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PhD Student/Postdoctoral Fellow Position, Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University

The Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University, Giessen, German, invites applications for the position as a PhD. student / predoctoral fellow.

The position is available from September 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).

We offer:

Participation in state-of-the-art research projects

Collaboration in an enthusiastic research team

Opportunities to develop strong research skills and a solid academic profile

Opportunity to obtain a doctoral degree

Key Responsibilities:

Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.

For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)

Required Qualifications:

Completed academic studies in biology, biochemistry, human biology or a similar subject (Master’s degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology and/or structural biology is advantageous.

The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.

Please send your application per Email as a single pdf file with all relevant documentation per Email to katja.straesser@nullchemie.bio.uni-giessen.de until the 19th of July 2019. Applications from disabled people of equal aptitude will be given preference.

Postdoctoral Fellow Position Available, Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University

The Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University, Giessen, German, invites applications for the position as a

Postdoctoral Fellow.

The position is available from September 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).

We offer:

  • Participation in state-of-the-art research projects
  • Collaboration in an enthusiastic research team
  • Opportunities to develop strong research skills and a solid academic profile

Key Responsibilities:

Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.

For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)

Required Qualifications:

Completed Ph.D. thesis in biology, biochemistry, human biology or a similar subject (Ph.D. degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology and/or structural biology is advantageous.

The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.

Please send your application per Email as a single pdf file with all relevant documentation to per Email to katja.straesser@nullchemie.bio.uni-giessen.de until the 19th of July 2019. Applications from disabled people of equal aptitude will be given preference.

Faculty Position Available, W3 Professorship of Molecular Immunology

The Faculty of Biology and Chemistry invites applications for the position of a W3 Professorship of Molecular Immunology as of October 1st, 2020.

Reference is made to § 61 Para. 7 Hessian Higher Education Act (HHG) and to conditions of employment based on § 62 HHG. Proficient knowledge of German is expected.

Requirements:

Candidates are expected to have a strong profile in molecular immunology. Successful, third-party funded research should primarily cover the topics of gene regulation, signal transduction pathways, molecular infection research and/or molecular biomedicine. The complementation of existing methods and expertise (e.g. Omics technologies, single cell analyses, genome editing, protein and/or nucleic acid modification) and a focus on innovative and immunologically relevant animal or cell culture systems is also desirable. A high level of competence in these research fields should be reflected by international, high-profile publications.

Responsibilities:

Your responsibilities will focus on the above-mentioned subjects. Teaching duties will cover all bachelor and master courses (partly in English). Active participation in establishing new teaching courses is required. The candidate will be expected to cooperate with related bioscience disciplines of the Justus Liebig University Giessen (JLU) and neighbouring universities, to have experience in the acquisition of extra mural funding, to be integrated in high-profile national as well as international research networks and to participate in graduate education. Particular importance is attached to a commitment to promote the faculty’s internationalization strategy as well as to strengthen existing and to establish future research alliances.

The JLU aims to employ more women in academic research. We therefore particularly encourage female candidates to apply. JLU also pursues the goal at faculty leadership level of increased competence in dealing with gender and family-related issues. JLU is regarded as a family-friendly university. Applicants with children are very welcome. Applications from disabled people of equal aptitude will be given preference.

Please send your letter of application (no e-mails, please) with a CV and a documentation of your qualifications and teaching competence to: The President of Justus Liebig University Giessen, Erwin-Stein-Gebaeude, Goethestrasse 58, 35390 Giessen, Germany, quoting reference number 8-10/19. Applications must be received by July 5th, 2019 at the latest.

Candidates are strongly recommended to refer to our webpage on application procedures at http://www.uni-giessen.de/stellenmarkt/merkblatt.pdf. Please only submit copies of your application documents without document files or folders, as they cannot be returned after the application procedure has been completed

Postdoctoral Research Position Available, Laboratory of Dixie J. Goss, Hunter College, City University of New York

A postdoctoral research position is available in the laboratory of Dixie J. Goss, Hunter College, City University of New York.  Our NIH- and NSF-funded research uses state-of-the-art biophysical, biochemical and molecular biology approaches to characterize molecular mechanisms of (1) non-canonical modes of translation initiation in mammals, (2) physiologically important specific cases of translation and (3) novel mechanisms of translation in plant viruses, especially as models for mammalian viruses.

Required qualifications include a Ph.D. in Biophysics/Biochemistry/Molecular Biology and practical experience in RNA and/or protein biochemistry, including expression and purification of native/recombinant proteins and functional analyses of protein-RNA complexes.  Experience in investigating aspects of eukaryotic translation and structural probing of RNA are desirable.  We are actively involved in collaborations with leading cryoEM laboratories, and experience in structural biology would be helpful.  Candidates should be highly motivated, able to work independently and show excellent critical thinking and communication skills.

A salary of $45-60K is available depending on experience, plus benefits including health insurance.  Review of applicants will begin immediately until the position is filled.  To apply, please send a cover letter discussing your interest in a position and mentioning expected availability date, your curriculum vitae (with summary of research experience, including techniques and methods used) and contact information for three references.

To apply, please go to rfcuny.org. and click on EMPLOYEES and “Search & Apply for a Job”.

The Research Foundation of the City University of New York is an Affirmative Action/Equal Opportunity/Americans with Disabilities Act/Protected Veterans Status/ E-Verify Employer

 

 

University of Michigan Medical School Postdoc Recruitment Event

The University of Michigan Medical School will host its next postdoctoral recruitment event October 10-11, 2019. We kindly ask that you explore Postdoc Preview (https://medicine.umich.edu/medschool/education/postdoctoral-fellows/prospective-postdocs/postdoc-preview) and share this information with trainees, colleagues and departments from around the U.S. that are especially strong in your field.

Postdoc Preview introduces upper-level graduate students in the biomedical sciences to the excellent research and training opportunities here at Michigan. During a fully-funded visit, recruits interview with two or more prospective mentors, learn about our NIH-funded training programs, and network with current postdocs (tentative schedule here https://medicine.umich.edu/medschool/education/postdoctoral-fellows/prospective-postdocs/postdoc-preview#tentative-schedule). Applicants are selected from a national pool of highly qualified individuals who expect to complete their thesis research over the course of the next year and be U.S. citizens or permanent residents or be currently enrolled in a U.S. graduate institution. Our office sponsors and manages the logistics of their visit.

Applications for the event can be found at https://postdocpreview.smapply.io/. Deadline: August 5, 2019. Please contact the main office (postdocoffice@nullmed.umich.edu) with questions.

Faculty Fellow in RNA Biology or RNA Chemistry, Depart of Cardiovascular Sciences, Houston Methodist Research Institute (HMRI)

The Department of Cardiovascular Sciences at the Houston Methodist Research Institute (HMRI) welcomes applications for Faculty Fellow in RNA biology or RNA chemistry within the Center for Cardiovascular Regeneration.  The Faculty Fellow is a mentored transitional position between the postdoctoral years and a faculty position.   The position offers increased compensation compared to traditional postdoc stipends, and includes a research budget to implement your independent research project.  Candidates are typically outstanding postdoctoral fellows in their second or third year of training. Optimal candidates will have a track record of innovative research in RNA biology or chemistry; are capable of attracting external funding, e.g. from NIH; are highly collaborative; and are excited about innovation, invention, translation and making transformative contributions to human health.  Candidates will be considered for promotion in 2 -3 years to an independent faculty scientist position after demonstrating the ability to establish a robust program in RNA sciences and collaborate with the RNACore team to translate their research innovations into RNA therapeutics in regenerative medicine .  In addition, candidates are expected to show promise in establishing a vigorous externally funded research program and contribute to the intellectual vitality of the HMRI scientific community. Formal teaching is not required, although there will be opportunities for those who wish to do so.   Faculty will also have the opportunity to affiliate with the Cornell University Weill Cornell Medical College and/or Texas A&M University, and to work with students from these universities.

We are a highly translational scientific Center, with faculty that are making fundamental insights and translating these toward transformative RNA therapeutics.  Our RNACore is funded by NIH and CPRIT for performing pre-clinical studies in RNA therapeutics; for generating innovative research grade constructs for the scientific community; and for producing RNA Therapeutics in our cGMP manufacturing facility for clinical trials.  Houston Methodist Hospital Research Institute is located in the heart of the Texas Medical Center, which is the largest medical center in the world. The institute is surrounded by an unparalleled biomedical research environment, which consists of the Houston Methodist Hospital, Rice University, Baylor College of Medicine, UT MD Anderson Cancer Center, and more than 50 additional top institutes and hospitals. Texas is the #1 state to make a living, as recently ranked by Forbes. Houston is the largest city in Texas and the 4th largest in US, with an attractive living cost and a vibrant culture. It was recently named the most prosperous US city by The Business Journal. Salary and benefits can be highly competitive and commensurate with experience. Houston Methodist Hospital is frequently ranked by the FORTUNE Magazine in the list of the best employers in USA.

To apply for the position, submit an application and send your CV, cover letter, plus a one page description of your proposed independent research project, and contact information for 3 references, to the Medical Director of the RNA Therapeutics Program, John P. Cooke MD PhD at jpcooke@nullhoustonmethodist.org.

Post-Doc Position in Edinburgh, UK – Brook and Gray labs.

An 18-month post-doctoral position is available immediately at the University of Edinburgh to establish whether mammalian RNA-binding proteins (approx. 1500 in human) can be regulated via “histone-code” like switches, where specific lysine modification regulates competing protein-protein interactions. Such a switch would provide unique insight into the basis of the multi-functionality of many RNA-binding proteins. This BBSRC funded work builds upon work by three collaborating Edinburgh labs (Matt Brook’s newly-formed lab [Twitter: @BrookLab3] and the established labs of Nicola Gray and Atlanta Cook) and involves collaborating labs in Liverpool, Dundee and Birmingham. The post-holder will determine the modification-dependent effects on post-transcriptional gene regulation (mRNA translation and stability), primarily through mammalian cell line-based and/or cell-free reporter assays, quantify modification stoichiometry under specific cellular conditions and investigate the effector enzymes involved. They will work closely with another post-doctoral scientist who focuses on the biophysical and structural consequences of these modifications on protein-protein interactions. Applicants with a proven track record in studying RNA-binding protein-mediated regulation of mRNA translation and stability, and/or the interrogation of lysine acetylation/methylation pathways are particularly welcomed. The post is particularly suitable for candidates with relevant post-doctoral experience but those with strong, relevant, publication records from their PhD would also be considered. The post involves short periods of work at other locations (e.g. Liverpool) leveraging specialised collaborative expertise/training (e.g. quantitative mass spectrometry).

 

For full details of the vacancy and to apply, please visit: https://edin.ac/2QvDLlv

Postdoctoral fellowship position available at the University of Oregon

The Postdoctoral Fellow will carry out studies of eukaryotic epigenetic regulation using mostly biochemical, genetic, and cell biological techniques in yeast and mammalian cells. The purpose is to make high-impact discoveries in the field of epigenetics and RNA. The work will involve study of prion proteins (non-toxic) that regulate RNA. See garcialab.org for more information. Experience culturing yeast and mammalian cells, and doing molecular biology, high-throughput sequencing, and microscopy are highly desirable but not essential. We are particularly interested in candidates with RNA/protein biochemistry experience.

Our lab is part of the Institute of Molecular Biology, a research institute that has 18 labs and approximately 150 employees. We have an administrative structure, which includes accounting, purchasing, personnel, building management, and three service centers, including genomics/cell characterization, and imaging.

The University of Oregon is located in Eugene, nestled in the Willamette Valley, with outstanding outdoor opportunities in every direction. Housing costs are sensible. Plus great food+beer, no traffic, an airport, and a friendly community.

This position is available immediately, for at least one year with annual renewals based on research progress and contingent with continued funding. Please email David at dmgarcia@nulluoregon.edu. Include your CV (including names+contact info of three references), and a brief statement about your research interests (1/2 to 1 page).

Analytical Development Scientist Position Available, Ulragenyx Pharmaceutical Inc.

TITLE: Scientist, Analytical Development (mRNA-LNP)

COMPANY: Ultragenyx Pharmaceutical Inc.

LOCATION: South San Francisco, CA 94080

DEPARTMENT: CMC AD/QC

WORK TYPE: FULL-TIME

Why Join Us?

To be a hero for our rare disease patients

Ultragenyx is a biopharmaceutical company committed to bringing to patients novel products for the treatment of rare and ultra-rare diseases, with a focus on serious, debilitating genetic diseases. Founded in 2010, the company has rapidly built a diverse portfolio of small molecule, monoclonal antibody, mRNA and gene therapy candidates with the potential to address diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.

Developing new treatments for rare genetic diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Ultragenyx we push each other to perform at our very best, because we never lose sight of our mission – to make a difference in our patients’ lives.

Come join our team during this exciting time of growth and opportunities!

Position Summary

ultrainnovative – Tackle rare and dynamic challenges

Ultragenyx is looking for an experienced Analytical Development Scientist with the passion and creativity for method development and characterization of great medicines for rare and ultra-rare diseases.  The Analytical Scientist will be part of the CMC AD/QC group under the Quality Organization.  This position will be responsible for developing novel mRNA lipid nanoparticle (LNP) drug substance and drug product analytical methods to support early stage product development, characterization, and testing within the Process Development Lab at the Ultragenyx South San Francisco site. This position will collaborate closely with cross-functional departments to achieve corporate goals and objectives.

The successful candidate should have a strong experience working with nucleic acid therapeutic in LNP formulation.  Past industry or academic experience in either mRNA biology or LNP physicochemical characterization is required.  The ideal candidate should be a self-starter with the ability to work in the lab under limited supervision.  This position will be instrumental in growing the company’s therapeutic portfolio, from early-discovery development stage to commercial launch and be a critical part of creating an innovative team for the development of the company’s next generation of products.

Responsibilities including, but not limited to:

  • Design and develop novel biochemical or biophysical methods to analyze and characterize the structure and function of mRNA-LNP
  • Elucidate the structure and function of mRNA drug substance, such as higher ordered RNA structure and conformation
  • Design and develop LNP encapsulation method to analyze and characterize the LNP integrity, stability, and payload encapsulation efficiency
  • Design and develop novel LNP disruption and extraction methods to allow effective analysis of the encapsulated nucleic acids payload
  • Utilize Sanger sequencing or next generation sequencing (NGS) based platform methods to analyze mRNA drug substance and characterize product variance
  • Design and develop sensitive methods to analyze double stranded RNA (dsRNA) impurities and residual DNA impurities in mRNA drug substance
  • Provide routine in-house analytical testing support to process development and formulation development groups
  • Perform in-house assay pre-qualification/qualification or assist contract lab to conduct assay qualification and validation following appropriate regulatory guidelines
  • Perform timely data trending and statistical analysis to evaluate assay performance
  • Author and review method SOP, technical reports, and relevant sections of regulatory IND/BLA fillings
  • Maintain and oversee AD/QC analytical method life cycle

Technical Requirements & Skills:

  • B.S. with 8+ years or M.S. with 5+ years or Ph.D. with 2+ years of industry experience in Biochemistry, Molecular Biology, Analytical Chemistry, or a related discipline
  • Candidate must have at least one of the following experience – technical expertise in either mRNA biology, including gel electrophoresis, qPCR, mRNA sequence analysis using traditional or next generation sequencing (NGS) platforms, or LNP physicochemical properties analysis, for example, particle size, charge, aggregation, and polydispersity analysis
  • Understand the common approaches of LNP disruption and payload extraction methods and could apply DoE approach to systematically optimize such conditions
  • Familiar with RiboGreen, ELISA and Slot Blot methods is highly desired
  • Previous experience with biophysical structure characterization methods, such as light scattering (DLS, MALS), Differential scanning calorimetry (DSC), and circular dichroism (CD) is a plus
  • Familiar with analytical method development, qualification, and data analysis and statistical analysis software, such as MS Excel, SoftMax, PLA, and JMP
  • Attention to detail, excellent organizational skills and the ability to work on multiple projects
  • Excellent oral and written presentation skills and proven ability to work autonomously in a matrix environment

Contact: zmeng@nullultragenyx.com

Computational Geneticist Position Available, Panorama Medicine, Philadelphia PA

Panorama Medicine is seeking an experienced computational geneticist with a strong background in human and medical genetics at their Philadelphia office.

Responsibilities:

  • Work with a team of bioinformaticians and RNA biologists to interpret the clinical significance of genetic variants in genomic data
  • Deliver testable hypotheses and insights from complex genomics data to inform target selection. Interpret drug effects on disease
  • Review and curate disease database

Qualifications:

  • All applicants MUST have a PhD in computational biology, human genetics, genomics, bioinformatics, biology, or closely related fields. Fundamental knowledge of human genetics is essential. Post-doctoral experience is preferred.
  • Previous experience with genomic data analysis is required. Familiar with public disease databases, such as OMIM, HGMD etc.
  • Good programming and scripting abilities in languages, such as R, Python. Familiar with Linux/Unix systems.
  • A strong record of publication.
  • Excellent problem-solving, teamwork, organization, and communication skills.

About Panorama Medicine:

Panorama Medicine is a VC-backed startup founded by a multidisciplinary team of world-renowned computational and experimental RNA biologists. Panorama has leveraged the founding team’s expertise to create a drug discovery platform that integrates genomics, big data, and computing to develop therapeutic interventions for RNA defects in disease. Panorama is young and fast-growing, offering rewarding career development opportunities.

Benefits:

Panorama strives to build a Google-like work environment, creative, fun, hardworking, and highly productive. We offer a strong compensation package that includes competitive salary, generous stock options, and a comprehensive health benefits package. Flexible time off, productivity perks, paid parental leave, company sponsored learning and development opportunities.

Panorama is an Equal Opportunity Employer and Prohibits Discrimination and Harassment of Any Kind.

Interested applicants should send a cover letter and a CV to hratpanoramamedicine.com.

PhD Positions in RNA Biology at the University of Regensburg

Several PhD positions are available within the RNA biology program associated with the collaborative research center SFB960 ‘RNP biogenesis: assembly of ribosomes and non-ribosomal RNPs and control of their function’ at the University of Regensburg.

The University of Regensburg with its over 21.000 students is an innovative and interdisciplinary university, which provides a broad variety of research projects and disciplines for German and foreign students. The collaborative research center SFB960 investigates different aspects of the exciting field of RNA – protein complex formation and function in various model organisms. The network is embedded into a modern and excellent research infrastructure at the University of Regensburg and the nearby University Hospital providing state-of-the-art technologies for biophysical, biochemical, molecular, cellular and systems biological approaches. We invite highly motivated and dedicated students who are excited about modern, cutting edge RNA biology research especially in the areas of lncRNAs, miRNAs, piRNAs, RNA localization, RNA methylation, RNA-protein structure and translational control, RNA synthesis and maturation, and RNA pathobiology of cancer (for more information, please visit www.sfb960.de).

Successful applicants will be invited to a final selection symposium planned for July 2019.

Your profile:

  • An excellent Master’s degree in Biology / Biochemistry / Molecular Biology / Molecular Medicine or a similar discipline
  • Dedication for basic research in modern life science and particularly in RNA biology
  • Team spirit, extraordinary motivation and the ability to work in highly competitive research fields

We offer:

  • A very well equipped research environment and expertise in state-of-the-art methodology (e.g. high-end mass spectrometry, nuclear magnetic resonance spectroscopy, protein-RNA crystallography, cryo-electron microscopy, confocal microscopy, single molecule analysis).
  • Integration into the structured PhD program (degree awarded: Dr. rer. nat.) of the Regensburg International Graduate School of Life Sciences (www.rigel-regensburg.de) and the Graduate Research Academy RNA Biology (www.graduate-academy.sfb960.de) including mentoring by an expert group, soft skill courses etc.
  • Employment as research assistant according to the German pay scale TV-L 13 for 3 years (with possible extension).

Application:

Please submit your application including a motivation letter indicating your project(s) preference(s) within the SFB960 framework, a full CV, appropriate certificates and the names and contact information of two referees as a single pdf by no later than June 24, 2019 via email to the following address: Application.SFB@nullur.de.

The University of Regensburg is committed to the compatibility of family and career (for more information, please visit www.uni-regensburg.de/equal-opportunities). Preference will be given to people with disabilities in the case of otherwise equal aptitude. Unfortunately, expenses associated with a possible interview cannot be completely reimbursed.

Post Doc Fellow Position Available, Weill Cornell Medical College

We are currently looking for a highly motivated postdoctoral researcher or (junior or senior) research associate to join our lab. The position is geared towards the application of our new transcriptome analytical approaches1-3 to study neurodegeneration, as well as the development of further novel technologies in this space. Wet-lab experience is essential, e.g. single-cell RNA-, RNA-, Chip-, or ClIP-seq or long-read sequencing or targeting protocols would be a strong background. The work can include bioinformatic analysis or the collaboration with computational postdocs in the lab. Exposure and interest in neuroscience and computational biology/data analysis would be a plus.

We are located at Weill Cornell Medical College on Manhattan’s Upper East Side. Candidates should send their CVs to tilgnerLab@nullgmail.com and should arrange for two letters of recommendation to be sent to the same e-mail. More information about the lab is available on www.tilgnerLab.com.

  1. https://www.nature.com/articles/nbt.4259
  2. https://www.nature.com/articles/nbt.3242
  3. https://www.nature.com/articles/nbt.2705

Postdoctoral and research associate/technician position available at The Ohio State University

The Kearse Lab (www.kearselab.org) in the Department of Biological Chemistry and Pharmacology at The Ohio State University in Columbus, OH is currently recruiting for two open positions–a postdoctoral fellow and a research associate/technician. Our lab is interested in how mRNA translation is regulated and how it is linked to human biology and disease. Initial projects will be focused on investigating aberrant translation initiation at atypical start codons (those that differ from the canonical AUG start codon) during cell stress and in cancer. Please visit www.kearselab.org for more information on our lab’s overall research focus and interests.

New team members for both positions should be self-motivated and career oriented. All members of the lab will be expected to contribute to a rigorous but highly supportive environment, and also be active participants of the Center for RNA Biology. Postdoctoral applicants should have (or soon be defending) a PhD in biochemistry/cell biology/genetics/molecular biology, at least one peer reviewed first-author publication, and ideally some experience in RNA biology. Research associate/technician applicants should have a BS or MS in the life sciences or chemistry, have at least one year of lab experience, and willing to commit for at least 1-2 years. Women and other underrepresented minorities in science are extremely encouraged to apply. Both positions are to start mid-September 2019 or as soon as possible thereafter.

Please apply by email to Michael Kearse, PhD at michael.kearse@nullosumc.edu and include a cover letter describing their research experience and career goals, a current CV, and contact information for 2-3 references.

Postdoctoral position at Johns Hopkins University

A postdoctoral position is available in the laboratory of Dr. Ryuya Fukunaga at Johns Hopkins University School of Medicine. The laboratory is focused on understanding RNA biology, including the molecular mechanisms of (1) biogenesis and function of small silencing RNAs such as miRNAs and siRNAs and (2) post-transcriptional gene regulation by RNA-binding proteins, RNases, RNA helicases, and RNA modification enzymes.

We employ a wide range of approaches that include biochemistry, Drosophila genetics, cell culture system, high-throughput sequencing, and structural analysis.

We are looking for a highly motivated and enthusiastic new member of the lab. Candidates must have received (or be expecting) a Ph.D. or M.D. within the past three years in molecular biology, biochemistry, genetics, cell biology, structural biology, or a related discipline. Candidates with strong background in biochemical, molecular, cellular, and genetic analyses in RNA biology and/or Drosophila genetics are encouraged to apply.

More information is available at:

https://sites.google.com/site/fukunagalabjhmi/

https://bcmb.bs.jhmi.edu/people/faculty/ryuya-fukunaga

Please email [1] cover letter, [2] CV, [3] a brief summary of research interests, accomplishments, and career goals, and [4] contact information of at least three references to Dr. Ryuya Fukunaga at fukunaga@nulljhmi.edu

The Ke Lab at The Jackson Laboratory, Two Post-doc Positions Available

1) RNA Biology Postdoc:

https://careers-jax.icims.com/jobs/25230/postdoctoral-associate—ke-lab/job

2) Computational Biology Postdoc:

https://careers-jax.icims.com/jobs/25557/postdoctoral-associate—ke-lab/job

The Laboratory of Dr. Shengdong Ke has two postdoctoral associate openings (one in RNA biology, and the other in computational biology) at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in the fundamental mechanism of m6A RNA genomics; and regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation, Genes & Development 2015, 29:2037-53.)

Requirements for RNA Biology Postdoc:

Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, cancer biology or computational biology. Biochemistry and/or computational background and interest is a plus.

Requirements for Computational Biology Postdoc:

The successful candidate will develop and apply computational methods for genomic data analyses, have novel opportunities at the intersection of algorithms, data interpretation, and experimental design in close collaboration with the experimental team in the lab.  A good publication record and excellent communication skills are essential. A PhD. in a quantitative area is required: computational biology, computer science, statistics, physics and/or applied math.  Programming in Python, Perl, R or C++ is desired, as well as experience in genomic dataset analysis and integration.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA is a world leader in mammalian genetics.  JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health. JAX is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

E-mail Shengdong.Ke@nulljax.org
URL https://www.jax.org/research-and-faculty/faculty/shengdong-ke

Postdoctoral Associate Position in RNA Biology

The Kiledjian laboratory in the Dept. Cell Biology & Neuroscience at Rutgers University is seeking an outstanding postdoctoral associate to study the regulation of RNA turnover in the control of gene expression. The laboratory is interested in understanding the molecular mechanism by which 5´ end cap epitranscriptomic modifications such as a nicotinamide adenine diphosphate (NAD) cap (see Jiao et al., 2017 Cell; Grudzien-Nogalska et al., 2019 Nature Chemical Biology) or m6Am cap (see Mauer et al., 2017 Nature) regulate RNA levels and gene expression. Other areas of investigation include the role of decapping proteins in human cognitive disability. Please refer to the Kiledjian Lab web page (https://cbn.rutgers.edu/kiledjian-lab-home) for more information on research areas of interest in the lab.

We are seeking highly motivated candidates with a Ph.D. in molecular/cellular biology or a related discipline with good communications skills and a publication track record in peer reviewed journals.  Preference will be given to applicants with research experience in the areas of post-transcriptional gene regulation, RNA metabolism and computational biology.

Interested individuals should apply by email (Kiledjian@nullbiology.rutgers.edu) to Mike Kiledjian, Ph.D., and include a cover letter describing interests and past accomplishments, a current curriculum vitae, and contact information for three references.

Postdoctoral Position Available

A post-doctoral position is available in the group of Michael Jantsch, studying the interaction of the RNA-editing enzyme ADAR1 with its transport protein tranportin1. This interaction is regulated by RNA-binding and seemingly controls the shuttling behavior of this protein. In a collaborative research grant with the structural biologist Pierre Barraud in Paris, the interaction between transporter and cargo and its regulation via RNA-binding shall be studied.

The work will involve construction of fusion proteins and mutations thereof, binding assays, nuclear import assays, RNA-crosslinking assays, and cell transfection assays

The position is funded for  up to 24 months following Austrian Post doctoral salaries of ~67k€ gross annual salary. The position is open immediately.

If interested, please send your application together with a motivation letter and a CV to Michael.Jantsch@nullmeduniwien.ac.at

For background on this project see: https://www.pnas.org/content/111/18/E1852.short?rss=1

Two Postdoctoral Positions Available, Kwok Lab, Dept of Chemistry, City University of Hong Kong

Two postdoctoral positions (one RNA biologist, one bioinformatician) are available immediately at the Kwok Lab, Department of Chemistry, City University of Hong Kong. (www.kitkwok.com)

Our research focus is to develop chemical and biochemical technologies to decipher the hidden layers of information in RNA such as RNA structures; identify the RNA binding partners and molecular basis of interactions; and elucidate the mechanistic roles of RNA in regulatory pathways, stress physiologies, cell differentiation, organism development, as well as disease pathology. Interested candidates may referred to our recent reviews, e.g. PMID 30853244, PMID 30459069, PMID 29967010, PMID 28755976

Candidates with excellent molecular biology, chemical biology, and/or biochemistry will be considered for the RNA biologist postdoc post.

Candidates with excellent computational skills in transcriptomics and related areas will be considered for the bioinformatician postdoc post.

Qualified candidates should have recently accomplished their Ph.D. degree and have strong written and spoken english.

Candidates should send their Curriculum Vitae and a cover letter summarizing:

– A description of research accomplishments.

– Research interests in RNA and transcriptomics.

– Contact information for two references to: Chun Kit Kwok, Ph.D. mailto:ckkwok42@nullgapps.cityu.edu.hk