Employment Opportunities

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Investigate the Structure and Mechanism of Functional Noncoding RNAs

A postdoctoral position is available immediately in Sarah Keane’s laboratory in the Departments of Biophysics and Chemistry at the University of Michigan. Our lab aims to investigate the structure and mechanism of functional noncoding RNAs. We utilize an array of biochemical and biophysical techniques to characterize RNA structure, RNA-RNA, RNA-protein, and RNA-small molecule interactions. We seek a highly motivated postdoc with experience in RNA biochemistry, RNA structural biology, and/or biomolecular NMR spectroscopy. Successful applicants should hold (or will obtain shortly) a Ph.D. in: Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related field. More information about the lab can be found on our website (http://sites.lsa.umich.edu/keane-lab/).

Postdocs in the Keane lab are expected to assume leadership of their projects and serve as mentors to both graduate and undergraduate students in the lab. Interested candidates should send their Curriculum Vitae and the names and contact information for three references via email (sckeane@nullumich.edu) with the subject POSTDOC APPLICATION. This position is a full-time, 12-month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.

Postdoctoral Position in Prokaryotic RNA Biology

I am seeking a qualified and motivated candidate to study the role of DEAD-box proteins in messenger RNA regulation in E. coli. The focus of the lab is on prokaryotic RNA metabolism, with particular emphasis on the cellular roles of DEAD-box proteins and Ribonucleases. Candidates with a recent Ph.D. degree and a background studying any aspects of RNA metabolism in prokaryotes are welcome to apply. Applicants should send by e-mail (as a single PDF) a cover letter, CV, summary of research experience and contact information of three references.

Chaitanya Jain, University of Miami Miller School of Medicine
Email: cjain@nullmiami.edu

Postdoctoral Position

We are looking for highly motivated postdoctoral scientist with an interest in gene regulation. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genes in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford) (Wittmann et al., 2017 Nature Communication, in press). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, have at least one first authorship publication, show excellent critical thinking and good communication skills and have the ability to work as part of a team. Interested applicant should contact Dr Lidia Vasiljeva directly:

Dr. Lidia Vasiljeva: lidia.vasilieva@nullbioch.ox.ac.uk
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675
phone:(+44)-1865613352
The post is funded by the Wellcome Trust Senior Research Fellowship for 1 year in the initial instance.

Postdoctoral Research Associate Position

A postdoctoral research associate position is available to develop multiplex assays to monitor host and parasite genotype / phenotype in clinical samples obtained from patients with the parasitic disease leishmaniasis. The post is funded by a recently awarded MRC Global Challenges Research Fund Foundation Award (in collaboration with researchers in Brazil, India and Sri Lanka) that aims to develop new tools and research approaches to combatting the neglected tropical disease leishmaniasis.

You will work alongside others in the research group, as part of a multidisciplinary team, but will take on a leading role in the development of new assays for use on FFPE and frozen skin tissue. You will have a PhD in molecular biology, immunology or a related discipline, as well as previous experience of assay development based on RNA and antibody probes. Additional experience in skin immunity and histopathology, or biomarker assay development would be advantageous.

The research will be conducted in the CII, which provides state of the art facilities for pathogen related research, and will make extensive use of the resources on offer in the Biosciences Technology Facility. There will be opportunities to visit collaborative laboratories overseas.
The post is offered in the Grade 6 scale of £31,076 – £38,183 per annum. The post is fixed term for two years.

Informal enquiries may be made to either Paul Kaye (email: paul.kaye@nullyork.ac.uk), Dimitris Lagos (Dimitris.lagos@nullyork.ac.uk) or Pegine Walrad (pegine.walrad@nullyork.ac.uk)
Interviews will take place on the 9 May 2017.
Vacancy Reference: 5554

Director and Professor, The RNA Institute, College of Arts and Sciences

The University at Albany, State University of New York, invites applications for the position of Director of The RNA Institute.  Reporting to the Dean  of the College of Arts and Sciences, the Director should have  a background in the broad  area of RNA science and technology.  He or she is expected to take the lead in shaping the future of the Institute, articulating a vision that defines its standard of excellence, mentoring young  faculty and  evolving the Institute to the next level of scientific distinction.

The RNA Institute serves as a resource for research and discovery. Work is focused on developing tools and analytics with applications to biotechnology, disease models and interventions.  Current  research strengths include RNA structure and function, RNA-based determinants of gene regulation, RNA-linked components of disease etiology and  RNA-based therapeutics.

The Institute is a joint venture backed by university, corporate, and government entities in New York’s Capital Region. Housed in newly constructed space, the Institute is located in the interdisciplinary Life Sciences Research Building and financed by state, federal and corporate funds. The Institute is well staffed and equipped with an advanced instrumentation facility, a mass spectrometry center and a computational facility.

Located in New York’s capital city, the University at Albany is within easy reach of the major metropolitan areas of New York City, Boston and Montreal and outstanding recreational areas including the Berkshires, the Catskills and the Adirondacks. The University offers its more than 17,000  students the expansive opportunities of a major research university and an environment designed to foster success. UAlbany students choose from 120 undergraduate majors and minors and more than 125 graduate programs many of which are nationally ranked.

The ideal candidate will possess a distinguished record  of academic success, significant scholarly achievement and  an entrepreneurial spirit. Department assignment will be in Biological Sciences or Chemistry, appropriate to their research interests. The successful candidate will be an investigator with proven  excellence in leadership, a commitment to mentor  and  develop junior faculty and  an outstanding record  of funded research, as well as the desire to build bridges with other schools, corporations and media outlets.  He or she will have  demonstrated the ability to foster a climate where  learning and discovery flourish. The director will show the ability to balance strong academic and intellectual leadership with effective external relationship-building and resource development.

A complete application will include a letter describing relevant experiences and interest in the position; current  curriculum vitae; and the names of five references with titles, mailing addresses, business/home telephone numbers, and email addresses. Applicants must address in their letter their ability to work with and instruct a culturally diverse population. Individuals who wish to nominate a candidate should submit a letter of nomination, including the name, position, address, telephone number, and email address of the nominee. Greenwood/Asher & Associates, an executive search firm, is assisting the University at Albany in the search. Applications and letters of nominations should be submitted to: Jan Greenwood, Betty Turner Asher, Partners, Executive Search Consultant, Greenwood/Asher & Associates, Inc., 42 Business Centre Drive, Suite 206, Miramar Beach, Florida 32550;  Phone: 850-650-2277 / Fax: 850-650-2272; Email: jangreenwood@nullgreenwoodsearch.com; bettyasher@nullgreenwoodsearch.com

For more information about  the University at Albany and the RNA Institute please visit:
http://www.albany.edu/ and   https://www.rna.albany.edu/

Job opening for the Department Chair of Biochemistry

The Department of Biochemistry is seeking nominations and applications for the Department Chair of Biochemistry at the University of Missouri-Columbia. The candidate must be a world-class scientist with a commitment to fostering a spirit of excellence within the department.

Our faculty members are internationally known researchers and prize-winning teachers, including two members of the National Academy of Sciences and multiple members of disciplinary academics and honorary organizations.

Essentially all facets of contemporary biochemical research are represented in the department with particular strengths in medical biochemistry, plant biochemistry and biophysical and structural and mechanistic biochemistry. Our research groups are well-funded by the National Institutes of Health, the National Science Foundation and many other federal and private sources.

For more details see http://www.biochem.missouri.edu/employment/faculty.php
For additional information about the position, please contact Dr. Jinglu Tan, Chair of Search Committee (tanj@nullmissouri.edu).

To apply for the position, the candidate must submit the following documents at http://hrs.missouri.edu/find-a-job/academic.
1. Cover letter
2. Curriculum vitae
3. A two-page summary of research accomplishments and future plans
4. A narrative of administrative and leadership philosophy, including a statement describing efforts to increase diversity and inclusion
5. A narrative of teaching philosophy
6. Names and contact information of four references.

Seeking Outstanding Scientists for Independent Research Group Leader Positions

The Wellcome Trust Centre for Cell Biology (WTCCB) is a world-renowned research centre located within the School of Biological Sciences at the University of Edinburgh. The WTCCB’s mission is to make ground-breaking discoveries that bridge the knowledge gap between genotype and cellular phenotype in health and disease. The Centre has an outstanding track record in fundamental molecular and cellular mechanisms underlying nuclear organization, genome packaging and transmission, chromatin states and RNA biology. The WTCCB fosters an interactive, collaborative environment and is equipped with state-of-the art facilities and instrumentation for molecular and cell biological research, including core support in microscopy, bioinformatics, proteomics and structural biology.

With recently renewed core funding, the WTCCB is in an exciting phase of growth. We seek outstanding scientists for independent Research Group Leader positions at both Junior and Senior levels. Successful candidates will have an impressive track record, appropriate for their career stage and a vision for independent research in any area of cell and molecular biology. Although research excellence is our primary criterion, we encourage applications with demonstrable links to medicine or the physical sciences.

Most group leaders within the WTCCB are supported by independent research fellowships and successful candidates would be supported in seeking independent funding.

Email: d.tollervey@nulled.ac.uk

Post-Doctoral Positions, Laboratory of Sandra Wolin, National Cancer Institute

The Wolin laboratory has recently moved to the National Cancer Institute (NCI) at the National Institutes of Health (NIH) as part of a major new initiative in RNA Biology.

Fully funded postdoctoral positions are available in the areas of noncoding RNA function, RNA surveillance pathways, and the mechanisms by which defects in RNA decay pathways contribute to diseases such as cancer and autoimmunity. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin

Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research. We are part of the Center of Cancer Research’s RNA Initiative, which includes more than 50 laboratories evenly split between the Frederick and Bethesda campuses of the National Cancer Institute. The environment is highly collaborative and collegial, with the ability to interact with a wide range of scientists and clinicians. The positions are ideal for motivated candidates who are seeking additional training in RNA biology.

Candidates should have a Ph.D. and/or an M.D. and should have less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics or biochemistry, as evidenced by publications.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to sandra.wolin@nullnih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.

Postdoctoral opportunity in RNA and Cancer Biology.

A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence suggests an involvement in a broad range of biological processes and in human disease, including cancer. We select candidates based on their regulation by key oncogenes and tumor suppressors or based on their involvement in cancer processes, such as the DNA damage response, oncogenic transformation, and metastasis. Our goal is to understand how candidate lncRNAs contribute to oncogenic and tumor suppressive networks at the molecular, cellular, and organismal level and how deregulation of lncRNAs leads to cellular transformation and tumor development. At the molecular level, we aim to elucidate the diverse mechanisms by which cis- and trans-regulatory lncRNAs fine-tune oncogenic and tumor suppressive networks by modulating transcriptional and translational pathways. At the cellular level, we aim to understand how lncRNAs participate in the decision-making processes in complex transcriptional networks and what are the consequences of lncRNA activity for cellular homeostasis and stress response. Finally, to bring insights into the vastly understudied contribution of lncRNAs to tumorigenesis in vivo, we are testing how inappropriate expression of regulatory lncRNAs influences tumor development in mouse models of lung adenocarcinoma.

A successful candidate will hold a Ph.D. degree, will be highly motivated to perform cutting edge research and to interact with a dynamic, young group of investigators. Candidates from diverse scientific backgrounds are strongly encouraged to apply.

Additional information can be found at dimitrovalab.yale.edu

Candidates should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to: nadya.dimitrova@nullyale.edu

Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Highly Structured Viral RNAs

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a paucity of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to deepen current work on gene-regulatory riboswitches, highly structured viral RNAs, circular and other structured long noncoding RNAs. https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html

Current manuscripts and recent publications:

  1. Li et al., & Zhang (2017) Structural basis of amino acid sensing on the tRNA by a T-box riboswitch. In preparation.
  1. Bahmanjah et al., & Zhang (2017) Structural basis of functional repurposing of an aminoacyl-tRNA synthetase in stress response. In preparation.
  1. Hood et al., & Zhang (2017) Structural mimicry of codon-anticodon interactions by a viral noncoding RNA. In preparation.
  1. Zhang & Ferré-D’Amaré (2014) Dramatic improvement of crystals of large RNA by cation replacement and dehydration. Structure 22, 1363-1371.
  1. Zhang & Ferré-D’Amaré (2014) Direct evaluation of tRNA aminoacylation status by the T-box riboswitch using tRNA-mRNA stacking and steric readout. Molecular Cell 55, 148-155.
  1. Zhang & Ferré-D’Amaré (2013) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature 500, 363-7.

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The well-supported lab has dedicated access to state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, for X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by NIH OITE and FAES.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular or structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, and structural biology is desirable.

To apply: Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nullnih.gov. The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer.

Ph.D. Position in Molecular Mechanisms of Pre-mRNA Splicing, University of Evry, France

This Ph.D. project is funded for three years by a CIFRE contract between the SABNP laboratory (INSERM research unit UMR1204 http://sabnp.univ-evry.fr/?lang=en) at Evry University (near Paris and closed to the Genopole biocluster) and Synsight a company specialized in molecular modeling, bioinformatic and structural biology.

The Ph.D. laboratory work will be performed at the SABNP laboratory as part of a research program on pre-mRNA splicing and protein expression at the cellular and molecular levels. Based on a multidisciplinary approach, the SABNP laboratory notably explores the dynamics and structure of RNA/protein complexes. Novel technologies are also currently developed to explore cellular and molecular processes involved in gene expression regulation. This project is supervised by Pr. David Pastré and Dr. Alexandre Maucuer.
Additional information at http://sabnp.univ-evry.fr/?page_id=1170&lang=en

Candidate profile: Candidates should have a master 2 degree or equivalent in September 2017 and be highly motivated individuals with knowledge in molecular and cellular biology. French skills are not required if the candidate is fluent in English.

Interested candidates should send their application, including a CV and cover letter, detailing their motivation for this particular PhD project to lydia.lebouil@nulluniv-evry.fr.

The project will start around 1st October 2017.

Department of Cellular and Molecular Physiology at Yale School of Medicine

A postdoctoral position is available in the laboratory of Carson Thoreen in the Department of Cellular and Molecular Physiology at Yale School of Medicine. Our lab is studying molecular mechanisms that control the translation and stability of mRNAs. We have a particular interest in the functions of such mechanisms in the maintenance of growth and quiescent cell states. A position is immediately available to develop new strategies for transcriptome-wide profiling of mRNA synthesis and stability. Creative individuals with a PhD or MD, and preferably a strong background in biochemistry and/or cell biology and a quantitative bent, are encouraged to apply. Applicants should send a current CV to carson.thoreen@nullyale.edu.

Study RNA-mediated Stress Responses, Biology of tRNA-derived RNAs and RNA Granules

Postdoctoral positions are available to study RNA-mediated stress responses, biology of tRNA-derived RNAs and RNA Granules. We are seeking to recruit two new colleagues that will have joint appointment in the laboratories of Paul Anderson and Pavel Ivanov at the Brigham and Women’s Hospital and Harvard Medical School, Boston, USA. Positions are available immediately and supported by NIH grants. Initial appoitments will be made for two years with the possibility of extension.

Our laboratories work at the cutting-edge of RNA biology and cell biology. We focus on two major overlapping topics. The first is investigating stress-induced adaptation of mRNA translation and functions of novel non-coding RNAs derived from tRNAs (so called stress-induced tRNA-derived RNAs or tiRNAs) (see Yamasaki et al. J Cell Biol 2009; Ivanov et al. Mol Cell 2011; Ivanov et al. PNAS 2014; Lyons et al. NAR 2016; Lyons et al. RNA Biol 2016). The second is investigating Stress Granules, RNA granules with multiple functions in cellular physiology and pathophysiology (Kedersha et al. J Cell Biol 2016; Szaflarski et al. Oncotarget 2016; Panas et al. J Cell Biol 2016; Aulas et al. J Cell Science 2016) . We employ diverse RNA-based tools to illuminate the biological and biomedical significance of tiRNAs and Stress Granules.

Candidate requirements: A PhD degree (or equivalent) in the biological sciences or a closely related field. Previous experience in molecular and cell biology is necessary. Prior knowledge of basic RNA biology methodology is desired. Evidence of scholarly ability (record of publication in peer-reviewed journals, conference presentations, etc). The candidate is expected to have adequate writing skills, prepare and write research papers, conference presentations and research proposals. Two major requirements include the ability to work independently as well as in the team and a high level of motivation.
It is expected that high quality publications will result from this work.

Brigham and Women’s Hospital and Harvard Medical School are equal opportunity employers. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

Interested individuals should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to:

pivanov@nullrics.bwh.harvard.edu

Pavel Ivanov, PhD
Assistant Professor of Medicine / Associate Immunologist
Brigham and Women’s Hospital & Harvard Medical School
Associate Member, Broad Institute of Harvard & MIT

Investigate the Mechanisms Underlying Translational Control of Gene Expression

A postdoctoral position is immediately available in Kristin Koutmou’s lab in the Department of Chemistry at the University at Michigian to investigate the mechanisms underlying translational control of gene expression. We use an arsenal of biochemical, biophysical, genetic and genome-wide approaches to ask how translation factors interact within cells to regulate mRNA translation. We seek a motivated postdoc with a positive outlook, experience in biochemistry or genome-wide expression set analyses, and the adaptability to quickly learn new skills. Applicants should hold (or will obtain shortly) a PhD in: Biochemistry, Molecular Biology, Chemistry, Biophysics, Bioinformatics, or related field. Previous experience in a research laboratory and writing papers are essential. Skills that are desired, but not certainly not required, include the ability to analyze large (genome wide) data sets and code in Python. Projects are tailored to the skills and interests of the individual.

Postdocs in the Koutmou lab are expected to assume leadership of their projects and mentor graduates students and undergraduates working alongside them to answer questions and communicate findings. Applicants should e-mail their Curriculum Vitae and names of three references to: Dr. Kristin Koutmou, Assistant Professor of Chemistry, via email: kkoutmou@nullumich.edu. Informal inquiries regarding these positions are welcome.

This position is a full-time, 12 month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.

PhD position in RNA Genetics and Cancer

The newly established research group “RNA Biology and Pathogenesis” (Head: Jun.-Prof. Dr. Tony Gutschner) at the Martin-Luther-University Halle-Wittenberg, Germany, is seeking an exceptionally talented and highly motivated PhD student with an interest and experience in the area of molecular biology and cancer research, ideally in RNA biology or functional genomics.
The PhD position (13 TV-L, 65%) is available immediately and limited to three years.

The successful candidate will investigate the function of RNA-binding proteins (RBPs) in human tumors and characterize associated phenotypic dependencies. Specifically, the PhD candidate will (I) establish cellular models of cancer-associated RBPs by genome engineering using CRISPR/Cas9 technology and/or lentiviral gene and shRNA transfer; (II) extensively characterize these engineered cell lines phenotypically through, for example, assays for invasion, migration, anchorage independence, proliferation, apoptosis, and tumor growth in mice; (III) profile these cell lines functionally using CRISPR/Cas9 libraries to identify dependencies; and (IV) mechanistically characterize the most interesting RBPs and functional dependencies in detail in vitro and in vivo using biochemical, molecular and cell biology methods (e.g. Cloning, qRT-PCR, RNA-IP, Immunofluorescence).
This position provides an opportunity for the candidate to be creative and innovative, and to work on a challenging, multidisciplinary topic. We offer a close supervision and mentoring. The candidate will have the opportunity to present his/her results at conferences.

Applicants must hold a Diploma or Master’s degree in the field of life sciences (biology, biochemistry, molecular medicine, or related disciplines). The successful candidate is a highly motivated, creative, ambitious, and hard-working individual with excellent grades who is passionate about making a difference through cancer research. Strong communication skills, a reliable and accurate scientific working ethic, and the ability to work efficiently, independent as well as in a team, are required. An excellent written and oral command of English is essential. The ideal candidate has a solid background in the field of cancer biology and expertise in molecular and cellular biology, with specific focus on the techniques described above. Knowledge in statistics and bioinformatics would be advantageous.

Applications should consist of (I) a motivation letter mentioning the expected availability date, (II) a recent curriculum vitae incl. an overview of techniques and methods used in the past, (III) a list of publications, (IV) academic degrees and certificates, and (V) contact information of two individuals who could provide an evaluation of the candidate upon request.
Please submit your full application (in electronic form as a single pdf) with registration number 7-015/17-H in the subject line until March, 16, 2017 to Jun.-Prof. Dr. Tony Gutschner, E-mail: tony.gutschner@nulluk-halle.de

More information can be found on the website:
http://www.medizin.uni-halle.de/index.php?id=7456

The Martin-Luther-University Halle-Wittenberg is an equal opportunity employer. Disabled candidates with equal qualifications will be given preference. Women are strongly encouraged to submit an application.
The announcement takes place pending on fund availability and any possible budget restriction. Application expenses cannot be reimbursed by the Martin-Luther-University.

RNA biology of circadian clocks molecular mechanisms, physiological functions, implications for disease

Our group is seeking to recruit two new colleagues, a PhD student and a Postdoc, to investigate how regulatory mechanisms occurring at the RNA level impact on rhythmic gene expression, physiology and behaviour regulated by the circadian clock. We recently started to cover this broad topic with work on miRNAs (Du et al., eLife 2014) and on translation (Janich et al., Genome Research 2015; Castelo-Szekely et al., bioRxiv 060368) using mice and cultured cells as our experimental models.

The proposed projects will build on findings that we made in our work on rhythmic protein translation. They will entail a multidisciplinary mix of molecular biological, cellular and mouse genetics/behavioural approaches, in combination with state-of-the-art genomics (ribosome profiling) and bioinformatics techniques. Briefly, one of the projects will address how circadian rhythms are regulated by “upstream open reading frames” (uORFs), an emerging high-interest class of regulatory elements. The other project aims to unravel molecular mechanisms and physiological functions of rhythmic translation in the liver. Of note, we are also open to new research ideas that collaborators wish to bring into the lab.

The Gatfield lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig). It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area.
Through the Gatfield lab’s membership in the National Centre of Competence in Research RNA & Disease (http://www.nccr-rna-and-disease.ch), lab members benefit from networking and training opportunities throughout Switzerland, with access to other leading RNA research labs in Zürich, Bern, Basel and Geneva.
Full funding for the positions is available (max. 5 years), although application to personal, international fellowship programs will be encouraged. Envisaged start date: negotiable (earliest April 1st, 2017).

To apply, please send – as a single PDF file – a motivation letter describing why you are interested in joining our group, a CV (potential PhD students should include their Bachelors/Masters grades; post-docs should list their scientific publications), and contact details for 2 or more referees to david.gatfield@nullunil.ch

Lab homepage: http://www.unil.ch/cig/gatfield

University of Colorado School of Medicine – RNA Bioscience Initiative Summer Internship Program

Hands-on, mentored research opportunities in RNA Biology, Chemistry, Biochemistry, Genomics, and Bioinformatics

The RNA Bioscience Initiative (RBI) at the University of Colorado School of Medicine in the Denver metro area offers a summer research internship program in the areas of RNA Biology, Chemistry, Biochemistry, Genomics, and Bioinformatics.  Interns are matched with one of the faculty from the biomedical research departments on the campus, including researchers studying the molecular bases of cancer, developmental biology, autoimmunity, and infectious disease.  Undergraduate students with a strong interest in RNA research are encouraged to apply for this program.  The program is especially intended for undergrads wishing to gain more research experience in advance of applying to graduate school.  Applicants may designate three preferred potential mentors from RBI faculty or they may contact an RBI faculty member ahead of applying and pre-arrange an internship (please note this on the application).

The RNA Bioscience Initiative was started with a $20 million dollar award from the University of Colorado Anschutz Medical Campus.  The mission of the RBI is to create and expand a vibrant center of discovery and innovation in RNA research, diagnostics and therapy. Our goal is to provide a fluid pipeline from basic to clinical RNA research at the Anschutz Medical Campus.

Important Information:

  • 10-week program. June 1-August 11. $4000 stipend.
  • Opportunities to work hands-on in the lab of a research mentor on one of a broad range of cutting-edge RNA research projects.
  • An orientation day to the RNA Bioscience Initiative and Internship Program.
  • Weekly RNA-related small group lunch seminars from core RBI faculty.
  • A short oral presentation at the end of the project to develop science speaking skills.
  • Spend the summer in Denver, CO, which offers a great balance of urban and outdoor activities.

Apply at: rnabio.co/summer-interns

RNA structural Biology

The Protein-Nucleic Acid Interaction Section (PNAI), the Structural Biophysics Laboratory (SBL) of National Cancer Institute (NCI), National Institutes of Health (NIH), seeks a postdoctoral candidate with training/expertise in structural biology/biochemistry or/and macromolecular X-ray crystallography. The candidate should have expertise and research experience in the structural biology or/and biochemistry of RNA or proteins, which includes: 1) Sample preparation and crystallization techniques, 2) Theory and practice of X-ray diffraction methods, and processing crystallographic data, and 3) Structure determination, analysis, and refinement. Applicants are expected to have a strong background in physical chemistry and/or physics with excellent analytical and computational skills. The ideal candidates should have a number of years of research experience in the relevant fields with strong problem-solving skills, be willing to work cooperatively with teams of structural biologists and biologists, and be self-motivated to conduct research independently.

The PNAI section operates a high-end in-house diffractometer and small angle X-ray scattering core facility, with regular access to synchrotron beamlines at the Argonne National Laboratory. We are well equipped with two crystallization robots, as well as a Rock Imager for efficient crystal detection, which includes UV-absorption, UV-fluorescence, and SONICC imaging. In addition, the SBL Biophysics Core Facility contains an array of instruments for biophysical characterization of solution and crystalline samples.

The PNAI section is currently at the forefront of developing, exciting, state-of-the-art technologies and methods for biomacromolecule structure determination, including application of X-ray free electron laser (XFEL) for RNA structural biology. We also apply various other biophysical tools to study the structure and dynamics of challenging RNA molecules of great biological significance. We are looking for an enthusiastic, talented and dedicated scientist to join our exciting research team. Salary is commensurate with experience and achievements. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS, NIH, and NCI are Equal Opportunity Employers.

Email: wangyunx@nullmail.nih.gov

Applications Scientist to work on gene expression regulation at the ribosomal level

Immagina Biotechnology s.r.l. is looking for a highly motivated individual to join the Team as an Applications Scientist to work on gene expression regulation at the ribosomal level. We are seeking for a MSc/PhD who is energetic, enthusiastic, and enjoys collaborative and applied science.
This exciting and challenging role involves developing and delivering novel applications and protocols. Duties for this position include interdisciplinary scientific interactions with the University of Trento, The Bruno Kessler Foundation and the Institute of Biophysics of the National Research Council.

Responsibilities and Skills
The candidate will be engaged in an exciting area of a rapidly growing company. The successful candidate will have experience with:
• Molecular biology experiments (genetics, epigenetics, proteomics).
• Cloning, protein purification, gene editing, immunoprecipitation, RNA-seq, Pol-seq, Ribo-Seq.
• Sucrose gradient purification
• Cell culture techniques: mouse and human cell maintenance and differentiation
• Preparation of biological and chemical reagents and cell lines, including transduction with viral vectors, transfection, electroporation, etc
• Ability to work in a high-pace and dynamic scientific environment
• Excellent organizational and analytical skills
• Excellent inter-personal and communication skills / ability to build good working relations
• Proven ability to present and publish research data
• Proficiency in spoken and written English
Important but not essential are:
Analytical chemistry testing, including: HPLC, UPLC, UV, CE

Who we are
Immagina BioTechnology s.r.l is a start-up hosted in the Laboratory for Biomolecular Sequence and Structure Analysis for Health (LaBSSAH). Immagina has developed RiboLace™, an antibody-free technology for the characterization of native and active ribosomes.

Job ID No: 003

Contact: Dr. Massimiliano Clamer. @: mclamer@nullimmaginabiotech.com

The Deaconescu Lab at Brown University

The Deaconescu Lab at Brown University is seeking a motivated and energetic and postdoctoral. The laboratory’s interest is the interplay between DNA repair and other cellular processes including transcription and chromatin remodeling, and is focused on elucidating the function and mechanochemistry of nucleic acid-based motors using a combination of biochemical, biophysical and structural techniques. (e.g. X-Ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Kutter et al. JMB (2016), Deaconescu et al., PNAS (2012), Szyk et al, Cell (2014), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013). A successful candidate should have the following qualifications: a Ph.D. in the field of Molecular Biology, Cell Biology, Biochemistry or related field; an established track-record of publications in peer-reviewed journals; solid experience in the biochemistry of nucleic acind-binding proteins, their purification from E.coli/yeast expression systems as well as their characterization using functional studies such as by isothermal titration calorimetry and fluorescence. Prior knowledge of crystallography is desired. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply. Salary and starting date are negotiable.

Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@nullbrown.edu. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header