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PhD Position in RNA Biology and Cancer

The control of the messenger RNA translation (mRNA) in human cells contributes to the accurate expression of genes in space and time. There are different factors which contribute to the regulation of translation and their deregulation can lead to the development of cancers. The decision as to whether the mRNA will be translated or repressed is based on complex parameters encompassing various factors binding to the 5 ‘and 3’UTR mRNA, the secondary structure of the mRNA and changes in the mRNA itself (methylation). In addition, some proteins that have the ability to bind mRNA in the cytoplasm block / facilitate the expression of certain genes.

The overall goal of this PhD project is to investigate the role of an mRNA-binding protein highly expressed in cancer cells on the formation of an RNA nucleoprotein filament as well as its role in translation regulation in cancer cells. In addition, we want to develop small molecule that would target the mechanism leading to the formation of the nucleoprotein filament or protein partners that interact with the nucleoprotein filament that would be proposed as putative drug candidates for cancer.

We will use different approaches (nuclear magnetic resonance spectroscopy (NMR), atomic force microscopy, molecular dynamics and cellular biology). All the facilities (NRM, AFM , microscopy, cell culture) are available in the laboratory.

Lab and Location:

The SABNP lab is an INSERM research unit with widely respected expertise in the structure/function relationships of RNA:Protein complexes involved in translation and splicing control (http://sabnp.univ-evry.fr/?lang=en). Our aim is to foster applications in medicine and biotechnology notably in cancer biology. To that end, the SABNP laboratory develops innovative and integrative approaches encompassing structural biology, bioinformatics and cell biology to enlighten the role of RNA-binding proteins related to cancer growth.

Research will take place in the Genopole campus. Genopole is france’s leading biocluster for biotechnologies and research in genomics and genetics. Genopole unites innovative high-tech life sciences companies, public and private research and higher education facilities at a single site in Evry/Corbeil-Essonnes, just south of Paris.

Skills: The candidate should have skills in molecular and cellular biology. An expertise in RNA biology or structural biology will be appreciated.

For more information about this project, contact us directly at david.pastre@nulluniv-evry.fr

Postdoc in Bioinformatics in the Gorodkin Lab – Application deadline Feb 10, 2019

A two-year Postdoc position is available in the Gorodkin lab (http://ivh.ku.dk/bioinformatics), Center for non-coding RNA in Technology and Health (RTH), (http://rth.dk) at Department of Veterinary and Animal Sciences (http://ivh.ku.dk/english), Faculty of Health and Medical Sciences at University of Copenhagen. The Postdoc position concerns bioinformatics analyses of transcriptomic data from neurodegenerative diseases. The position is available from 1 March 2019 or as soon as possible thereafter.

You will be a team player working with great excitement, and a key person in the project essential for obtaining successful results. The Postdoc position is part of the Indo-Danish NeuroStem project, which aims to discover RNA mediated regulation in neurodegeneration through stem cell models. The Postdoc will be interacting closely with the Group for Stem Cells and Embryology (https://ivh.ku.dk/english/research/anatomy-biochemistry-physiology/stemcells/). See http://neurostem.dk for details. The Neurostem project is supported by Innovation Fund Denmark. The project holds strong synergy to the BrainStem center: http://brainstem.dk.

Background

The NeuroStem project aims at identifying the underlying neuronal pathology of causative genes and regulatory elements to obtain novel functional insight in Alzheimer’s and Parkinson’s diseases that can enable improved treatment. Transcripts will be extracted from neurons derived from iPSC, previously generated from patient skin fibroblasts. In cases where the patients carry specific disease-causing mutations, the iPSCs are gene corrected using CRISPR/Cas9 (isogenic control) allowing for strict comparisons of diseased and isogenic neuronal cells. In addition neurons from engineered healthy control iPSC, into which the genetic mutation is introduced, will be part of the analyses to circumvent the low numbers of samples due to rare mutations. Finally neurons from sporadic iPSC will be investigated to identify novel disease causative genes and pathways as well as validation of common pathways affected in both sporadic and familial forms of Alzheimer’s disease.

Job description

The project takes outset in differential expression analysis of transcripts between disease and gene edited and healthy control neurons. This involves detection and analysis of coding and noncoding transcripts as well as structured RNA and other regulatory elements. From the differential expression analysis, relevant pathways will further be included to obtain candidates for downstream functional analysis in terms of knock-out and knock-in experiments. In addition to transcriptome analysis and gene network methods in silico methods concerning structured RNA and RNA-RNA interactions will be can be incorporated in the integrated pipelines and relevant method development be included in the project.

Required qualifications and selection criteria

The applicant should hold the professional as well as personal skills and qualifications as stated below:

  • A completed PhD degree in bioinformatics, computer science or in a similar area
  • General background knowledge of biological areas of genome structure and transcriptomes
  • Strong experience with script languages such as Perl or Python (or similar)
  • Strong experience with the Linux/Unix environment, command lines and shell scripting
  • Solid experience with transcriptome analysis
  • Good interpersonal skills
  • Excellent in English both in writing and speech

Candidates fulfilling one or more of the following qualifications will be prioritised:

  • Strong experiences with transcriptome data analysis
  • Algorithmic insight broad and for RNA (2D) structure
  • Experience with transcriptomic data from neurodegenerative diseases
  • Experience in at least one of the following programming languages: C, C++ or Java

It is recommended that the applicant address the qualification requirements one by one in the cover letter.

Terms of employment

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organisations. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

The gross basic salary range for Postdoctoral Fellows is DKK 33,766 to DKK 35,552 per month (level 6 to 8). To the basic salary a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is limited to a two-year period.

Place of employment

RTH is located on Frederiksberg Campus; however, as part of the NeuroStem project research visits to project partners will be a part of the Postdoc employment. Our research environment is highly international and stimulating. We frequently organise seminars, workshops, PhD summer schools with international speakers and have retreats with our international collaborators.

Questions

For further information about the scientific content of the position please contact Professor Jan Gorodkin, email gorodkin@nullsund.ku.dk, phone +45 23375667.

Application procedure

Apply by clicking “Apply online” below. Please note that only online applications will be accepted.

Applications – in English – must include:

  • Cover letter detailing your motivation and background for applying for the specific Postdoc project
  • CV
  • Diploma and detailed transcripts of records
  • Other information for consideration, e.g. list of publications, peer reviewed and other
  • Personal Recommendations (if any)
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment

The deadline for applications is 10 February 2019. Any applications received after this time or incomplete will not be considered.

Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application.

The further process

Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background. All applications must be submmitted via the University of Copenhagen’s website: https://employment.ku.dk/faculty/?show=148717

POST-DOCTORAL POSITION to study molecular defects in fragile X syndrome and other neurodevelopmental disorders.

A Post-Doctoral Position is open in the Maquat lab at the University of Rochester Medical Center in Rochester, NY. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular or structural biology. The goal is to study post-transcriptional defects in axon guidance, synaptic function and other neurologic processes in fragile X syndrome, autism spectrum disorders, and other neurodevelopmental diseases. Among approaches currently in use are patient-derived iPSCs that we differentiate to various neural cell types, organoids, and mice. A background in computational biology is a plus but not required.

Interested individuals should submit:

1)      a complete curriculum vitae,

2)      the names and email addresses of three references (applicants should state their relationship to each), and

3)      a description of research experience, including experimental approaches and technologies with which the applicant has experience.

Successful applicants will join a very productive and interactive lab and a lively and supportive RNA community, which consists of more than 25 labs spanning the University of Rochester Medical Center and the adjacent College of Arts & Sciences and Engineering. The Maquat lab offers an outstanding research environment and excellent opportunities to collaborate with basic scientists and clinicians.

Please submit applications to:
Liz Leverenz at elizabeth_leverenz@nullurmc.rochester.edu

Maquat Lab:  https://www.urmc.rochester.edu/labs/Maquat-Lab/

Center for RNA Biology:  http://www.urmc.rochester.edu/rna-biology/

The University of Rochester is committed to diversity and equality in education and employment. EOE Minorities/Females/Protected Veterans/Disabled.

Postdoctoral Training Position Available in the Laboratory of Yunsun Nam, UT Southwestern Medical Center

A postdoctoral training position is currently available in the laboratory of Yunsun Nam, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study the RNAs that regulate gene expression, especially those important for human diseases such as cancer. Our laboratory has several exciting projects related to the molecular mechanisms of various protein/nucleic acid complexes. The specific projects include regulation and processing of small RNAs (eg. microRNAs), as well as RNA modification (eg. methylation). Postdoctoral scholars will have many opportunities to learn the newest methods in biochemistry and biophysics, in addition to working in an exciting, fast evolving area in the field of biological and biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, cryo-electron microscopy (cryo-EM), molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, drug discovery, and mammalian cell-based studies.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry (protein or nucleic acids), cell biology, genomics, and/or structural biology leading to publication in peer-reviewed journals is recommended.

Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.

Interested individuals should send a CV, statement of interests, and a list of three references to:

Yunsun Nam, Ph.D.

UT Southwestern Medical Center

5323 Harry Hines Blvd.

Dallas, TX 75390-8511

Yunsun.Nam@nullutsouthwestern.edu

www.ynamlab.org

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer.  Women, minorities, veterans and individuals with disabilities are encouraged to apply.

 

Postdoctoral Research Fellow: Function and Structure of Specialised Ribosomes in Drosophila melanogaster

Are you an ambitious researcher looking for your next challenge? Do you have an established background in either mRNA translation or cryo-EM? Are you keen to develop new skills in a range of approaches? Do you want to further your career in one of the UKs leading research intensive Universities?

Applications are invited for a BBSRC-funded postdoctoral research fellow position, to dissect the function and structure of specialised ribosomes. This exciting, timely and transformative research project has the potential to provide a step-change in our understanding of protein synthesis. Together we will characterise the composition, function and structure of specialised ribosomes in the Drosophila testis. This research project is a collaboration between two experts in the fields of mRNA translation/initiation (Dr Julie Aspden) and cryo-EM (Dr Juan Fontana), combining genetic, biochemical, genomic and structural approaches to tackle an important, outstanding question on the structure-function relationship of specialised ribosomes. We have already obtained evidence by mass spectrometry of the existence specialised ribosomes in different tissues from Drosophila melanogaster, and we have obtained cryo-EM averages of these ribosomes at ~4Å resolution. Therefore this is an active project that requires someone to drive it forward. You will join a vibrant research community within the Faculty of Biological Sciences at Leeds, including LeedsOmics and The Astbury Centre for Structural Molecular Biology.

We are looking for someone who will have;

  • A PhD (or close to completion) in RNA and/or structural biology or a closely allied discipline;
  • Experience in mRNA translation and/or cryo-EM of macro-molecular complexes;
  • Drive to pursue cutting-edge research in the field of mRNA translation using a range of approaches (biochemical, genetic, genomic and structural);
  • Aptitude for computational analysis e.g. NGS and/or cryo-EM data analysis;

You may also have:

  • Experience in biochemical purification of translation complexes, Drosophila melanogaster husbandry and genetics, analysis of RNA-Seq or similar data, structural biology, genomics, CRISPR or RNAi;
  • Evidence of pursuing external funding to support research;
  • Experience in public engagement and/or outreach.

To apply:

https://jobs.leeds.ac.uk/Vacancy.aspx?id=13818&forced=2

Postdoctoral Position Available in the Lab of Dr. Paul F. Agris, Duke University Department of Medicine

A postdoctoral position is available in the Lab of Dr. Paul F. Agris recently established at Duke University Department of Medicine.

Applicants are sought with expertise in the following areas: cellular and molecular biology/biochemistry with experience in RNA and protein expression and mammalian cell culture. Applicants must provide a complete curriculum vitae with publication list, three names and contact information for references, and a cover letter summaring the experience with RNA molecular/cellular biology.

Email: Paul.Agris@nullDuke.edu
Phone: 919-681-1218

Two Post-doctoral Positions at Boston University Medical Campus

Two Postdoctoral Scholar positions are available in the laboratory of Dr. Ruslan Afasizhev at the Department of Molecular and Cell Biology, Boston University Medical Campus.

Our NIH-funded program focuses on mechanisms of RNA processing in trypanosomes. Current projects cover mitochondrial transcription, mRNA editing, stability and translation, and small RNA biogenesis. Our collaborations extend into structural biology, mass spectrometry, drug design and bioinformatics.

For more details, see recent publications listed below.

For Position #1, the required qualifications include a strong background in molecular biology and biochemistry, and a record of peer-reviewed publications. Experience in RNA-Seq, ribosome profiling, protein purification, mass spectrometry and parasite genetics is desirable.

Position #2 is for a bioinformatician interested in joining a state-of-the-art molecular laboratory with emphasis on deep sequencing and interaction networks.

Starting postdoc salary at BU is $50,000 plus standard employee benefits. Funding will be provided for at least three years. Boston University Medical Campus is in the vibrant South End area of Boston and offers a highly collaborative environment, unlimited networking possibilities in a thriving biomedical community, excellent core facilities and outstanding cultural and recreational opportunities.

To apply, please send a letter of intent, CV and contact information for three references to ruslana@nullbu.edu.

Suematsu et al, Molecular Cell, 2016; Zhang et al, EMBO J, 2017; Sement et al, PNAS, 2018; Mesitov et al, Nature Communications, 2019.

Post-doctoral Position, Group of Dr. Giulia Palermo University of California Riverside (UCR)

Post-doctoral position is available in the group of Dr. Giulia Palermo at the University of California Riverside (UCR) in computational biophysics.

Research in the Palermo lab focuses on applying and developing novel computational methods to unravel the function and improve applications of key macromolecular complexes responsible of gene regulation, DNA cleavage and replication, RNA transcription and in translation. The appointee will apply a variety of computational methods, spanning from conventional Moleuclar Dynamics (MD) simulations, enhanced sampling methods, ab-initio MD and emerging cryo-electron microscopy (cryo-EM) refinement/processing methods. As well, she/he will have the opportunity to join ongoing collaborations with leading experimental scientists at UCR, UC Berkeley and at UC San Diego.

We are seeking a postdoctoral fellow with the following research background and interests:

1) MD simulations of protein and nucleic acid systems, including but not limited to DNA/RNA dynamics, protein-protein interactions, and ion-protein interactions. Experiences with enhanced sampling and unconventional analysis methods, including but not limited to the dimensionality reduction methods, correlation analysis and Markov state modeling is preferred.

2) Knowledge of QM/MM approaches based on ab-initio methods (such as the Born-Oppenheimer and Car-Parrinello approaches) is preferred but not strictly required.

3)  Applicants should hold a PhD in physics, chemistry, computational sciences or related fieds. Motivation in learning and developing unconventional computational approaches during the appointment will be key for the successful applicant.

The University of California Riverside is a public research University belonging to the University of California system, located in the vibrant research area of southern California. The appointee will be employed in the Department of Bioengineering, receiving competitive salary and benefits, in agreement with the UC salary scale.

To apply, please email your CV and contact information for 2-3 references to gpalermo@nullengr.ucr.edu

More information: https://palermolab.com

 

Cancer Postdoctoral Fellowship Position, National Cancer Institute

The Protein-Nucleic Acid Interaction Section in Structural Biophysics Laboratory, National Cancer Institute, invites applications for a Cancer Postdoctoral Fellowship position.  Applicants should have training/expertise in RNA biology and biochemistry.  The postdoctoral fellow recruited for the position will work on exciting RNA biotechnology and cancer immunotherapy projects and have opportunities to train and learn multiple techniques for the research projects.  We seek an enthusiastic, creative and dedicated scientist to join our team.

The position is open until a qualified candidate is identified.  NIH offers a competitive stipend and comprehensive health insurance.  The appointment will be one year initially and renewable up to a total of 5 years based on performance.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation.  To apply, please send a cover letter and a curriculum vitae.  In addition, please arrange three reference letters to be sent to wangyunx@nullmail.nih.gov on behalf of applicants.

DHHS, NIH, and NCI are Equal Opportunity Employers

Faculty Positions Available, Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative

The newly founded Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative, solicits applications for faculty positions at the assistant professor level, but appointment at a more senior level is possible for applicants with suitable experience. The faculty position will be tenure track or tenured with a university year appointment starting September 1, 2019 or January 1, 2020.

Candidates must have the following qualifications:

  • A PhD, MD, or other terminal degree
  • Evidence of superlative scientific accomplishment and scholarly promise
  • Depending on field, evidence of teaching excellence

Primary school and departmental affiliation(s) will be determined by the applicant’s qualifications and preferences, and by relevance of the applicant’s research program to departmental initiatives and themes. We welcome applications from outstanding scientists in any area of RNA research complementary to existing expertise at Michigan, with particular emphasis on RNA drug targeting or as medicine, structural biology of RNA nanomachines, RNA structural in vivo profiling, RNA protein interaction profiling, and in vivo analysis of long non-coding RNA function. For further information about the Center for RNA Biomedicine’s current research areas, please visit https://www.umichrna.org.

All applications must be submitted online at https://rna.lsa.umich.edu/facRecruiting/application.php. You will be asked to upload the following materials: a cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, and a statement of teaching interests and philosophy. Candidates for appointment as an assistant professor should provide names and contact information for at least three references, as instructed in the on-line application form. To ensure full consideration, all materials should be received by January 15, 2019.

Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.

For more information, contact us directly at mjerant@nullumich.edu or 734-615-8213

Learn more about the Biosciences Initiative at University of Michigan: biosciences.umich.edu

RNA Biochemist position(s), Sixfold Bioscience, London

Job summary

Utilise RNA in innovative ways to cure disease.

At Sixfold we’re building a better way to deliver cures. We see the huge potential of gene therapies being limited to how effectively they can be systemically delivered in people. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic.

We’re seeking a highly motivated and independent researcher to join our team. Specifically, we are looking for skilled scientists that are passionate about utilising nucleic acids in innovative and transformative ways to cure disease. As a rapidly growing start-up, your work will make invaluable contributions to the scientific and strategic direction of the company.

Requirements

  • PhD with specialisation in RNA Biochemistry/Biophysics, Molecular Biology, Chemical Engineering, Nanotechnology or equivalent scientific discipline.

Extra credit

  • Hands-on experience in RNA synthesis, purification, characterisation formulation, and stability testing.
  • mRNA translational control and RNA processing.
  • Expertise in analytical techniques including HPLC, LC-MS GC-MS.
  • Cell biology expertise in mammalian cell culture and cell visualisation using techniques such as confocal microscopy and flow cytometry.

Who you are

  • Use creativity and scientific intuition for designing and undertaking experiments.
  • Can work in a highly collaborative research environment.
  • Drive innovative research through the internalisation of new techniques and technology, as well as forming internal and external collaborations.
  • Have a desire to work in a dynamic and fast-paced environment.

What you’ll do

  • Lead the development and optimisation of RNA for therapeutic use.
  • Design and execute robust laboratory experiments, interpret data, communicate findings, and maintain high-quality records.
  • Support and contribute to publishing and grant writing efforts.

Perks

  • Highly competitive salary based on experience.
  • Equity based remuneration.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • Inclusive company culture.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Opportunities for personal, professional and scientific development.
  • Team-wide social events.

About us
Who we are Located in London, Sixfold is a YCombinator and venture-backed startup. Founded by researchers from the University of Cambridge and the Francis Crick Institute, we’re dedicated to expanding the potential of gene therapies, so that ultimately we can cure more diseases in more people. It’s why we started Sixfold — to make a difference. We work at the cutting edge of science by fostering collaborations with the world’s best institutions and the sharpest minds. If you want to help cure the incurable, you belong with us.

It’s important to mention that although disease affects us all, our industry still displays a huge lack of diversity — this needs to change. Our founding team is comprised of different nationalities and is 2/3rds female founders. Our goal is to create a company culture that promotes ideas and the inclusion of scientist and engineers from all backgrounds.

Find out more

 

  

 

Postdoctoral Fellow Position Available, Department of Biomedicine in the group of Professor Ruth Brenk

At the Faculty of Medicine, Department of Biomedicine in the group of Professor Ruth Brenk (http://www.uib.no/en/rg/brenk ) a full-time (100 %) position as Postdoctoral Fellow is available for a period of 3 years. The position is part of the project “Exploration of the TPP riboswitch as a new target for antibiotics” financed by The Research Council of Norway under the Joint Programming Initiative on Antimicrobial Resistance(JPIAMR) initiative.

The main focus of the project will be hit discovery and optimization for the TPP riboswitch which is a target for new antibiotics (https://www.jpiamr.eu/wp-content/uploads/2018/11/Summary_Explore.pdf). The role of this postdoc will be high-throughput screening (HTS) assay development, hit validation (using binding assays and X-ray crystallography) and structure-based ligand design.

More information can be found here: https://www.jobbnorge.no/ledige-stillinger/stilling/161277/postdoctoral-fellow-3-years-for-hit-discovery-for-riboswitches

Ph.D. Studentships, Dept of Molecular Genetics, University of Groningen (the Netherlands)

Applications are invited for two 4-year Ph.D. studentships, starting April 2019, in the newly established research group of Dr. Danny Incarnato (embedded in the department of Molecular Genetics, headed by Prof. Dr. Oscar Kuipers) at the University of Groningen (the Netherlands), to study in vivo RNA folding dynamics.

What

The successful applicants will work on a multidisciplinary project aimed at understanding the mechanistic aspects underlying in vivo RNA structure formation. Particularly, they will:

–        study the role of different factors, such as macromolecular crowding, RNA binding proteins (RBPs) and RNA post-transcriptional modifications (PTMs), in regulating RNA folding (and their crosstalk)

–        develop novel approaches for the accurate interrogation on a transcriptome-wide scale of RNA structures and PTMs

–        integrate the wet-lab work with a substantial component of bioinformatics analyses (developing novel analysis tools where needed)

Ph.D. candidates will receive excellent training through cutting-edge research projects, advanced courses and training opportunities, complemented by workshops on generic research, transferable skills and teaching. Ph.D. candidates are committed to conduct independent and original scientific research, to report on this research in international publications and presentations, and to present the results of the research in a Ph.D. dissertation, to be completed within 4 years. Moreover, Ph.D. candidates are expected to contribute 10% of their overall workload to teaching.

Who

The ideal candidates must be highly motivated, hard-working, ambitious, creative, really enthusiastic about RNA and interested in doing both wet-lab and bioinformatics. They must hold a Diploma or Master’s degree in the field of life sciences (molecular biology, biochemistry, or related disciplines) and have at least 6 months of lab experience (ideally with a focus on RNA biology and/or Next-Generation Sequencing). Strong communication skills and the ability to work efficiently, independently as well as in a team, are required. An excellent written and oral fluency in English is essential. Prior knowledge of UNIX/Linux computing environments and of a programming language (Perl, Python, Ruby, C++) is not required but is a plus.

How

Our lab uses both prokaryotic and eukaryotic cellular models and exploits (or develops where needed) cutting-edge Next-Generation Sequencing approaches (Incarnato et al., 2017 [PMID: 28934475]; Incarnato et al., 2017 [PMID: 28180324]; Incarnato et al., 2014 [PMID: 25323333]) and bioinformatics analysis tools (Incarnato et al., 2018 [PMID: 29893890]; Incarnato et al., 2016 [PMID: 26487736]; Incarnato et al., 2013 [PMID: 23863844]), complemented by traditional molecular genetics and biochemistry techniques.

Where

Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 30,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.

The “RNA Folding Dynamics” lab is hosted in the prestigious Groningen Biomolecular Sciences and Biotechnology Institute (GBB), located in the Zernike Campus, at the northern edge of the city of Groningen.

The GBB is one of the larger institutes of the Faculty of Science and Engineering (FSE) and provides an excellent environment for top-notch research in the field of biomolecular sciences. Twelve vibrant research groups with strong roots in biophysics, biochemistry & molecular biology, cell biology, chemistry, computational biology, microbiology or genetics are organized in two focal areas: ‘Molecular Mechanisms of Biological Processes’ and ‘Physiology and Systems Biology’.

When

The preferred starting date is April 1st, 2019.

Conditions of employment

The University of Groningen offers a salary of € 2,325 gross per month in the first year to a maximum of € 2,972 gross per month in the final year (salary scale Dutch Universities), based on a full-time position (1.0 FTE) excluding an 8% holiday allowance and an 8.3% end of the year bonus.

The position offered is for four years. Each successful candidate will first be offered a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the contract period is to be expected. A Ph.D. training programme is part of the agreement and the successful candidate will be enrolled in the Graduate School Science and Engineering of the Faculty.

How to apply

Applications should consist of:

–        a cover letter with background and motivation to apply for this position

–        a curriculum vitae, including details of bachelor and master degrees, labwork experience and a publication list, if applicable

–        detailed (1-2 pages) description of previous research experience, such as the bachelor/master research projects

–        contact details of 2 academic references who can provide information on candidate’s suitability for the position

Interviews are scheduled to take place in February 2019, in Groningen.

Please refer to the official job announcement of the University of Groningen with further details on the appointment and remuneration and apply online at:

https://www.rug.nl/about-us/work-with-us/job-opportunities/overview?details=00347-02S0006PLP

Deadline

Applications for this position can be sent until January 30 23:59 h / before January 31, 2019 (Dutch local time) by means of the online application form (click on “Apply” below on the advertisement on the University website).

Information

Question regarding the open positions and the objectives of the research can be obtained by contacting: Dr. Danny Incarnato (E-mail: dincarnato@nullincarnatolab.com; Skype: incarnatolab).

Additional information on the university, faculty, institute, research groups and the city:

–        University of Groningen: https://www.rug.nl/

–        Groningen Biomolecular Science and Biotechnology Institute (GBB): https://www.rug.nl/research/gbb/

–        RNA Folding Dynamics research group: http://www.incarnatolab.com

–        The conditions of employment: https://www.rug.nl/about-us/work-with-us/

–           The city of Groningen: http://www.rug.nl/about-us/who-are-we/discover-groningen/

Seeking an Experienced RNA Computational Biologist with a strong RNA biology background

Panorama Medicine is seeking an experienced RNA Computational Biologist with a strong RNA biology background to analyze large-scale RNA data at their Philadelphia office.

Responsibilities:

  • Analyze large-scale RNA-seq data.
  • Discover underlying mechanisms of observed data results.
  • Closely work with molecular biologist for target validation.

Minimum Qualifications:

  • All applicants must have a PhD in genetics, biology, bioinformatics, or closely related fields. Post-doctoral experience is preferred.
  • Excellent understanding of RNA biology. Exposure to rare disease research and a strong record of publication is preferred.
  • Good programming and scripting abilities in languages, such as R, Python. Familiar with Linux/Unix systems.
  • Familiar with public genomics databases, such as TCGA, GTEx, LINCS, ENCODE, OMIM, etc.
  • Strong knowledge of statistics and machine learning algorithms.
  • Strong writing skills for scientific reports. Experience in grant application is preferred.
  • Excellent problem-solving, teamwork, organization, and communication skills.
  • US citizen or permanent resident only.

About Panorama Medicine:

Panorama Medicine is a VC-backed startup founded by a multidisciplinary team of world-renowned computational and experimental RNA biologists. Our mission is to use genomics and computing to accelerate drug discovery. Panorama is young and fast-growing, offering rewarding career development opportunities.

Benefits:

Panorama strives to build a Google-like work environment, creative, fun, hardworking, and highly productive. We offer a strong compensation package that includes competitive salary, generous stock options, and a comprehensive health benefits package. Flexible time off, productivity perks, paid parental leave, company sponsored learning and development opportunities.

Panorama is an Equal Opportunity Employer and Prohibits Discrimination and Harassment of Any Kind.

Interested applicants should send a cover letter and a CV to hr@nullpanoramamedicine.com.

Postdoctoral position at the Very High Field NMR Center (CRMN) in Lyon

Project: The work will focus on visualizing RNA conformational dynamics and interactions at very high resolution using NMR spectroscopy. This position is provided in the context of a recently accepted ERC project and will be centered on the development of new RNA synthesis to obtain uniquely informative RNA for NMR spectroscopy. By accessing those RNA it will become possible to study highly flexible non-coding RNA at atomic resolution and understand the role of RNA complex conformational dynamics in the biological function.

Requirements: Candidates should hold a PhD in chemistry, molecular biology, biophysics or related field. Skills in RNA biochemistry and spectroscopy are highly desirable. The candidate will be working in an international, collaborative environment and is expected to demonstrate good creative thinking and communication skills.

Lab: The CRMN is a worldwide unique interdisciplinary NMR center (up to 1GHz spectrometers, liquid/solid/DNP). It hosts leading NMR research groups, provides excellent working conditions and is located in Lyon, one of the most dynamic French city, internationally recognized for its life quality.

Application: Interested candidates are welcome to contact me for further information. Application should be submitted via the web interface: http://bit.ly/2BaYm8t and include a cover letter and a CV with a publication list and three references.

Postdoctoral Research Fellow in Cardiac RNA Biology (University of Illinois at Chicago)

A postdoctoral position is immediately available in the laboratory of Dr. Sang-Ging Ong in the Department of Pharmacology and the Center for Stem Cell and Regenerative Medicine at the University of Illinois at Chicago. The Ong lab is stably funded by the National Heart, Lung, and Blood Institute and institutional funding.

Using mouse models, patients’ samples, and patient-specific induced pluripotent stem cells, the Ong lab seeks to understand the molecular and biological mechanisms underlying various cardiovascular diseases through cellular, genetic, and biochemical approaches. We are currently seeking a candidate to lead a new research program on how post-transcriptional regulation of RNA including RNA modifications lead to metabolic changes in the heart under both physiological and pathological conditions. We are also interested in studying how non-coding RNAs regulate the response of cardiac cells during stress.

Qualifications: Recent or upcoming PhD or MD/PhD degree (must be within 3 years of obtaining PhD) and a strong record of peer-reviewed publications with at least one first-author manuscript (IF>5) in RNA biology, is essential. Ideal candidates should have experience working in two or more of the following areas: 1) stem cell biology/chemical biology, 2) epigenetics/epitranscriptomics, 3) sequencing techniques e.g. ChIP-Seq, MeRIP-seq, and CLIP-seq, 4) RNA biology, genomics or bioinformatics, and 5) gene-editing techniques including CRISPR.

Interested candidates should submit a CV with the names of three referees to Dr. Sang-Ging Ong (sangging@nulluic.edu). The position is open immediately until filled.

The University of Illinois at Chicago is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply. The University of Illinois may conduct background checks on all job candidates upon acceptance of a contingent offer. Background checks will be performed in compliance with the Fair Credit Reporting Act.

Lab Manager, University of Michigan

Our laboratory studies basic mechanisms in RNA biology and RNA defects in neurologic diseases.  We are particularly interested in how RNA structure and sequence regulate cell function.

Applicants with at least 5 years of work experience in a molecular biology laboratory and familiarity with bioinformatics are required.  Candidates should have a Ph.D. or M.D.  S/he must be able to work independently and has excellent communication skills.  Besides designing and carrying out experimental and analytical work, the position will include lab management.  Experience with RNA sequencing and analysis is highly desired.  The position provides opportunities for growth and independent research.  The position is ideal for someone with deep interests in mechanistic aspects of RNA biology but does not wish to be concerned with grant writing.

Please send a cover letter, curriculum vitae, including names and contact information for at least three references to:

Vivian G. Cheung, MD
HHMI/ University of Michigan
vgcheung@nullumich.edu

Postdoc Position: Bioinformatics of Long Noncoding RNA Functional Elements

The “Genomics of Long Non-Coding RNAs in Disease” Laboratory (GOLD Lab) at the University of Bern has an opportunity for a Bioinformatics Postdoc.

The Project: Understanding how long noncoding RNA (lncRNA) functions are encoded in their sequence is a great challenge in biology. Our goal is to discover, classify and characterise lncRNA functional elements by means of an integrative bioinformatic / experimental approach. You will lead the bioinformatic component to develop novel methods for identifying lncRNA elements and predicting their functions. In collaboration our experimental team, you will have ample opportunities for experimental validation of in silico-generated hypotheses.

The Group: We are an international and interdisciplinary group of researchers with a passion for lncRNA research. We foster an open and collaborative working environment. Our work is funded by the Swiss National Center for Competence in Research (NCCR) “RNA & Disease” (nccr-rna-and-disease.ch), and we participate in the GENCODE project and International Cancer Genome Consortium (ICGC). We also have excellent biomedical links at the University Hospital of Bern. For more information about us: gold-lab.org / twitter.com/goldlab_bern

The City: Bern, the capital of Switzerland, has a vibrant international community, numerous outdoors and cultural activities, and ranks among the best cities worldwide for quality of life (https://tinyurl.com/y9vrtb7d).

The Person: We seek a dedicated and dynamic colleague to integrate into our diverse team. You should have strong background in bioinformatics or computer science, and specifically some/all of: Unix environment, R, perl/python, analysis of NGS data, webservers/databases. Experience in lncRNAs, CRISPR-Cas9 is a plus.

Details: Ideal start date will be Q1 of 2019. Project is fully funded for 4 years. Salary is according to (generous) University of Bern scales.

Recent publications:

Carlevaro-Fita et al. Biorxiv https://www.biorxiv.org/content/early/2017/10/23/189753

Uszczynska-Ratajczak B et al. Nat Rev Genet. 2018 Sep;19(9):535-548. doi: 10.1038/s41576-018-0017-y.

Lagarde J et al. Nat Genet. 2017 Dec;49(12):1731-1740. doi: 10.1038/ng.3988.

To apply: Please send a motivation letter, publications list, list of references, and CV to rory.johnson@nulldbmr.unibe.ch with subject title: “Job application Bioinformatics Postdoc”. Informal enquiries are also welcome.

Postdoctoral Position, Dr. Zhipeng Lu lab at USC School of Pharmacy, Dept of Pharmacology and Pharmaceutical Sciences

A postdoctoral position is immediately available in Dr. Zhipeng Lu lab at USC School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences. Our research is focused on “RNA machines” in living cells. We develop and apply novel technologies to understand the structures and functions of RNA molecules in basic cellular processes, with the ultimate goal of targeting human diseases, including genetic disorders, cancers and viral infections.

We have recently developed a powerful new technology, PARIS (Psoralen Analysis of RNA Interactions and Structures), a crosslinking based method for high throughput mapping of RNA duplexes in living cells at single-molecule level with near base-pair resolution (Lu et al. 2016 Cell). These unique strengths allow direct determination of alternative conformations, long-range and complex structures and RNA-RNA interactions across the transcriptome. This work was featured on the cover of Cell and a video abstract “Get an Eye-full (Eiffel)” (https://www.youtube.com/watch?v=1GXibPeUUGQ). A more complete description of our science can be found at http://zhipenglulab.org.

Current projects in the lab span the development of new computational and chemical tools for the analysis of RNA structures and interactions, and application of these technologies to important problems in the RNA field. The questions that we are interested in include structural basis of mRNAs and noncoding RNAs in post-transcriptional regulation of gene expression, roles of RNA structures and interactions in human diseases, such as neurological disorders and cancers. We also welcome and support novel and unconventional ideas that are related to the current work in the lab.

Research in the Lu lab is highly interdisciplinary and collaborative. Postdocs are exposed to research questions and techniques in the forefront of various fields centered around RNA. This training environment is exceptionally valuable for individuals who are interested in pursuing careers in academia or scientific leadership positions in the pharmaceutical industry. The PI is fully committed to empowering trainees with the capabilities to fulfill their ambitions.

USC School of Pharmacy is located in Health Sciences Campus, immediately adjacent to the USC Keck School of Medicine and Caltech. This rich scientific environment provides unique research training opportunities, such as research seminars given by leaders in science from throughout the U.S. and abroad, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities.

Candidates should have a Ph.D. and/or an M.D. and less than three years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics, biochemistry, or chemical biology, as evidenced by publications. Experience in computational biology is highly valued. Starting date is flexible from December 2018, and funding is guaranteed for at least three years.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to zhipengl@nullusc.edu.

Postdoctoral position to study RNA-protein complexes and non-coding RNA in New York

Postdoctoral positions are available immediately in the laboratory of Dr. Alexander Serganov at New York University School of Medicine. We are looking for enthusiastic, highly motivated and creative individuals with a strong interest in applying multidisciplinary approach and cutting-edge methodology to study RNA-mediated gene expression control. We are presently focusing our efforts on RNA-protein complexes and non-coding RNAs from bacteria and mammals, using structural (cryo-EM and X-ray), biochemical (including genome-wide) and biophysical methods. Research topics include transcriptional and translational control, mRNA modification, RNA degradation, and RNA-protein complexes in human diseases.

Candidates should hold a Ph.D. degree in structural biology, biochemistry, molecular biology, or related fields. Qualified candidates should have strong background in routine molecular biology techniques and protein purification. Good communication in English is expected.

The first position requires prior experience in genome-wide methods (RNAseq, CLIP, etc) or in vitro RNA studies. Projects will be primarily focused on genome-wide and in vitro characterization of RNA-protein interactions, with less emphasis on structural methods.

The second position requires experience in X-ray crystallography or cryo-EM and will primarily involve structural studies.

The Serganov laboratory (www.serganovlab.com) is located on the NYU Langone campus at 31st Street and First Avenue in midtown Manhattan, New York, USA. Postdocs will benefit from the vibrant scientific environment and the outstanding School infrastructure that supports the most advanced technologies including robotic X-ray facility, cryo-EM facility with Titan Krios, genome center and over 20 other facilities. Postdocs will be involved in collaboration with leading groups and receive a competitive salary, excellent benefits, and subsidized housing.

Interested applicants should submit a detailed CV, brief statement of research interests with description of previous research experience and contact information (email addresses and telephone numbers) of three references to Dr. Alexander Serganov at alexander.serganov@nullNYUMC.org. Consideration of submitted applications will start immediately and continue until positions are filled.