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Postdoctoral Research Associates

The Zamudio lab in the Department of Molecular Cellular and Developmental Biology and the Broad Stem Cell Research Center at UCLA is seeking career-driven and creative Postdoctoral Research Associates to join our multidisciplinary team. We are studying new mechanisms of gene regulation by functional noncoding RNAs using a combination of genomic, system biology, biochemistry and cell biology approaches. Laboratory research will involve a variety of cutting-edge approaches in RNA and stem cell biology providing an ‪excellent research training opportunity in genomics, bioinformatics and translational science. ‬

Ph.D. in Molecular Biology, Cell Biology, Genetics/Genomics, Bioinformatics, Chemistry or a related field is required. ‪Experience and publication record in statistical genomics, computational biology, stem cell biology or related fields‬ including analysis of CLIP, ChIP, WGBS and RNA-seq data is preferred, but not required. ‪Applicants with strong background in RNA molecular biology, genetics or related fields who are interested in developing new genomic approaches in mouse cancer models are also encouraged to apply. ‬Competitive candidates will have a record of scientific productivity, leadership and collaborations.‬‬

Start Date: ASAP

Applicants should submit the following to jesse.zamudio@nullucla.edu:
1) Cover letter stating: laboratory experience in RNA biology and bioinformatics; your long-term career goals; date of availability to begin postdoc research
2) Curriculum vitae (including publications and awards/honors)
3) List of at least three references

Jesse Zamudio was trained in the laboratory of Dr. Phil Sharp at the MIT Cancer Center. At MIT, he characterized regulation by the RNAi pathway in mammalian cells. Using system biology approaches, he found new species of RNA bound to Argonaute in a Dicer-dependent and Dicer-independent manner. The Zamudio lab’s research goal is to characterize new mechanisms of RNA-mediated regulation essential for development and involved in disease progression.

Research technician in biochemistry / molecular biology

Research technician in biochemistry / molecular biology

We are looking for a technician interested in biochemistry and molecular biology, and motivated to develop a career in an interdisciplinary and international team.
Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. We offer you a chance to be a part of this success as an interdisciplinary team as a biochemist/structural biologist, and develop your skills (both in experiment and in theory) while answering exciting scientific questions.
You will work in one of the top-ranked research institutes in Poland. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many opportunities to make your collaborative research a success.
You must have experience in experimental analyses of RNA, techniques of molecular biology, biochemistry and biophysics, RNA structure probing and high-throughput analyses of small molecules (screening, binding assays).

Requirements:
• MSc or PhD in biochemistry, molecular biology or related discipline
• Documented extensive experience in biochemical/biophysical analyses of biomacromolecules and/or in next-generation sequencing of RNA
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl
Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• Contract: 8000 PLN of full remuneration cost, i.e. expected net salary at ~4500 PLN/month, with social security and benefits
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
You will be a member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many opportunities to make your collaborative research a success.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-technician” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

Postdoctoral Fellow position in biochemistry and structural biology of RNAs and RNPs

Postdoctoral Fellow position in biochemistry and structural biology of RNAs and RNPs

We are looking for an experienced postdoctoral researcher, interested in molecular and structural biology of RNA and RNPs, and motivated to develop a career in an interdisciplinary and international team.

About us:
• Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. Our main area of experimental research is to study RNAs and proteins acting on RNAs, analyze their structures, interactions and mechanisms of action, and to design and engineer enzymes with new functions. Experiments are planned and carried out in close collaboration with theoretical research focused on macromolecular modeling. We offer opportunities for international and national collaborations with academia and industry. We expect the candidate to fit into the profile of the laboratory, contribute his/her own unique skills, use the collaborative opportunities to generate significant synergy, and participate actively in our success. To have an idea of the working activity of the group, check the website http://genesilico.pl
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc. IIMCB is an equal opportunity employer, distinguished by Human Resources Excellence in Research logo.

We offer:
• Initially we offer a postdoctoral position in an ongoing grant project (until June 2018) focused on analysis and engineering of ribonucleases that cleave specific sequences in RNA (“restriction enzymes for RNA”).
We are looking forward to recruit a scientist who is at a mid-early stage of their postdoctoral career, interested in longer collaboration and professional development, and who could continue this or similar line of work in our laboratory, as a postdoctoral researcher or as senior scientist. The degree of independence of the follow-up position (after June 2018) will be commensurate with experience of the candidate and willingness to be involved in leadership and management, and will depend on the candidate’s success in raising additional funding for joint research projects in the future.
• We offer strong institutional support (e.g. grants office, couching by experienced scientists etc.) for candidates able and willing to apply for grants or fellowships that can provide full or partial support for the extension of their employment (e.g. from Polish sources such as FNP: HOMING or FIRST TEAM, NCBR: LIDER, NCN: SONATA or SONATA-BIS or from international sources such as EMBO LTF, FEBS LTF, MCS IF, etc.), and hence we expect the candidates to present a CV compatible with requirements of one or more of such grant/fellowship schemes, including a list of significant achievements and scientific publications.
• Initial contract (September 2017 – June 2018): gross salary 11000 PLN/month (av.net salary 6000 PLN/month)
• Reduced-rate for individual medical care packages for you and your family.
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/).
• Position with 100% focus on research, with elements of research management (no teaching obligations).
• Access to modern equipment.
• Participation in courses, conferences, scientific training, support from peers, academic mentoring.
• Follow-up employment depending on success in research and in efficiency of grant/fellowship applications.
• For those interested: support towards habilitation and full independence in the future (e.g. coaching towards ERC StG or CoG grant application).

Requirements:
• PhD in biochemistry, structural biology, molecular biology or related discipline.
• Documented experience in biochemical and/or biophysical analyses of biomacromolecules.
• ~2-4 years of postdoctoral experience with demonstrated significant research output will be strong advantage.
• Publication track record.
• Excellent organizational skills: self- time- and project-management.
• Ability to plan and execute tasks assigned by the supervisor as well as to report progress, combined with creativity and initiative to propose, discuss, adapt, and lead new actions contributing to the key goals of the team.
• Excellent communication skills and ability to work in a dynamic, interdisciplinary environment.
• Excellent command of English, spoken and written, is a must.
• Command of Polish is advantageous, but not essential.
• Experience in experimental studies on RNA is advantageous, but not essential.
• Experience in protein engineering is advantageous, but not essential.
• Experience in structural biology is advantageous, but not essential.
• Priority will be given to candidates with expertise most relevant to the initial project (protein engineering of RNases) as well as to the general profile of the laboratory (strong potential to develop new, joint projects).
Ability and interest to pursue challenging, interdisciplinary problems, and the ability to work in strong collaboration with the team and deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply.

How to apply:
• We will collect applications until 14 July 2017.
• Best candidates will be invited for an interview that will take place in IIMCB on 21 July 2017.
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl • In the subject include “Postdoc-PBS-biochemist” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

Postdoctoral Fellow position in computational structural biology of RNA

Postdoctoral Fellow position in computational structural biology of RNA

We are looking for a junior postdoctoral researcher interested in software development, bioinformatics and molecular modeling, and motivated to develop a career in an interdisciplinary and international team.

Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. We are one of the most successful RNA modeling teams in the world: see rankings of RNA Puzzles. We offer you a chance to be a part of this success as a software programmer or molecular modeler.

TEAM-programmer: You will be a leading programmer in the development of a new method for modeling of RNA-ligand complexes, based on our successful tool SimRNA.
You must have skills in programming: experience with C/C++ is essential, coding in Python is advantageous. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

TEAM-modeler: You will be involved in the application of modeling methods to predict RNA 3D structures and their complexes with small molecules.
You must have experience in structural bioinformatics, molecular simulations, and/or computational chemistry. Experience in programming (especially C/C++ or Python) is advantageous, but not essential.

Requirements:
• PhD in computer science, computational biology, computational chemistry, computational biophysics or related area, defended in 2012 or later
• Documented experience in programming (C/C++ & Python) and/or in molecular modeling
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl

Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• Contract 15000 PLN/month gross salary (~8000 PLN/month netto), with social security and benefits
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. This project offers various opportunities including leading the development of a major software package, practical application of a new cutting edge modeling approach towards computational drug development. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “postdoc-TEAM-programmer or postdoc-TEAM-modeller” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

PhD student position in modeling of RNA-small molecule interactions

PhD student position in modeling of RNA-small molecule interactions

We are looking for a PhD student interested in bioinformatics, molecular modeling and software development, and motivated to develop a career in an interdisciplinary and international team. Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. We are one of the most successful RNA modeling teams in the world: see rankings of RNA Puzzles. We offer you a chance to be a part of this success as a software programmer or molecular modeler.

TEAM-modeler: You will be involved in the application of modeling methods to predict RNA 3D structures and their complexes with small molecules.
You must have experience in structural bioinformatics, molecular simulations, and/or computational chemistry. Experience in programming (especially C/C++ or Python) is advantageous, but not essential.

TEAM-programmer: You will be a leading programmer in the development of a new method for modeling of RNA-ligand complexes, based on our successful tool SimRNA.
You must have skills in programming: experience with C/C++ is essential, coding in Python is advantageous. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

Requirements:
• MSc in life sciences, computer science or related area, and eligibility for PhD studies in Poland
• Documented experience in molecular modeling or in computer programming (C/C++ & Python)
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl
Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• PhD fellowship 3500 PLN/month
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. This project offers various opportunities including leading the development of a major software package, practical application of a new cutting edge modeling approach towards computational drug development. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications, and ultimately to include them in your PhD thesis.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-programmer or PhD-TEAM-modeller” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

PhD student position in biochemistry and structural biology

PhD student position in biochemistry and structural biology

We are looking for a PhD student interested in biochemistry and structural biology, and motivated to develop a career in an interdisciplinary and international team.
Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. We offer you a chance to be a part of this success as an interdisciplinary team as a biochemist/structural biologist, and develop your skills (both in experiment and in theory) while answering exciting scientific questions.
You will be involved in the experimental analyses of RNA, using techniques of molecular biology, biochemistry and biophysics as well as in structure determination of RNA and its complexes using structural biology methods. You must have experience in molecular or structural biology. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

Requirements:
• MSc in biochemistry, structural biology, molecular biology or related discipline and eligibility for PhD studies in Poland
• Documented experience in biochemical analyses of biomacromolecules.
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• PhD fellowship 3500 PLN/month
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications, and ultimately to include them in your PhD thesis.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-biologist” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.
http://genesilico.pl

2 Postdoctoral positions in RNA regulation in Lai Lab, Sloan-Kettering, New York City

We seek experienced and motivated scientists with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to discover and functionally elucidate small RNA biogenesis and mRNA processing, especially within the context of in vivo biology and phenotypes. We have several ongoing projects available, including:

(1) Molecular genetic analysis of endo-siRNA systems and adaptive gene regulation across Drosophila species (e.g. Wen Molecular Cell 2015). We have successfully used CRISPR/Cas9 to knockout the RNAi pathway in non-model fly species, revealing profound phenotypes that stem from de novo genetic conflicts. We seek to characterize the mechanistic bases of these meiotic drive systems, how they induce phenotypes, and how they are resolved by RNAi.

(2) Mechanism and biology of tissue-specific alternative polyadenylation pathways (e.g., Smibert Cell Reports 2012, Sanfilippo Development 2016). We have completed largescale 3′ end profiling across multiple tissues of multiple fly species, revealing cis-regulatory changes that alter 3′ end usage across evolution. We seek to couple this to a mechanistic understanding. We also identified RBPs that alter neural 3′ end lengthening, which figure into the equation. Finally, we are using CRISPR/Cas9 to delete selected highly conserved 3’UTRs, which reveal critical phenotypic requirements for post-transcriptional regulation, and we will further these studies.

(3) Tailing and trimming pathways in Drosophila and mammals (e.g. Bortolamiol-Becet, Molecular Cell 2015, Lin RNA 2017). Extending these recent studies, we identified new factors that are involved in restricting the accumulation of structured RNAs, and mutant analysis shows their involvement in gonadogenesis. We are combining molecular, genetic, and genomewide strategies to understand the scope of these inferred RNA quality control pathways.

We have opening for highly motivated postdoctoral fellows with broad interest in integrative strategies to join our team. Relevant candidates will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods. Bioinformatics and Drosophila expertise are beneficial. Positions are available immediately and funded by federal grants. Generous compensation, benefits, and housing package is provided to all fellows (https://www.mskcc.org/education-training/postdoctoral/current-incoming). Please send letter of inquiry, CV and references to laie@nullmskcc.org.

Tenure Track Faculty Position (Open Rank)

The Center for RNA Science and Therapeutics at Case Western Reserve University School of
Medicine in Cleveland, Ohio invites applications for a tenure track faculty position (open rank)
with focus on the connection of RNA biology and medicine. Preference will be given to
candidates applying modern RNA methodologies to questions with direct medical relevance.
Particular interest lie in the use of RNA for cancer immunotherapy, treatment of metabolic
disorders, and immunity.

The Center for RNA Science and Therapeutics, a free-standing academic unit with several
primary and more than 20 affiliated faculty, is a vibrant and collaborative environment for
research on a wide range of RNA-related topics. Proximity to the Seidman Cancer Center,
University Hospitals, the Cleveland Clinic, and the Louis Stokes Cleveland VA Medical Center
provides abundant opportunities for collaborations with clinical groups or for direct clinical work.

Candidates holding a PhD, MD/PhD, or MD with an outstanding record of research are invited to
submit a curriculum vitae, a statement of future research plans, and contact information for
three references. Applicants at the Associate or Full Professor level should also submit a
synopsis of past research accomplishments. Junior candidates should demonstrate exceptional
potential to develop an innovative, externally funded research program and should arrange for 3
letters of reference to be sent independently.

Please submit application materials by September 1, 2017, as single PDF file to Debra Klocker
(dmk42@nullcase.edu)

Case Western Reserve University is committed to Equal Opportunity and Diversity. Women,
veterans, members of underrepresented minority groups, and individuals with disabilities are
encouraged to apply.

Structure and Mechanisms of Cellular and Viral Noncoding RNAs and RNPs

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a lack of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to work on gene-regulatory riboswitches, highly structured viral RNAs, circular and other structured long noncoding RNAs and their RNP complexes. See https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The well-supported lab has dedicated access to complete suites of state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc. for X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE and FAES.

We apply innovative technologies to study RNA and RNP structure and dynamics, such as RNA cryo-EM, time-resolved XFEL, picosecond multi-temperature SAXS, etc. Ongoing projects include structural and mechanistic elucidations of how the T-box riboswitches (in bacteria) and Gcn2 kinase (in eukaryotes) recognize the structure and aminoacylation state of tRNA, and couple this readout of nutrient availability with initiating cellular starvation response. A second project addresses how viral and cellular RNA structures differentially manipulate immune response protein activities such as dsRNA-binding PKR. We are delineating what structural features of RNA are deterministic for activation or suppression of immune protein activity. The lab also works closely with the Center of HIV RNA Studies (CRNA) as a core lab. https://sites.google.com/a/umich.edu/the-center-for-hiv-rna-studies/faculty-cores. Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can take to your independent positions.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular or structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, RNA, or structural biology is desirable.

To apply: Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nullnih.gov. The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer.

Post-Doctoral Associate Position

A Post-Doctoral Associate position is open immediately in the lab of Dr. Paul F. Agris  within The RNA Institute of the University at Albany (SUNY). Research of antibiotic resistant bacterial infection, Type 2 Diabetes, modified nucleoside enzyme mechanisms will be conducted with the study of, RNA, RNA-RNA, RNA-protein and small molecule interactions. Applicants are sought with expertise in modern high-field NMR instrumentation for determination of macromolecular structure, and experience in molecular biology/biochemistry with experience in RNA preferred. Foreign nationals must have a visa to be a postdoctoral fellow in the US for at least two years. An H1B application will not be financially sponsored. Apply to Dr. Paul F. Agris by email (PAgris@nullalbany.edu) with the subject line of NMR Postdoc and include: letter of interest including date of availability, complete curriculum vitae with list of publications, statement of research experience in macromolecular NMR, and list of three or more contacts for letters of reference.

Postdoctoral Position in the Hargrove Lab

The Hargrove Lab is searching for a postdoc interested in exploring RNA as a therapeutic target. Funded projects include targeting long noncoding RNAs and alternatively spliced mRNAs that impact prostate cancer progression. Ideal candidates will have experience in RNA biochemistry and be familiar with molecular RNA experimental techniques.

The Hargrove Lab is broadly interested in the molecular recognition of RNA, including by proteins, nucleic acids, and small drug-like molecules. Current lab members benefit from a range of chemical and biological backgrounds, and collaboration both within and outside of the laboratory is recognized as a key component of success. This position is an excellent opportunity for enthusiastic, creative, and motivated researchers seeking interdisciplinary training in a rapidly expanding field.

For more information about the Hargrove Lab and list of recent publications, please see our webpage: https://chem.duke.edu/labs/hargrove

Degree requirements: PhD by Sept 1, 2017
Start date: As soon as available
Duration: 1-2 years

To apply: Submit cover letter, CV, research statement, and information for three references at https://academicjobsonline.org/ajo/jobs/8788

For questions, contact Professor Hargrove: amanda.hargrove@nullduke.edu

Postdoctoral Position Available to Study Eukaryotic RNA modifications

A postdoctoral position is immediately available in Anders Byström’s laboratory at the Department of Molecular Biology, Umeå University, Sweden. Our lab is using a combination of genetics, biochemistry and molecular biology to study the biosynthesis and function of modified nucleosides in tRNA and mRNA. Defects in the formation of several RNA modifications are linked to human disease. We are predominantly using Saccharomyces cerevisiae as the model organism and we have shown that the lack of specific modifications in tRNA leads to pleiotropic cellular phenotypes including defects in G1/ S transition, vesicular trafficking, telomeric gene silencing, and DNA check point control. In our on-going work we are investigating the mechanisms by which RNA modifications modulate gene expression.

Required qualifications are a PhD degree or equivalent with a documented background in RNA biology. Previous experience in yeast genetics and analysis of RNA modifications is an advantage. Applications should be written in English, comprise of a cover letter with a brief statement of research interests, CV with a publication list and contact information of at least two referees. Documents should be in MS Word or PDF format and submitted via e-mail (anders.bystrom@nullumu.se).

This position is a full-time, 12 month scholarship appointment with an opportunity for renewal based on performance and funding. Informal inquiries regarding this position are welcome.

Postdoctoral Research Fellow Position at Alberta RNA Research and Training Institute, University of Lethbridge, Canada

A postdoctoral research fellow position is available in the Kothe lab focusing on transcriptomics of RNA modification. This research addresses fundamental as well as disease-relevant aspects of RNA modification integrating transcriptomic approaches with cellular and biochemical studies. Thereby, the potential candidate will elucidate the complex contribution of RNA modifications to regulation of gene-expression. This position is fully funded for 2.5 years by Alberta Innovates.

This project builds on the expertise in the Kothe lab in studying pseudouridine formation and other RNA modifications in all types of RNA as well as investigating the ribosome. In our research, we apply a multidisciplinary approach including techniques such as protein/RNA biochemistry, fluorescence spectroscopy, rapid kinetics, cellular studies, E. coli and yeast genetics, next-generation sequencing and molecular dynamics simulations (http://scholar.ulethbridge.ca/kothe).

The Kothe lab is part of the Alberta RNA Research and Training Institute (ARRTI) with eight research groups spanning all areas of RNA research. ARRTI fosters a highly collaborative training and research environment with ample opportunities for scientific exchange and collaborative projects. Together, the ARRTI groups have access to a comprehensive suite of state-of-the-art equipment for biophysical, biochemical, cellular and computational studies (http://www.uleth.ca/research/centres-institutes/alberta-rna-research-and-training-institute-0).

Highly motivated researchers with a recent Ph.D. in biochemistry, molecular biology, cellular biology or a similar discipline are encouraged to apply. It is expected that candidates will have proven their research accomplishments by peer-reviewed publications. Next-generation sequencing and bioinformatics skills are highly desirable. Excellent verbal and written communication skills, teamwork ability and some experience in supervising students are expected.

Interested candidates should send a CV including at least three references, a motivation letter and copies of their most significant publications by email to Dr. Ute Kothe (ute.kothe@nulluleth.ca). Applications will be considered starting June 12th 2017 until the position is filled.

RNA Biology and Gene Regulation PhD/Postdoc Positions Available at the University of Regensburg

The University of Regensburg with its over 20,000 students is an innovative and interdisciplinary university, which provides a broad variety of research projects and disciplines. The Institute of Biochemistry, Genetics, and Microbiology, Chair of Biochemistry, Professor Meister, at the University of Regensburg is offering positions as

PhD student or postdoc with a strong background in biochemistry/molecular biology.

Job specification:
Our research focuses on the various functions of human non-coding RNAs in gene regulation. We use biochemical and molecular biological approaches to dissect non-coding RNA pathways. In particular, we characterize regulatory processes guided by microRNAs, circRNAs or lncRNAs and in addition we analyze protein components of these pathways. Furthermore, we study RNA base modifications (e.g. m6A) and their roles in gene expression. We perform deep sequencing studies to identify such modifications under different conditions as well as structure-function experiments to characterize writer, reader and eraser enzymes that are involved in such pathways. We routinely characterize RNA-protein interactions using various experimental approaches including X-ray crystallography and molecular biological or biophysical strategies. Modern Cryo-electron-microscopy is used for structural analysis and can be learned and applied.

Qualifications:
Candidates should hold a Master/Diplom/PhD or equivalent in Biochemistry, Molecular Biology or a closely related subject.

We expect good communication skills, high motivation, dedication to molecular life sciences and the willingness to work in a competitive research field.

General framework:
We offer a state-of-the-art biochemistry lab in an international environment with a long-standing experience in non-coding RNA biology. Well-equipped mass spectrometry, protein purification as well as deep sequencing platforms are available. A cryo-electron-microscope will be installed in the near futuer. The lab is generously funded by several national and international grants including an ERC consolidator grant. The successful candidate will be embedded into the international graduate school RIGEL.

The University of Regensburg is committed to the compatibility of family and career (for more information, please visit http://www.uni-regensburg.de/equal-opportunities). Severely disabled applicants are given preference in instances where applicants demonstrate an equal level of qualification. Please mention any severe disabilities, if applicable, in the application. Unfortunately, we do not provide reimbursement for expenses associated with interviewing.

For further enquiries please contact Professor Gunter Meister, phone +49 941 943-2847, gunter.meister@nullur.de. Please send your application no later than 15.06.2017 to gunter.meister@nullur.de

Postbaccalaureate Fellow Position

The RNA Biology Division of New England Biolabs (NEB) invites applications for the position of Postbaccalaureate Fellow. NEB will provide recent college graduates who are planning to attend graduate or professional schools an opportunity to spend one year at NEB performing full-time research. The goal of this program is to engage undergraduates to consider basic and applied science related careers and providing them the opportunities for competitive science related education and careers.

The fellow will work with NEB scientists, and projects will be a part of a research program on different aspects of RNA biology. Research will be undertaken in a highly collaborative and academic environment and will offer motivated and talented students an opportunity to confirm their interest in basic and applied research.

Fellows will also have the opportunity to participate in a variety of scientific activities:

  • Group meetings to discuss research
  • Research seminars, science talks
  • Receive exposure to the upcoming trends in science and technology

Primary Responsibilities:

  • Conduct hypothesis-driven scientific research in a laboratory setting
  • Execute a variety of molecular biology techniques including: PCR, in vitro RNA synthesis, gel electrophoresis
  • Maintain detailed records of research activities
  • Summarize and communicate research results in a group setting

Required Qualifications:

Candidates must have been granted a Bachelor degree with a cumulative GPA of at least 3.3 on a 4.0 scale no more than 3 years before the date of application to the NEB Postbaccalaureate program

In addition, candidates must meet one of the following criteria:

  • Have been accepted into graduate/professional school and delayed entrance for up to one year to pursue research
  • Have completed or are pursuing their master’s degree and are applying to doctoral or professional programs

Preferred Qualifications:

  • Prior research experience in a lab setting (as part of a course or research program)
  • Excellent verbal and written communications skills and an aptitude for learning

Application Procedure:

The application package must contain:

  • A cover letter (limit to 300-500 words) describing your short-term and long-term career goals highlighting prior research experience relevant to the program.
  • A resume or curriculum vitae.
  • A list of coursework and grades.
  • The names and contact information for three references (preference should be given to those who can comment on specific research experience or lab-related courses).

Apply online: https://chk.tbe.taleo.net/chk05/ats/careers/requisition.jsp?org=NEB&cws=1&rid=297

For more information, visit: https://www.neb.com

Two Postdoctoral Research Associate Positions

Two postdoctoral research associate positions are available to study molecular mechanisms of viral and cellular translation and of translation-associated quality control processes in eukaryotes in the laboratories of Tatyana Pestova and Christopher Hellen at the State University of New York Downstate Medical Center in Brooklyn, NY, USA. Our NIH-funded research uses a range of biochemical and molecular biology approaches, and currently focuses on characterization of (1) canonical and non-canonical modes of translation initiation in mammals, including IRES-mediated initiation, (2) mechanisms of translation termination and ribosome recycling, and (3) events downstream of termination, with a focus on quality control processes.

Required qualifications include a Ph.D. in the field of Molecular Biology, Biochemistry or a related field, and practical experience in modern RNA and/or protein biochemistry, including the expression and purification of native/recombinant proteins and the functional analysis of proteins and RNA-protein complexes. Our research involves active collaborations with cryoEM laboratories, and experience in structural biology and/or in investigating aspects of eukaryotic translation and associated quality control processes is therefore desirable. Candidates should be highly motivated, be able to work independently and show excellent critical thinking, scholarly ability and communication skills.

These positions are available immediately, and carry a starting salary of $45,000 – $50,000 (depending on experience) plus health insurance. To apply, please send a cover letter discussing your interest in a position and mentioning the expected availability date, your curriculum vitae (with a summary of research experience, including techniques and methods used, and a list of publications) and contact information for three references to:
christopher.hellen@nulldownstate.edu.

Ph.D. Fellowship at the SABNP Laboratory

Laboratory and Context:
This thesis is funded for three years (09/2017-08/2020) through a CIFRE convention between the SABNP laboratory (INSERM public research unit (U1204)) and MSD France, a company with interest in oncology.  Research will take place at the SABNP laboratory in the Genopole campus (Evry, South suburb of Paris). Genopole is the France’s leading biocluster for biotechnologies and research in genomics and genetics.

Research at the SABNP laboratory (http://sabnp.univ-evry.fr/?lang=en) aims at deciphering the mechanisms involved in the control of protein expression at the cellular and molecular levels and their deregulation associated to cancer. Based on a multidisciplinary approach, the SABNP laboratory notably explores the dynamics and structure of RNA/protein complexes. Novel technologies are also currently developed to explore cellular and molecular processes involved in gene expression regulation.

Subject of the thesis:
Cancer cells display major metabolic alterations and have an increased ability to cope with stress. Besides transcription, translation is also altered to favor the expression of oncogenes involved in different processes like cancer invasiveness and drug resistance. In line with this, two mRNA-binding proteins which share a similar structure appear to be excellent molecular markers of cancer progression and drug resistance in a variety of cancers. We planned to decipher the mechanisms of translation regulation exerted by these proteins in cancer cells. To address this issue, we will combine structural investigations by Atomic force Microscopy (AFM), microscopy analyses (fluorescence microscopy) and functional studies (RT-PCR, RNA-Seq, in vitro translation).

Candidate profile:
Master 2 degree or equivalent in September 2017.  Knowledge in gene regulation in mammalian cells and background in Molecular and Cellular Biology. French skills is not required if the candidate has a good level in in English. To express an interest in the offer, please send a cover letter stating your research interests and your CV to david.pastre@nulluniv-evry.fr and loic.hamon@nulluniv-evry.fr.

Investigate the Structure and Mechanism of Functional Noncoding RNAs

A postdoctoral position is available immediately in Sarah Keane’s laboratory in the Departments of Biophysics and Chemistry at the University of Michigan. Our lab aims to investigate the structure and mechanism of functional noncoding RNAs. We utilize an array of biochemical and biophysical techniques to characterize RNA structure, RNA-RNA, RNA-protein, and RNA-small molecule interactions. We seek a highly motivated postdoc with experience in RNA biochemistry, RNA structural biology, and/or biomolecular NMR spectroscopy. Successful applicants should hold (or will obtain shortly) a Ph.D. in: Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related field. More information about the lab can be found on our website (http://sites.lsa.umich.edu/keane-lab/).

Postdocs in the Keane lab are expected to assume leadership of their projects and serve as mentors to both graduate and undergraduate students in the lab. Interested candidates should send their Curriculum Vitae and the names and contact information for three references via email (sckeane@nullumich.edu) with the subject POSTDOC APPLICATION. This position is a full-time, 12-month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.

Postdoctoral Position in Prokaryotic RNA Biology

I am seeking a qualified and motivated candidate to study the role of DEAD-box proteins in messenger RNA regulation in E. coli. The focus of the lab is on prokaryotic RNA metabolism, with particular emphasis on the cellular roles of DEAD-box proteins and Ribonucleases. Candidates with a recent Ph.D. degree and a background studying any aspects of RNA metabolism in prokaryotes are welcome to apply. Applicants should send by e-mail (as a single PDF) a cover letter, CV, summary of research experience and contact information of three references.

Chaitanya Jain, University of Miami Miller School of Medicine
Email: cjain@nullmiami.edu