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Postdoctoral Position Available to Study Eukaryotic RNA modifications

A postdoctoral position is immediately available in Anders Byström’s laboratory at the Department of Molecular Biology, Umeå University, Sweden. Our lab is using a combination of genetics, biochemistry and molecular biology to study the biosynthesis and function of modified nucleosides in tRNA and mRNA. Defects in the formation of several RNA modifications are linked to human disease. We are predominantly using Saccharomyces cerevisiae as the model organism and we have shown that the lack of specific modifications in tRNA leads to pleiotropic cellular phenotypes including defects in G1/ S transition, vesicular trafficking, telomeric gene silencing, and DNA check point control. In our on-going work we are investigating the mechanisms by which RNA modifications modulate gene expression.

Required qualifications are a PhD degree or equivalent with a documented background in RNA biology. Previous experience in yeast genetics and analysis of RNA modifications is an advantage. Applications should be written in English, comprise of a cover letter with a brief statement of research interests, CV with a publication list and contact information of at least two referees. Documents should be in MS Word or PDF format and submitted via e-mail (anders.bystrom@nullumu.se).

This position is a full-time, 12 month scholarship appointment with an opportunity for renewal based on performance and funding. Informal inquiries regarding this position are welcome.

Postdoctoral Research Fellow Position at Alberta RNA Research and Training Institute, University of Lethbridge, Canada

A postdoctoral research fellow position is available in the Kothe lab focusing on transcriptomics of RNA modification. This research addresses fundamental as well as disease-relevant aspects of RNA modification integrating transcriptomic approaches with cellular and biochemical studies. Thereby, the potential candidate will elucidate the complex contribution of RNA modifications to regulation of gene-expression. This position is fully funded for 2.5 years by Alberta Innovates.

This project builds on the expertise in the Kothe lab in studying pseudouridine formation and other RNA modifications in all types of RNA as well as investigating the ribosome. In our research, we apply a multidisciplinary approach including techniques such as protein/RNA biochemistry, fluorescence spectroscopy, rapid kinetics, cellular studies, E. coli and yeast genetics, next-generation sequencing and molecular dynamics simulations (http://scholar.ulethbridge.ca/kothe).

The Kothe lab is part of the Alberta RNA Research and Training Institute (ARRTI) with eight research groups spanning all areas of RNA research. ARRTI fosters a highly collaborative training and research environment with ample opportunities for scientific exchange and collaborative projects. Together, the ARRTI groups have access to a comprehensive suite of state-of-the-art equipment for biophysical, biochemical, cellular and computational studies (http://www.uleth.ca/research/centres-institutes/alberta-rna-research-and-training-institute-0).

Highly motivated researchers with a recent Ph.D. in biochemistry, molecular biology, cellular biology or a similar discipline are encouraged to apply. It is expected that candidates will have proven their research accomplishments by peer-reviewed publications. Next-generation sequencing and bioinformatics skills are highly desirable. Excellent verbal and written communication skills, teamwork ability and some experience in supervising students are expected.

Interested candidates should send a CV including at least three references, a motivation letter and copies of their most significant publications by email to Dr. Ute Kothe (ute.kothe@nulluleth.ca). Applications will be considered starting June 12th 2017 until the position is filled.

RNA Biology and Gene Regulation PhD/Postdoc Positions Available at the University of Regensburg

The University of Regensburg with its over 20,000 students is an innovative and interdisciplinary university, which provides a broad variety of research projects and disciplines. The Institute of Biochemistry, Genetics, and Microbiology, Chair of Biochemistry, Professor Meister, at the University of Regensburg is offering positions as

PhD student or postdoc with a strong background in biochemistry/molecular biology.

Job specification:
Our research focuses on the various functions of human non-coding RNAs in gene regulation. We use biochemical and molecular biological approaches to dissect non-coding RNA pathways. In particular, we characterize regulatory processes guided by microRNAs, circRNAs or lncRNAs and in addition we analyze protein components of these pathways. Furthermore, we study RNA base modifications (e.g. m6A) and their roles in gene expression. We perform deep sequencing studies to identify such modifications under different conditions as well as structure-function experiments to characterize writer, reader and eraser enzymes that are involved in such pathways. We routinely characterize RNA-protein interactions using various experimental approaches including X-ray crystallography and molecular biological or biophysical strategies. Modern Cryo-electron-microscopy is used for structural analysis and can be learned and applied.

Qualifications:
Candidates should hold a Master/Diplom/PhD or equivalent in Biochemistry, Molecular Biology or a closely related subject.

We expect good communication skills, high motivation, dedication to molecular life sciences and the willingness to work in a competitive research field.

General framework:
We offer a state-of-the-art biochemistry lab in an international environment with a long-standing experience in non-coding RNA biology. Well-equipped mass spectrometry, protein purification as well as deep sequencing platforms are available. A cryo-electron-microscope will be installed in the near futuer. The lab is generously funded by several national and international grants including an ERC consolidator grant. The successful candidate will be embedded into the international graduate school RIGEL.

The University of Regensburg is committed to the compatibility of family and career (for more information, please visit http://www.uni-regensburg.de/equal-opportunities). Severely disabled applicants are given preference in instances where applicants demonstrate an equal level of qualification. Please mention any severe disabilities, if applicable, in the application. Unfortunately, we do not provide reimbursement for expenses associated with interviewing.

For further enquiries please contact Professor Gunter Meister, phone +49 941 943-2847, gunter.meister@nullur.de. Please send your application no later than 15.06.2017 to gunter.meister@nullur.de

Postbaccalaureate Fellow Position

The RNA Biology Division of New England Biolabs (NEB) invites applications for the position of Postbaccalaureate Fellow. NEB will provide recent college graduates who are planning to attend graduate or professional schools an opportunity to spend one year at NEB performing full-time research. The goal of this program is to engage undergraduates to consider basic and applied science related careers and providing them the opportunities for competitive science related education and careers.

The fellow will work with NEB scientists, and projects will be a part of a research program on different aspects of RNA biology. Research will be undertaken in a highly collaborative and academic environment and will offer motivated and talented students an opportunity to confirm their interest in basic and applied research.

Fellows will also have the opportunity to participate in a variety of scientific activities:

  • Group meetings to discuss research
  • Research seminars, science talks
  • Receive exposure to the upcoming trends in science and technology

Primary Responsibilities:

  • Conduct hypothesis-driven scientific research in a laboratory setting
  • Execute a variety of molecular biology techniques including: PCR, in vitro RNA synthesis, gel electrophoresis
  • Maintain detailed records of research activities
  • Summarize and communicate research results in a group setting

Required Qualifications:

Candidates must have been granted a Bachelor degree with a cumulative GPA of at least 3.3 on a 4.0 scale no more than 3 years before the date of application to the NEB Postbaccalaureate program

In addition, candidates must meet one of the following criteria:

  • Have been accepted into graduate/professional school and delayed entrance for up to one year to pursue research
  • Have completed or are pursuing their master’s degree and are applying to doctoral or professional programs

Preferred Qualifications:

  • Prior research experience in a lab setting (as part of a course or research program)
  • Excellent verbal and written communications skills and an aptitude for learning

Application Procedure:

The application package must contain:

  • A cover letter (limit to 300-500 words) describing your short-term and long-term career goals highlighting prior research experience relevant to the program.
  • A resume or curriculum vitae.
  • A list of coursework and grades.
  • The names and contact information for three references (preference should be given to those who can comment on specific research experience or lab-related courses).

Apply online: https://chk.tbe.taleo.net/chk05/ats/careers/requisition.jsp?org=NEB&cws=1&rid=297

For more information, visit: https://www.neb.com

Two Postdoctoral Research Associate Positions

Two postdoctoral research associate positions are available to study molecular mechanisms of viral and cellular translation and of translation-associated quality control processes in eukaryotes in the laboratories of Tatyana Pestova and Christopher Hellen at the State University of New York Downstate Medical Center in Brooklyn, NY, USA. Our NIH-funded research uses a range of biochemical and molecular biology approaches, and currently focuses on characterization of (1) canonical and non-canonical modes of translation initiation in mammals, including IRES-mediated initiation, (2) mechanisms of translation termination and ribosome recycling, and (3) events downstream of termination, with a focus on quality control processes.

Required qualifications include a Ph.D. in the field of Molecular Biology, Biochemistry or a related field, and practical experience in modern RNA and/or protein biochemistry, including the expression and purification of native/recombinant proteins and the functional analysis of proteins and RNA-protein complexes. Our research involves active collaborations with cryoEM laboratories, and experience in structural biology and/or in investigating aspects of eukaryotic translation and associated quality control processes is therefore desirable. Candidates should be highly motivated, be able to work independently and show excellent critical thinking, scholarly ability and communication skills.

These positions are available immediately, and carry a starting salary of $45,000 – $50,000 (depending on experience) plus health insurance. To apply, please send a cover letter discussing your interest in a position and mentioning the expected availability date, your curriculum vitae (with a summary of research experience, including techniques and methods used, and a list of publications) and contact information for three references to:
christopher.hellen@nulldownstate.edu.

Ph.D. Fellowship at the SABNP Laboratory

Laboratory and Context:
This thesis is funded for three years (09/2017-08/2020) through a CIFRE convention between the SABNP laboratory (INSERM public research unit (U1204)) and MSD France, a company with interest in oncology.  Research will take place at the SABNP laboratory in the Genopole campus (Evry, South suburb of Paris). Genopole is the France’s leading biocluster for biotechnologies and research in genomics and genetics.

Research at the SABNP laboratory (http://sabnp.univ-evry.fr/?lang=en) aims at deciphering the mechanisms involved in the control of protein expression at the cellular and molecular levels and their deregulation associated to cancer. Based on a multidisciplinary approach, the SABNP laboratory notably explores the dynamics and structure of RNA/protein complexes. Novel technologies are also currently developed to explore cellular and molecular processes involved in gene expression regulation.

Subject of the thesis:
Cancer cells display major metabolic alterations and have an increased ability to cope with stress. Besides transcription, translation is also altered to favor the expression of oncogenes involved in different processes like cancer invasiveness and drug resistance. In line with this, two mRNA-binding proteins which share a similar structure appear to be excellent molecular markers of cancer progression and drug resistance in a variety of cancers. We planned to decipher the mechanisms of translation regulation exerted by these proteins in cancer cells. To address this issue, we will combine structural investigations by Atomic force Microscopy (AFM), microscopy analyses (fluorescence microscopy) and functional studies (RT-PCR, RNA-Seq, in vitro translation).

Candidate profile:
Master 2 degree or equivalent in September 2017.  Knowledge in gene regulation in mammalian cells and background in Molecular and Cellular Biology. French skills is not required if the candidate has a good level in in English. To express an interest in the offer, please send a cover letter stating your research interests and your CV to david.pastre@nulluniv-evry.fr and loic.hamon@nulluniv-evry.fr.

Investigate the Structure and Mechanism of Functional Noncoding RNAs

A postdoctoral position is available immediately in Sarah Keane’s laboratory in the Departments of Biophysics and Chemistry at the University of Michigan. Our lab aims to investigate the structure and mechanism of functional noncoding RNAs. We utilize an array of biochemical and biophysical techniques to characterize RNA structure, RNA-RNA, RNA-protein, and RNA-small molecule interactions. We seek a highly motivated postdoc with experience in RNA biochemistry, RNA structural biology, and/or biomolecular NMR spectroscopy. Successful applicants should hold (or will obtain shortly) a Ph.D. in: Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related field. More information about the lab can be found on our website (http://sites.lsa.umich.edu/keane-lab/).

Postdocs in the Keane lab are expected to assume leadership of their projects and serve as mentors to both graduate and undergraduate students in the lab. Interested candidates should send their Curriculum Vitae and the names and contact information for three references via email (sckeane@nullumich.edu) with the subject POSTDOC APPLICATION. This position is a full-time, 12-month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.

Postdoctoral Position in Prokaryotic RNA Biology

I am seeking a qualified and motivated candidate to study the role of DEAD-box proteins in messenger RNA regulation in E. coli. The focus of the lab is on prokaryotic RNA metabolism, with particular emphasis on the cellular roles of DEAD-box proteins and Ribonucleases. Candidates with a recent Ph.D. degree and a background studying any aspects of RNA metabolism in prokaryotes are welcome to apply. Applicants should send by e-mail (as a single PDF) a cover letter, CV, summary of research experience and contact information of three references.

Chaitanya Jain, University of Miami Miller School of Medicine
Email: cjain@nullmiami.edu

Postdoctoral Position

We are looking for highly motivated postdoctoral scientist with an interest in gene regulation. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genes in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford) (Wittmann et al., 2017 Nature Communication, in press). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, have at least one first authorship publication, show excellent critical thinking and good communication skills and have the ability to work as part of a team. Interested applicant should contact Dr Lidia Vasiljeva directly:

Dr. Lidia Vasiljeva: lidia.vasilieva@nullbioch.ox.ac.uk
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675
phone:(+44)-1865613352
The post is funded by the Wellcome Trust Senior Research Fellowship for 1 year in the initial instance.

Postdoctoral Research Associate Position

A postdoctoral research associate position is available to develop multiplex assays to monitor host and parasite genotype / phenotype in clinical samples obtained from patients with the parasitic disease leishmaniasis. The post is funded by a recently awarded MRC Global Challenges Research Fund Foundation Award (in collaboration with researchers in Brazil, India and Sri Lanka) that aims to develop new tools and research approaches to combatting the neglected tropical disease leishmaniasis.

You will work alongside others in the research group, as part of a multidisciplinary team, but will take on a leading role in the development of new assays for use on FFPE and frozen skin tissue. You will have a PhD in molecular biology, immunology or a related discipline, as well as previous experience of assay development based on RNA and antibody probes. Additional experience in skin immunity and histopathology, or biomarker assay development would be advantageous.

The research will be conducted in the CII, which provides state of the art facilities for pathogen related research, and will make extensive use of the resources on offer in the Biosciences Technology Facility. There will be opportunities to visit collaborative laboratories overseas.
The post is offered in the Grade 6 scale of £31,076 – £38,183 per annum. The post is fixed term for two years.

Informal enquiries may be made to either Paul Kaye (email: paul.kaye@nullyork.ac.uk), Dimitris Lagos (Dimitris.lagos@nullyork.ac.uk) or Pegine Walrad (pegine.walrad@nullyork.ac.uk)
Interviews will take place on the 9 May 2017.
Vacancy Reference: 5554

Director and Professor, The RNA Institute, College of Arts and Sciences

The University at Albany, State University of New York, invites applications for the position of Director of The RNA Institute.  Reporting to the Dean  of the College of Arts and Sciences, the Director should have  a background in the broad  area of RNA science and technology.  He or she is expected to take the lead in shaping the future of the Institute, articulating a vision that defines its standard of excellence, mentoring young  faculty and  evolving the Institute to the next level of scientific distinction.

The RNA Institute serves as a resource for research and discovery. Work is focused on developing tools and analytics with applications to biotechnology, disease models and interventions.  Current  research strengths include RNA structure and function, RNA-based determinants of gene regulation, RNA-linked components of disease etiology and  RNA-based therapeutics.

The Institute is a joint venture backed by university, corporate, and government entities in New York’s Capital Region. Housed in newly constructed space, the Institute is located in the interdisciplinary Life Sciences Research Building and financed by state, federal and corporate funds. The Institute is well staffed and equipped with an advanced instrumentation facility, a mass spectrometry center and a computational facility.

Located in New York’s capital city, the University at Albany is within easy reach of the major metropolitan areas of New York City, Boston and Montreal and outstanding recreational areas including the Berkshires, the Catskills and the Adirondacks. The University offers its more than 17,000  students the expansive opportunities of a major research university and an environment designed to foster success. UAlbany students choose from 120 undergraduate majors and minors and more than 125 graduate programs many of which are nationally ranked.

The ideal candidate will possess a distinguished record  of academic success, significant scholarly achievement and  an entrepreneurial spirit. Department assignment will be in Biological Sciences or Chemistry, appropriate to their research interests. The successful candidate will be an investigator with proven  excellence in leadership, a commitment to mentor  and  develop junior faculty and  an outstanding record  of funded research, as well as the desire to build bridges with other schools, corporations and media outlets.  He or she will have  demonstrated the ability to foster a climate where  learning and discovery flourish. The director will show the ability to balance strong academic and intellectual leadership with effective external relationship-building and resource development.

A complete application will include a letter describing relevant experiences and interest in the position; current  curriculum vitae; and the names of five references with titles, mailing addresses, business/home telephone numbers, and email addresses. Applicants must address in their letter their ability to work with and instruct a culturally diverse population. Individuals who wish to nominate a candidate should submit a letter of nomination, including the name, position, address, telephone number, and email address of the nominee. Greenwood/Asher & Associates, an executive search firm, is assisting the University at Albany in the search. Applications and letters of nominations should be submitted to: Jan Greenwood, Betty Turner Asher, Partners, Executive Search Consultant, Greenwood/Asher & Associates, Inc., 42 Business Centre Drive, Suite 206, Miramar Beach, Florida 32550;  Phone: 850-650-2277 / Fax: 850-650-2272; Email: jangreenwood@nullgreenwoodsearch.com; bettyasher@nullgreenwoodsearch.com

For more information about  the University at Albany and the RNA Institute please visit:
http://www.albany.edu/ and   https://www.rna.albany.edu/

Job opening for the Department Chair of Biochemistry

The Department of Biochemistry is seeking nominations and applications for the Department Chair of Biochemistry at the University of Missouri-Columbia. The candidate must be a world-class scientist with a commitment to fostering a spirit of excellence within the department.

Our faculty members are internationally known researchers and prize-winning teachers, including two members of the National Academy of Sciences and multiple members of disciplinary academics and honorary organizations.

Essentially all facets of contemporary biochemical research are represented in the department with particular strengths in medical biochemistry, plant biochemistry and biophysical and structural and mechanistic biochemistry. Our research groups are well-funded by the National Institutes of Health, the National Science Foundation and many other federal and private sources.

For more details see http://www.biochem.missouri.edu/employment/faculty.php
For additional information about the position, please contact Dr. Jinglu Tan, Chair of Search Committee (tanj@nullmissouri.edu).

To apply for the position, the candidate must submit the following documents at http://hrs.missouri.edu/find-a-job/academic.
1. Cover letter
2. Curriculum vitae
3. A two-page summary of research accomplishments and future plans
4. A narrative of administrative and leadership philosophy, including a statement describing efforts to increase diversity and inclusion
5. A narrative of teaching philosophy
6. Names and contact information of four references.

Seeking Outstanding Scientists for Independent Research Group Leader Positions

The Wellcome Trust Centre for Cell Biology (WTCCB) is a world-renowned research centre located within the School of Biological Sciences at the University of Edinburgh. The WTCCB’s mission is to make ground-breaking discoveries that bridge the knowledge gap between genotype and cellular phenotype in health and disease. The Centre has an outstanding track record in fundamental molecular and cellular mechanisms underlying nuclear organization, genome packaging and transmission, chromatin states and RNA biology. The WTCCB fosters an interactive, collaborative environment and is equipped with state-of-the art facilities and instrumentation for molecular and cell biological research, including core support in microscopy, bioinformatics, proteomics and structural biology.

With recently renewed core funding, the WTCCB is in an exciting phase of growth. We seek outstanding scientists for independent Research Group Leader positions at both Junior and Senior levels. Successful candidates will have an impressive track record, appropriate for their career stage and a vision for independent research in any area of cell and molecular biology. Although research excellence is our primary criterion, we encourage applications with demonstrable links to medicine or the physical sciences.

Most group leaders within the WTCCB are supported by independent research fellowships and successful candidates would be supported in seeking independent funding.

Email: d.tollervey@nulled.ac.uk

Post-Doctoral Positions, Laboratory of Sandra Wolin, National Cancer Institute

The Wolin laboratory has recently moved to the National Cancer Institute (NCI) at the National Institutes of Health (NIH) as part of a major new initiative in RNA Biology.

Fully funded postdoctoral positions are available in the areas of noncoding RNA function, RNA surveillance pathways, and the mechanisms by which defects in RNA decay pathways contribute to diseases such as cancer and autoimmunity. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin

Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research. We are part of the Center of Cancer Research’s RNA Initiative, which includes more than 50 laboratories evenly split between the Frederick and Bethesda campuses of the National Cancer Institute. The environment is highly collaborative and collegial, with the ability to interact with a wide range of scientists and clinicians. The positions are ideal for motivated candidates who are seeking additional training in RNA biology.

Candidates should have a Ph.D. and/or an M.D. and should have less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics or biochemistry, as evidenced by publications.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to sandra.wolin@nullnih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.

Postdoctoral opportunity in RNA and Cancer Biology.

A postdoctoral position is available in the laboratory of Dr. Nadya Dimitrova, Assistant Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. Research in the Dimitrova laboratory focuses on investigating the roles of a novel class of genes, called long noncoding RNAs (lncRNAs) in cancer biology. To date, lncRNAs have remained largely uncharacterized but emerging evidence suggests an involvement in a broad range of biological processes and in human disease, including cancer. We select candidates based on their regulation by key oncogenes and tumor suppressors or based on their involvement in cancer processes, such as the DNA damage response, oncogenic transformation, and metastasis. Our goal is to understand how candidate lncRNAs contribute to oncogenic and tumor suppressive networks at the molecular, cellular, and organismal level and how deregulation of lncRNAs leads to cellular transformation and tumor development. At the molecular level, we aim to elucidate the diverse mechanisms by which cis- and trans-regulatory lncRNAs fine-tune oncogenic and tumor suppressive networks by modulating transcriptional and translational pathways. At the cellular level, we aim to understand how lncRNAs participate in the decision-making processes in complex transcriptional networks and what are the consequences of lncRNA activity for cellular homeostasis and stress response. Finally, to bring insights into the vastly understudied contribution of lncRNAs to tumorigenesis in vivo, we are testing how inappropriate expression of regulatory lncRNAs influences tumor development in mouse models of lung adenocarcinoma.

A successful candidate will hold a Ph.D. degree, will be highly motivated to perform cutting edge research and to interact with a dynamic, young group of investigators. Candidates from diverse scientific backgrounds are strongly encouraged to apply.

Additional information can be found at dimitrovalab.yale.edu

Candidates should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to: nadya.dimitrova@nullyale.edu

Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Highly Structured Viral RNAs

A fully funded postdoctoral position (up to 5 years) is available in the Structural Biology of Noncoding RNAs and Ribonucleoproteins Section, Laboratory of Molecular Biology (LMB), NIDDK, in NIH’s vibrant main campus in Bethesda, MD near Washington DC. The lab addresses a widening gap between the accelerated discovery and functional description of the noncoding transcriptome, and a paucity of 3D structures and mechanistic understanding of complex noncoding RNAs. We seek a new member to join our diverse group to deepen current work on gene-regulatory riboswitches, highly structured viral RNAs, circular and other structured long noncoding RNAs. https://www-mslmb.niddk.nih.gov/zhang/zhanglab.html

Current manuscripts and recent publications:

  1. Li et al., & Zhang (2017) Structural basis of amino acid sensing on the tRNA by a T-box riboswitch. In preparation.
  1. Bahmanjah et al., & Zhang (2017) Structural basis of functional repurposing of an aminoacyl-tRNA synthetase in stress response. In preparation.
  1. Hood et al., & Zhang (2017) Structural mimicry of codon-anticodon interactions by a viral noncoding RNA. In preparation.
  1. Zhang & Ferré-D’Amaré (2014) Dramatic improvement of crystals of large RNA by cation replacement and dehydration. Structure 22, 1363-1371.
  1. Zhang & Ferré-D’Amaré (2014) Direct evaluation of tRNA aminoacylation status by the T-box riboswitch using tRNA-mRNA stacking and steric readout. Molecular Cell 55, 148-155.
  1. Zhang & Ferré-D’Amaré (2013) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature 500, 363-7.

The lab is part of the Earl Stadtman Investigator program for high-risk, high-impact research at the NIH intramural program consisting of 1100 labs. The well-supported lab has dedicated access to state-of-the-art equipment in structural biology (Mosquito, Dragonfly, Rock Imager, Akta Pures, FSEC, for X-ray crystallography; new Titan Krios for single-particle Cryo-EM; SAXS, AFM, etc), efficient biochemistry, biophysics (ITC, DSC, SPR, BLI, AUC, DLS, SEC-MALS, CD, fluorescence, thermophoresis, etc), fermentation, genomics, and proteomics core facilities with hands-on training or service by PhD-level staff scientists. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees through numerous courses and workshops offered by NIH OITE and FAES.

Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular or structural biology, biochemistry, or biophysics, and be strongly self-motivated to lead innovative and rigorous research projects. Strong background in protein expression and purification, enzyme kinetics, and structural biology is desirable.

To apply: Please email a preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: jinwei.zhang@nullnih.gov. The NIH is dedicated to building a diverse community and DHHS/NIH is an Equal Opportunity Employer.

Ph.D. Position in Molecular Mechanisms of Pre-mRNA Splicing, University of Evry, France

This Ph.D. project is funded for three years by a CIFRE contract between the SABNP laboratory (INSERM research unit UMR1204 http://sabnp.univ-evry.fr/?lang=en) at Evry University (near Paris and closed to the Genopole biocluster) and Synsight a company specialized in molecular modeling, bioinformatic and structural biology.

The Ph.D. laboratory work will be performed at the SABNP laboratory as part of a research program on pre-mRNA splicing and protein expression at the cellular and molecular levels. Based on a multidisciplinary approach, the SABNP laboratory notably explores the dynamics and structure of RNA/protein complexes. Novel technologies are also currently developed to explore cellular and molecular processes involved in gene expression regulation. This project is supervised by Pr. David Pastré and Dr. Alexandre Maucuer.
Additional information at http://sabnp.univ-evry.fr/?page_id=1170&lang=en

Candidate profile: Candidates should have a master 2 degree or equivalent in September 2017 and be highly motivated individuals with knowledge in molecular and cellular biology. French skills are not required if the candidate is fluent in English.

Interested candidates should send their application, including a CV and cover letter, detailing their motivation for this particular PhD project to lydia.lebouil@nulluniv-evry.fr.

The project will start around 1st October 2017.