Employment Opportunities

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Fully Funded Postdoctoral Position Working on Viral Epitranscriptomics

While it has been known for some time that both cellular and viral mRNAs are subject to post-transcriptional modifications that do not change their inherent coding capacity, the importance of these “epitranscriptomic” changes as regulators of gene expression has only recently come into focus. The most prevalent epitranscriptomic mark is addition of a methyl group to the N6 position of adenosine (m6A) and this modification is not only essential for embryonic viability and development in both plants and animals but also greatly influences viral replication, as documented in recent publications from this laboratory (1, 2) and discussed in more detail in a review from my group (3). We have also recently begun to investigate other epitranscriptomic marks found on viral RNAs, including m5C and 2’OMe. The field of viral epitranscriptomics, while clearly important for understanding viral gene regulation, is nevertheless currently at a very early stage of development. As a result, this area of research offers a tremendous opportunity for an ambitious individual to contribute to an emerging but clearly important area of research that they eventually will be able to take with them when they start their own research group. In the interim, the Cullen laboratory has a long record of high productivity (current ISI h index 105), is well funded and has a history of training post-docs, such as Michael Malim at King’s College, Paul Bieniasz at HHMI and, more recently, Rebecca Skalsky at OHSU, who have gone on to successful independent careers, many in academic research.

Candidates should be less than two years out from their Ph.D and should have documented expertise in the fields of virology and/or molecular biology. I will require three letters of reference and a copy of the applicant’s CV. Candidates must apply online at https://academicjobsonline.org/ajo/jobs/11295 to be considered.

  1. Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, Cullen BR. (2016) Posttranscriptional m6A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe; 19: 675-685.
  2. Courtney, David G., Kennedy, Edward M., Dumm, Rebekah E., Bogerd, Hal P., Tsai, Kevin, Heaton, Nicholas S. and Cullen, Bryan R. (2017) Epitranscriptomic enhancement of influenza A virus gene expression and replication. Cell Host & Microbe, 22: 377-386.
  3. Kennedy EM, Courtney DG, Tsai K, Cullen BR. (2017) Viral epitranscriptomics. Journal of Virology 91, e02263-16.

The Ke Lab at JAX – Two Post-Doc Positions

The Ke Lab has two postdoctoral associate openings (one in computational biology, and the other in RNA biology) at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in the fundamental mechanism of m6A RNA genomics; and regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation, Genes & Development 2015, 29:2037-53.)

The Ke Lab at JAX two Post-doc positions application website:
1) Computational Biology Postdoc: https://jax.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=221943&company_id=15987&version=2&source=ONLINE&JobOwner=968714&startflag=1

2) RNA Biology Postdoc:
https://jax.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=221616&company_id=15987&version=2&source=ONLINE&JobOwner=968714&startflag=1

Requirements for Computational Biology Postdoc:

The successful candidate will develop and apply computational methods for genomic data analyses, have novel opportunities at the intersection of algorithms, data interpretation, and experimental design in close collaboration with the experimental team in the lab.  A good publication record and excellent communication skills are essential. A PhD. in a quantitative area is required: computational biology, computer science, statistics, physics and/or applied math.  Programming in R, Python, Perl or C++ is desired, as well as experience in genomic dataset analysis and integration.

Requirements for RNA Biology Postdoc:

Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including computational biology, biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, or cancer biology.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA is a world leader in mammalian genetics.  JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health. JAX is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

Postdoctoral Fellow Position Available, Nelson Lau Lab, Dept of Biochemistry, Boston University School of Medicine

The Nelson Lau lab in the Dept of Biochemistry is looking for a candidate with a PhD and prior molecular biology and biochemistry experience, a record of publications, and some proficiency with bioinformatics. Skills with Drosophila fly genetics or mosquitoes will also be highly considered. Genomics and deep sequencing experience will also be a plus.

https://www.bumc.bu.edu/biochemistry/profiles/nelson-lau/

Our group studies basic gene regulation mechanisms by small RNAs and the RNA interference pathway in animals. Specifically, we are interested in dissecting the molecular mechanisms of RNAi in the control of viruses and transposons during animal aging and brain function.

Candidates should send a CV, list of publications, and arrange for three recommendation letters to be sent to me.

Email: nclau@nullbu.edu

Postdoc Position Available, Lab of Dr. Elizabeth Tran, Dept of Biochemistry at Purdue University

A postdoc position is available in the laboratory of Dr. Elizabeth Tran in the Department of Biochemistry at Purdue University to explore connections between RNA helicases and specific cancers that have been historically resistant to chemotherapies.  Interested applicants should have a Ph.D. in a related life science field with experience in human tissue culture, immunohistochemistry, and basic molecular biology techniques.  Mouse handling is a plus but not required.

Successful applicants will have the opportunity to work in a highly multidisciplinary laboratory and learn a diverse array of techniques from classic biochemistry to bioinformatics to cancer biology while working with a collaborative team of colleagues. The initial appointment is for one year with a minimum starting salary of $47,500 and benefits. Longer term funding is available for a minimum of two additional years with yearly raises commensurate with performance.

West Lafayette, Indiana is a wonderful community with a diverse population that has a low cost of living, high quality of life, and an exceptional public school system.

Interested applicants should send a cover letter, CV, and a list of the contact information for three references to Elizabeth Tran at ejtran@nullpurdue.edu.

Please visit www.TranLabRNA.com for more information.

Postdoc Position Available, Dept of Microbial Pathogenesis & Immunology, Texas A&M Health Science Center

A postdoctoral position is available in the Department of Microbial Pathogenesis and Immunology at Texas A&M Health Science Center to study post-transcriptional regulation of the innate immune response to bacterial infection.

We are looking for a motivated, hard-working researcher to join the NIH-funded lab of Drs. Kristin Patrick and Robert Watson. Our lab is uniquely positioned to pursue exciting biology at the host-pathogen interface, leveraging Dr. Patrick’s expertise in eukaryotic mRNA processing and Dr. Watson’s expertise in innate immunity and host-pathogen interactions. We have strong evidence that pre-mRNA splicing in a major regulatory node during the innate immune response to infection. We are interested in understanding how innate immune signaling influences splicing and how changes to the spliceosome (primarily at the level of post-translational modification of splicing regulatory proteins (SR/hnRNPs)) determine innate immune gene expression outcomes.

The position will require expertise in eukaryotic RNA biology with a skill set including, but not limited to: tissue culture, molecular biology techniques (cloning, RNA isolation, RT-qPCR, immunoprecipitation, western blotting, EMSA, ChIP/RIP), and fluorescent microscopy. Applicants with a background in pre-mRNA splicing/regulation of gene expression will receive additional consideration. This individual will be expected to independently conceive, troubleshoot and interpret experimental results while also working collaboratively in a dynamic, interactive environment.

Applicants should have a Ph.D. in Immunology, Genetics, Microbiology, Molecular Biology, Biochemistry, or a related field, outstanding interpersonal skills, a strong work ethic, and a passionate enthusiasm for host-pathogen interaction/innate immunity research.

Applicants should submit a cover letter, describing ones background and goals, a CV, and contact information for 3 references (at the end of your CV) to the URL below. Questions can be directed to the lab email at thewatsonlab.tamhsc@nullgmail.com. Position will remain open until it is filled. Start date is flexible. Visit our website for more info about the lab: www.thepatrickwatsonlab.com

Apply at: https://tamus.wd1.myworkdayjobs.com/TAMHSC_External/job/Bryan-TAMHSC/Postdoctoral-Research-Associate_R-008154

Postdoctoral Position to Investigate the Molecular Mechanisms of Regulation of Alternative pre-mRNA Splicing

A postdoctoral position is available to work on a Wellcome Trust funded project to investigate the molecular mechanisms of regulation of alternative pre-mRNA splicing in the group of Prof. Chris Smith (https://www.bioc.cam.ac.uk/research/uto/smithc).

The position will be based in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge. The project focuses on the mechanisms by which regulatory RNA binding proteins, such as PTBP1 and RBPMS control splicing complex assembly at regulated splice sites, and builds upon our recent discovery of RBPMS as a master splicing regulator that acts in smooth muscle cells. It will involve a range of biochemical, molecular, proteomic, biophysical, structural and single-molecule techniques based in the PI’s and collaborators labs. Candidates should have experience in two or more of the following areas: structural biology, biophysical analyses of protein-protein or protein-nucleic acid assemblies, molecular cell biology, pre-mRNA splicing/RNA biology, and bioinformatics.

The successful candidate will work in a research team comprising further post-doctoral researchers and Ph.D. students. They will need to have the initiative to work independently and as part of a team. The research will involve interaction with collaborators groups so good communication and interpersonal skills are required. In addition to carrying out research they will be expected to present research findings, contribute to writing manuscripts and supervise students in the laboratory.

The successful candidate will have a PhD or has recently submitted for a PhD.

Fixed-term: The funds for this post are available for 5 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/17208. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.

Interested candidates are welcome to make informal enquiries to cwjs1@nullcam.ac.uk

Any enquiries relating to the application process please contact the HR team – personnel@nullbioc.cam.ac.uk.

Postdoc Position Available in the Laboratory of Dr. Elizabeth Tran in the Department of Biochemistry at Purdue University

A postdoc position is available in the laboratory of Dr. Elizabeth Tran in the Department of Biochemistry at Purdue University to explore connections between RNA helicases and specific cancers that have been historically resistant to chemotherapies.  Interested applicants should have a Ph.D. in a related life science field with experience in human tissue culture, immunohistochemistry, and basic molecular biology techniques.  Mouse handling is a plus but not required.

Sucessful applicants will have the opportunity to work in a highly multidisciplinary laboratory and learn a diverse array of techniques from classic biochemistry to bioinformatics to cancer biology while working with a collaborative team of colleagues. The initial appointment is for one year with a minimum starting salary of $47,500 and benefits. Longer term funding is available for a minimum of two additional years with yearly raises commensurate with performance.

West Lafayette, Indiana is a wonderful community with a diverse population that has a low cost of living, high quality of life, and an exceptional public school system.

Interested applicants should send a cover letter, CV, and a list of the contact information for three references to Elizabeth Tran at ejtran@nullpurdue.edu.

Please visit www.TranLabRNA.com for more information.

Senior Postdoctoral Fellow in Bioinformatics within the UK Dementia Research Institute (DRI) at King’s College London

The Ruepp group is seeking to appoint a senior postdoctoral fellow in Bioinformatics within the UK Dementia Research Institute (DRI) at King’s College London. Funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK, the UK DRI is a national consortium focused on cutting-edge dementia research.

The post-holder will work within a friendly, productive and dynamic team of molecular biologists/biochemists/geneticists and contribute to the study of altered RNA metabolism in cellular and animal models of neurodegeneration using RNA-Seq and CLIP-Seq data. The successful candidate should hold a PhD in bioinformatics, computer science or a related field coupled with significant postdoctoral bioinformatics expertise. Bioinformaticians with experience in isoform-level analysis (mRNA splicing/processing) and/or in CLIP-Seq are strongly encouraged to apply.

The post is fixed-term for three years, start date ideally between 01. August to 01. October 2018 or upon mutual agreement.

All applications must be submitted online here: https://www.hirewire.co.uk/HE/1061247/MS_JobDetails.aspx?JobID=79293

Closing date is the 19th of July 2018

Postdoctoral Positions to study RNA-Mediated Stress Responses, Biology of tRNA-derived RNAs and RNA Granules

Postdoctoral positions are available to study RNA-mediated stress responses, biology of tRNA-derived RNAs and RNA Granules. We are seeking to recruit two new colleagues that will have joint appointment in the laboratories of Paul Anderson and Pavel Ivanov at the Brigham and Women’s Hospital and Harvard Medical School, Boston, USA. Positions are available immediately and supported by recently obtained NIH grants. Initial appoitments will be made for three years with the possibility of extension.

Our laboratories work at the cutting-edge of RNA biology and cell biology. We focus on two major overlapping topics. The first is investigating stress-induced adaptation of mRNA translation and functions of novel non-coding RNAs derived from tRNAs (so called stress-induced tRNA-derived RNAs, or tiRNAs) (see Yamasaki et al. J Cell Biol 2009; Ivanov et al. Mol Cell 2011; Ivanov et al. PNAS 2014; Lyons et al. NAR 2016; Lyons et al. Nature Communications 2017). The second is investigating Stress Granules, RNA granules with multiple functions in cellular physiology and pathophysiology (Kedersha et al. J Cell Biol 2016; Fay et al. Cell Reports 2017; Panas et al. J Cell Biol 2016; Aulas et al. J Cell Science 2016) . We employ diverse  RNA-based tools to illuminate the biological and biomedical significance of tiRNAs and Stress Granules.

Candidate requirements: A PhD degree (or equivalent) in the biological sciences or a closely related field. Previous experience in molecular and cell biology is necessary. Prior knowledge of basic RNA biology methodology is desired. Evidence of scholarly ability (record of publication in peer-reviewed journals, conference presentations, etc). The candidate is expected to have adequate writing skills, prepare and write research papers, conference presentations and research proposals. Two major requirements include the ability to work independently as well as in the team and a high level of motivation.

It is expected that high quality publications will result from this work.

Brigham and Women’s Hospital and Harvard Medical School  are  equal opportunity employers. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

Interested individuals should send a CV, names of three references, and a cover letter with a brief statement of future research interests and career goals to:

pivanov@nullrics.bwh.harvard.edu

Pavel Ivanov, PhD
Assistant Professor of Medicine / Associate Immunologist
Brigham and Women’s Hospital & Harvard Medical School

Two Postdoctoral Positions Available at the University of California, Davis

Two postdoctoral positions are available at the University of California, Davis to work on an interdisciplinary research grant within the Montpetit, Fraser, and Shah laboratories focused on positive-strand RNA viruses, including Zika, Dengue, and Hepatitis C. Research will involve investigating aspects of viral RNA transport, viral protein translation, and viral RNA interactions with host cell factors that are required for infection. Candidates with a strong research track record in virology, RNA biology, single molecule imaging, and/or computational biology with significant publications from their PhD are encouraged to apply. Positions will remain open until filled with start dates available August 2018. To apply, please email a single pdf containing a cover letter and CV with the contact information for three referees to benmontpetit@nullucdavis.edu.

For more information about being a Postdoctoral scholar at UC Davis visit https://grad.ucdavis.edu/postdoctoral.

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/dod4000376/NondiscrimAffirmAct.

RNA Editing and Genome Stability: Postdoctoral Positions Available

RNA Editing and Genome Stability: Postdoctoral positions are available to study the biology of RNA editing and the functions of ADAR (adenosine deaminase acting on RNA) (Nishikura 2010 Annu Rev Biochem 79: 321; Nishikura 201. Nat Rev Mol Cell Biol 17: 83).

ADARs are involved in adenosine-to-inosine editing of coding- and non-coding RNAs as well as microRNAs in the nucleus (Kawahara et al. 2007 Science 315: 1137).  In the cytoplasm, ADAR interacts with the RNAi mechanism (Ota et al 2103 Cell 153: 575) and regulates decay of a class of mRNAs required for stress response (Sakurai et al. 2017 Nat Struct Mol Biol 24: 534).

More recently we discovered that ADAR knockdown results in mitotic catastrophe, indicating that ADAR plays an important role in the maintenance of genome stability.

We are investigating the mechanism of this newly found ADAR function in regulation of genome stability and also its relation to the embryonic lethal phenotype of ADAR null mice.

Previous experience in molecular techniques, protein purification, fluorescent microscopy, bioinformatics as well as in the handling of gene knock-out mice is essential.

Persons who received their degree within the last two years and are able to take the position immediately and stay for at least 3 years are preferred.

Send a cover letter describing your research interests, curriculum vitae, and names of three references to: Dr. Kazuko Nishikura (https://wistar.org/our-scientists/kazuko-nishikura): The Wistar Institute, 3601 Spruce Street, Philadelphia, PA  19104. E-mail: kazuko@nullwistar.org.

Postdoctoral position in post-transcriptional regulation – Boston University School of Medicine

A funded postdoctoral position is available for immediate incorporation in the Cifuentes laboratory at Boston University School of Medicine for a talented and extremely motivated candidate willing to address fundamental questions in post-transcriptional regulation of RNA using zebrafish and viruses as model systems.

The long-term goals of the laboratory and the available projects involve:
i) to uncover the RNA-protein interactions and microRNA regulation networks using iCLIP and CRISPR mutagenesis, ii) to understand how these interactions regulate RNA at post-transcriptional level and finally, iii) to integrate mRNA methylation and epitranscriptomics into this regulatory framework.

To address these goals, the lab combines zebrafish microinjection together with powerful genetic, genomic, and proteomic approaches. We are located in a renovated lab space at Boston University School of Medicine in the Department of Biochemistry, with close access to scientific core facilities and immersed in the lively city of Boston.

Candidates should have a PhD, MD, or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important is their motivation to learn and adapt to scientific challenges and become positive members of the lab. The position is funded for at least three years, contingent on performance. Additional information can be found at: http://www.bumc.bu.edu/biochemistry/people/faculty/daniel-cifuentes/

To apply please send to Dr. Cifuentes a cover letter stating research interests and accomplishments, CV, and contact information for three references in a single PDF document by email to cifulab@nullbu.edu with the subject “Postdoc RNA BU”. Applications will be reviewed until position is filled.

Postdoctoral Position, Study RNA-Guided Genome Rearrangements, Columbia University, New York

Postdoctoral Position to study RNA-Guided Genome Rearrangements at Columbia University in the City of New York

Postdoctoral Research positions are available in our newly renovated lab overlooking the Hudson River in the Department of Biochemistry and Molecular Biophysics, with a research focus on Non-Coding RNA-Mediated Genome Rearrangement, Editing, Epigenetics, Chromatin, Genome Evolution, and Transposon Involvement.

Laura Landweber is seeking to hire postdoctoral researchers to study the mechanism of gene and genome unscrambling in the ciliate Oxytricha, particularly the role of long non-coding RNAs and piRNAs in this process.

Requirements:  PhD in molecular biology or relevant field. Strong experimental training, experience, and publications from the Ph.D., ability to work independently and creatively, as well as collaboratively and strong research and written/oral communication skills are necessary.

This is a one-year initial appointment with opportunity for renewal. Funding is available for longer. Please email Laura.Landweber@nullcolumbia.edu to apply. Include a cover letter, CV, statement of research interests and email addresses for three references. Application review will begin immediately; start date is flexible.

The Landweber lab has a strong commitment to diversity and to supporting its students, postdocs, and alumni at all career stages. Many lab alumni have gone on to receive tenure in academic positions or chosen other successful options. Conference participation is encouraged throughout the postdoc period, as part of training for a scientific career.

The Landweber lab is located at Columbia University Medical Center in the Department of Biochemistry & Molecular Biophysics, with joint appointments in Systems Biology and Biological Sciences on the Arts & Sciences campus. Housing assistance is available.

Email: Laura.Landweber@nullcolumbia.edu
URL: biology.columbia.edu/people/landweber

Postdoctoral Position Available, Laboratory of Dr. Colleen McHugh, Dept. of Chemistry & Biochemistry, University of California San Diego

A postdoctoral position is available in the laboratory of Dr. Colleen McHugh in the Department of Chemistry and Biochemistry at the University of California San Diego. The research for this position will focus on the functions of long non-coding RNAs in gene regulation and cancer progression.

Applicants should have a recent Ph.D. in biochemistry or a related field, and have demonstrated research productivity through primary publications in peer-reviewed journals. Research experience in RNA and/or protein structure and biochemistry is preferred, and human cell culture experience is a plus. The successful applicant will have excellent organizational and interpersonal skills and be highly motivated to work collaboratively with other lab members, including graduate and undergraduate students.

The initial appointment will be for one year. The minimum salary will be $48,000 with adjustments according to experience, based on the standard UC San Diego guidelines.

To apply, please email a single pdf containing the following items to c1mchugh@nullucsd.edu

(1)     Cover letter describing your experience and suitability for this position

(2)     Curriculum vitae

(3)     Contact information for three references

Include the subject line “Postdoc Position – your name” in the email. Consideration of applications will begin immediately and the position will remain open until filled.

UC San Diego is an Equal Opportunity/Affirmative Action Employer with a strong institutional commitment to excellence through diversity. All qualified applicants will receive consideration for employment without regard to gender, race, color, religion, sex, sexual orientation, national origin, disability, age, or protected veteran status.

Immagina Biotechnology s.r.l. is Seeking an Experienced Senior Scientist

Immagina Biotechnology s.r.l. is seeking an experienced senior scientist who is energetic, enthusiastic, and enjoys team working in a growing startup environment.

Skills:
Experience/PhD related to Biomedical or Biological Sciences; RNA-Seq, immunoblotting, cloning, genome editing and cell transfection.

Strong background in proteomics (SILAC or PUNCH-P) with hands-on expertise in mass spectrometry and relative data interpretation (e.g. HPLC, Maldi-MS, MS/MS, UPLC, UV).

Cell culture techniques: mouse and human cell maintenance and differentiation; Ability to work in a high-pace and dynamic scientific environment.

Excellent organizational and analytical skills; Excellent inter-personal and communication skills / ability to build good working relations; Proven ability to present and publish research data.

Proficiency in spoken and written English.

Happy to work together with, and supervise, other lab members.

Ideally, you should have considerable experience in experimentally investigating proteins, protein-RNA interactions, small molecules-RNA interaction. You will need to be able to develop sensible and creative methods to study ribosome/mRNA targeted small molecule activity. 1+ year contract. Salary net >1700 Euro/month. Start ASAP.

E-mail info@nullimmaginabiotech.com
URL www.immaginabiotech.com

Post-Doctoral Position Available – Maquat Lab, University of Rochester Medical Center

POST-DOCTORAL POSITION
LAB OF LYNNE MAQUAT, PhD
Director, Center for RNA Biology
Professor, Departments of Biochemistry & Biophysics and Oncology

A Post-Doctoral Position is open in the Maquat lab at the University of Rochester Medical Center in Rochester, NY. Applicants should hold a PhD or MD/PhD degree(s) and have expertise in molecular, cellular or structural biology to study one of a number of on-going projects, including but not limited to microRNA decay, FMRP function in Fragile X Syndrome, RNP structure, links between gene transcription/pre-mRNA processing/mRNA export/mRNA translation and decay, and post-transcriptional regulatory steps mediated by SINE-containing mRNAs and lncRNAs. A background in computational biology is a plus but not required, as is a background in structural biology.

Interested individuals should submit:

1)      a complete curriculum vitae,

2)      the names and email addresses of three references (applicants should state their relationship to each), and

3)      a description of RNA research experience, including experimental approaches and technologies with which the applicant has experience.

Successful applicants will join a very productive, interactive lab and a lively, supportive RNA community that consists of more than 25 labs spanning the University of Rochester Medical Center and the adjacent Colleges of Arts & Sciences and Engineering. The Maquat lab offers an outstanding research environment and excellent opportunities to collaborate with basic scientists and clinicians.

Please submit applications to:
Liz Leverenz at elizabeth_leverenz@nullurmc.rochester.edu

Maquat Lab: https://www.urmc.rochester.edu/labs/Maquat-Lab/
Center for RNA Biology: http://www.urmc.rochester.edu/rna-biology/

The University of Rochester is committed to diversity and equality in education and employment. EOE Minorities/Females/Protected Veterans/Disabled.

Post Doctoral Fellow or Research Associate (staff) – Bass Laboratory, Biochemistry Dept., University of Utah

The Bass Laboratory in the Biochemistry Department at the University of Utah seeks a postdoctoral fellow, or Research Associate (staff), to take a leadership role in designing, performing, and supervising biochemistry and molecular biology experiments involving double-stranded RNA binding proteins such as Dicer and ADAR.

The ideal candidate will be adept at, and interested in, acquiring mechanistic insight from results of biochemistry and molecular biology experiments. Experience in protein purification is required, and familiarity with baculovirus expression systems preferred. Previous experience in RNA biochemistry would be helpful. Experiments using biochemistry and molecular biology techniques will be the main focus, but opportunities to collaborate with structural biologists, and participate in experiments using C. elegans or mammalian cells may arise.

Responsibilities:

  • conduct independent research in collaboration with the Principle Investigator
  • design and purify customized RNA molecules
  • express and purify proteins
  • supervise and coordinate efficient laboratory maintenance and operation
  • supervise students and technical support
  • assist in writing reports, manuscripts and grants

Minimum Qualifications:

  • Ph.D. in biochemistry, molecular biology or related field
  • Previous research experience in protein purification and biochemistry techniques
  • Experience in keeping up with the scientific literature relating to ongoing projects
  • Experience in evaluating scientific literature towards the goal of identifying relevant techniques and protocols
  • Ability to work interactively on projects with a variety of researchers
  • Ability to articulate research design and results effectively with other researchers and trainees

Salary range: $48,000-$60,000 depending on experience

To apply, send your C.V. and names of three references to bbass@nullbiochem.utah.edu

If you will be at the RNA Society meeting in Berkeley, please introduce yourself to me.

Senior Research Associate Position Available – Eclipse BioInnovations Inc.

Eclipse BioInnovations Inc. is an RNA genomics service company spin-out from UC San Diego. Our founders are the leading experts in using RNA binding proteins to identify RNA genes and regulatory elements involved in many human diseases including neuromuscular disorders and cancer. Eclipse has also licensed and is developing new cutting edge genomics services and products in the fast growing field of Crispr and others related technologies.

Eclipse’s first product, eCLIP, is in strong demand from global biopharma and academic researchers seeking to identify and screen RNA binding elements to advance therapeutic, translational and basic drug discovery programs in a wide range of human diseases. We are currently seeking a highly motivated Senior Research Associate to join our growing team and who seeks the opportunity to be a key player in driving the growth and success of our new startup.

Candidates must have strong experience and demonstrated track record working with RNA. Consideration will also be given to those with strong stem cell laboratory experience.

Job responsibilities will include but not be limited to:

  • Plan, execute and analyze experiments under manager supervision, utilizing standard biochemical and molecular techniques
  • Examine data and preparing technical reports, summaries, protocols and quantitative analysis and ensuring experiments are well documented
  • Tracking and reporting of ongoing service contracts
  • Development, characterization and optimization of assay protocols and reagents
  • General lab tasks including ordering, organizing, and instrument maintenance

Requirements

  • BS/MS/PhD in Molecular/ Cell Biology or related discipline with 5+ years experience in an R&D laboratory; industry experience highly preferred.

Hands-on experience with the following specialties:

  • Standard biochemical and molecular biological procedures, with a particular emphasis on strong RNA isolation and handling experience, as well as western analysis, qPCR, transfection and gel electrophoresis
  • Specific experience in stem cell and stem cell culture techniques
  • General sterile cell culture techniques
  • Validation and design of new laboratory protocols
  • Excellent written and oral communication skills.
  • Attention to detail, proficient reasoning skills in experimental design, data analysis, statistical methods and experimental interpretation, resourcefulness and the ability to work independently in a fast paced team environment.

Preference will be given to candidates with the following additional hands-on experience:

  • Experience in high-throughput sequencing library preparation
  • Development of molecular biology research and reagent kits
  • Ability to run command-line analysis tools for basic data analysis

We offer competitive salary commensurate with candidate’s experience, and an excellent benefits package including medical, dental, vision and paid time leave.

Visit our website at www.eclipsebio.com to learn more about us.

Job Type: Full-time

Salary: $60,000.00 to $80,000.00/year

E-mail jobs@nulleclipsebio.com

Two Postdoctoral Fellow Positions Available – USC School of Pharmacy, Lab of Dr. Zhipeng Lu

Two postdoctoral positions are available in Dr. Zhipeng Lu lab at USC School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences. Our research is focused on “RNA machines” in living cells. We develop and apply novel technologies to understand the structures and functions of RNA molecules in basic cellular processes, with the ultimate goal of targeting human diseases, including genetic disorders, cancers and viral infections.

We have recently developed a new technology, PARIS (Psoralen Analysis of RNA Interactions and Structures), a crosslinking based method for high throughput mapping of RNA duplexes in living cells at single-molecule level with near base-pair resolution (Lu et al. 2016 Cell). These unique strengths allow direct determination of alternative conformations, long-range and complex structures and RNA-RNA interactions across the transcriptome. This work was featured on the cover of Cell and a video abstract “Get an Eye-full (Eiffel)” (https://www.youtube.com/watch?v=1GXibPeUUGQ). A more complete description of our science can be found at http://zhipenglulab.org.

Current projects in the lab span the development of new computational and chemical tools for the analysis of RNA structures and interactions, and application of these technologies to important problems in the RNA field. The questions that we are interested in include structural basis of mRNAs and noncoding RNAs in post-transcriptional regulation of gene expression, roles of RNA structures and interactions in human diseases, such as neurological disorders and RNA virus infections. We also welcome and support novel and unconventional ideas that are related to the current work in the lab.

Research in the Lu lab is highly interdisciplinary and collaborative. Postdocs are exposed to research questions and techniques in the forefront of various fields centered around RNA. This training environment is exceptionally valuable for individuals who are interested in pursuing careers in academia or scientific leadership positions in the pharmaceutical industry. The PI is fully committed to empowering trainees with the capabilities to fulfill their ambitions.

USC School of Pharmacy is located in Health Sciences Campus, immediately adjacent to the USC Keck School of Medicine and Caltech. This rich scientific environment provides unique research training opportunities, such as research seminars given by leaders in science from throughout the U.S. and abroad, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities.

Candidates should have a Ph.D. and/or an M.D. and less than three years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics, biochemistry, or chemical biology, as evidenced by publications. Experience in computational biology is highly valued. Starting date is flexible from October 2018, and funding is guaranteed for three years.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to zhipengluchina@nullgmail.com.

Postdoctoral Fellow Position – University of Colorado School of Medicine, Dept. Biochemistry and Molecular Genetics

The laboratory of Dr. Olivia S. Rissland seeks to hire a Postdoctoral Fellow to work on leading edge questions in RNA biology. Our lab is in the Department of Biochemistry and Molecular Genetics and part of the newly formed RNA Bioscience Initiative at the University of Colorado School of Medicine.

Our lab studies mRNA decay—its connections with translation, its role during early embryogenesis, and its evolution in eukaryotes. We have projects looking at how translation elongation can alter mRNA stability and others investigating how mRNA decay during early Drosophila development is controlled. The long-term goal of our research program is to understand the molecular mechanisms linking translation and mRNA decay, especially in the context of disease and early development. Our research program is at the intersection of molecular biology, bioinformatics, developmental biology, and evolutionary biology, and we are looking for scientists who think RNA is as cool as we do.

Candidates will be expected to plan and execute independent work, write and submit fellowship applications, assist in writing and publishing experimental results, and contribute towards the atmosphere and culture of the lab.

We are committed to fostering a diverse and inclusive work environment. We encourage applications from under-represented minorities, including women, individuals from disadvantaged backgrounds, under-represented racial or ethnic groups, and individuals with disabilities. We will make every effort to remove barriers to the success of the hired individual(s).

Qualifications:

A successful candidate is highly motivated, has scientific curiosity, has strong interpersonal skills, and will contribute to the collegial atmosphere of the laboratory and the department.

Minimum requirements:

  • PhD in biology-related field
  • Strong record of productivity as evidenced by peer-reviewed publications in internationally recognized English language journals
  • Excellent communication skills in the English language
  • Experience in molecular biology and cell culture techniques
  • Experience in computational biology techniques is preferred but not required

Salary Range:

Salary is commensurate with skills and experience, as well as NIH Guidelines.  The University of Colorado offers a full benefits package.  Information on University benefits programs, including eligibility, is located at www.cu.edu/employee-services.

Applications must contain the following and be submitted electronically via CUCareers

  • Curriculum vitae
  • Statement of past research (one page)
  • Statement of your interest in the lab’s research program and your long term plans (one page).
  • Contact information for three references
  • Start date availability

For further details please send an email to risslandlab@nullgmail.com.

Special Notices to Applicants:

The University of Colorado at Denver is committed to providing a safe and productive learning and living community.  To achieve that goal, we conduct background investigations for all final applicants being considered for employment.  Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. Alternative formats of this ad are available upon request for persons with disabilities.

Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references other than those listed in your application during the search process.

The University of Colorado is committed to diversity and equality in education and employment.