study microRNA functions in single cells (2)” and click the “Apply” button on this page.
The instructions for applicants are available at: Instructions – Applicants.
You are welcome to apply!
Stockholm University – our education and research produce results.
Assistant or Associate Professor (10 month), Genome to Phenome Biology
The Department of Biological Sciences at the University at Buffalo, The State University of New York at Buffalo (http://biology.buffalo.edu) invites applications for an assistant or associate professor-level position (rank negotiable based on experience) from individuals who study the complex relationships between genotype and phenotype, and are committed to establishing robust, extramurally-funded research programs. Specifically, this hiring initiative focuses on understanding the relationships linking genome to phenome at all levels of life. In this round of recruitment, the Department seeks to hire an assistant or associate professor in the area of gene regulation at several different levels, including the epigenetic.
The University at Buffalo (UB) has a tradition of research excellence in biology. UB is the largest and most comprehensive campus in the State University of New York system. The Department of Biological Sciences is the major focal point for interdisciplinary research and education in life sciences at the University at Buffalo. The Department’s strengths include the biochemistry of gene expression, molecular evolution and genomics, and sensory transduction and development. As part of its ongoing strategic growth plan, the Department has recently hired faculty in neurogenetics studying development and connection patterns of diverse neural cell types, and in genome-to-phenome biology studying the genetic and molecular mechanisms responsible for phenotypic differences between species. Opportunities for interdisciplinary interactions among UB, Roswell Park Comprehensive Cancer Center, and the NYS Center of Excellence in Bioinformatics and Life Sciences are available. The position will provide a 10-month, state-supported salary plus a competitive startup package.
With backing from the College of Arts and Sciences, the Department aims to achieve disciplinary excellence in addressing “the large genome” challenge of understanding the genetic control of phenotype. The successful candidate is expected to: (1) develop a nationally-recognized, externally-funded research program; 2) participate in research laboratory training of baccalaureate, masters and doctoral students; and 3) teach undergraduate and graduate level courses. Applicants must have a doctoral or equivalent degree in an appropriate field, relevant postdoctoral experience, documented evidence of high-quality research productivity, and a solid commitment to excellence in both research and teaching.
To apply, submit electronic versions of a cover letter, a curriculum vitae, a summary of research accomplishments and future plans, and a statement of teaching interests and philosophy to UB Jobs at: http://www.ubjobs.buffalo.edu/postings/21704. Please include the names of three colleagues who could be contacted for letters of recommendation.
Completed applications will be reviewed beginning November 1, 2019, and will continue until the position is filled. Please consult our website: http://biology.buffalo.edu for information about UB, our department and our community.
University at Buffalo is an affirmative action equal opportunity employer and, in keeping with our commitment, welcomes all to apply including veterans and individuals with disabilities.
Minimum Qualifications: PhD or equivalent
Preferred Qualifications: Postdoctoral research experience; history of peer-reviewed publications and successful funding
Special Instructions to Applicants: Review of applications will begin November 1, 2019. All application materials should be submitted via UB Jobs. Application materials submitted directly to the posting contact will not be acknowledged and cannot be considered.
The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL; funded by the MRC/FAPESP) offers two Postdoctoral Positions
PROJECT: Epigenetic regulation of Leishmania gene expression
Two Post-Doctoral Positions are available to work on the project “Epigenetic regulation of
Leishmania gene expression” in the laboratories of molecular parasitology under the supervision
of Angela K. Cruz (University of São Paulo, Ribeirão Preto, Brazil) and Drs. Pegine Walrad and Michael Plevin (York Biomedical Research Institute, Dept of Biology, University of York, UK) as part of the UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL); 12 collaborative research groups from the UK and Brazil. Appointed postdoctoral fellows will study the putative regulatory role of novel non-coding RNAs at the Brazilian laboratory and identify and characterise RBPs which bind and regulate these ncRNAs in the UK laboratory.
Summary: Leishmania gene expression control occurs mainly at the posttranscriptional
level. At the centre of the regulatory complexes are cis- and transregulatory elements, mainly represented by mRNA elements (cis-elements) and RNA binding proteins (RBPs) which may well bind an unexplored content of noncoding transcripts (ncRNAs), recently detected in these parasites. Cruz and co-workers have demonstrated that ncRNAs appear a common feature of Leishmania transcriptomes and hundreds of putative ncRNAs were identified as differentially expressed (DE) transcripts. Such DE L. braziliensis ncRNAs and interacting RBPs will be functionally investigated. The post-doctoral fellows will use state of the art technologies for genome editing to generate knockout (KO) of DE ncRNAs in L. braziliensis and to endogenously tag these ncRNAs to evaluate phenotypic changes and identify interacting partners. The Brazilian post-doctoral fellow will engage in the complementary study developed in the UK, under the guidance of Drs. Pegine Walrad and Michael Plevin for two 6-months visits.
Applicants must have a Ph.D. in Parasitology, Biochemistry, Genetics, Molecular Biology or related fields. Preference will be given to highly motivated individuals with proven expertise in molecular parasitology/microbiology/ncRNAs. Candidates should be creative, personally motivated, have excellent oral and written communication skills and a sense of teamwork. It is mandatory that all applicants are fluent in English. Applicants for the USP post should have previous experience with both in vivo and in vitro infection procedures.
The Brazilian post is available for a period of up to 36 months full time, with formal review after the first year. Interested individuals should contact Angela K. Cruz by email at email@example.com using “PostDoc_Leishmania_ncRNAs” in the subject line with the following documents attached: 1) Letter of intent stating the candidate’s motivations and qualifications for the position; 2) A short version of Curriculum Vitae containing a list of publications and professional experience; 3) Two letters of recommendation from previous mentors/ supervisors of the applicant should be sent to the same email address.
Candidates meeting the requirements will be contacted and interviewed (in-person or via Skype).
The UK post is available for a period of up to 18 months full time, within the salary range £32,817 – £40,322 per annum (Grade 6 of the University of York salary scales). Targetted start date is December 1st, 2019. Informal enquiries for the UK post are encouraged and may be made to Dr. Pegine Walrad, (email: firstname.lastname@example.org, tel: +44 (0)1904 328918).
Applications should be made directly at http://jobs.york.ac.uk.
The Gavis Lab at Princeton University is seeking motivated post-doctoral candidates who are interested in working at the interface of RNA biology and developmental biology. We study post-transcriptional mechanisms that spatially control gene expression during development. Research opportunities are available to investigate the assembly of ribonucleoprotein granules and how they regulate the localization, translation, and stability of mRNAs for Drosophila germ cell and neuronal development. Approaches include high resolution microscopy, biochemistry, and genome level analyses, supported by the power of Drosophila genetics.
More information about current work in the Gavis Lab and our publications can be found at https://scholar.princeton.edu/gavislab.
Applicants must have a Ph.D., preferably with training in molecular biology, cell biology, biochemistry, or genetics. Candidates with computational biology skills are encouraged to apply.
Please submit a CV, a cover letter describing research interests and motivation for joining the lab, and contact information of three references to Liz Gavis at email@example.com.
POSTDOCTORAL FELLOW POSITION Starting JAN 1, 2020 to study RNA-protein and small molecule interactions, drug design and mechanism, Duke University Medical Center
The Agris Lab in the Department of Medicine at Duke University is seeking a full-time Postdoctoral fellow for research in antibiotic resistance, and type 2 diabetes. We are a new lab at Duke focused on a mechanistic understanding of RNAs that control function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development and RNA.
Under the general direction of the Principal Investigator, the Postdoctoral fellow will conduct cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein and small molecule interactions, and contribute to lab maintenance and organization.
- Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.
- Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.
- Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.
- Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).
- Maintain a detailed laboratory notebook.
- Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.
- Help ensure general lab safety standards.
- Perform miscellaneous job-related duties as assigned.
- Bachelor’s degree and two years of job-related experience or equivalent combination of education and experience. Degree in Biochemistry, Chemistry, Molecular Biology, Bioengineering, or related field preferred.
- Experience in a biochemical research laboratory.
- Experience with molecular cloning and protein expression and purification methods. Experience with AKTA FPLC is a plus.
- Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.
- Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.
- Ability to work both independently and as part of a team.
- Enthusiasm to learn new techniques and take on new roles.
- Excellent communication and organizational skills.
Enthusiastic, imaginative and dedicated RNA scientists wishing to join our research team will find that the RNA community of Duke and UNC is dynamic, diverse and supportive with a history of the longest regional RNA community, seminars, monthly meetings, separate RNA modification group and annual Symposium (https://sites.duke.edu/ncrna2019/).
Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references sent to Dr. Paul F. Agris (Paul.Agris@nullduke.edu). Informal inquires are welcome.
The Faculty of Medicine at the Julius Maximilians University of Würzburg and the Helmholtz Institute for RNA-based Infection Research (HIRI) jointly invite applications for a
Full Professorship (W3) in RNA-based Infection Research.
The professorship is a permanent position to be filled at the earliest possible date. We seek to appoint a leading expert with an internationally visible research profile at the interface of RNA biology and infectious diseases research. At this point, we particularly welcome applications from experts on the function and dynamics of RNA molecules in the host or the pathogen during bacterial or viral infections, on RNA therapeutics approaches including the delivery of nucleic acids, and on RNA localization and RNA modification. In addition, we are interested in candidates who focus on emerging RNA-centric techniques such as single-cell RNA-seq.
The Helmholtz Institute for RNA-based Infection Research (HIRI) was established in May 2017 as joint venture between the Helmholtz Centre for Infection Research (HZI) Braunschweig and the Julius Maximilians University of Würzburg (JMU). Located on the Würzburg medical campus, it is the first research institution in the world to fully focus on the role of RNA in infection processes. HIRI also takes an integrative approach to exploit the vast potential of RNA as a diagnostic molecule, as a target or as a drug for new strategies to combat infectious diseases. The HIRI offers an international and vibrant scientific environment and state-of-the-art infrastructure for RNA and infection research. For further information, please visit www.helmholtz-hiri.de or send an email to Jörg Vogel, the founding director of the HIRI (firstname.lastname@example.org).
The Helmholtz Society and the JMU seek to increase the number of women holding professorships and explicitly invite outstanding female scientists to apply.
Equally qualified applicants with disabilities will be given preference.
The legally binding German version of this announcement has been published in “DIE ZEIT” on August 29th, 2019. The advertisement is also available at www.med.uni-wuerzburg.de/fakultaet/berufungsverfahren/.
Please submit your application in English (or German) with the usual documentation (cover letter, signed curriculum vitae, copies of academic certificates and appointments, list of teaching activities including evaluations, list of publications, third-party funding) by October 1st, 2019. The application form can be downloaded at www.med.uniwuerzburg.de/fakultaet/berufungsverfahren/
Applications should be addressed to:
Professor Dr. M. Frosch
Dean of the Medical Faculty
University of Würzburg
Josef-Schneider-Straße 2 / Building D7
D-97080 Würzburg, Germany
NIH-funded postdoc position is available for two years with a strong possibility of extension, starting October 2019.
The laboratory represents two joined labs with diverse projects, a friendly and scientifically vibrant atmosphere, active staff and is ran by two young and active PIs:
Several lines of investigation are currently open to choose from:
1) To understand the molecular alterations that occur on a ribosome during stress and to examine how modified ribosomes behave during translation in vitro and in cells. These projects might result in new supportive data on ribosome heterogeneity.
2) To study effects of mitochondrial communication with translational apparatus (i.e. ribosomes) under different physiological settings.
3) Co-translational protein quality control: does it work beyond 60S subunit?
4) Investigation of ribosome degradation pathway.
Position requires a Ph.D. (or equivalent) in Molecular Biology or a related field. Preference will be given to candidates with the experience in yeast cell biology and/or biochemistry. Experience in high-throughput technologies (RNA-seq, ribosome profiling) is not necessary but highly desirable. The candidate must have a strong publication record, written and verbal communication skills, sound analytical and organizational skills, and ability to work independently as well as collaboratively.
The successful candidate will join an interactive environment of Rowan University School of Osteopathic Medicine (Rowan-SOM, the former University of Medicine and Dentistry of New Jersey, UMDNJ) with multiple laboratories investigating important questions in molecular/cellular biology utilizing yeast, worm and mammalian systems. The University offers state of the art facilities including Mass Spectroscopy, Next Generation sequencing, Microscopy facility. In addition, Rowan-SOM offers help in a future career planning/building, including teaching opportunities (if desirable), iJOBs seminars, Career Development Workshop and others.
Rowan-SOM is located in Stratford, a suburban south New Jersey community with an easy commute by train or car to Center City Philadelphia. This location combines and an affordable living environment, good school district, multiple child-care facilities. Due to close location to scientific hub of Philadelphia, Rowan-SOM gives the opportunity to collaborate with scientists at the University of Pennsylvania, Thomas Jefferson University, Temple University, Drexel University and the Fox Chase Cancer Center. To apply, please send a single pdf file, consisting of a one-page motivation letter, CV, publication list and the names and contact information of three references to Dr. Natalia Shcherbik at: email@example.com or firstname.lastname@example.org
Post-doctoral positions are available in the Lyons Lab at Boston University School of Medicine. We are a new laboratory; thus, there are ample opportunities for motivated candidates to drive their research in a growing and dynamic environment. Our lab studies cellular stress responses and how cells modulate RNA processing and mRNA translation to promote survival. Perturbations to these pathways can result in devastating disease states. Cancer cells co-opt stress response pathways to promote their survival at the expense of surrounding cells. Alternatively, an ineffective response to cellular insults leads to cell death. Dysregulation of these pathways is particularly detrimental to long-lived cells or cells that have a reduced capacity for self-renewal. As a result, many neurodegenerative diseases result from conditions that alter responses to stress. Our lab is uncovering the molecular determinants of these pathways with an aim at treating disease.
We are actively hiring post-doctoral fellows to aid in the exploration of these topics, including:
- How is ribosomal RNA processing and modification altered during a stress response?
- How does alteration in ribosomal RNA processing/modification effect ribosome biogenesis or the production of specialized ribosomes?
- How do these alterations affect the phase-separated nature of the nucleolus?
- How do translation initiation factors promote non-canonical mechanisms of translation initiation during a stress response?
- How do non-canonical RNA structures drive cap-independent translation in response to stress?
For more information, visit our lab website: TheLyonsLab.com
Candidates with a background in RNA biology, biochemistry or cell biology are encouraged to apply. Approaches will utilize proteomics, high-throughput sequencing and CLIP, immunofluorescence and live imaging, classical biochemistry techniques, and any other techniques that the candidate can bring to the lab. The successful candidate will be encouraged to take on new challenges, learn new technologies, and promote their career by applying for fellowships to foster research independence for their future careers.
There are multiple positions available beginning on October 1st, although the start date is negotiable. Review of applications will begin immediately and continue until the positions are filled. Interested applicants should send a cover letter describing their interests and experience along with a C.V. to:
Shawn Lyons, Assistant Professor of Biochemistry, email@example.com