Employment Opportunities

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NIH-funded Postdoctoral Fellowship Position, to begin as early as June 2019 (duration: 2-5 yrs).

NIH-funded Postdoctoral Fellowship in RNA Metabolism in Innate Immunity

National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to cytoplasmic RNA polymeradse III (cyto-Pol III)-mediated innate immune mRNA induction and metabolism. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience.  Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation.  The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.

Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.

  • Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:

Richard J. Maraia, M.D.

Email: maraiar@nullmail.nih.gov

Post-doctoral Research Associate, University College London, Research Dept of Structural & Molecular Biology

We are recruiting a post-doctoral Research Associate to investigate the interactions between the RNA binding proteins regulating local mRNA translation in neurons and their RNA and protein partners – and relate these interactions to the mRNA transport, stability and translation functions of the proteins. The Research Associate will use single molecule Microscopy, together with Cell and Molecular Biology methods and transcriptome wide analysis of in cell interactions (e.g. iCLIP) to define the key regulatory principles of the proteins in Neurons at the molecular level. The Research Associate will work in close collaboration with a Structural Biologist within the RNA Regulation Laboratory and with collaborating teams in the UK and US.

The position is available in principle from the 1st of January 2019 to 31st of December 2020, in first instance for two years with the possibility of extension.

The successful candidate will have a PhD (or about to submit) in Cellular and Molecular Biology. The S/he must have skills in cell culture, basic cellular and molecular assays and basic bioinformatics and data analysis. S/he must have experience in RNA Biology. Experience in the iCLIP and equivalent techniques is desirable.

Please see also  https://www.nature.com/naturecareers/job?id=653569

Postdoctoral Associate Position in Single-Cell Ribosome Translation and Microbial Pathogenesis-University of Maryland, College Park

A postdoctoral position is immediately available in the laboratory of Dr. Jiqiang (Lanny) Ling at The University of Maryland, College Park to study single-cell ribosomal translation, microbial pathogenesis, and antibiotic resistance. The Ling lab is interested in combining state-of-the-art single-cell, microbiology, biochemical, genetic, genomic, and proteomic approaches to understand the mechanisms and disease connections of the protein synthesis machinery. Recent work from the Ling lab has been published in leading journals such as Molecular Cell, New England Journal of Medicine, and American Journal of Human Genetics. For more information please visit Dr. Ling’s website: https://cbmg.umd.edu/faculty/lanny-ling/

UMD is a vibrant place to work, home to three Nobel laureates, five Pulitzer Prize recipients, and more than 40 members of the most prestigious national academies. The 1,250-acre campus is centrally located on the Baltimore, Annapolis and Washington, D.C. corridor. The postdoctoral position will be supported by NIH funding with a competitive salary. Highly motivated candidates with bacteriology, yeast biology, and microscopy expertise are particularly encouraged to apply. If interested, please contact Dr. Ling at jling12@nullumd.edu and include a brief description of research interests, career goals, and a detailed CV.

Job requirement: Ph.D. with at least 3 years of research experience in RNA biology or microbiology.

Job duration: Initial appointment of 1 years with possible extension.

Postdoctoral Researcher Position, Lab of Dr. Mingyi Xie, Dept. of Biochemistry & Molecular Biology, Cancer Center, University of Florida

Postdoctoral Researcher position available immediately in the Laboratory of Dr. Mingyi Xie (Assistant Professor, Department of Biochemistry and Molecular Biology, Cancer Center, University of Florida) to study the Function and biogenesis of alternatively-processed microRNAs and Integrator complex-mediated RNA processing. Postdoc salary starts at $47,476 per year.

Applicants should submit the following to mingyi.xie@nullufl.edu:

1)      Cover letter stating: laboratory experience in RNA/protein biochemistry and bioinformatics; your long-term career goals; date of availability to begin postdoc research

2)      Curriculum vitae (including publications and awards/honors)

3)      List of at least three references

Dr. Mingyi Xie was trained in the laboratory of Dr. Joan Steitz at Yale University (2010-2016), where he documented two surprising microRNA (miRNA) biogenesis pathways:

  • Herpesvirus saimiri (HVS)-miRNAs are processed by the host Integrator complex, a 14-subunit complex best known for executing the 3′-end cleavage of cellular small nuclear RNAs (snRNAs) (Cazalla, Xie and Steitz-Molecular Cell-2011; Xie et al.,-Genes & Development-2015).
  • Mammalian m7G-capped precursor miRNAs are generated from RNA polymerase (Pol) II transcription initiation sites. Whereas the nuclear-cytoplasmic export of capped pre-miRNAs is mediated by Exportin-1 (Xie et al.,-Cell-2013; Xie and Steitz-RNA Biology-2014).

The Xie lab’s immediate research goal is to further delineate the unique modes of miRNA production (Sheng et. al.-Nucleic Acids Res.-2018, Miller et. al.-RNA-2018), including Integrator-mediated RNA metabolism, and understand the functions of these special miRNAs in herpesviruses and their hosts. Such research will allow the design of therapies for related oncogenic herpesviruses and cancers.

Visit Xie lab website: xie.biochem.med.ufl.edu for more information.

Postdoctoral Fellow Position, Alberta RNA Research & Training Institute, University of Lethbridge, Medicinal Biophysics Laboratory

A postdoctoral researcher position is available at the Medicinal Biophysics Laboratory,
led by Dr. Trushar Patel, to study the RNA-protein and protein-protein interactions that
play crucial roles in cell signaling. The candidate will perform cell biology and mass
spectrometry assays and validate the results using biophysical methods. This is a 1-year
position with the possibility of extension for a second year and builds on the expertise in
the Patel laboratory in studying structure-function relationships of RNA and protein
molecules. We employ a variety of cell biology, biochemical and structural-biophysical
approaches.

Highly motivated researchers with a recent Ph.D. in biochemistry, molecular biology,
cellular biology or a similar discipline are encouraged to apply. It is expected that the
candidate will have proven their research accomplishments by peer-reviewed
publications. Mass Spectrometry experience is highly desirable. Interested candidates
should send a CV including the names of at least three referees, a motivation letter and
links to publications by email to Dr. Trushar Patel (trushar.patel@nulluleth.ca).
Lethbridge is located in Southern Alberta, not far from the Rocky Mountains, the city of
Lethbridge enjoys a sunny, dry climate that is surprisingly mild, has excellent cultural
and recreational amenities, and offers attractive economic conditions. The University is
situated on the west side of Lethbridge and stretches across the coulees, with a great view
of the Oldman River valley.

Postdoctoral Fellow Position, Karolinska Institute, Medical Biochemistry & Biophysics Dept.

Background:

Possibly more than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these cellular functions are largely unknown.

Our research group is interested in understanding how RNAs adopt their structures in order to select specific functions in a pool if RNAs. We employ different biochemical and biophysical techniques (e.g. EMSA, NMR, UV melting experiments), to investigate the molecular mechanism of RNA function (Nature 2012 & 2015).

Project:

(A) The Postdoc will work on a collaborative project together with the Lab from E.R. Andersson (andersonlab.com) and will therefore be working on an interface from molecular biology to biophysical/biochemical methods.

(B) The Postdoc will work on a project to study RNA biophysics in cellular conditions. Therefore the Postdoc will establish and develop biophysical, biochemistry and molecular biology methods for this task.

You will work in a team together with other lab members and regularly present your research work in lab-meetings, seminars and at international conferences.

We are looking for a highly motivated Postdoc that will work in Katja Petzold’s group at the Division of Molecular Structural Biology.

Eligibility:

To apply for the position, the applicant must have a PhD degree not older than 4 years. Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. This educational scholarship is tax-exempt.

To qualify, the applicant should have a background in biochemistry and biophysics of RNA with an interest in inter-disciplinary research. Of advantage are knowledge in NMR and/or molecular biology, but not required.

We are looking for a highly motivated, well organized, driven and enthusiastic person interested in our area of research, who is ready to explore new avenues in science. The candidate should have a high degree of independence but should also show a collaborative approach to research and be able to work productively in a team. Fluency in English is a requirement (written and oral).

Start-date upon agreement.

Contact: Katja Petzold
Email: katja.petzold@nullki.se
Apply: https://ki.mynetworkglobal.com/se/what:job/jobID:230326/type:job/where:4/apply:1

Faculty Position in the Biology of RNA and Chromatin Regulation

The Therapeutic Innovation Center (THINC) at Baylor College of Medicine (BCM) invites applications for a tenure-track Assistant Professor, Associate Professor, or Professor position for colleagues studying the biology of gene control, especially RNA or chromatin regulation.  Applicants’ research programs may focus on the basic mechanisms of gene control and/or therapeutics targeting this area of biology.  Diverse research programs studying gene control are welcome, including genetics and epigenetics, computational biology, chemical biology, structural biology, biochemistry, and genomics.  Experience in studying or developing therapeutics is encouraged but not required.

THINC (thincbcm.org) is a center of excellence at BCM that seeks to discover fundamental mechanisms of gene control, especially RNA and chromatin regulation, and to translate these discoveries into early therapeutic development.  THINC brings together colleagues across BCM and the Texas Medical Center who study gene regulation from multiple disciplines and are leveraging these discoveries in diseases of aberrant gene control including cancer, neurodegeneration, and infectious disease.

BCM is the premier medical school of Texas and has the top-ranked Genetics and Cell Biology Departments in the U.S. based on NIH funding.  BCM has internationally recognized strengths in structural biology and biochemistry, a long-standing NIH human genome sequencing center, cutting edge Advanced Technology Cores, exceptional Ph.D. graduate programs, a commitment to technology transfer for faculty discoveries, and a rich history of translating basic science into clinical implementation. BCM is also home to the NCI-designated Dan L. Duncan Comprehensive Cancer Center (bcm.edu/centers/cancer-center) and centered in Texas Medical Center, the world’s largest biomedical research complex.

THINC and BCM offer premier recruitment packages and resources to enhance the candidate’s research program.  Applicants should email a PDF of their curriculum vitae, a 4-page research statement, and a cover letter stating the position to which they are applying to THINC-communications@nullbcm.edu. Applicants should also request 3 letters of reference to be emailed directly from recommenders to THINC-communications@nullbcm.edu.  All materials should be received by October 22, 2018.

Postdoctoral Fellowship in Epigenetics and RNA Biology

Postdoctoral fellowship in epigenetics and RNA biology at the Department of Medical Biosciences and Wallenberg Centre for Molecular Medicine, Umeå University (Sweden)

A funded postdoctoral position (2 years) is available in the Aguilo laboratory (www.aguilolab.com) at Umeå University for a highly talented and motivated candidate willing to address fundamental questions in post-transcriptional regulation of RNA in connection with epigenetic regulation in breast cancer.

Project description

The research group investigates how changes epigenetic changes and aberrant RNA modification contribute to breast cancer progression as well as drug resistance. The successful applicant will combine cellular biology with state-of-the-art molecular biology approaches, including ChIP-seq, RNA-seq, MeRiP-seq, CLIP-seq and other large-scale epigenomic and epitranscriptomic analyses, including single-cell RNA-seq. In addition, 2D and 3D cell culture models, patient samples as well as mouse transgenic models will be used to study the central RNA-based regulatory circuitry in breast tumorigenesis.

Application

The application should include the following:

  • A cover letter (max two A4 pages) with a summary of research interests and accomplishments
  • Curriculum vitae (CV)
  • Copies of relevant degree certificates and PhD thesis
  • Contact information (name, address, telephone and e-mail) for three referees

Your complete application should be sent electronically (PDF format) to Dr. Francesca Aguilo francesca.aguilo@nullumu.se with subject POSTDOC_2018 no later than 30 November, 2019

 

 

Scientist, RNAi Discovery/Bioinformatics

Dicerna Pharmaceuticals is looking for a PhD scientist to help in its drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. Responsibilities will entail a combination of bioinformatics and drug discovery work. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

Key Responsibilities

  • Computational Biology analyses (e.g. RNA-seq data analysis); development and implementation of novel algorithmic tools for drug candidate screening
  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

Qualifications

  • PhD in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting.
  • Experience in informatics is required (e.g. next-gen sequencing data analysis; informatics tool development; data mining; with expertise in R and R:Bioconductor suite, Python, PERL and/or PHP preferred).
  • Expertise in statistical analysis is strongly preferred.
  • Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
  • Experience with RNAi is preferred.
  • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment.
  • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected.

Contact: Maire Osborn
Email: mosborn@nulldicerna.com

Research Associate, RNAi Discovery

Dicerna Pharmaceuticals is looking for a BS/MS scientist to help in its drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

Key Responsibilities

  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR
  • In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

Qualifications

  • BS/MS in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting (junior or senior candidates considered, with level and compensation commensurate with experience)
  • Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
  • Experience with RNAi is preferred; experience with in vitro screening is preferred.
  • Experience with in vivo methodologies is desirable (e.g. mouse handling; dosing; sample analysis; histology).
  • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment.
  • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected.

Contact: Maire Osborn
Email: mosborn@nulldicerna.com

Postdoctoral position in post-transcriptional regulation – Boston University School of Medicine

A funded postdoctoral position is available for immediate incorporation in the Cifuentes laboratory at Boston University School of Medicine for a highly talented and motivated candidate willing to address fundamental questions in post-transcriptional regulation of RNA in viruses and vertebrate systems.

The available projects involve uncovering 1) novel RNA-protein interactions, 2) microRNA regulatory networks and 3) epitranscriptomic modifications in zebrafish and several viruses relevant to human health. Our long-term goal is to integrate these mechanisms into a single post-transcriptional regulatory framework.

To address these goals, the lab combines iCLIP and CRISPR mutagenesis together with other powerful genetic, genomic, and proteomic approaches applied to zebrafish and several viruses. We are located in a renovated lab space at Boston University School of Medicine in the Department of Biochemistry, with close access to scientific core facilities and immersed in the lively city of Boston.

Candidates should have a Ph.D., M.D., or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important is their motivation to learn and adapt to scientific challenges and become positive members of the lab. The position is funded for at least three years, contingent on performance. Additional information can be found at http://www.bumc.bu.edu/biochemistry/people/faculty/daniel-cifuentes/

To apply please send to Dr. Cifuentes a cover letter stating research interests and accomplishments, CV, and contact information for three references in a single PDF document by email to cifulab@nullbu.edu with the subject “Postdoc RNA BU”. Applications will be reviewed until position is filled.

Faculty Positions in Genetics, Genomics, and Cell Biology

The Department of Biochemistry at Boston University School of Medicine (http://www.bumc.bu.edu/biochemistry/), in collaboration with the Genome Science Institute, is undertaking a major expansion in the areas of genetics and genomics, including the application of genetic/genomic techniques to key problems in cell biology. We invite applications at the Assistant, Associate, and Full Professor levels. Several positions are available, and these will be highly competitive with regard to start-up funds, space, and salary.

We are interested in creative scientists working in a broad range of research areas, including, but are not limited to, chromatin structure and function, epigenetics, RNA biology, single-cell genomics, metabolic regulation, control of gene expression, DNA damage and repair, stem cells/development, and cancer genomics. We welcome applications from individuals utilizing genetically tractable model organisms, novel computational/bioinformatic approaches, and functional genomic methods (e.g., CRISPR/Cas screening) to address significant cell biological problems. The position requires a Ph.D. and/or M.D., and relevant postdoctoral experience.  It is a full time position with a flexible start date.

Over the past several years, the Department of Biochemistry has enjoyed a major transformation in its personnel and infrastructure, including hiring of eight new faculty members at all levels, renovation of 35,000 square feet of research space, and establishment of a new Center for Network Systems Biology focused on proteomics and protein interaction networks. These changes have dramatically expanded the scope of our research efforts beyond those of a traditional biochemistry department, to include “big data” approaches (genomics, proteomics), studies of non-coding RNAs, and use of new model organisms (zebrafish, C. elegans, Xenopus, Drosophila). The department has long-standing strengths in the areas of metabolism, obesity, and diabetes, and virtually every faculty member does work with important translational applications. The department now encompasses six thematic research concentrations: Development, Cell Biology, Genomics, Neuroscience, Metabolism, and Proteomics/Glycomics.

Applicants should submit a cover letter, curriculum vitae, statement of research interests, and list of publications to https://academicjobsonline.org/ajo/jobs/11993

Candidates at the Assistant Professor level should provide a minimum of three letters of recommendation at the time of application. Applications will be reviewed on a rolling basis, but should be submitted by October 31, 2018 for full consideration. Please direct email queries to biochem@nullbu.edu.

Boston University is an equal opportunity and affirmative action employer.

Scientist, RNAi Discovery

Dicerna Pharmaceuticals is looking for a PhD scientist to help in its drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

Key Responsibilities
• siRNA drug candidate screening, hit identification, and lead optimization
• Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR
• In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

Qualifications
• PhD in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting
• Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
• Experience with RNAi is preferred
• Experience with in vivo methodologies is desirable (e.g. mouse handling; dosing; sample analysis; histology)
• The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment
• Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected

Contact: Maire Osborn
E-mail mosborn@nulldicerna.com

Post Doc Opportunities, Ditlev E. Brodersen Lab, Aarhus University, Denmark

Post doc opportunities are available in the Ditlev E. Brodersen lab at Aarhus University, Denmark, to work on structural and functional aspects of microbial defence mechanisms, including ribonuclease toxins, transcriptional regulation og toxin-antitoxin modules, and the interplay between toxin-antitoxin modules and CRISPR-Cas in bacteria and archaea. Candidates must have previous hands-on experience with either x-ray crystallography or cryo-electron microscopy.

Start date: 1 Oct 2018, or later as agreed.

Duration: Initially 1 year, but with possibility of extension

To apply, send a cover letter with your motivation and include a CV to Ditlev Brodersen (deb@nullmbg.au.dk).