Employment Opportunities

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University of Oregon Tenure-Track Biochemistry Faculty Member at the Assistant Professor level

The Department of Chemistry and Biochemistry at the University of Oregon (chemistry.uoregon.edu) invites applications for a tenure-track Biochemistry faculty member at the Assistant Professor level to begin in Fall 2018 or later. Biochemistry research at the University of Oregon takes place in the context of the Institute of Molecular Biology (molbio.uoregon.edu), which promotes interdisciplinary interactions between life science researchers in the departments of Chemistry and Biochemistry, Biology and Physics. A Ph.D. is required.

We seek applicants from all areas of biochemistry and structural biology who are using advanced approaches to study mechanisms of cellular function. New faculty will join a rich and collaborative atmosphere with existing strengths in host-pathogen interactions, stem cell biology, epigenetics, RNA metabolism, cell polarity, and cytoskeletal function. Successful candidates will have the potential for establishing an outstanding independent research program and excellence in teaching at the undergraduate and graduate levels. They will also support and enhance a diverse learning and working environment.

To assure full consideration, application materials should be received by October 9, 2017. Please upload a cover letter, curriculum vitae, a statement of research plans and objectives, and a brief statement of teaching philosophy or interests here: https://academicjobsonline.org/ajo/jobs/9448. The candidate should also arrange for three letters of recommendation to be uploaded directly by the recommenders. Review of application materials will continue until the position is filled.

UO is dedicated to the goal of building a culturally diverse and pluralistic faculty committed to teaching and working in a multicultural environment and strongly encourages applications from minorities, women, and people with disabilities. Applicants are encouraged to include in their cover letter information about how they will further this goal.

Kieft Lab Seeking Post-Doctoral Researchers

The Kieft Lab is seeking motivated, enthusiastic, creative post-doctoral researchers to join us at the University of Colorado School of Medicine. This is an excellent opportunity to join a dynamic, cohesive, enthusiastic and thriving research group, and to establish an independent project on a novel RNA-focused scientific problem. New post-doctoral researchers in the Kieft Lab have the chance to design and pursue a project that melds their own interests and ideas with the established expertise of the lab. Positions are fully funded and available immediately.

Currently, the Kieft Lab is dedicated to understanding diverse roles played by RNA in healthy and diseased cells, with a particular interest in how RNA structure and structural dynamics drive function. We have focused mainly on RNAs of viral origin; we hope to understand how these RNAs are critical for viral diseases and also to learn fundamental rules of how RNA works in biology. Our approaches include cell culture-based methods with disease relevant cells, in vitro activity assays, biochemical studies, x-ray crystallography, cryo-EM, biophysical methods, and virology. However, we are is always open to new questions and different approaches, driven by curiosity!

The lab is located on the new Anschutz Medical Campus within the highly collegial Department of Biochemistry and Molecular Genetics and is part of the RNA BioScience Initiative. Denver is a great place to live and to do research. Motivated, curious and independent individuals interested in joining the Kieft Lab should send (by e-mail) a letter of inquiry stating research interests along with a CV and contact information of three references: Jeffrey.kieft@nullucdenver.edu

Open Post-doc positions for research on circular RNAs (circRNAs) in the Kadener lab at Brandeis University

The Kadener lab recently relocated to the Boston area and we are looking for highly motivated post-doctoral fellows for exciting research on circular RNAs (circRNAs).

We are looking for 2 post-doctoral fellows for performing research on circRNA function. Our lab uses both Drosophila and mammalian systems to unravel the role of circRNAs in brain function and behavior. Our laboratory is one of the leaders in this new and exciting field of research. The studies will require the use of the most advanced biochemical, computational, genomic and neurobiology tools to determine the mechanisms by which circRNA regulate behavior and other neuron-related process. Our studies range from mechanistic biochemical and molecular characterization to the role of these molecules in neurobiology and behavior. Our work utilizes genomic, computational and system-level approaches.  These positions are set to start on October 1st but later start dates are possible.

Relevant publications from our lab in the field include: Pamudurti et al. Mol. Cell 2017;  Rybak-Wolf et al. Mol Cell 2015; Ashwall-Fluss et al. Mol. Cell 2014

In addition, we are looking for at least one post-doctoral researcher to study molecular and neural aspects of the circadian clock. This project involves the development and use of advance molecular, genomic, system-biology and neurobiology techniques to unravel mechanisms behind the robustness and plasticity of the circadian clock. The start date of the position is flexible.

Relevant publications of our lab in the field include: Buchumenski et al., PLoS Genetics 2017; Afik et al., NAR 2017; Mezan et al., Cell Reports 2016; Lerner et al., Nat Communications 2015; Bartok et al., EMBO J 2015; Weiss et al., PLoS Genetics, 2014

Previous experience in Drosophila genetics or neurobiology is advisable but not required. Computational applicants are encouraged to apply.

For more information about the lab, visit http: http://www.bio.brandeis.edu/faculty/kadener.html and http://kadenerlab.huji.ac.il

Note for German Applicants: Prof. Kadener is an Alexander von Humboldt Foundation award winner, so the Kadener lab can act as a host lab for Germans applying to the Feodor Lynen Research fellowship.

If you are interested, please email skadener@nullbrandeis.edu with a cover letter and CV.

Tenure Track Faculty Position (Open Rank)

The Center for RNA Science and Therapeutics at Case Western Reserve University School of Medicine in Cleveland, Ohio invites applications for a tenure track faculty position (open rank) with focus on the connection of RNA biology and medicine. Preference will be given to candidates applying modern RNA methodologies to questions with direct medical relevance.
Particular interest lie in the use of RNA for cancer immunotherapy, treatment of metabolic
disorders, and immunity.

The Center for RNA Science and Therapeutics, a free-standing academic unit with several
primary and more than 20 affiliated faculty, is a vibrant and collaborative environment for
research on a wide range of RNA-related topics. Proximity to the Seidman Cancer Center,
University Hospitals, the Cleveland Clinic, and the Louis Stokes Cleveland VA Medical Center provides abundant opportunities for collaborations with clinical groups or for direct clinical work.

Candidates holding a PhD, MD/PhD, or MD with an outstanding record of research are invited to submit a curriculum vitae, a statement of future research plans, and contact information for three references. Applicants at the Associate or Full Professor level should also submit a synopsis of past research accomplishments. Junior candidates should demonstrate exceptional potential to develop an innovative, externally funded research program and should arrange for 3 letters of reference to be sent independently.

Please submit application materials by September 1, 2017, as single PDF file to Debra Klocker (dmk42@nullcase.edu)

Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Apply for a Postdoctoral Position on Pre-mRNA Splicing in the Staley Lab

Our goal is to understand the mechanisms that underlie nuclear pre-mRNA splicing, an essential step in eukaryotic gene expression. Pre-mRNA splicing is catalyzed by a massive ribonucleoprotein machine called the spliceosome. Using a variety of model organisms, especially baker’s yeast, we leverage a broad array of tools including genetics, genomics, cell biology, mathematical modeling, biochemistry, single molecule approaches, and structural approaches to gain a deep understanding of how the spliceosome catalyzes and regulates pre-mRNA splicing. Our lab comprises a group of creative, thoughtful, and motivated individuals at all career stages, including high school students, undergraduates, graduate students, postdocs and research professionals.

Find out more about our research and lab at our website: http://staley.uchicago.edu.

The Staley Lab now seeks a postdoctoral researcher to pursue one of a number of available projects; a suitable project will be selected based on the postdoc’s interests and experience. We seek applicants who are independent, motivated, rigorous, creative, and innovative. Applicants should have a solid publication record. Additionally, applicants should have strong written and oral communication skills and work well with others. Applicants should have or will shortly earn a PhD in molecular biology, cell biology, and/or genetics, although individuals from other disciplines seeking to change or bridge fields are encouraged to apply. Experience with RNA and approaches that include genetics, genomics, cell biology, biochemistry, biophysics, and/or mathematical modeling is preferred.

The interdisciplinary approach of our lab to research provides an exceptional environment for postdoctoral training. Our interdisciplinary approaches are facilitated by the lab’s proximity to other top disciplines within just a five minute walk, including the physical, medical, and evolutionary sciences; our lab is centered in the Biological Sciences Division at the University of Chicago (for more information, visit: http://biologicalsciences.uchicago.edu). Further, the broader community at the University of Chicago provides a unique and invigorating environment, where inquiry, debate, and all points of view are valued (for more information, visit: http://www.uchicago.edu). Note that the city of Chicago offers an enriching environment to live, with opportunities ranging from theater, art, comedy, and dining to professional sports and outdoor activities (for more information, visit: https://biosciences.uchicago.edu/life).

Interested and qualified candidates should submit the following to jstaley@nulluchicago.edu:

  1. i) a CV
  2. ii) contact information for three references

iii) a cover letter that includes a brief summary of your research accomplishments, your research interests – including your motivation for working in our lab, and your long term goals

The postdoctoral position is available immediately.

PhD Positions Available

PhD positions are available in Prof. Chun Kit Kwok’s lab in the Department of Chemistry at the City University of Hong Kong. We are looking for bright and motivated PhD students to investigate the role of RNA structure in co- and post-transcriptional regulation in the mammalian system. Researchers within the group will be exposed to diverse chemical and biochemical techniques at our laboratory. For more information, please visit kitkwok.weebly.com or contact Dr. Kwok by email.

Applicants with background in RNA biochemistry and molecular biology, as well as next generation sequencing are preferred.

If you are interested to join the group, please kindly send your i) cover letter, ii) academic transcripts and GPA, and iii) CV which includes a summary of past research experience and publication records, your research interests, and contact information of 2 referees to:

Chun Kit KWOK, Ph.D.
Assistant Professor
Department of Chemistry
City University of Hong Kong
Office: AC1-B6608
Lab: AC1-P2405
Phone: (852) 3442 6858
Fax: (852) 3442 0522
Email: ckkwok42@nullcityu.edu.hk

Two Ph.D. positions in circRNA biology available

We are looking for excellent and highly motivated young researchers to investigate the formation and functional role of circular RNAs in the mammalian system. These two positions are integrated in an EC-funded International Training Network (ITN) called cirRTrain (https://circrtrain.eu/), which focusses on circRNA biology. Research in circRTrain includes
● biochemistry and computational biology, genetics
● sequencing, imaging, RNA knockdown, CRISPR/Cas9
● model systems like worm, fly, mouse, human
● medical applications, biomarkers, new therapeutic strategies

Specifically, the two positions in the Bindereif group at the University of Giessen, Germany, are available immediately, for three years, and are for Ph.D. students working on the two projects (#5 / #6) described below.
http://www.uni-giessen.de/fbz/fb08/Inst/biochem/bindereif/Positions

Please send applications including motivation letter, your CV, transcripts of previous studies, and two names of references (as one single pdf) to:

Prof. Dr. Albrecht Bindereif
Institute of Biochemistry
Department of Biology and Chemistry
Justus Liebig University of Giessen
Heinrich-Buff-Ring 17
D-35392 Giessen
Germany
Tel: 49-641-99 35 420
FAX: 49-641-99 35 419
e-mail: albrecht.bindereif@nullchemie.bio.uni-giessen.de

Postdoctoral Positions Available

Postdoctoral positions are available in Dr. Junjie Guo’s lab in the Department of Neuroscience at Yale School of Medicine. The Guo lab studies questions at the intersection between RNA biology and neuroscience. Currently, we are interested in the roles of mRNA and noncoding RNA structures in neural development and neurodegenerative diseases, taking a combination of computational, biochemical, genetic, and genomic approaches. For more information, please visit our website (www.guo-lab.com) or contact Junjie by email.

Start date is flexible and can be as early as September 1, 2017. Researchers with strong interest in RNA biology and neuroscience, regardless of their training background, are welcomed to apply.  Expertise in any of the following areas is highly valued though not required:

  • RNA biochemistry
  • Mouse/fly genetic models
  • In vitro and in vivo models of neurodevelopment
  • High-throughput sequencing
  • Advanced imaging techniques

Please email your application to jguo1766@nullgmail.com, including:

  • A cover letter describing your past training, research interests and career goals
  • A detailed CV
  • Contact information of referees

Postdoctoral Position Immediately Available

A postdoctoral position is immediately available in the lab of Fátima Gebauer to investigate the role of novel RNA binding proteins (RBPs) in cancer progression. Fátima Gebauer leads a team of motivated researchers working on RNA regulation and translational control in Drosophila and human cancerous cells. For more information about the group, please visit http://www.crg.es/fatima_gebauer. The position is available to determine the molecular mechanisms underlying the effects of selected RBPs in melanoma progression, with a special focus on those involved in translational control and metabolism.

Qualified individuals should be highly motivated, self-driven, independent, proficient in English and with a solid publication record. Experience in RNA regulation, metabolism, and standard molecular biology and tissue culture techniques is essential. Experience in animal handling and/or proficiency with the manipulation of high-throughput data is desirable.
We offer work in a highly stimulating environment with state-of-the-art infrastructures, providing the successful applicant with unique professional career opportunities. The contract will have a maximum duration of 5 years, and a competitive salary based on professional experience.

Interested applicants, please contact Fátima Gebauer at fatima.gebauer@nullcrg.eu, and include a CV, motivation letter and the contact details of 2 referees.

Postdoctoral Position Immediately Available

A postdoctoral position is immediately available in the Landthaler laboratory at the Max-Delbrück Center for Molecular Medicine in Berlin, Germany.

The main research interest of the lab is the regulation of gene expression by RNA-binding proteins. The objectives are to explore the connection between distinct cellular metabolic programs and regulation of gene expression at the posttranscriptional level. The aim is to identify metabolic pathways that modulate protein-RNA complexes, RNA structure and RNA modifications using high-throughput approaches.

Required qualifications are a PhD degree or equivalent with a documented background in RNA biology. Applications should be written in English, comprise of a cover letter with a brief statement of research interests, CV with a publication list and contact information of at least two referees. Documents should be in PDF format and submitted via e-mail (markus.landthaler@nullmdc-berlin.de and sabrina.deter@nullmdc-berlin.de).
This position is a full-time, 24 month appointment with an opportunity for renewal based on performance and funding. Informal inquiries regarding this position are welcome.

Seeking Highly Motivated Postdoctoral Associates

The Meyer lab in the Department of Biochemistry at Duke University is currently seeking highly motivated postdoctoral associates who are interested in RNA biology. Studies in the lab are focused on understanding the role of RNA methylation in nervous system function, as well as elucidating the complex regulatory pathways that control RNA modifications. Individuals with experience in RNA biology, biochemistry, genetics, or neurobiology are especially encouraged to apply.

Requirements:
– PhD in a relevant field (such as biology, biochemistry, neurobiology, or genetics).
– Excellent communication skills and an ability to work well with others.
– Demonstration of past research productivity (publications and/or patents).

How to apply:

Send a cover letter, your CV, and the names/contact information of three references to Dr. Kate Meyer (kate.meyer@nullduke.edu).

For more information on our lab, visit www.themeyerlab.com.

Postdoctoral Research Associates

The Zamudio lab in the Department of Molecular Cellular and Developmental Biology and the Broad Stem Cell Research Center at UCLA is seeking career-driven and creative Postdoctoral Research Associates to join our multidisciplinary team. We are studying new mechanisms of gene regulation by functional noncoding RNAs using a combination of genomic, system biology, biochemistry and cell biology approaches. Laboratory research will involve a variety of cutting-edge approaches in RNA and stem cell biology providing an ‪excellent research training opportunity in genomics, bioinformatics and translational science. ‬

Ph.D. in Molecular Biology, Cell Biology, Genetics/Genomics, Bioinformatics, Chemistry or a related field is required. ‪Experience and publication record in statistical genomics, computational biology, stem cell biology or related fields‬ including analysis of CLIP, ChIP, WGBS and RNA-seq data is preferred, but not required. ‪Applicants with strong background in RNA molecular biology, genetics or related fields who are interested in developing new genomic approaches in mouse cancer models are also encouraged to apply. ‬Competitive candidates will have a record of scientific productivity, leadership and collaborations.‬‬

Start Date: ASAP

Applicants should submit the following to jesse.zamudio@nullucla.edu:
1) Cover letter stating: laboratory experience in RNA biology and bioinformatics; your long-term career goals; date of availability to begin postdoc research
2) Curriculum vitae (including publications and awards/honors)
3) List of at least three references

Jesse Zamudio was trained in the laboratory of Dr. Phil Sharp at the MIT Cancer Center. At MIT, he characterized regulation by the RNAi pathway in mammalian cells. Using system biology approaches, he found new species of RNA bound to Argonaute in a Dicer-dependent and Dicer-independent manner. The Zamudio lab’s research goal is to characterize new mechanisms of RNA-mediated regulation essential for development and involved in disease progression.

Research technician in biochemistry / molecular biology

Research technician in biochemistry / molecular biology

We are looking for a technician interested in biochemistry and molecular biology, and motivated to develop a career in an interdisciplinary and international team.
Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. We offer you a chance to be a part of this success as an interdisciplinary team as a biochemist/structural biologist, and develop your skills (both in experiment and in theory) while answering exciting scientific questions.
You will work in one of the top-ranked research institutes in Poland. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many opportunities to make your collaborative research a success.
You must have experience in experimental analyses of RNA, techniques of molecular biology, biochemistry and biophysics, RNA structure probing and high-throughput analyses of small molecules (screening, binding assays).

Requirements:
• MSc or PhD in biochemistry, molecular biology or related discipline
• Documented extensive experience in biochemical/biophysical analyses of biomacromolecules and/or in next-generation sequencing of RNA
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl
Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• Contract: 8000 PLN of full remuneration cost, i.e. expected net salary at ~4500 PLN/month, with social security and benefits
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
You will be a member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many opportunities to make your collaborative research a success.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-technician” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

Postdoctoral Fellow position in biochemistry and structural biology of RNAs and RNPs

Postdoctoral Fellow position in biochemistry and structural biology of RNAs and RNPs

We are looking for an experienced postdoctoral researcher, interested in molecular and structural biology of RNA and RNPs, and motivated to develop a career in an interdisciplinary and international team.

About us:
• Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. Our main area of experimental research is to study RNAs and proteins acting on RNAs, analyze their structures, interactions and mechanisms of action, and to design and engineer enzymes with new functions. Experiments are planned and carried out in close collaboration with theoretical research focused on macromolecular modeling. We offer opportunities for international and national collaborations with academia and industry. We expect the candidate to fit into the profile of the laboratory, contribute his/her own unique skills, use the collaborative opportunities to generate significant synergy, and participate actively in our success. To have an idea of the working activity of the group, check the website http://genesilico.pl
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc. IIMCB is an equal opportunity employer, distinguished by Human Resources Excellence in Research logo.

We offer:
• Initially we offer a postdoctoral position in an ongoing grant project (until June 2018) focused on analysis and engineering of ribonucleases that cleave specific sequences in RNA (“restriction enzymes for RNA”).
We are looking forward to recruit a scientist who is at a mid-early stage of their postdoctoral career, interested in longer collaboration and professional development, and who could continue this or similar line of work in our laboratory, as a postdoctoral researcher or as senior scientist. The degree of independence of the follow-up position (after June 2018) will be commensurate with experience of the candidate and willingness to be involved in leadership and management, and will depend on the candidate’s success in raising additional funding for joint research projects in the future.
• We offer strong institutional support (e.g. grants office, couching by experienced scientists etc.) for candidates able and willing to apply for grants or fellowships that can provide full or partial support for the extension of their employment (e.g. from Polish sources such as FNP: HOMING or FIRST TEAM, NCBR: LIDER, NCN: SONATA or SONATA-BIS or from international sources such as EMBO LTF, FEBS LTF, MCS IF, etc.), and hence we expect the candidates to present a CV compatible with requirements of one or more of such grant/fellowship schemes, including a list of significant achievements and scientific publications.
• Initial contract (September 2017 – June 2018): gross salary 11000 PLN/month (av.net salary 6000 PLN/month)
• Reduced-rate for individual medical care packages for you and your family.
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/).
• Position with 100% focus on research, with elements of research management (no teaching obligations).
• Access to modern equipment.
• Participation in courses, conferences, scientific training, support from peers, academic mentoring.
• Follow-up employment depending on success in research and in efficiency of grant/fellowship applications.
• For those interested: support towards habilitation and full independence in the future (e.g. coaching towards ERC StG or CoG grant application).

Requirements:
• PhD in biochemistry, structural biology, molecular biology or related discipline.
• Documented experience in biochemical and/or biophysical analyses of biomacromolecules.
• ~2-4 years of postdoctoral experience with demonstrated significant research output will be strong advantage.
• Publication track record.
• Excellent organizational skills: self- time- and project-management.
• Ability to plan and execute tasks assigned by the supervisor as well as to report progress, combined with creativity and initiative to propose, discuss, adapt, and lead new actions contributing to the key goals of the team.
• Excellent communication skills and ability to work in a dynamic, interdisciplinary environment.
• Excellent command of English, spoken and written, is a must.
• Command of Polish is advantageous, but not essential.
• Experience in experimental studies on RNA is advantageous, but not essential.
• Experience in protein engineering is advantageous, but not essential.
• Experience in structural biology is advantageous, but not essential.
• Priority will be given to candidates with expertise most relevant to the initial project (protein engineering of RNases) as well as to the general profile of the laboratory (strong potential to develop new, joint projects).
Ability and interest to pursue challenging, interdisciplinary problems, and the ability to work in strong collaboration with the team and deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply.

How to apply:
• We will collect applications until 14 July 2017.
• Best candidates will be invited for an interview that will take place in IIMCB on 21 July 2017.
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl • In the subject include “Postdoc-PBS-biochemist” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”

Postdoctoral Fellow position in computational structural biology of RNA

Postdoctoral Fellow position in computational structural biology of RNA

We are looking for a junior postdoctoral researcher interested in software development, bioinformatics and molecular modeling, and motivated to develop a career in an interdisciplinary and international team.

Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. We are one of the most successful RNA modeling teams in the world: see rankings of RNA Puzzles. We offer you a chance to be a part of this success as a software programmer or molecular modeler.

TEAM-programmer: You will be a leading programmer in the development of a new method for modeling of RNA-ligand complexes, based on our successful tool SimRNA.
You must have skills in programming: experience with C/C++ is essential, coding in Python is advantageous. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

TEAM-modeler: You will be involved in the application of modeling methods to predict RNA 3D structures and their complexes with small molecules.
You must have experience in structural bioinformatics, molecular simulations, and/or computational chemistry. Experience in programming (especially C/C++ or Python) is advantageous, but not essential.

Requirements:
• PhD in computer science, computational biology, computational chemistry, computational biophysics or related area, defended in 2012 or later
• Documented experience in programming (C/C++ & Python) and/or in molecular modeling
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl

Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• Contract 15000 PLN/month gross salary (~8000 PLN/month netto), with social security and benefits
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. This project offers various opportunities including leading the development of a major software package, practical application of a new cutting edge modeling approach towards computational drug development. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “postdoc-TEAM-programmer or postdoc-TEAM-modeller” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

PhD student position in modeling of RNA-small molecule interactions

PhD student position in modeling of RNA-small molecule interactions

We are looking for a PhD student interested in bioinformatics, molecular modeling and software development, and motivated to develop a career in an interdisciplinary and international team. Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. We are one of the most successful RNA modeling teams in the world: see rankings of RNA Puzzles. We offer you a chance to be a part of this success as a software programmer or molecular modeler.

TEAM-modeler: You will be involved in the application of modeling methods to predict RNA 3D structures and their complexes with small molecules.
You must have experience in structural bioinformatics, molecular simulations, and/or computational chemistry. Experience in programming (especially C/C++ or Python) is advantageous, but not essential.

TEAM-programmer: You will be a leading programmer in the development of a new method for modeling of RNA-ligand complexes, based on our successful tool SimRNA.
You must have skills in programming: experience with C/C++ is essential, coding in Python is advantageous. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

Requirements:
• MSc in life sciences, computer science or related area, and eligibility for PhD studies in Poland
• Documented experience in molecular modeling or in computer programming (C/C++ & Python)
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl
Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• PhD fellowship 3500 PLN/month
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. This project offers various opportunities including leading the development of a major software package, practical application of a new cutting edge modeling approach towards computational drug development. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications, and ultimately to include them in your PhD thesis.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-programmer or PhD-TEAM-modeller” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.

PhD student position in biochemistry and structural biology

PhD student position in biochemistry and structural biology

We are looking for a PhD student interested in biochemistry and structural biology, and motivated to develop a career in an interdisciplinary and international team.
Our big goal is to model RNA-ligand interactions, towards the development of new drugs, and to design new RNA molecules that bind to selected ligands. This project offers opportunities for international collaborations with academia and industry. Our group successfully combines experimental and theoretical analyses of RNA, proteins, small molecules, and their complexes. We offer you a chance to be a part of this success as an interdisciplinary team as a biochemist/structural biologist, and develop your skills (both in experiment and in theory) while answering exciting scientific questions.
You will be involved in the experimental analyses of RNA, using techniques of molecular biology, biochemistry and biophysics as well as in structure determination of RNA and its complexes using structural biology methods. You must have experience in molecular or structural biology. Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential.

Requirements:
• MSc in biochemistry, structural biology, molecular biology or related discipline and eligibility for PhD studies in Poland
• Documented experience in biochemical analyses of biomacromolecules.
• Priority will be given to candidates with expertise most relevant to the project and to the general profile of the laboratory. The ability and interest to pursue challenging, interdisciplinary problems, and the ability to deliver results are essential. Highly motivated individuals with a strong desire to work in an interdisciplinary environment, who are comfortable working in strict collaboration with colleagues, and are willing to be directly responsible for their duties are encouraged to apply. To have an idea of the working activity of the host group, check the website http://genesilico.pl Key information about us:
• We are an interdisciplinary team that combines basic science (to solve the mysteries of nature) and applied science (to make the discoveries practically useful). In our laboratory, software developers meet with experimental biologists, and high-throughput data analysis combines with sophisticated studies of individual biomacromolecules. We develop new computational methods, new tools for biotechnology, and molecules that will hopefully become drugs against diseases. Our current research goals are based on a wild ambition: to understand the structure of all RNA molecules that exist, and design molecules that do not exist yet.
• We are driven towards publication and application of our results. Our recent focus and biggest successes are in computational and experimental analyses of RNA and protein-RNA complexes. For examples, see: Smietanski et al. Nature Commun 2014, Boniecki et al. Nucleic Acids Res 2015. We are also involved in efforts towards commercialization of our results.
• We are hosted by IIMCB (http://iimcb.gov.pl), the top-ranked (A+) Polish research institute in biology. The institute provides cutting-edge equipment and facilities, in particular for bioinformatics (e.g. a computing cluster with >2000 cores), experimental molecular biology, and structural biology. IIMCB also provides support for science commercialization, development of spin-off companies etc.

We offer:
• PhD fellowship 3500 PLN/month
• Reduced-rate for individual medical care packages for you and your family
• Reduced-rate memberships in MultiSport programme (https://www.benefitsystems.pl/en/for-you/multisport/)
• Position with 100% focus on research (no teaching obligations)
• Appointment starting 2 October 2017, funding guaranteed for 3 years, possible extension beyond this project.
• Participation in courses, scientific training, support from peers, and academic mentoring
You will be a key member of a group working on a focused scientific project with well-defined goals that combines a big scientific challenge with opportunities to collaborate with other researchers. You will have access to modern equipment and support from other experienced researchers. The project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g. with software developers, molecular modelers and experimentalists), as well as international collaborations with academia and industry. You will have many chances to make your collaborative research a success and you will be expected to present your results at scientific conferences and co-authorize scientific publications, and ultimately to include them in your PhD thesis.

How to apply:
• We will collect applications until 14 July 2017
• Apply now (or ask any questions you may have) to employment@nullgenesilico.pl
• In the subject include “PhD-TEAM-biologist” and your first and last name.
• Your application must be in English and should contain a CV, a motivation letter (What is your scientific dream and how to you want to fulfill it? What are your key strengths? Why do you want to work with us?), a list of your significant achievements, and contacts to at least two potential referees, including at least one former or current direct supervisor.
• Please include the following statement in your application: “I hereby give consent for my personal data included in my application to be processed for the purposes of the recruitment process under the Personal Data Protection Act as of 29 August 1997, consolidated text: Journal of Laws 2016, item 922 as amended.”
• Best candidates will be invited for an interview that will take place 19-21 July.

The project “Modeling of dynamic interactions between RNA and small molecules and its practical applications” is carried out within the TEAM Programme, being a Grant Project of the Foundation for Polish Science funded by the European Regional Development Fund within the framework of Smart Growth Operational Programme 2014-2020 (SG OP), Axis IV: Increasing the research potential, Measure 4.4: Increasing the human potential in R&D sector.
http://genesilico.pl

2 Postdoctoral positions in RNA regulation in Lai Lab, Sloan-Kettering, New York City

We seek experienced and motivated scientists with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to discover and functionally elucidate small RNA biogenesis and mRNA processing, especially within the context of in vivo biology and phenotypes. We have several ongoing projects available, including:

(1) Molecular genetic analysis of endo-siRNA systems and adaptive gene regulation across Drosophila species (e.g. Wen Molecular Cell 2015). We have successfully used CRISPR/Cas9 to knockout the RNAi pathway in non-model fly species, revealing profound phenotypes that stem from de novo genetic conflicts. We seek to characterize the mechanistic bases of these meiotic drive systems, how they induce phenotypes, and how they are resolved by RNAi.

(2) Mechanism and biology of tissue-specific alternative polyadenylation pathways (e.g., Smibert Cell Reports 2012, Sanfilippo Development 2016). We have completed largescale 3′ end profiling across multiple tissues of multiple fly species, revealing cis-regulatory changes that alter 3′ end usage across evolution. We seek to couple this to a mechanistic understanding. We also identified RBPs that alter neural 3′ end lengthening, which figure into the equation. Finally, we are using CRISPR/Cas9 to delete selected highly conserved 3’UTRs, which reveal critical phenotypic requirements for post-transcriptional regulation, and we will further these studies.

(3) Tailing and trimming pathways in Drosophila and mammals (e.g. Bortolamiol-Becet, Molecular Cell 2015, Lin RNA 2017). Extending these recent studies, we identified new factors that are involved in restricting the accumulation of structured RNAs, and mutant analysis shows their involvement in gonadogenesis. We are combining molecular, genetic, and genomewide strategies to understand the scope of these inferred RNA quality control pathways.

We have opening for highly motivated postdoctoral fellows with broad interest in integrative strategies to join our team. Relevant candidates will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods. Bioinformatics and Drosophila expertise are beneficial. Positions are available immediately and funded by federal grants. Generous compensation, benefits, and housing package is provided to all fellows (https://www.mskcc.org/education-training/postdoctoral/current-incoming). Please send letter of inquiry, CV and references to laie@nullmskcc.org.

Structure and Mechanisms of Cellular and Viral Noncoding RNAs and RNPs

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a lack of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to work on gene-regulatory riboswitches, highly structured viral RNAs, circular and other structured long noncoding RNAs and their RNP complexes. See https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The well-supported lab has dedicated access to complete suites of state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, etc. for X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, NMR, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by OITE and FAES.

We apply innovative technologies to study RNA and RNP structure and dynamics, such as RNA cryo-EM, time-resolved XFEL, picosecond multi-temperature SAXS, etc. Ongoing projects include structural and mechanistic elucidations of how the T-box riboswitches (in bacteria) and Gcn2 kinase (in eukaryotes) recognize the structure and aminoacylation state of tRNA, and couple this readout of nutrient availability with initiating cellular starvation response. A second project addresses how viral and cellular RNA structures differentially manipulate immune response protein activities such as dsRNA-binding PKR. We are delineating what structural features of RNA are deterministic for activation or suppression of immune protein activity. The lab also works closely with the Center of HIV RNA Studies (CRNA) as a core lab. https://sites.google.com/a/umich.edu/the-center-for-hiv-rna-studies/faculty-cores. Incoming fellows are also encouraged to bring your own ideas that you could develop into research programs that you can take to your independent positions.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular or structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, RNA, or structural biology is desirable.

To apply: Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nullnih.gov. The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer.

Post-Doctoral Associate Position

A Post-Doctoral Associate position is open immediately in the lab of Dr. Paul F. Agris  within The RNA Institute of the University at Albany (SUNY). Research of antibiotic resistant bacterial infection, Type 2 Diabetes, modified nucleoside enzyme mechanisms will be conducted with the study of, RNA, RNA-RNA, RNA-protein and small molecule interactions. Applicants are sought with expertise in modern high-field NMR instrumentation for determination of macromolecular structure, and experience in molecular biology/biochemistry with experience in RNA preferred. Foreign nationals must have a visa to be a postdoctoral fellow in the US for at least two years. An H1B application will not be financially sponsored. Apply to Dr. Paul F. Agris by email (PAgris@nullalbany.edu) with the subject line of NMR Postdoc and include: letter of interest including date of availability, complete curriculum vitae with list of publications, statement of research experience in macromolecular NMR, and list of three or more contacts for letters of reference.