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Post Doctoral Fellow or Research Associate (staff) – Bass Laboratory, Biochemistry Dept., University of Utah

The Bass Laboratory in the Biochemistry Department at the University of Utah seeks a postdoctoral fellow, or Research Associate (staff), to take a leadership role in designing, performing, and supervising biochemistry and molecular biology experiments involving double-stranded RNA binding proteins such as Dicer and ADAR.

The ideal candidate will be adept at, and interested in, acquiring mechanistic insight from results of biochemistry and molecular biology experiments. Experience in protein purification is required, and familiarity with baculovirus expression systems preferred. Previous experience in RNA biochemistry would be helpful. Experiments using biochemistry and molecular biology techniques will be the main focus, but opportunities to collaborate with structural biologists, and participate in experiments using C. elegans or mammalian cells may arise.

Responsibilities:

  • conduct independent research in collaboration with the Principle Investigator
  • design and purify customized RNA molecules
  • express and purify proteins
  • supervise and coordinate efficient laboratory maintenance and operation
  • supervise students and technical support
  • assist in writing reports, manuscripts and grants

Minimum Qualifications:

  • Ph.D. in biochemistry, molecular biology or related field
  • Previous research experience in protein purification and biochemistry techniques
  • Experience in keeping up with the scientific literature relating to ongoing projects
  • Experience in evaluating scientific literature towards the goal of identifying relevant techniques and protocols
  • Ability to work interactively on projects with a variety of researchers
  • Ability to articulate research design and results effectively with other researchers and trainees

Salary range: $48,000-$60,000 depending on experience

To apply, send your C.V. and names of three references to bbass@nullbiochem.utah.edu

If you will be at the RNA Society meeting in Berkeley, please introduce yourself to me.

Senior Research Associate Position Available – Eclipse BioInnovations Inc.

Eclipse BioInnovations Inc. is an RNA genomics service company spin-out from UC San Diego. Our founders are the leading experts in using RNA binding proteins to identify RNA genes and regulatory elements involved in many human diseases including neuromuscular disorders and cancer. Eclipse has also licensed and is developing new cutting edge genomics services and products in the fast growing field of Crispr and others related technologies.

Eclipse’s first product, eCLIP, is in strong demand from global biopharma and academic researchers seeking to identify and screen RNA binding elements to advance therapeutic, translational and basic drug discovery programs in a wide range of human diseases. We are currently seeking a highly motivated Senior Research Associate to join our growing team and who seeks the opportunity to be a key player in driving the growth and success of our new startup.

Candidates must have strong experience and demonstrated track record working with RNA. Consideration will also be given to those with strong stem cell laboratory experience.

Job responsibilities will include but not be limited to:

  • Plan, execute and analyze experiments under manager supervision, utilizing standard biochemical and molecular techniques
  • Examine data and preparing technical reports, summaries, protocols and quantitative analysis and ensuring experiments are well documented
  • Tracking and reporting of ongoing service contracts
  • Development, characterization and optimization of assay protocols and reagents
  • General lab tasks including ordering, organizing, and instrument maintenance

Requirements

  • BS/MS/PhD in Molecular/ Cell Biology or related discipline with 5+ years experience in an R&D laboratory; industry experience highly preferred.

Hands-on experience with the following specialties:

  • Standard biochemical and molecular biological procedures, with a particular emphasis on strong RNA isolation and handling experience, as well as western analysis, qPCR, transfection and gel electrophoresis
  • Specific experience in stem cell and stem cell culture techniques
  • General sterile cell culture techniques
  • Validation and design of new laboratory protocols
  • Excellent written and oral communication skills.
  • Attention to detail, proficient reasoning skills in experimental design, data analysis, statistical methods and experimental interpretation, resourcefulness and the ability to work independently in a fast paced team environment.

Preference will be given to candidates with the following additional hands-on experience:

  • Experience in high-throughput sequencing library preparation
  • Development of molecular biology research and reagent kits
  • Ability to run command-line analysis tools for basic data analysis

We offer competitive salary commensurate with candidate’s experience, and an excellent benefits package including medical, dental, vision and paid time leave.

Visit our website at www.eclipsebio.com to learn more about us.

Job Type: Full-time

Salary: $60,000.00 to $80,000.00/year

E-mail jobs@nulleclipsebio.com

Two Postdoctoral Fellow Positions Available – USC School of Pharmacy, Lab of Dr. Zhipeng Lu

Two postdoctoral positions are available in Dr. Zhipeng Lu lab at USC School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences. Our research is focused on “RNA machines” in living cells. We develop and apply novel technologies to understand the structures and functions of RNA molecules in basic cellular processes, with the ultimate goal of targeting human diseases, including genetic disorders, cancers and viral infections.

We have recently developed a new technology, PARIS (Psoralen Analysis of RNA Interactions and Structures), a crosslinking based method for high throughput mapping of RNA duplexes in living cells at single-molecule level with near base-pair resolution (Lu et al. 2016 Cell). These unique strengths allow direct determination of alternative conformations, long-range and complex structures and RNA-RNA interactions across the transcriptome. This work was featured on the cover of Cell and a video abstract “Get an Eye-full (Eiffel)” (https://www.youtube.com/watch?v=1GXibPeUUGQ). A more complete description of our science can be found at http://zhipenglulab.org.

Current projects in the lab span the development of new computational and chemical tools for the analysis of RNA structures and interactions, and application of these technologies to important problems in the RNA field. The questions that we are interested in include structural basis of mRNAs and noncoding RNAs in post-transcriptional regulation of gene expression, roles of RNA structures and interactions in human diseases, such as neurological disorders and RNA virus infections. We also welcome and support novel and unconventional ideas that are related to the current work in the lab.

Research in the Lu lab is highly interdisciplinary and collaborative. Postdocs are exposed to research questions and techniques in the forefront of various fields centered around RNA. This training environment is exceptionally valuable for individuals who are interested in pursuing careers in academia or scientific leadership positions in the pharmaceutical industry. The PI is fully committed to empowering trainees with the capabilities to fulfill their ambitions.

USC School of Pharmacy is located in Health Sciences Campus, immediately adjacent to the USC Keck School of Medicine and Caltech. This rich scientific environment provides unique research training opportunities, such as research seminars given by leaders in science from throughout the U.S. and abroad, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities.

Candidates should have a Ph.D. and/or an M.D. and less than three years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics, biochemistry, or chemical biology, as evidenced by publications. Experience in computational biology is highly valued. Starting date is flexible from October 2018, and funding is guaranteed for three years.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to zhipengluchina@nullgmail.com.

Postdoctoral Fellow Position – University of Colorado School of Medicine, Dept. Biochemistry and Molecular Genetics

The laboratory of Dr. Olivia S. Rissland seeks to hire a Postdoctoral Fellow to work on leading edge questions in RNA biology. Our lab is in the Department of Biochemistry and Molecular Genetics and part of the newly formed RNA Bioscience Initiative at the University of Colorado School of Medicine.

Our lab studies mRNA decay—its connections with translation, its role during early embryogenesis, and its evolution in eukaryotes. We have projects looking at how translation elongation can alter mRNA stability and others investigating how mRNA decay during early Drosophila development is controlled. The long-term goal of our research program is to understand the molecular mechanisms linking translation and mRNA decay, especially in the context of disease and early development. Our research program is at the intersection of molecular biology, bioinformatics, developmental biology, and evolutionary biology, and we are looking for scientists who think RNA is as cool as we do.

Candidates will be expected to plan and execute independent work, write and submit fellowship applications, assist in writing and publishing experimental results, and contribute towards the atmosphere and culture of the lab.

We are committed to fostering a diverse and inclusive work environment. We encourage applications from under-represented minorities, including women, individuals from disadvantaged backgrounds, under-represented racial or ethnic groups, and individuals with disabilities. We will make every effort to remove barriers to the success of the hired individual(s).

Qualifications:

A successful candidate is highly motivated, has scientific curiosity, has strong interpersonal skills, and will contribute to the collegial atmosphere of the laboratory and the department.

Minimum requirements:

  • PhD in biology-related field
  • Strong record of productivity as evidenced by peer-reviewed publications in internationally recognized English language journals
  • Excellent communication skills in the English language
  • Experience in molecular biology and cell culture techniques
  • Experience in computational biology techniques is preferred but not required

Salary Range:

Salary is commensurate with skills and experience, as well as NIH Guidelines.  The University of Colorado offers a full benefits package.  Information on University benefits programs, including eligibility, is located at www.cu.edu/employee-services.

Applications must contain the following and be submitted electronically via CUCareers

  • Curriculum vitae
  • Statement of past research (one page)
  • Statement of your interest in the lab’s research program and your long term plans (one page).
  • Contact information for three references
  • Start date availability

For further details please send an email to risslandlab@nullgmail.com.

Special Notices to Applicants:

The University of Colorado at Denver is committed to providing a safe and productive learning and living community.  To achieve that goal, we conduct background investigations for all final applicants being considered for employment.  Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. Alternative formats of this ad are available upon request for persons with disabilities.

Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references other than those listed in your application during the search process.

The University of Colorado is committed to diversity and equality in education and employment.          

 

Postdoctoral Fellow Position Available, Houston Methodist Research Institute

We are seeking a Postdoctoral Fellow (open rank) to work in a lab at the instersection of RNA biology and cancer molecular biology. Candidates will have the opportunity to do both basic science and translational research in a fast-paced and collaborative research environment in the heart of the Texas Medical Center at the Houston Methodist Research Institute mentored by Dr. Daniel Kiss. The Kiss RNA Lab has two main lines of research. The first project investigates how cytoplasmic capping of RNAs modulates the expression of the epitranscriptome in cancer and during different stress responses. The second line of research involves better defining how the FHIT tumor suppressor controls the translation of cancer-linked mRNAs in lung cancer.

Some prior RNA molecular biology experience is required. Previous experience with ribosome profiling, qPCR, polysome gradients, making stable clonal cell lines, and a detailed knowledge of translational control, and RNA processing (specifically alternative splicing and/or polyadenylation) are all particularly useful but not required. This position will not involve work with animals, but may include the handling of deidentified human samples from a tissue bank. Your training will be tailored to you with an individual development plan (IDP) which will focus on the many aspects of research relevant to your long-term career goals (including those away from the bench).

Excellent organizational, communication and critical thinking skills, self-motivation, plus the ability to work both independently and in a team-based environment, are required. Postdocs belonging to underrepresented groups, those with non-traditional career tracks, and those interested in eventually transitioning to industry positions are all encouraged to apply. Postdocs with bioinformatics backgrounds that are looking to learn wet lab techniques are also encouraged to apply.

If interested, please attach a letter of interest, curriculum vitae and list of three references with your application. In your letter of interest, please describe your research background (please link skills to published papers where possible), current research interests and future career goals.

Note: If you are attending RNA 2018 in Berkely, CA between May 29-June 2nd, we can set up an in person interview sometime during the conference.

Start date: After June 1st, 2018
Duration : open, 2 year minimum commitment desired

Daniel L. Kiss, Ph.D.
Scientist, Biomarker Research Program
Email: dlkiss@nullhoustonmethodist.org

Postdoctoral Scholar – Dept of Molecular and Cell Biology, Boston University Medical Campus

Postdoctoral Scholar position is available in the laboratory of Prof. Ruslan Aphasizhev at the Department of Molecular and Cell Biology, Boston University Medical Campus. Our NIH-funded program focuses on mechanisms of RNA processing in trypanosomes, including mitochondrial transcription, mRNA editing, mRNA stability, small RNAs biogenesis and translation. For more details, see recent publications below. Our collaborations extend into structural biology, mass spectrometry, drug design and bioinformatics. Strong background in molecular biology and biochemistry, and a record of peer-reviewed publications are required.

Experience in RNAi, bioinformatics, RNA-Seq, ribosome profiling, protein purification, mass spectrometry and parasite genetics is desirable, but not required. This position is available immediately; it carries a starting salary of $48,500 plus comprehensive health insurance. Funding will be provided for up to three years although fellowship applications are encouraged. Boston University Medical Campus is in the vibrant South End area of Boston and offers a collaborative environment, unlimited networking possibilities, excellent core facilities and outstanding cultural and recreational opportunities. To apply, please send a letter of intent, CV and contact information of three references to ruslana@nullbu.edu.

Aphasizheva and Aphasizhev, Trends in Parasitology, 2015. Aphasizheva et al., Molecular Microbiology, 2016. Suematsu et al, Molecular Cell, 2016. Rappa et al, Nucleic Acid Research, 2016. Zhang et al, EMBO Journal, 2017.

Postdoctoral Position – RNA biology and epigenetics University of California, Riverside

We are looking for a talented and motivated Postdoctoral Researcher to work on RNA biology and epigenetics in neuronal development.

The position is in the laboratory of Dr. Jernej Murn in the Department of Biochemistry at the University of California, Riverside. A successful applicant will have a strong background in molecular biology, neurobiology, and genetics. Prior experience with stem cells and/or computational biology is desirable. For more information about the lab, please visit https://www.murnlab.info/.

The position is available starting immediately. Interested applicants should send their CV and contact information of three referees to Dr. Murn at jernej.murn@nullucr.edu.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, or any other characteristic protected by law.

Postdoc in Bioinformatics within Neurodegenerative Diseases

Department of Veterinary and Animal Sciences
Faculty of Health and Medical Sciences
University of Copenhagen

A two-year Postdoc position is available in the bioinformatics group (http://ivh.ku.dk/bioinformatics), Center for non-coding RNA in Technology and Health (RTH), (http://rth.dk) at Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences at University of Copenhagen. The Postdoc position in Bioinformatics within Neurodegenerative Diseases is available from 1 August 2018 or as soon as possible thereafter.

Information about the department can be found at http://ivh.ku.dk/english/.

You will be a team player working with great excitement, and a key person in the project essential for obtaining successful results. The Postdoc position is part of the Indo-Danish NeuroStem project, which aims to discover RNA mediated regulation in neurodegeneration through stem cell models. The Postdoc will be interacting closely with the Group for Stem Cells and Embryology. See http://neurostem.dk for details. The Neurostem project is supported by Innovation Fund Denmark.

Background

The NeuroStem project aims at identifying and manipulating non-coding RNA to obtain novel functional insight in Alzheimer´s and Parkinson’s diseases that can enable improved treatment. The non-coding RNAs will be extracted from expression experiments of patient-specific neuronal cells derived from induced pluripotent stem cells obtained from skin fibroblasts. Further details can be found at http://neurostem.dk.

Job description

The project involves detection and analysis of non-coding and structured RNA and their correlation of transcriptomic data in regards to the neurodegenerative diseases. Relevant methods will be employed for the transcriptome analysis and methods for detecting structured RNA and RNA-RNA interactions will be developed and incorporated in the integrated pipelines. There will be close synergy to the experimental side in e.g. the set up for mechanistic experiments to further verify RNA functions in relation to neurodegeneration.

Required qualifications and selection criteria

The applicant should hold the professional as well as personal skills and qualifications as stated below:

  • A completed PhD degree in bioinformatics, computer science or in a similar area
  • General background knowledge of biological areas of genome structure and transcriptomes
  • Algorithmic insight broad and for RNA 2D structure
  • Strong experience with script languages such as Perl or Python (or similar)
  • Strong experience with the Linux/Unix environment, command lines and shell scripting
  • Solid experience with transcriptome analysis
  • Familiarity or experience in at least one of the following programming languages: C, C++ or Java
  • Good interpersonal skills
  • Excellent in English both in writing and speech

Candidates fulfilling one or more of the following qualifications will be prioritised:

  • Experience with transcriptomic data from neurodegenerative diseases
  • Strong experience in at least one of the following programming languages: C, C++ or Java

It is recommended that the applicant address the qualification requirements one by one in the cover letter.

Terms of employment

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 34,980 per month (level 6 to 8). To the basic salary a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is limited to a two-year period.

Place of employment

RTH is located on Frederiksberg Campus; however, as part of the NeuroStem project research visits to project partners will be a part of the Postdoc employment. Our research environment is highly international and stimulating. We frequently organise seminars, workshops, PhD summer schools with international speakers and have retreats with our international collaborators.

Questions

For further information about the scientific content of the position please contact Professor Jan Gorodkin, email gorodkin@nullsund.ku.dk, phone +45 2337 5667 or for application procedure and formalities please contact HR on email mailto:sund-hr-ivh@nullsund.ku.dk.

Application procedure

Apply by clicking “Apply online” below. Please note that only online applications will be accepted.

Applications – in English – must include:

  • Cover letter detailing your motivation and background for applying for the specific Postdoc project
  • CV
  • Diploma and detailed transcripts of records
  • Other information for consideration, e.g. list of publications, peer reviewed and other
  • Personal Recommendations (if any)
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment

The deadline for applications is 18 June 2018. Any applications received after this time or incomplete will not be considered.

Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application.

The further process

Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

All applications must be submitted via the University of Copenhagen’s website: https://candidate.hr-manager.net/ApplicationForm/SinglePageApplicationForm.aspx?cid=1307&departmentId=19008&ProjectId=147152&MediaId=4636.

Postdoc in Systems Biology for non-coding RNA, Bacterial Cell Factories

Department of Veterinary and Animal Sciences
Faculty of Health and Medical Sciences
University of Copenhagen

A two-year Postdoc position is available in the bioinformatics group (http://ivh.ku.dk/bioinformatics), Center for non-coding RNA in Technology and Health (RTH), (http://rth.dk) at Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences at University of Copenhagen. The Postdoc position in Systems Biology for non-coding RNA in Bacterial Cell Factories is available from 1 August 2018 or as soon as possible thereafter.

Information about the department can be found at http://ivh.ku.dk/english/.

You will be a team player working with great excitement and a key person in the project essential for obtaining successful results. The Postdoc position is part of the NextProd project, which aims to discover non-coding and structured RNA (ncRNA) that can affect the yield of cell factories. The Postdoc will be interacting closely with the involved people in the Vinter lab and Novozymes A/S; see http://nextprod.dk for details. The NextProd project is supported by Innovation Fund Denmark.

Background

Cell factories are based on organisms, which have been carefully optimised to produce protein-based products such as enzymes and pharmaceutical proteins with the highest possible yield. However, current technology is saturated with respect to yield improvement although the theoretical maximum has not yet been reached. Within the NextProd project, the goal is to improve the yield by manipulating ncRNAs. See more at http://nextprod.dk.

Job description

Transcriptomic data sets from relevant strains of the model cell-factory Bacillus subtilis will be used as outset for identification of ncRNAs and their pathways through integrative analysis. This will also include in silico analysis of expression data, RNA structure and RNA-RNA interactions. An integrated workflow will be established including both known tools and tools developed on demand when relevant. The workflow will be employed directly within the context of the data generated in the project and is expected to give rise to further experimental analysis.

Required qualifications and selection criteria

The applicant should hold the professional as well as personal skills and qualifications as stated below:

  • A completed PhD degree in bioinformatics, systems biology, computer science or in a similar area
  • General background knowledge of biological areas of genome structure and transcriptomes
  • Solid experience with transcriptome analysis
  • Experience with gene network and pathway analysis
  • Algorithmic insight broad and for RNA 2D structure and RNA-RNA interactions
  • Strong experience with script languages such as Perl or Python (or similar)
  • Strong experience with the Linux/Unix environment, command lines and shell scripting
  • Familiarity or experience in at least one of the following programming languages: C, C++ or Java
  • Good interpersonal skills
  • Excellent in English both in writing and speech

Candidates fulfilling one or more of the following qualifications will be prioritized:

  • Experience with transcriptomic data in bacteria
  • Strong experience in at least one of the following programming languages: C, C++ or Java

It is recommended that the applicant address the qualification requirements one by one in the cover letter.

Terms of employment

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 34,980 per month (level 6 to 8). To the basic salary, a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is limited to a two-year period.

Place of employment

RTH is located on the Frederiksberg Campus; however, as part of the NextProd project research visits with project partners or collaborators will be a part of the Postdoc employment. Our research environment is highly international and stimulating. We frequently organise seminars, workshops, PhD summer schools with international speakers and have retreats with our international collaborators.

Questions

For further information about the scientific content of the position please contact Professor Jan Gorodkin, email gorodkin@nullsund.ku.dk, phone +45 2337 5667 or for application procedure and formalities please contact HR, email sund-hr-ivh@nullsund.ku.dk.

Application procedure

Apply by clicking “Apply online” below. Please note that only online applications will be accepted.

Applications – in English – must include:

  • Cover letter detailing your motivation and background for applying for the specific Postdoc project
  • CV
  • Diploma and detailed transcripts of records
  • Other information for consideration, e.g. list of publications, peer reviewed and other
  • Personal Recommendations (if any)
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment

The deadline for applications is 18 June 2018. Any applications received after this time or incomplete will not be considered.

Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application.

The further process

Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

All applications must be submitted via the University of Copenhagen’s website:https://candidate.hr-manager.net/ApplicationForm/SinglePageApplicationForm.aspx?cid=1307&departmentId=19008&ProjectId=147153&MediaId=4636

Postdoctoral Scholar Position in Lab of Prof. Ruslan Aphasizhev, Dept of Molecular and Cell Biology, Boston University Medical Campus

A Postdoctoral Scholar position is available in the laboratory of Prof. Ruslan Aphasizhev at the Department of Molecular and Cell Biology, Boston University Medical Campus.

Our NIH-funded program focuses on mechanisms of RNA processing in trypanosomes, including mitochondrial transcription, mRNA editing, mRNA stability, small RNAs biogenesis and translation. For more details, see recent publications below. Our collaborations extend into structural biology, mass spectrometry, drug design and bioinformatics.

Strong background in molecular biology and biochemistry, and a record of peer-reviewed publications are required. Experience in RNAi, bioinformatics, RNA-Seq, ribosome profiling, protein purification, mass spectrometry and parasite genetics is desirable, but not required. This position is available immediately; it carries a starting salary of $48,500 plus comprehensive health insurance. Funding will be provided for up to three years although fellowship applications are encouraged. Boston University Medical Campus is in the vibrant South End area of Boston and offers a collaborative environment, unlimited networking possibilities, excellent core facilities and outstanding cultural and recreational opportunities.

To apply, please send a letter of intent, CV and contact information of three references to ruslana@nullbu.edu.

Aphasizheva and Aphasizhev, Trends in Parasitology, 2015. Aphasizheva et al., Molecular Microbiology, 2016. Suematsu et al, Molecular Cell, 2016. Rappa et al, Nucleic Acid Research, 2016. Zhang et al, EMBO Journal, 2017. Sement et al, EMBO Journal, 2018.

Postdoctoral Position at Johns Hopkins University

A postdoctoral position is available in the laboratory of Dr. Ryuya Fukunaga at Johns Hopkins University School of Medicine. The laboratory is focused on understanding RNA biology, including the molecular mechanisms of (1) biogenesis and function of small silencing RNAs such as miRNAs, siRNAs, and piRNAs and (2) post-transcriptional gene regulation by RNA-binding proteins. For (2), Postdoctoral position at Johns Hopkins University

A postdoctoral position is available in the laboratory of Dr. Ryuya Fukunaga at Johns Hopkins University School of Medicine. The laboratory is broadly interested in understanding RNA biology.

More specifically, we are studying (1) the molecular mechanisms of biogenesis and function of small silencing RNAs such as miRNAs, siRNAs, and piRNAs and (2) biological and molecular functions and mechanisms of post-transcriptional gene regulation by RNA-binding proteins. For the projects (2), we are currently mostly focused on those in Drosophila oocytes.

We employ a wide range of approaches that include biochemistry, Drosophila genetics, cell culture system, deep-sequencing, and X-ray crystallography.

We are looking for a highly motivated and enthusiastic new member of the lab. Candidates must have received (or be expecting) a Ph.D. or M.D. within the past three years in molecular biology, biochemistry, genetics, cell biology, structural biology, or a related discipline. Candidates with strong background in biochemical, molecular, cellular, and genetic analyses in RNA biology and/or Drosophila genetics are encouraged to apply.

We have one R01 grant and one AHA grant.

Start date will be anytime including as soon as possible.

More information is available at:

https://sites.google.com/site/fukunagalabjhmi/

https://bcmb.bs.jhmi.edu/people/faculty/ryuya-fukunaga

Please email a cover letter, CV, a brief summary of research interests, accomplishments, and career goals, and contact information of at least three references to Dr. Ryuya Fukunaga at fukunaga@nulljhmi.edu

Postdoctoral Positions Available in Dr. Cheng’s Lab, Baylor College of Medicine

Postdoctoral positions are open in Dr. Chonghui Cheng’s lab at Baylor College of Medicine. Work in our lab is at the interface between RNA biology and cancer biology. We are seeking highly motivated postdoctoral fellows to join us. Current research areas include:

– RNA biology. We are fascinated by how RNA is dynamically regulated during normal and pathological processes. We employ a wide range of wet-lab techniques and bioinformatics approaches to investigate the mechanisms by which RNA alternative splicing is regulated in a cell-type dependent manner, such as in epithelial-mesenchymal transition (EMT).

– RNA’s role in breast cancer metastasis. We are investigating the functional consequences of RNA alternative splicing in EMT and EMT-associated cancer metastatic phenotype. Our research also extends to RNA regulation in tumor immunology.

– RNA bioinformatics. We utilize machine learning and big data from patient clinical trials and our own experimentally relevant datasets to investigate RNA dysregulation in driving therapeutics resistance in breast cancer. We are integrating omics data to identify key players that govern breast cancer progression at the RNA level.

Representative publications are Genes Dev. PMID: 29269483; PNAS. PMID: 28716909; Genes Dev. PMID: 24840202; J Clin Invest. PMID: 21393860. For a glance of our work please visit our website at https://www.bcm.edu/research/labs/chonghui-cheng

Postdoc fellows will be exposed to tremendous training opportunities, research collaboration opportunities, and superior research environment at the Baylor College of Medicine, which is located within the Texas Medical Center, the largest medical complex in the world.

Successful applicants should be recent Ph.D graduates, and have excellent experimental expertise in RNA and molecular and cell biology or computational expertise. Interested applicants should send a curriculum vitae, 1 – 2 publication reprints, and names/contact information of three references to: chenglab.bcm@nullgmail.com. Please indicate “postdoc application” in the subject line.

Postdoc in microRNA turnover and microRNA functions in embryogenesis – Bethesda, MD

A fully-funded postdoc position is available in the McJunkin lab at the NIH main campus in Bethesda, Maryland. Our research has two major long-term goals: 1) to define the biological functions of miRNAs during embryogenesis and 2) to elucidate mechanisms of miRNA turnover. Using C. elegans as a model organism to address these questions, we are combining the strengths of classical forward genetics with CRISPR-Cas-9-mediated genome editing, next-generation sequencing, cell biology, and biochemical techniques. Because embryonically-expressed miRNAs exhibit a sharp decrease in abundance at the end of embryogenesis, our efforts to simultaneously study the biology of these miRNAs and the mechanisms of miRNA decay has the potential to uncover regulatory modules that couple miRNA decay to developmental timing.

The NIH main campus is a vibrant and collaborative research environment boasting over four hundred research groups and an active postdoc community. Bethesda, Maryland is part of the Washington, D.C. metropolitan area, and the NIH main campus is easily accessible by the Washington, D.C. subway system.

Applicants must have completed a Ph.D. and/or M.D. within the last three years. Expertise in molecular biology and strong verbal and written communication skills are required. Experience in either RNA biology or C. elegans research is desirable. International scientists and U.S. citizens are equally eligible for this fully-funded position.

For more information, please see www.mcjunkinlab.org. To apply, please send a cover letter describing which aspect of our research program you are interested to pursue, a CV, and contact information for three references to mcjunkin@nullnih.gov.

Email: mcjunkin@nullnih.gov

Postdoctoral Positions: RNA pathways in development and disease, NIH/NCI – Bethesda, Maryland – USA

We have open postdoctoral positions in our lab. We are looking for researchers interested in understanding the mechanisms through which non-coding RNAs and RNA metabolic pathways regulate gene expression in mammals and how these mechanisms impact animal development and disease. Our lab uses a combination of mouse models and genetic tools together with biochemical and computational approaches to stringently define the roles of these pathways in vivo. Learn more at vidigallab.com

Who you are:

• You share our enthusiasm for RNA biology, gene regulation, mouse development, and tumor biology
• You have PhD-experience in one or more of the following: RNA biology, mouse genetics, developmental biology, tumorigenesis, massively-parallel sequencing techniques, or computational biology

What we offer:

• Fully-funded postdoctoral positions.
• A stimulating and collaborative environment.
• Opportunity to start your own research program or lead ongoing projects.

Apply: Send the following to vidigal.lab@nullgmail.com

• 2 paragraph cover letter explaining your scientific trajectory and why you would like to join us.
• CV and email contacts for 3 references.

NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.

Postdoctoral Fellow in Immunology

We are seeking a postdoctoral fellow to join our growing research group in the Department of Immunology at the University of Pittsburgh. We work at the interface of immunology and the RNA biology to uncover the functions and the mechanism of novel long noncoding RNAs (lncRNA) and RNA-binding proteins (RBPs) in innate immunity, inflammation, and host defense against RNA viruses.

Our multidisciplinary approach includes RNA-sequencing and bioinformatics to map the lncRNA transcriptome, development and the application of RNA-guided proteomics to identify novel RBPs, primary cell culture and in vivo mouse models for functional studies, and the methodologies in the RNA biochemistry, proteomics and genomics to dissect the RNA-dependent mechanisms.

Some of the ongoing research projects include:

  1. The role of lncRNAs in normal and pathological functions of macrophage
  2. Functions and the mechanism of lncRNAs in type I Interferon signaling
  3. RNA-guided proteomics to dissect host-virus interaction
  4. RBPs in the post-transcriptional regulation of innate immunity

Candidate will have the opportunity to select, and develop their own research based on their expertise and career goals. Candidates with a recent Ph.D., and a strong background in one of these areas are encouraged to apply: 1) immunology, 2) RNA biology, 3) Bioinformatics, and 4) Virology.

The salary is in accordance with the NIH guidelines. The start date is flexible. Candidates should send a CV including the contact information for three references to Dr. Maninjay Atianand (atianand@nullpitt.edu). Graduate students who are close to completing their training are encouraged to send an informal enquiry to discuss potential projects.

Postdoctoral Fellow Positions at the Zheng Lab, University of California Riverside

The Zheng lab studies the mechanism and function of RNA processing in the brain. Current research projects investigate the emerging roles of alternative splicing and nonsense-mediated mRNA decay. For details please visit http://zhenglab.ucr.edu.

The position offers an amazing opportunity to continue training in neuroscience and RNA biology with an emphasis on cell and molecular biology, imaging, stem cells, genome editing, genetics, biochemistry, ribogenomics, and informatics approaches.  PhDs with expertise in one or more of the following, biochemistry, live cell imaging, cytoskeleton, in utero electroporation, single cell sequencing, genome editing, and DNA repair/recombination are strongly encouraged to apply.

Salary is commensurate upon experience and qualifications. Please send CV, a description of research experience and interests, representative publications, and two or three references with contact information to sika.zheng@nullucr.edu as a single PDF file. And arrange reference letters sent separately. We welcome and strongly support scientists with diverse backgrounds who are energetic and highly motivated for career advancement.

University of California Riverside is the fastest growing campus of UC with a vibrant research environment (including 7 current NAS members and 2 HHMI investigators). Our lab is fully equipped with modern instruments for neurogenetics research and is currently housed in a research building opened in 2011. We have been selected and expected to move into the newest multidisciplinary research building with the most state-of-the-art facility in 2019.

Riverside is a wonderful place to live, providing ample cultural and entertainment opportunities in a safe and comfortable community with affordable housing and living expenses. Riverside is about an hour away from ski slopes, surfing, or hiking in mountain. The city offers all the cultural advantages of any U.S. city, together with the amazing all-year-round weather of sunny Southern California. The campus is also located in a prime position close to other universities, research institutes, and biotech industries present in Southern California.

Postdoctoral Position, Laboratory of Sandra Wolin, National Cancer Institute

The Wolin laboratory recently moved to the National Cancer Institute (NCI) at the National Institutes of Health (NIH) as part of a major new initiative in RNA Biology.

A fully funded postdoctoral position is available to study RNA surveillance pathways and the mechanisms by which defects in RNA decay pathways contribute to diseases such as cancer and autoimmunity. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin

Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research. We are part of the Center for Cancer Research’s RNA Initiative, which includes more than 50 laboratories at the National Cancer Institute. The environment is highly collaborative and collegial, with the ability to interact with a wide range of scientists and clinicians. The stable funding and extraordinary resources available at the NIH make this an ideal position for a motivated candidate who is seeking additional training in RNA biology.

Candidates should have a Ph.D. and/or an M.D. and less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics or biochemistry, as evidenced by publications.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to sandra.wolin@nullnih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.

Senior Scientist, mRNA Process Development

About MaxCyte:
MaxCyte is the leader in cell transfection with a world-wide marketed flow electroporation platform spanning the discovery, development, clinical, and manufacturing applications of virtually all classes of innovative therapeutics. MaxCyte’s customers and partners utilize its technologies in the development and commercialization of cell-based therapies in regenerative medicine and active cell immunotherapies and in the discovery and development of protein drugs, monoclonal antibodies, vaccines, and small molecule drugs. MaxCyte is located in Gaithersburg, Maryland.

Job Summary:
The Senior Scientist, mRNA Process Development develops and designs mRNA molecules, conducts independent research to identify novel methods for enhancing mRNA stability or function, establishes processes for the manufacture and scale-up of mRNA production, establishes analytical development of mRNA, and performs internal and external technology transfers. This individual collaborates across various functions to achieve optimized project plans, with the ultimate goal to deliver mRNA molecules for use in ex- vivo loading for pre-clinical and clinical development of engineered cell therapies. This individual works independently.

Job Duties:

  •  Leads and establishes mRNA technology platform program by designing and executing experiments; and through strategic partnerships and management of internal and external technology transfer.
  •  Conducts process development efforts for scale up of mRNA manufacturing processes ensuring smooth technology transfer to cGMP and CDMOs.
  •  Provides technical support and resolves scale-up and manufacturing issues, develops solutions to improve process efficiency and product quality, in collaboration with multidisciplinary team of internal and external stakeholders.
  • Develops analytical assays for mRNA translation and protein expression; functional optimization and production.
  • Establishes and leads program to enhance mRNA stability following ex vivo cell loading; and extending duration and level of protein expression from loaded cells.
  • Maintains and establishes new relationships with outside collaborators which provide key insight and access to appropriate quality of raw materials and reagents for mRNA production.
  •  Supports and contributes to IND filings/regulatory documentation for use of mRNA as critical raw material in ex vivo engineering of cells.
  • Complies with all applicable policies regarding health, safety, and environmental policies.

Job Requirements:

  •  Ph.D. in a scientific field (biochemistry, biology, chemistry, chemical engineering, etc.) or related area and at least 8 years of experience working for a biotech/pharmaceutical company or in academia (post-doctorate); or equivalent
  •   Hands on experience in mRNA synthesis (both small and large scale), purification, formulation, and stability testing required
  • Strong background in nucleic acid chemistry, enzymatic and chemical reactions, PCR, plasmid processing, and standard analytical techniques for macromolecules
  • Demonstrated experience with nucleic acid analytical characterization, production, purification, and formulation
  • Ability to design and execute laboratory experiments
  • Strong writing skills and presentation skills required. Demonstrated ability to communicate scientific data and ideas to a large audience of varying scientific disciplines clearly and effectively
  • Experience working with CROs/CDMOs effectively
  • Ability to establish and build relationships
  • Excellent organizational, project management and time-management skills

MaxCyte, Inc. is an equal opportunity employer. To apply, please send your resume and cover letter to careers@nullmaxcyte.com.  Please reference mRNA Scientist in the subject line.

 

 

The Jackson Laboratory is hiring a Post-Doc of RNA Biology

The Ke Lab at JAX Post-doc position application website.

The Ke Lab at The Jackson Laboratory in Bar Harbor, Maine is seeking a postdoctoral associate. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanism of RNA, the Ke lab utilizes multidisciplinary approaches, including cutting-edge computational biology, biochemistry, innovative bio-technologies, genetics and molecular biology. We are especially interested in m6A RNA biology: 1) the fundamental mechanism of m6A RNA biology, and 2) the biological effects of m6A regulation in nerve system, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation, Genes & Development 2015, 29:2037-53.)

The successful candidate will be encouraged to develop an independent research program using a broad array of resources and expertise available to the lab (https://www.jax.org/research-and-faculty/tools/scientific-research-services). Exceptional postdoctoral candidates will have the opportunity to apply for the title of JAX Postdoctoral Scholar, an internal award addressing the national need for research scientists who are accomplished in the broadly defined fields of genetics and genomics. The award includes an independent research budget, travel funds, and a salary above standard postdoctoral scale.

Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology. Skills in quantitative programming or biochemistry are preferred but not required.(Post-doc position application website)

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA, is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

Two postdoctoral fellow positions available at the Mayo Medical School – Mayo Clinic (Rochester, Minnesota)

Two postdoctoral fellow positions are available at the Mayo Medical School – Mayo Clinic (Rochester, Minnesota) to study the functions and mechanisms of post-transcriptional regulations in innate immune responses.

Mayo Clinic is widely regarded as one of the United States’ greatest hospitals and ranked No. 1 in the country on the 2016–2017 U.S. News & World Report List of “Best Hospitals” of the United States, maintaining a position near the top for more than 25 years.

The potential candidate will utilize primary cell culture systems and mouse models in combination with high throughput RNA sequencing, ribosome-profiling, CLIP-seq to study how mRNA binding proteins and long noncoding RNAs control gene expression under normal and pathological conditions.

Highly motivated individuals with a recent Ph.D. and a background in immunology or Molecular Biology are encouraged to apply. Evidence of scientific publications is required and previous experience with either of the following are desirable: 1) mouse embryonic stem cells; 2) immunology; 3) RNA biology; 4) Bioinformatics.

The salary is in accordance with the NIH standard. The start time is flexible in 2017.

Please send a CV including the contact information for at least two references to Dr. Wenqian Hu (whu.lab.mayo@nullgmail.com)