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Are you interested in joining a Molecular Analytics group within Analytical R&D department in the US? If so, we are looking for a highly motivated Scientist for this high impact role and the Scientist Molecular Analytics position could be an ideal opportunity to explore. As a Scientist Molecular Analytics, you will work with high-performing CMC scientists on industry disruptive technology platform. The primary role of this Scientist will be to design and develop analytical methods, using Quality by Design (QbD) principles, to support drug substance/drug product characterization, product and process development and/or, the development and transfer of release methods for GMP testing, for the entire local US products portfolio of Technical R&D. He/she will be involved in implementing NGS technology to enhance CMC platforms and has the opportunity to serve as Subject Matter Expert in NGS data analysis. The successful candidate will work in a highly collaborative environment and spend 50-70% of the time in the lab. This role will provide YOU the opportunity to lead key activities to progress YOUR career.
These responsibilities include some of the following:
o Develop, optimize, and qualify methods in preparation for execution to assess safety and quality of vaccine candidates.
o Work together with other Analytical Department teams to determine the quality control strategy and identify resources for method development. Support for validation activities and impact assessments.
o Streamline workflows related to method development, qualification, training, transfer, and comparability.
o Serve as a subject matter expert for molecular methods. Provide Regulatory support.
o Support new technology assessment and licensing activities.
o Prioritize the deliverables from multiple programs and competing interests
We are looking for professionals with these required skills to achieve our goals:
o PhD or Master Degree with 5+ years’ industry experience in biology, biochemistry, pharmaceutical science related fields
o Experience with nucleic acid analysis and wet lab experience with molecular biology and biochemistry techniques;
If you have the following characteristics, it would be a plus:
o Working experience with gene therapies or specifically mRNA based vaccines or therapeutics;
o Experience with analytical assay development, including release assay, characterization assay, GMP testing in industry settings;
o Experience or knowledge of working in an environment under regulatory compliance;
o Industry experience relevant to molecular testing and diagnostics;
o Experience with PCR, Real-time PCR, digital PCR, DNA and RNA isolation, DNA cloning, molecular probe techniques
o NGS sequencing experience with bioinformatics knowledge and skills is appreciated;
o Research experience in RNA biology field;
o Experience with nucleic acid formulation and bioprocess development.
A postdoctoral position is available in the RNA Mediated Gene Regulation Section (RNA MGRS), RNA Biology Laboratory (RBL), Center for Cancer Research (CCR) – Frederick, MD, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS). The candidate will perform basic research on small RNA functions.
The goal of our program is to uncover the mechanisms by which the function of miRNA is regulated in health and disease and to apply those in developing effective treatments for cancer. Using genetic functional studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory focuses on elucidating mechanisms of miRNA biogenesis and the roles of post-maturation modifications.
In particular, we are interested in studying the biogenesis and function of miRNA isoforms (isomiRs). Multiple lines of evidence suggest that isomiRs possess unique biological roles . We have developed a novel algorithm to accurately detect and analyze miRNA isomiRs based on next-generation-sequencing (NGS) data . We demonstrated that miR-9-alt, an 5′ isomiR resulted from alternative Drosha cleavage of pri-miR-9-1, expands miR-9 target repertoires and functions as a tumor suppressor in low grade gliomas (LGG) . We also identified a set of non-canonical targets in human cells that are exclusively regulated by uridylated isomiRs and therefore revealed a novel function of 3′ isomiRs . Combining classical biochemistry techniques with high-throughput sequencing, the successful candidate will continue investigating the underlying mechanisms of isomiR biogenesis and function.
Recent publications from our group:
- IsomiRs: Expanding the miRNA repression toolbox beyond the seed. Biochim Biophys Acta Gene Regul Mech. 2019 Apr 4
- QuagmiR: a cloud-based application for isomiR big data analytics. Bioinformatics. 2019 May
- Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires. Cell Rep. 2019 Jan 8;26(2):447-459.e4.
- 3′ Uridylation Confers miRNAs with Non-canonical Target Repertoires. Mol Cell. 2019 June
Interested candidates must have a Ph.D. and/or an M.D. and have less than 2 years of postdoctoral experience. Ph.D. students who just received or expect to receive their degree in the coming summer, are particularly encouraged to apply. Applicants must have a strong background in molecular biology and biochemistry. Experience with RNA research and/or deep sequencing data analysis is a strong plus. Salary is commensurate with research experience and accomplishments.
Assistant Professor Positions, Columbia University, Department of Biochemistry and Molecular Biophysics
The Department of Biochemistry and Molecular Biophysics at Vagelos College of Physicians and Surgeons invites outstanding candidates to apply for TENURE-TRACK faculty positions at the level of Assistant Professor. The department seeks individuals with exceptional accomplishments and abilities in Biochemistry and Molecular Biophysics. Areas of particular interest are RNA Biology and Chromosome Structure and Function, but exceptional candidates in other areas are strongly encouraged to apply. Examples of such areas include, but are not limited to: single molecule studies and live imaging; phase transitions and granules; and biophysical studies of cellular phenomena. We seek colleagues committed to scientific excellence, collaboration, and collegiality.
The Department of Biochemistry and Molecular Biophysics offers a rigorous and stimulating environment for conducting research. Faculty use the full spectrum of contemporary biophysical, biochemical, molecular biological, and cellular techniques to study developmental biology; gene expression, regulation and signal transduction; macromolecular structure, function and dynamics; and molecular neurobiology. The Department has a rich history of excellence in molecular and structural biology and molecular neuroscience. Cross-appointment with other departments or centers is also possible.
All applicants must have a Ph.D., M.D., or equivalent degree. In addition, applicants must have a very strong record of research productivity and demonstrated ability to develop a rigorous research program.
Applicants should provide a summary of their scientific accomplishments and a description of their scientific vision, emphasizing one or more major unsolved problems in their field and how they plan to solve them (no more than three pages).
Completed applications, including the research statement, curriculum vitae, PDF copies or links for three reprints (which may be uploaded as a single PDF file), and contact information for three references must be submitted online via the following website:
Consideration of completed applications will begin in November, 2019 and continue until the positions are filled.
Columbia University is an equal opportunity/affirmative action employer. Women and minorities are especially encouraged to apply.
Department of Biochemistry and Molecular Biology at University of Texas Medical Branch
A post-doctoral fellow position is available immediately in the laboratory of Dr. Muge Kuyumcu-Martinez to study post-transcriptional gene regulation by RNA binding proteins in normal and diseased hearts. We utilize inter-disciplinary approaches that combine mouse genetics, cell biology, genome editing, biochemistry, and genome-wide analyses (e.g. RNA-seq, CLIP-Seq, PolyA seq and nanopore sequencing) to investigate molecular mechanisms that dictate post-transcriptional decisions in the heart.
We are looking for a highly motivated, bright and enthusiastic candidate with a background in RNA biology, heart development or cardiac physiology. The candidate should be to able to work as a team member, learn new skills rapidly, and have excellent communication skills. It is highly desirable that the applicant received his/her PhD within the last year.
University of Texas Medical Branch is a part of the Texas Medical Center, which is the largest medical complex in the world comprised of 54 highly collaborative and interactive medically oriented institutions including MD Anderson Cancer Center, Baylor College of Medicine, University of Texas Medical School at Houston, and Methodist Research Institute to name a few.
If you are interested, please provide your curriculum vitae, a statement of career interests (1 paragraph long), and contact information for three references to email@example.com.
Postdoctoral Positions Available – Wolin Lab, National Cancer Institute, National Institutes of Health
Fully funded postdoctoral positions are available in Sandra Wolin’s laboratory at the National Cancer Institute in Frederick Maryland. We are seeking candidates with expertise in molecular biology, biochemistry or structural biology to join one of our ongoing projects. A major interest of our laboratory is a class of noncoding RNA-protein complexes, called Ro60 RNPs, that are present in animal cells, bacteria and archaea. Our work revealed that the Ro60 protein is ring-shaped and binds defective RNAs in its central cavity and that noncoding RNAs called Y RNAs scaffold the interactions of Ro60 with other proteins such as nucleases. Our current studies are focused on characterizing ways in which Ro60 RNPs contribute to the biogenesis of other ncRNAs and to the surveillance of defective RNAs. We are also determining how defects in RNA surveillance pathways contribute to diseases such as cancer and autoimmunity. We use a wide variety of approaches, including mouse and bacterial genetics, biochemistry, molecular biology and structural biology. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin
Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research, National Cancer Institute, National Institutes of Health. We are part of the National Cancer Institute’s RNA Biology Initiative, which includes more than 50 laboratories spanning the Frederick and Bethesda campuses. The environment is highly collaborative, with the ability to interact with a wide range of scientists and clinicians. The extraordinary resources and opportunities available at the National Cancer Institute and the National Institutes of Health make these positions ideal for motivated candidates who are seeking additional training in RNA biology.
Candidates should have a Ph.D. and/or an M.D. and less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, biochemistry or structural biology, as evidenced by publications.
To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to firstname.lastname@example.org
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.
Postdoctoral Position Available Immediately, Lab of Sarah Keane, Departments of Biophysics & Chemistry, University of Michigan
A postdoctoral position is available immediately in the laboratory of Sarah Keane in the Departments of Biophysics and Chemistry at the University of Michigan. Our lab aims to investigate the structure and mechanism of functional noncoding RNAs. We utilize an array of biochemical and biophysical techniques to characterize RNA structure, RNA-RNA, RNA-protein, and RNA-small molecule interactions. We seek a highly motivated postdoc with experience in RNA biochemistry and/or RNA structural biology (biomolecular NMR spectroscopy, X-ray crystallography, small angle X-ray scattering, chemical probing). Successful applicants should hold (or will obtain shortly) a Ph.D. in: Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related field. More information about the lab can be found on our website (http://sites.lsa.umich.edu/keane-lab/).
Postdocs in the Keane lab are expected to assume leadership of their projects and serve as mentors to both graduate and undergraduate students in the lab. Interested candidates should send a cover letter, their CV, and the names and contact information for three references via email (email@example.com) with the subject POSTDOC APPLICATION. This position is a full-time, 12-month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.
The RNA Bioscience Initiative at the University of Colorado School of Medicine seeks to hire RNA Bioinformatics Fellows.
Two types of positions are currently available:
- Positions solely focused on informatic analysis and development
- Positions where time is spent both on wet-lab RNA method development and applications as well as informatic analysis and development
The Bioinformatics Fellowships are unique, semi-autonomous postdoctoral positions at the Senior Research Associate Level that provide informatics training with the goal of mastering the large skill set needed for RNA bioinformatics analysis. The Fellows (https://informatics-fellows.rnabio.co/) develop and apply software for the analysis of a variety of RNA sequencing and other experiments focused on:
- in-depth analysis of single cell sequencing data from multiple modalities
- characterizing mRNA isoforms generated by alternative splicing and polyadenylation
- the stability and processing of mRNAs after transcription
- identifying and characterizing the dynamics of RNA modifications
- integrating RNA sequencing data with genetic data
- ribosome profiling and the measurement of small and long non-coding RNAs
Wet-lab project may include:
- Development of new single-cell sequencing methods
- RNA-seq analysis of consequences of alterations in nonsense mediated RNA decay
- RNA-seq approaches to complement ongoing efforts in antisense oligonucleotide therapy development
The fellows have the opportunity to interact with a variety of RNA informatics researchers on campus, and support informatics analysis for the recipients of seed grants provided by the RNA Bioscience Initiative.
The fellows develop and help teach curricula (e.g., graduate level classes and week-long short courses) that promote the use of RNA methods and informatics on the Anschutz campus. Our ideal candidates have a Ph.D. in biological or computer sciences, and wish to expand their training to become proficient in both disciplines. The positions will be for two years with the possibility to extend the fellowship for an additional year. Toward the end of their tenure, Fellows have the opportunity to develop collaborations with faculty in the School of Medicine and liaise with pharmaceutical and biotech companies to secure a stable long-term position in Informatics.
Applicants should submit a cover letter, curriculum vitae and the contact information for 3 people who will provide letters of reference.
Materials should be submitted through CU Careers, posting # 17661
We will begin reviewing applications immediately and the search will remain open until the positions are filled.
- PhD in biological or computational discipline, MS candidates will also be considered
- Molecular or RNA biology experience for position that includes wet-lab
- Preferred expertise in R, Python or C++
- Working knowledge of computational and molecular biology, and high throughput DNA sequencing data analysis
- Demonstrated ability to teach bioinformatics, computational Biology and/or genomics courses and workshops
Special Notices to Applicants:
The University of Colorado at Denver is committed to providing a safe and productive learning and living community. To achieve that goal, we conduct background investigations for all final applicants being considered for employment. Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.
The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. Alternative formats of this ad are available upon request for persons with disabilities.
Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references other than those listed in your application during the search process.
The University of Colorado is committed to diversity and equality in education and employment.
University of Colorado School of Medicine
Dept. Biochemistry and Molecular Genetics
Are you an ambitious researcher looking for your next challenge? Do you have an established background in RNA biology? Are you keen to develop new skills in both research approaches and group leadership? Do you want to further your career in one of the UKs leading research intensive Universities?
We are seeking an ambitious scientist to join a dynamic research group pursuing RNA research to address key questions in translational control and lncRNA functions. The position is to provide support for an academic lead taking maternity leave. In addition to RNA research this role involves mentoring of PhD students and some group management. This position would be an excellent career development opportunity for an outstanding RNA biologist to learn key skills on how to run a group with time and flexibility to write fellowships. The group use a combination of biochemical, genomic, genetic, and structural approaches to tackle important, outstanding questions in mRNA translation and lncRNA function. The successful applicant would help supervise the research group and will join a vibrant research community within the Faculty of Biological Sciences at Leeds, including LeedsOmics and the Astbury Centre for Structural Biology.
You should have a PhD in RNA biology with a strong background in mRNA translation, lncRNA biology or RNA-protein complexes. Experience in biochemical purification of RNA-protein complexes, Drosophila melanogaster husbandry and genetics, analysis of RNA-Seq or similar data, structural biology, genomics would be desirable.
The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.
RNA biology: lncRNAs, RNA-protein interactions or mRNA translation.
Looking for an experienced postdoc who wants career development opportunity to help manage group as PI goes on maternity leave. Great opportunity for someone wanting to write fellowships. 1 year fixed term, available from 1st Dec 2019
I am seeking a motivated, independent, creative entry level post-doctoral researcher to join my laboratory at the University of Colorado School of Medicine (position available immediately). My lab is interested in understanding the molecular mechanism of pre-mRNA splicing and its role in disease processes, using a combination of structural (cryoEM and crystallography), biochemical, molecular biology, and cell biology approaches. Below are examples of our recent publications:
CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017; 8:1035. PMID 29051543.
Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017; 358:1278-1283. PMID 29146870.
A unified mechanism for intron and exon definition and back-splicing. Nature. 2019; 573: 375-380. PMID 31485080.
My lab is located on the University of Colorado Denver Anschutz Medical Campus within the highly collegial Department of Biochemistry and Molecular Genetics and is part of the RNA BioScience Initiative. Denver is a great place to live and to do research. To apply, please send an email with a cover letter summarizing past research accomplishments, research interest, long term plans, and start date availability; CV; and contact information of three references to Rui.Zhao@nullcuanschutz.edu.
Job Overview. The RNA Bioscience Initiative (RBI; www.rockyrna.org) seeks to hire a Grant and Development Strategist. Through a $20 million dollar initiative at the University of Colorado Anschutz Medical Campus, the RBI has expanded and increased the excitement for RNA research through hiring of new RNA faculty and a RNA bioinformatics group, developing new research programs and approaches for data generation and analysis, funding seed projects focused on RNA science, and educating trainees at all levels in RNA biology. We seek a Grant and Development Strategist to capitalize on these accomplishments and co-ordinate the development of competitive PI-driven applications for large-scale funding from the NIH and other funding agencies, to lead the effort to liaise with researchers and clinicians on campus, and to work to develop strategic partnerships to secure long-term funding for our research and training mission.
Primary and initial responsibility will be to:
• Facilitate and coordinate multi-PI grant submissions, including a program project grant, PREP R25, and T32 grants.
Over time, the Grant and Development Strategist is expected to:
• Facilitate collaborations between RBI members and clinicians
• Interface with CU Innovations and CU Office of Advancement for purposes of fundraising and strategic development
The ideal candidate will have a Ph.D. and/or post-doctoral research experience in Molecular Biology or a related field, and experience in the preparation and submission of NIH grant applications. Exceptional candidates without extensive Molecular Biology experience will be considered if they have a demonstrated track record in grant writing or development activities. The candidate must be self-motivated, organized, communicate effectively, be a team player, and have scientific maturity.
• Ph.D. and/or post-doctoral research experience in Molecular Biology
• Strong interpersonal and organizational skills.
• Experience in grant writing
• Track record of coordinating multi-PI grants
• Experience in fundraising or other development activities
Instructions to Applicants
1). A letter of application which specifically addresses the job requirements and outlines qualifications.
2). A current resume/CV.
3). List of 3-5 professional references. Please be advised that the University does check references as part of the employment process.
Please do not submit any of your application material (via email) to the job posting contact. Applications are accepted electronically at CU Careers, refer to requisition ID: 17526.
Salary and Benefits:
The hiring salary is negotiable and commensurate with skills and experience.
We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of Cell and Gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.
As an RNA Chemist you’ll have the opportunity to build a radically different approach to how we deliver RNA therapeutics in vivo. You’ll be applying your knowledge of nucleic acid chemistry to design and synthesise RNA that enhances Sixfold’s proprietary drug delivery systems. You’ll be utilising intra- and extra-cellular systems to ‘hack’ biology for more effective therapeutic potential.
We know this is a big challenge, which is why you’ll be working in close collaboration with our multidisciplinary team of chemists, biologists and computational scientists. You’ll become familiar with areas of science and preclinical research you might not be typically exposed to. As we work towards our common goal you’ll see how teams function as part of a rapidly growing startup.
Your work will make invaluable contributions to the scientific and strategic direction of the company, which is why we will give you all the support to help achieve your goals. Oh, and being funded by a prestigious Horizon 2020 Innovation Associate grant from the European Commission means you’ll gain access to additional financial support to develop your skills and build your network!
During the first year, you’ll
- Lead the development and optimisation of RNA for therapeutic use including considerations of stability and translational efficiency.
- Establish innovative chemistries for increasing the potential of Sixfold’d drug delivery systems.
- Design and execute robust experiments, interpret data and communicate findings.
- Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).
Who you are
You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who is:
- Awarded or soon-to-be-awarded with a PhD degree in RNA (Bio)chemistry or equivalent scientific discipline.
- Strong background in RNA and/or DNA chemistry.
- €58,000-62,000 gross annual salary.
- €4,000 relocation package (e.g. removals, travel costs, family travel costs, visa costs).
- €5,500 for training and conferences.
- Three EU funded industrial innovation management training events in Belgium (2-3 days each).
- Working on world-changing technology with leaders in the field.
- Dynamic, innovative, passionate, entrepreneurial team.
- Inclusive company culture.
- The chance to see your ideas and research make an impact in a fast-growing start-up.
- Team-wide social events.
- 25 days paid vacation (not including bank holidays)
- PhD in (Bio)chemistry or equivalent scientific discipline.
- To have resided or carried out your main activity in the UK for no more than 12 months in the previous 3 years.
Should you have any questions, please email firstname.lastname@example.org
- Apply here: http://bit.ly/H2020-RNA
- Visit our website: https://www.sixfold.bio/
- Application deadline: November 30th 2019.
- Start Date: No later than December 31st
The Research Group of Prof. Dr. Katja Sträßer, Institute of Biochemistry, Justus Liebig University, Giessen, German, invites applications for the position as a PhD. student / predoctoral fellow as part of the ERC-funded project “Nuclear mRNP packaging and mRNP architecture”.
The position is available from December 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).
Participation in state-of-the-art research projects
Collaboration in an enthusiastic research team
Opportunities to develop strong research skills and a solid academic profile
Opportunity to obtain a doctoral degree
Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.
For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)
Completed academic studies in biology, biochemistry, human biology or a similar subject (Master’s degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology, the model organism S. cerevisiae and/or structural biology is advantageous.
The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.
Please send your application per Email as a single pdf file with all relevant documentation per Email to email@example.com until the 8th of November 2019. Applications from disabled people of equal aptitude will be given preference.