Employment Opportunities

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Postdoctoral Position Available, University of California, Davis

A postdoctoral position is available at the University of California, Davis to work on an interdisciplinary research grant spanning the Montpetit, Fraser, and Shah laboratories focused on positive-strand RNA viruses, including Zika, Dengue, and Hepatitis C. Research will involve investigating aspects of viral RNA transport, viral protein translation, and viral RNA interactions with host cell factors that are required for infection. Candidates with a strong research track record in virology, RNA biology, single molecule imaging, and/or molecular biology are encouraged to apply. Positions will remain open until filled with start dates available September 2019. To enquire, please email a cover letter and CV to benmontpetit@nullucdavis.edu.

For more information about being a Postdoctoral scholar at UC Davis visit https://grad.ucdavis.edu/postdoctoral.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/dod4000376/NondiscrimAffirmAct.

Post Doctoral Fellow Position Available, RNA Innovation

RNA Innovation is a unique partnership between the University of Lethbridge, Université de Sherbrooke, and industry collaborators, providing trainees with an exceptional learning experience during their graduate studies program. This NSERC Collaborative Research and Training Experience (CREATE) program aims to produce highly qualified personnel with skills in advanced RNA research, scientific leadership, and industry experience.

The major advantage of RNA Innovation will be access to industry collaborations. Each trainee cohort will work together with an industry partner to solve an R & D problem as part of the deepYellow Challenge. Together the trainees will learn to apply their research training, work as a team, and develop a final product.

Trainees will also receive funding for on-site industry training and project development through the Twinning Program. All participants will be matched with a specific internship, receive mentorship and a personalized networking experience.

In addition to academic and research skills, trainees will develop skills in management, leadership, communication, teaching, integrity and ethics through complementary workshops and courses.

Participation in the deepYellow challenge will encourage development of project management and entrepreneurial skills. Additional workshops providing some theoretical foundation in management will supplement the trainee’s learning experience.

All trainees will be required to participate in a new graduate level Scientific Leadership course. Modules will include professional communication, integrity & ethics, and leadership with respect to gender and minority representation.

Graduates of the RNA Innovation program will be uniquely trained, “job-ready” with knowledge of applied and basic research, and possess a diverse set of leadership skills. This multidisciplinary background will make them ideally suited to careers in a multitude of biotechnology fields.

RNA Innovation offers very competitive funding for trainees.

  • Undergraduate students receive up to $4,000* for summer placements
  • MSc students receive up to $10,000/year* for two years
  • PhD students receive up to $10,000/year* for three years
  • Postdoctoral fellows receive $30,000/year* for two years

*RNA Innovation funding can be combined with other funding resources.

RNA Innovation is the ideal program for students that desire real-world, hands-on experience during their research program. Funding is available for graduate students (MSc and PhD), as well as undergraduate students and post-doctoral fellows.

Applications for the RNA Innovation program will open July 1 and close September 10, 2019 at 11:59 pm MST. Students currently enrolled or accepted into graduate studies are encouraged to apply. Students accepted into RNA Innovation can commence their studies in January 2020.

Interested applicants should have a minimum GPA of 3.5 in their last two years of undergraduate studies, although applicants with a lower GPA are still encouraged to apply if they have sufficient research and/or industry experience.

Please submit:

  • Application Form (available at www.RNAInnovation.ca)
  • Two letters of reference from academic or industry referees
  • Transcripts (undergraduate, MSc, PhD, as applicable)

Application documents can be sent to admin@nullRNAInnovation.ca. This opportunity is open to Canadian and international students. We encourage international students interested in studying at the University of Lethbridge to apply to graduate studies for the February 1st deadline to avoid visa issues and a delay to their start in the program. Women and visible minorities are strongly encouraged to apply.

Postdoctoral trainees must have completed their doctoral degree within the last five years to be eligible to participate in a CREATE initiative. Parental leave taken for child bearing or rearing is not counted as part of the five-year period.

In order to participate in the RNA Innovation program, students must also be enrolled at one of the participating institutions. Application to RNA Innovation is meant for the allocation of fellowships and participation in the program. While acceptance into RNA Innovation does not guarantee acceptance at your institution, being accepted into the program with an awarded fellowship could positively impact your academic application.

Lab Manager Position, Research Group of Dr Kinga Kamieniarz-Gdula, AMU, Poznan, Poland

Adam Mickiewicz University, Poznan, Poland
Institute of Molecular Biology and Biotechnology, Faculty of Biology
Center of Advanced Technologies

Laboratory manager/ research assistant

We are seeking a highly motivated Lab Manager to join the new group of Dr Kinga Kamieniarz-Gdula at Adam Mickiewicz University in Poznan. You will be offered the opportunity to participate in cutting edge research aiming at understanding the role of transcription termination in gene expression regulation as well as support for your professional development. Dr Kamieniarz-Gdula carried out research at the Max Plank Institute in Freiburg and Oxford University for the past 13 years and in her group will implement the research practices established in those world-leading institutes. As the lab manager you will be responsible for the set up and smooth running of the laboratory, will work with a team of researchers and carry out experiments. The position is funded by the NAWA Polish Returns programme, full-time, for four years (initial contract will be signed for one year and then extended by three years).  Salary: 58000 PLN p.a.

Tasks:

-assistance with grant administration: budgeting, communication with university bodies and grant agencies

-managing supplies: making orders, ensuring laboratory is well stocked in advance of planned experiments; if necessary, preparing and maintaining stock solutions and buffers for the laboratory

-help with the set up of the laboratory and equipment purchase

-conducting molecular biology and cell culture experiments to assist lab needs: trouble-shooting, and modification of existing scientific protocols, recording and analyzing experimental data, drawing preliminary conclusions, keeping detailed records of experimental work

-assisting and training other lab members on research techniques and management for their independent projects

-writing and revision of scientific protocols

-ensuring that all laboratory members are compliant with required regulations for health and safety

Qualifications:

Bachelor’s, Master’s or PhD degree in biology or related life science field, laboratory experience. Background in basic molecular biology techniques and tissue culture. Enthusiasm toward new techniques, strong communication skills, ability to make independent decisions. Fluency in English and Polish.

Interested candidates should send their CV, the contacts of three referees, and a cover letter to kinga.kamieniarz-gdula@nullpath.ox.ac.uk

Deadline: 11th August, early application encouraged.

Earliest start date: 30th September 2019.

Informal inquiries and questions welcome.

Institute webpage:

http://ibmib.amu.edu.pl/en/main-page/

Recent publications:

https://www.ncbi.nlm.nih.gov/pubmed/31213387

https://www.ncbi.nlm.nih.gov/pubmed/30819644

 

Two Postdoctoral Positions on RNA Regulations in Cancer at Institute Curie (Paris, France).

Two postdoctoral positions on RNA regulations in cancer at Institute Curie (Paris, France).

Project:

We are seeking two highly motivated postdocs to join our lab studying RNA regulations in cancer, specifically for the following two projects:

(i) translation regulation in drug-resistant cancer cells; and

(ii) regulation of intronic polyadenylation in response/ resistance to genotoxic drugs.

These projects are based on our previous work, mainly: Cerezo et al., Nat Med 2018; Boussemart et al., Nature 2014; Dutertre et al., Nat Comm 2014, TIBS 2014, J Mol Biol 2017.

Lab:

The host team “RNA biology, signaling and cancer” is led by Stéphan VAGNER, includes 5 researchers, 4 engineers, 2 postdocs and 3 PhD students, and is part of the Department “Genotoxic stress and cancer” (UMR-3348 CNRS) at Institut Curie.

Website: https://science.institut-curie.org/research/biology-chemistry-of-radiations-cell-signaling-and-cancer-axis/umr3348-genotoxic-stress-and-cancer/team-vagner/

Institute:

Institut Curie is an internationally renowned foundation devoted to cancer care and clinical, transfer and basic research (from physics to biology). The institute has various technology platforms (including high-throughput sequencing, proteomics, bioinformatics, CRISPR, imaging, cell screening, in vivo and preclinical investigation, chemical library, tumor collections, etc.). With more than 80 nationalities, English is the commonly used language in the institute and in the lab.

Required skills:

Candidates must hold a PhD and be the first author of at least one accepted publication. Skills in molecular biology are required; expertise in RNA biology / post-transcriptional gene regulation is strongly desired.

Salary is available for 1 year but successful candidates will be expected to apply for their own postdoctoral fellowship.

Project supervisors: Stéphan VAGNER and Martin DUTERTRE

Application: Please send your CV, motivation letter and 2 letters of support to stephan.vagner@nullcurie.fr

PhD Student in RNA Structure and Transcriptome Bioinformatics

We are looking for a PhD student in RNA structure and transcriptome Bioinformatics

The Bioinformatics research group of  Prof. Irmtraud Meyer at the BIMSB and MDC in Berlin is seeking to recruit a PhD student in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/phd-student-bioinformatics and https://www.mdc-berlin.de/meyer

N.B. The application deadline is Friday, 16. August 2019.

Post-doctoral Fellow in RNA Structure and Transcriptome Bioinformatics

We are looking for a post-doctoral fellow in RNA structure and transcriptome Bioinformatics

The Bioinformatics research group of  Prof. Irmtraud Meyer at the BIMSB and MDC in Berlin is seeking to recruit a post-doctoral fellow in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/post-doc-bioinformatics and https://www.mdc-berlin.de/meyer

N.B. The application deadline is Friday, 16. August 2019.

Rfam Biocurator at EMBL-EBI, Cambridge, UK

Rfam is the database of RNA families, without analogs anywhere in the world. Continuously developed since 2002, it has grown to include >3,000 families and is used by many scientists for a wide range of applications, such as the annotation of new genomes and developing RNA structure prediction algorithms. Rfam is a key resource for RNA Biology that serves tens of thousands of users every year and is highly cited in the scientific literature.

The Rfam Biocurator will be responsible for creating new RNA families and updating the existing ones based on the scientific literature and the community input. The post-holder’s main task will be to update consensus secondary structures in Rfam multiple sequence alignments using the experimentally determined RNA 3D structures.

The post-holder will have a MSc (or higher) degree in Biology or a related subject and demonstrable experience working with RNA as well as undestanding of RNA 2D and 3D structure. See http://bit.ly/rfam-biocurator for further details.

The position is full-time for 1.5 years (or 3 years if part-time) and is based at EMBL-EBI near Cambridge, UK. Start date: October 1st, 2019 (can be negotiated). Deadline: August 9th, 2019.

Apply now: http://bit.ly/rfam-biocurator

Postdoctoral Position Available, RNA Mediated Gene Regulation, Frederick, MD

A postdoctoral position is available in the RNA Mediated Gene Regulation Section (RNA MGRS), RNA Biology Laboratory (RBL), Center for Cancer Research (CCR) – Frederick, MD, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS).  The candidate will perform basic research on small RNA functions.

The goal of our program is to uncover the mechanisms by which the function of miRNA is regulated in health and disease and to apply those in developing effective treatments for cancer. Using genetic functional studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory focuses on elucidating mechanisms of miRNA biogenesis and the roles of post-maturation modifications.

In particular, we are interested in studying the biogenesis and function of miRNA isoforms (isomiRs).  Multiple lines of evidence suggest that isomiRs possess unique biological roles [1]. We have developed a novel algorithm to accurately detect and analyze miRNA isomiRs based on next-generation-sequencing (NGS) data [2]. We demonstrated that miR-9-alt, an 5′ isomiR resulted from alternative Drosha cleavage of pri-miR-9-1, expands miR-9 target repertoires and functions as a tumor suppressor in low grade gliomas (LGG) [3]. We also identified a set of non-canonical targets in human cells that are exclusively regulated by uridylated isomiRs and therefore revealed a novel function of 3′ isomiRs [4]. Combining classical biochemistry techniques with high-throughput sequencing, the successful candidate will continue investigating the underlying mechanisms of isomiR biogenesis and function.

Recent publications from our group:

  1. IsomiRs: Expanding the miRNA repression toolbox beyond the seed. Biochim Biophys Acta Gene Regul Mech. 2019 Apr 4
  2. QuagmiR: a cloud-based application for isomiR big data analytics. Bioinformatics. 2019 May
  3. Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires. Cell Rep. 2019 Jan 8;26(2):447-459.e4.
  4. 3′ Uridylation Confers miRNAs with Non-canonical Target Repertoires. Mol Cell. 2019 June

Interested candidates must have a Ph.D. and/or an M.D. and have less than 2 years of postdoctoral experience. Ph.D. students who just received or expect to receive their degree in the coming summer, are particularly encouraged to apply. Applicants must have a strong background in molecular biology and biochemistry. Experience with RNA research and/or deep sequencing data analysis is a strong plus.  Salary is commensurate with research experience and accomplishments.

E-mail shuo.gu@nullnih.gov
URL https://ccr.cancer.gov/RNA-Biology-Laboratory/shuo-gu

Postdoctoral Position Available, RNA Mediated Gene Regulation Section, Frederick, MD, National Cancer Institute

A postdoctoral position is available in the RNA Mediated Gene Regulation Section (RNA MGRS), RNA Biology Laboratory (RBL), Center for Cancer Research (CCR) – Frederick, MD, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS).  The candidate will perform basic research on small RNA functions.

The goal of our program is to uncover the mechanisms by which the function of miRNA is regulated in health and disease and to apply those in developing effective treatments for cancer. Using genetic functional studies in living cells and animals, together with biochemical and next-generation sequencing (NGS) approaches, our laboratory focuses on elucidating mechanisms of miRNA biogenesis and the roles of post-maturation modifications.

In particular, we are interested in studying the biogenesis and function of miRNA isoforms (isomiRs).  Multiple lines of evidence suggest that isomiRs possess unique biological roles [1]. We have developed a novel algorithm to accurately detect and analyze miRNA isomiRs based on next-generation-sequencing (NGS) data [2]. We demonstrated that miR-9-alt, an 5′ isomiR resulted from alternative Drosha cleavage of pri-miR-9-1, expands miR-9 target repertoires and functions as a tumor suppressor in low grade gliomas (LGG) [3]. We also identified a set of non-canonical targets in human cells that are exclusively regulated by uridylated isomiRs and therefore revealed a novel function of 3′ isomiRs [4]. Combining classical biochemistry techniques with high-throughput sequencing, the successful candidate will continue investigating the underlying mechanisms of isomiR biogenesis and function.

Recent publications from our group:

  1. IsomiRs: Expanding the miRNA repression toolbox beyond the seed. Biochim Biophys Acta Gene Regul Mech. 2019 Apr 4
  2. QuagmiR: a cloud-based application for isomiR big data analytics. Bioinformatics. 2019 May
  3. Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires. Cell Rep. 2019 Jan 8;26(2):447-459.e4.
  4. 3′ Uridylation Confers miRNAs with Non-canonical Target Repertoires. Mol Cell. 2019 June

Interested candidates must have a Ph.D. and/or an M.D. and have less than 2 years of postdoctoral experience. Ph.D. students who just received or expect to receive their degree in the coming summer, are particularly encouraged to apply. Applicants must have a strong background in molecular biology and biochemistry. Experience with RNA research and/or deep sequencing data analysis is a strong plus.  Salary is commensurate with research experience and accomplishments.

E-mail shuo.gu@nullnih.gov

URL https://ccr.cancer.gov/RNA-Biology-Laboratory/shuo-gu

Postdoctoral Positions for RNA Cell Biologists

NIH-funded postdoctoral positions available immediately at the Albert Einstein College of Medicine (Einstein) in New York to study the cellular impact of the bone marrow failure syndrome dyskeratosis congenita (DC) on ribonucleoproteins and to investigate their biogenesis and localization within the cell nucleus. The ideal candidate will have a strong background in molecular cell biology and biochemistry with specific training in tissue culture, microscopy, and RNAseq.

Einstein caters to postdoctoral researchers through its Belfer Institute for Advanced Biomedical Studies. Postdoctoral housing is available. For more details check out the webpage of the Belfer Institute:

http://www.einstein.yu.edu/research/belfer-institute/

Interested candidates should send their CV, the contacts of three references, and a cover letter with past achievements and current and future research interests to tom.meier@nulleinstein.yu.edu

http://www.einstein.yu.edu/faculty/5249/u–thomas-meier/

PhD Student/Postdoctoral Fellow Position, Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University

The Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University, Giessen, German, invites applications for the position as a PhD. student / predoctoral fellow.

The position is available from September 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).

We offer:

Participation in state-of-the-art research projects

Collaboration in an enthusiastic research team

Opportunities to develop strong research skills and a solid academic profile

Opportunity to obtain a doctoral degree

Key Responsibilities:

Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.

For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)

Required Qualifications:

Completed academic studies in biology, biochemistry, human biology or a similar subject (Master’s degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology and/or structural biology is advantageous.

The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.

Please send your application per Email as a single pdf file with all relevant documentation per Email to katja.straesser@nullchemie.bio.uni-giessen.de until the 19th of July 2019. Applications from disabled people of equal aptitude will be given preference.

Postdoctoral Fellow Position Available, Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University

The Research Group of Prof. Dr. Katja Sträßer, Justus Liebig University, Giessen, German, invites applications for the position as a

Postdoctoral Fellow.

The position is available from September 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).

We offer:

  • Participation in state-of-the-art research projects
  • Collaboration in an enthusiastic research team
  • Opportunities to develop strong research skills and a solid academic profile

Key Responsibilities:

Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.

For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)

Required Qualifications:

Completed Ph.D. thesis in biology, biochemistry, human biology or a similar subject (Ph.D. degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology and/or structural biology is advantageous.

The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.

Please send your application per Email as a single pdf file with all relevant documentation to per Email to katja.straesser@nullchemie.bio.uni-giessen.de until the 19th of July 2019. Applications from disabled people of equal aptitude will be given preference.

Faculty Position Available, W3 Professorship of Molecular Immunology

The Faculty of Biology and Chemistry invites applications for the position of a W3 Professorship of Molecular Immunology as of October 1st, 2020.

Reference is made to § 61 Para. 7 Hessian Higher Education Act (HHG) and to conditions of employment based on § 62 HHG. Proficient knowledge of German is expected.

Requirements:

Candidates are expected to have a strong profile in molecular immunology. Successful, third-party funded research should primarily cover the topics of gene regulation, signal transduction pathways, molecular infection research and/or molecular biomedicine. The complementation of existing methods and expertise (e.g. Omics technologies, single cell analyses, genome editing, protein and/or nucleic acid modification) and a focus on innovative and immunologically relevant animal or cell culture systems is also desirable. A high level of competence in these research fields should be reflected by international, high-profile publications.

Responsibilities:

Your responsibilities will focus on the above-mentioned subjects. Teaching duties will cover all bachelor and master courses (partly in English). Active participation in establishing new teaching courses is required. The candidate will be expected to cooperate with related bioscience disciplines of the Justus Liebig University Giessen (JLU) and neighbouring universities, to have experience in the acquisition of extra mural funding, to be integrated in high-profile national as well as international research networks and to participate in graduate education. Particular importance is attached to a commitment to promote the faculty’s internationalization strategy as well as to strengthen existing and to establish future research alliances.

The JLU aims to employ more women in academic research. We therefore particularly encourage female candidates to apply. JLU also pursues the goal at faculty leadership level of increased competence in dealing with gender and family-related issues. JLU is regarded as a family-friendly university. Applicants with children are very welcome. Applications from disabled people of equal aptitude will be given preference.

Please send your letter of application (no e-mails, please) with a CV and a documentation of your qualifications and teaching competence to: The President of Justus Liebig University Giessen, Erwin-Stein-Gebaeude, Goethestrasse 58, 35390 Giessen, Germany, quoting reference number 8-10/19. Applications must be received by July 5th, 2019 at the latest.

Candidates are strongly recommended to refer to our webpage on application procedures at http://www.uni-giessen.de/stellenmarkt/merkblatt.pdf. Please only submit copies of your application documents without document files or folders, as they cannot be returned after the application procedure has been completed

Postdoctoral Research Position Available, Laboratory of Dixie J. Goss, Hunter College, City University of New York

A postdoctoral research position is available in the laboratory of Dixie J. Goss, Hunter College, City University of New York.  Our NIH- and NSF-funded research uses state-of-the-art biophysical, biochemical and molecular biology approaches to characterize molecular mechanisms of (1) non-canonical modes of translation initiation in mammals, (2) physiologically important specific cases of translation and (3) novel mechanisms of translation in plant viruses, especially as models for mammalian viruses.

Required qualifications include a Ph.D. in Biophysics/Biochemistry/Molecular Biology and practical experience in RNA and/or protein biochemistry, including expression and purification of native/recombinant proteins and functional analyses of protein-RNA complexes.  Experience in investigating aspects of eukaryotic translation and structural probing of RNA are desirable.  We are actively involved in collaborations with leading cryoEM laboratories, and experience in structural biology would be helpful.  Candidates should be highly motivated, able to work independently and show excellent critical thinking and communication skills.

A salary of $45-60K is available depending on experience, plus benefits including health insurance.  Review of applicants will begin immediately until the position is filled.  To apply, please send a cover letter discussing your interest in a position and mentioning expected availability date, your curriculum vitae (with summary of research experience, including techniques and methods used) and contact information for three references.

To apply, please go to rfcuny.org. and click on EMPLOYEES and “Search & Apply for a Job”.

The Research Foundation of the City University of New York is an Affirmative Action/Equal Opportunity/Americans with Disabilities Act/Protected Veterans Status/ E-Verify Employer

 

 

University of Michigan Medical School Postdoc Recruitment Event

The University of Michigan Medical School will host its next postdoctoral recruitment event October 10-11, 2019. We kindly ask that you explore Postdoc Preview (https://medicine.umich.edu/medschool/education/postdoctoral-fellows/prospective-postdocs/postdoc-preview) and share this information with trainees, colleagues and departments from around the U.S. that are especially strong in your field.

Postdoc Preview introduces upper-level graduate students in the biomedical sciences to the excellent research and training opportunities here at Michigan. During a fully-funded visit, recruits interview with two or more prospective mentors, learn about our NIH-funded training programs, and network with current postdocs (tentative schedule here https://medicine.umich.edu/medschool/education/postdoctoral-fellows/prospective-postdocs/postdoc-preview#tentative-schedule). Applicants are selected from a national pool of highly qualified individuals who expect to complete their thesis research over the course of the next year and be U.S. citizens or permanent residents or be currently enrolled in a U.S. graduate institution. Our office sponsors and manages the logistics of their visit.

Applications for the event can be found at https://postdocpreview.smapply.io/. Deadline: August 5, 2019. Please contact the main office (postdocoffice@nullmed.umich.edu) with questions.

Faculty Fellow in RNA Biology or RNA Chemistry, Depart of Cardiovascular Sciences, Houston Methodist Research Institute (HMRI)

The Department of Cardiovascular Sciences at the Houston Methodist Research Institute (HMRI) welcomes applications for Faculty Fellow in RNA biology or RNA chemistry within the Center for Cardiovascular Regeneration.  The Faculty Fellow is a mentored transitional position between the postdoctoral years and a faculty position.   The position offers increased compensation compared to traditional postdoc stipends, and includes a research budget to implement your independent research project.  Candidates are typically outstanding postdoctoral fellows in their second or third year of training. Optimal candidates will have a track record of innovative research in RNA biology or chemistry; are capable of attracting external funding, e.g. from NIH; are highly collaborative; and are excited about innovation, invention, translation and making transformative contributions to human health.  Candidates will be considered for promotion in 2 -3 years to an independent faculty scientist position after demonstrating the ability to establish a robust program in RNA sciences and collaborate with the RNACore team to translate their research innovations into RNA therapeutics in regenerative medicine .  In addition, candidates are expected to show promise in establishing a vigorous externally funded research program and contribute to the intellectual vitality of the HMRI scientific community. Formal teaching is not required, although there will be opportunities for those who wish to do so.   Faculty will also have the opportunity to affiliate with the Cornell University Weill Cornell Medical College and/or Texas A&M University, and to work with students from these universities.

We are a highly translational scientific Center, with faculty that are making fundamental insights and translating these toward transformative RNA therapeutics.  Our RNACore is funded by NIH and CPRIT for performing pre-clinical studies in RNA therapeutics; for generating innovative research grade constructs for the scientific community; and for producing RNA Therapeutics in our cGMP manufacturing facility for clinical trials.  Houston Methodist Hospital Research Institute is located in the heart of the Texas Medical Center, which is the largest medical center in the world. The institute is surrounded by an unparalleled biomedical research environment, which consists of the Houston Methodist Hospital, Rice University, Baylor College of Medicine, UT MD Anderson Cancer Center, and more than 50 additional top institutes and hospitals. Texas is the #1 state to make a living, as recently ranked by Forbes. Houston is the largest city in Texas and the 4th largest in US, with an attractive living cost and a vibrant culture. It was recently named the most prosperous US city by The Business Journal. Salary and benefits can be highly competitive and commensurate with experience. Houston Methodist Hospital is frequently ranked by the FORTUNE Magazine in the list of the best employers in USA.

To apply for the position, submit an application and send your CV, cover letter, plus a one page description of your proposed independent research project, and contact information for 3 references, to the Medical Director of the RNA Therapeutics Program, John P. Cooke MD PhD at jpcooke@nullhoustonmethodist.org.

Post-Doc Position in Edinburgh, UK – Brook and Gray labs.

An 18-month post-doctoral position is available immediately at the University of Edinburgh to establish whether mammalian RNA-binding proteins (approx. 1500 in human) can be regulated via “histone-code” like switches, where specific lysine modification regulates competing protein-protein interactions. Such a switch would provide unique insight into the basis of the multi-functionality of many RNA-binding proteins. This BBSRC funded work builds upon work by three collaborating Edinburgh labs (Matt Brook’s newly-formed lab [Twitter: @BrookLab3] and the established labs of Nicola Gray and Atlanta Cook) and involves collaborating labs in Liverpool, Dundee and Birmingham. The post-holder will determine the modification-dependent effects on post-transcriptional gene regulation (mRNA translation and stability), primarily through mammalian cell line-based and/or cell-free reporter assays, quantify modification stoichiometry under specific cellular conditions and investigate the effector enzymes involved. They will work closely with another post-doctoral scientist who focuses on the biophysical and structural consequences of these modifications on protein-protein interactions. Applicants with a proven track record in studying RNA-binding protein-mediated regulation of mRNA translation and stability, and/or the interrogation of lysine acetylation/methylation pathways are particularly welcomed. The post is particularly suitable for candidates with relevant post-doctoral experience but those with strong, relevant, publication records from their PhD would also be considered. The post involves short periods of work at other locations (e.g. Liverpool) leveraging specialised collaborative expertise/training (e.g. quantitative mass spectrometry).

 

For full details of the vacancy and to apply, please visit: https://edin.ac/2QvDLlv

Postdoctoral fellowship position available at the University of Oregon

The Postdoctoral Fellow will carry out studies of eukaryotic epigenetic regulation using mostly biochemical, genetic, and cell biological techniques in yeast and mammalian cells. The purpose is to make high-impact discoveries in the field of epigenetics and RNA. The work will involve study of prion proteins (non-toxic) that regulate RNA. See garcialab.org for more information. Experience culturing yeast and mammalian cells, and doing molecular biology, high-throughput sequencing, and microscopy are highly desirable but not essential. We are particularly interested in candidates with RNA/protein biochemistry experience.

Our lab is part of the Institute of Molecular Biology, a research institute that has 18 labs and approximately 150 employees. We have an administrative structure, which includes accounting, purchasing, personnel, building management, and three service centers, including genomics/cell characterization, and imaging.

The University of Oregon is located in Eugene, nestled in the Willamette Valley, with outstanding outdoor opportunities in every direction. Housing costs are sensible. Plus great food+beer, no traffic, an airport, and a friendly community.

This position is available immediately, for at least one year with annual renewals based on research progress and contingent with continued funding. Please email David at dmgarcia@nulluoregon.edu. Include your CV (including names+contact info of three references), and a brief statement about your research interests (1/2 to 1 page).

Analytical Development Scientist Position Available, Ulragenyx Pharmaceutical Inc.

TITLE: Scientist, Analytical Development (mRNA-LNP)

COMPANY: Ultragenyx Pharmaceutical Inc.

LOCATION: South San Francisco, CA 94080

DEPARTMENT: CMC AD/QC

WORK TYPE: FULL-TIME

Why Join Us?

To be a hero for our rare disease patients

Ultragenyx is a biopharmaceutical company committed to bringing to patients novel products for the treatment of rare and ultra-rare diseases, with a focus on serious, debilitating genetic diseases. Founded in 2010, the company has rapidly built a diverse portfolio of small molecule, monoclonal antibody, mRNA and gene therapy candidates with the potential to address diseases for which the unmet medical need is high, the biology for treatment is clear, and for which there are no approved therapies.

Developing new treatments for rare genetic diseases is challenging work. It takes courage, talent, and dedication to look past the easy answers and uncover new solutions that can make a meaningful impact. At Ultragenyx we push each other to perform at our very best, because we never lose sight of our mission – to make a difference in our patients’ lives.

Come join our team during this exciting time of growth and opportunities!

Position Summary

ultrainnovative – Tackle rare and dynamic challenges

Ultragenyx is looking for an experienced Analytical Development Scientist with the passion and creativity for method development and characterization of great medicines for rare and ultra-rare diseases.  The Analytical Scientist will be part of the CMC AD/QC group under the Quality Organization.  This position will be responsible for developing novel mRNA lipid nanoparticle (LNP) drug substance and drug product analytical methods to support early stage product development, characterization, and testing within the Process Development Lab at the Ultragenyx South San Francisco site. This position will collaborate closely with cross-functional departments to achieve corporate goals and objectives.

The successful candidate should have a strong experience working with nucleic acid therapeutic in LNP formulation.  Past industry or academic experience in either mRNA biology or LNP physicochemical characterization is required.  The ideal candidate should be a self-starter with the ability to work in the lab under limited supervision.  This position will be instrumental in growing the company’s therapeutic portfolio, from early-discovery development stage to commercial launch and be a critical part of creating an innovative team for the development of the company’s next generation of products.

Responsibilities including, but not limited to:

  • Design and develop novel biochemical or biophysical methods to analyze and characterize the structure and function of mRNA-LNP
  • Elucidate the structure and function of mRNA drug substance, such as higher ordered RNA structure and conformation
  • Design and develop LNP encapsulation method to analyze and characterize the LNP integrity, stability, and payload encapsulation efficiency
  • Design and develop novel LNP disruption and extraction methods to allow effective analysis of the encapsulated nucleic acids payload
  • Utilize Sanger sequencing or next generation sequencing (NGS) based platform methods to analyze mRNA drug substance and characterize product variance
  • Design and develop sensitive methods to analyze double stranded RNA (dsRNA) impurities and residual DNA impurities in mRNA drug substance
  • Provide routine in-house analytical testing support to process development and formulation development groups
  • Perform in-house assay pre-qualification/qualification or assist contract lab to conduct assay qualification and validation following appropriate regulatory guidelines
  • Perform timely data trending and statistical analysis to evaluate assay performance
  • Author and review method SOP, technical reports, and relevant sections of regulatory IND/BLA fillings
  • Maintain and oversee AD/QC analytical method life cycle

Technical Requirements & Skills:

  • B.S. with 8+ years or M.S. with 5+ years or Ph.D. with 2+ years of industry experience in Biochemistry, Molecular Biology, Analytical Chemistry, or a related discipline
  • Candidate must have at least one of the following experience – technical expertise in either mRNA biology, including gel electrophoresis, qPCR, mRNA sequence analysis using traditional or next generation sequencing (NGS) platforms, or LNP physicochemical properties analysis, for example, particle size, charge, aggregation, and polydispersity analysis
  • Understand the common approaches of LNP disruption and payload extraction methods and could apply DoE approach to systematically optimize such conditions
  • Familiar with RiboGreen, ELISA and Slot Blot methods is highly desired
  • Previous experience with biophysical structure characterization methods, such as light scattering (DLS, MALS), Differential scanning calorimetry (DSC), and circular dichroism (CD) is a plus
  • Familiar with analytical method development, qualification, and data analysis and statistical analysis software, such as MS Excel, SoftMax, PLA, and JMP
  • Attention to detail, excellent organizational skills and the ability to work on multiple projects
  • Excellent oral and written presentation skills and proven ability to work autonomously in a matrix environment

Contact: zmeng@nullultragenyx.com

Computational Geneticist Position Available, Panorama Medicine, Philadelphia PA

Panorama Medicine is seeking an experienced computational geneticist with a strong background in human and medical genetics at their Philadelphia office.

Responsibilities:

  • Work with a team of bioinformaticians and RNA biologists to interpret the clinical significance of genetic variants in genomic data
  • Deliver testable hypotheses and insights from complex genomics data to inform target selection. Interpret drug effects on disease
  • Review and curate disease database

Qualifications:

  • All applicants MUST have a PhD in computational biology, human genetics, genomics, bioinformatics, biology, or closely related fields. Fundamental knowledge of human genetics is essential. Post-doctoral experience is preferred.
  • Previous experience with genomic data analysis is required. Familiar with public disease databases, such as OMIM, HGMD etc.
  • Good programming and scripting abilities in languages, such as R, Python. Familiar with Linux/Unix systems.
  • A strong record of publication.
  • Excellent problem-solving, teamwork, organization, and communication skills.

About Panorama Medicine:

Panorama Medicine is a VC-backed startup founded by a multidisciplinary team of world-renowned computational and experimental RNA biologists. Panorama has leveraged the founding team’s expertise to create a drug discovery platform that integrates genomics, big data, and computing to develop therapeutic interventions for RNA defects in disease. Panorama is young and fast-growing, offering rewarding career development opportunities.

Benefits:

Panorama strives to build a Google-like work environment, creative, fun, hardworking, and highly productive. We offer a strong compensation package that includes competitive salary, generous stock options, and a comprehensive health benefits package. Flexible time off, productivity perks, paid parental leave, company sponsored learning and development opportunities.

Panorama is an Equal Opportunity Employer and Prohibits Discrimination and Harassment of Any Kind.

Interested applicants should send a cover letter and a CV to hratpanoramamedicine.com.