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Postdoctoral Position in the Gavis Lab at Princeton University

The Gavis Lab at Princeton University is seeking motivated post-doctoral candidates who are interested in working at the interface of RNA biology and developmental biology. We study post-transcriptional mechanisms that spatially control gene expression during development. Research opportunities are available to investigate the assembly of ribonucleoprotein granules and how they regulate the localization, translation, and stability of mRNAs for Drosophila germ cell and neuronal development. Approaches include high resolution microscopy, biochemistry, and genome level analyses, supported by the power of Drosophila genetics.

More information about current work in the Gavis Lab and our publications can be found at https://scholar.princeton.edu/gavislab.

Applicants must have a Ph.D., preferably with training in molecular biology, cell biology, biochemistry, or genetics. Candidates with computational biology skills are encouraged to apply.

Please submit a CV, a cover letter describing research interests and motivation for joining the lab, and contact information of three references to Liz Gavis at gavis@nullprinceton.edu.

Postdoctoral Fellow Position Available, Duke University Medical Center

POSTDOCTORAL FELLOW POSITION Starting JAN 1, 2020 to study RNA-protein and small molecule interactions, drug design and mechanism, Duke University Medical Center

The Agris Lab in the Department of Medicine at Duke University is seeking a full-time Postdoctoral fellow for research in antibiotic resistance, and type 2 diabetes. We are a new lab at Duke focused on a mechanistic understanding of RNAs that control function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development and RNA.

Under the general direction of the Principal Investigator, the Postdoctoral fellow will conduct cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein and small molecule interactions, and contribute to lab maintenance and organization.

MAJOR RESPONSIBILITIES:

  • Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.
  • Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.
  • Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.
  • Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).
  • Maintain a detailed laboratory notebook.
  • Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.
  • Help ensure general lab safety standards.
  • Perform miscellaneous job-related duties as assigned.

QUALIFICATIONS:

  • Bachelor’s degree and two years of job-related experience or equivalent combination of education and experience. Degree in Biochemistry, Chemistry, Molecular Biology, Bioengineering, or related field preferred.
  • Experience in a biochemical research laboratory.
  • Experience with molecular cloning and protein expression and purification methods. Experience with AKTA FPLC is a plus.
  • Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.
  • Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.
  • Ability to work both independently and as part of a team.
  • Enthusiasm to learn new techniques and take on new roles.
  • Excellent communication and organizational skills.

Enthusiastic, imaginative and dedicated RNA scientists wishing to join our research team will find that the RNA community of Duke and UNC is dynamic, diverse and supportive with a history of the longest regional RNA community, seminars, monthly meetings, separate RNA modification group and annual Symposium (https://sites.duke.edu/ncrna2019/).

Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references sent to Dr. Paul F. Agris (Paul.Agris@nullduke.edu). Informal inquires are welcome.

Full Professorship, RNA-based Infection Research, Germany

The Faculty of Medicine at the Julius Maximilians University of Würzburg and the Helmholtz Institute for RNA-based Infection Research (HIRI) jointly invite applications for a

Full Professorship (W3) in RNA-based Infection Research.

 The professorship is a permanent position to be filled at the earliest possible date. We seek to appoint a leading expert with an internationally visible research profile at the interface of RNA biology and infectious diseases research. At this point, we particularly welcome applications from experts on the function and dynamics of RNA molecules in the host or the pathogen during bacterial or viral infections, on RNA therapeutics approaches including the delivery of nucleic acids, and on RNA localization and RNA modification. In addition, we are interested in candidates who focus on emerging RNA-centric techniques such as single-cell RNA-seq.

The Helmholtz Institute for RNA-based Infection Research (HIRI) was established in May 2017 as joint venture between the Helmholtz Centre for Infection Research (HZI) Braunschweig and the Julius Maximilians University of Würzburg (JMU). Located on the Würzburg medical campus, it is the first research institution in the world to fully focus on the role of RNA in infection processes. HIRI also takes an integrative approach to exploit the vast potential of RNA as a diagnostic molecule, as a target or as a drug for new strategies to combat infectious diseases. The HIRI offers an international and vibrant scientific environment and state-of-the-art infrastructure for RNA and infection research. For further information, please visit www.helmholtz-hiri.de or send an email to Jörg Vogel, the founding director of the HIRI (joerg.vogel@nullhelmholtz-hiri.de).

The Helmholtz Society and the JMU seek to increase the number of women holding professorships and explicitly invite outstanding female scientists to apply.

Equally qualified applicants with disabilities will be given preference.

The legally binding German version of this announcement has been published in “DIE ZEIT” on August 29th, 2019. The advertisement is also available at www.med.uni-wuerzburg.de/fakultaet/berufungsverfahren/.

Please submit your application in English (or German) with the usual documentation (cover letter, signed curriculum vitae, copies of academic certificates and appointments, list of teaching activities including evaluations, list of publications, third-party funding) by October 1st, 2019. The application form can be downloaded at www.med.uniwuerzburg.de/fakultaet/berufungsverfahren/

Applications should be addressed to:

Professor Dr. M. Frosch
Dean of the Medical Faculty
University of Würzburg
Josef-Schneider-Straße 2 / Building D7
D-97080 Würzburg, Germany

NIH Funded Postdoc Position Available

NIH-funded postdoc position is available for two years with a strong possibility of extension, starting October 2019.

The laboratory represents two joined labs with diverse projects, a friendly and scientifically vibrant atmosphere, active staff and is ran by two young and active PIs:

https://som.rowan.edu/research/basicscience/cellbiology/facultybios/shcherbik.html

https://som.rowan.edu/research/basicscience/cellbiology/facultybios/pestov.html

Several lines of investigation are currently open to choose from:

1)      To understand the molecular alterations that occur on a ribosome during stress and to examine how modified ribosomes behave during translation in vitro and in cells. These projects might result in new supportive data on ribosome heterogeneity.

2)      To study effects of mitochondrial communication with translational apparatus (i.e. ribosomes) under different physiological settings.

3)      Co-translational protein quality control: does it work beyond 60S subunit?

4)      Investigation of ribosome degradation pathway.

Position requires a Ph.D. (or equivalent) in Molecular Biology or a related field. Preference will be given to candidates with the experience in yeast cell biology and/or biochemistry. Experience in high-throughput technologies (RNA-seq, ribosome profiling) is not necessary but highly desirable. The candidate must have a strong publication record, written and verbal communication skills, sound analytical and organizational skills, and ability to work independently as well as collaboratively.

The successful candidate will join an interactive environment of Rowan University School of Osteopathic Medicine (Rowan-SOM, the former University of Medicine and Dentistry of New Jersey, UMDNJ) with multiple laboratories investigating important questions in molecular/cellular biology utilizing yeast, worm and mammalian systems. The University offers state of the art facilities including Mass Spectroscopy, Next Generation sequencing, Microscopy facility. In addition, Rowan-SOM offers help in a future career planning/building, including teaching opportunities (if desirable), iJOBs seminars, Career Development Workshop and others.

Rowan-SOM is located in Stratford, a suburban south New Jersey community with an easy commute by train or car to Center City Philadelphia. This location combines and an affordable living environment, good school district, multiple child-care facilities. Due to close location to scientific hub of Philadelphia, Rowan-SOM gives the opportunity to collaborate with scientists at the University of Pennsylvania, Thomas Jefferson University, Temple University, Drexel University and the Fox Chase Cancer Center. To apply, please send a single pdf file, consisting of a one-page motivation letter, CV, publication list and the names and contact information of three references to Dr. Natalia Shcherbik at: shcherna@nullrowan.edu or nshcherb@nullgmail.com 

Post-doctoral Positions Available, Lyons Lab at Boston University School of Medicine

Post-doctoral positions are available in the Lyons Lab at Boston University School of Medicine. We are a new laboratory; thus, there are ample opportunities for motivated candidates to drive their research in a growing and dynamic environment. Our lab studies cellular stress responses and how cells modulate RNA processing and mRNA translation to promote survival. Perturbations to these pathways can result in devastating disease states. Cancer cells co-opt stress response pathways to promote their survival at the expense of surrounding cells. Alternatively, an ineffective response to cellular insults leads to cell death. Dysregulation of these pathways is particularly detrimental to long-lived cells or cells that have a reduced capacity for self-renewal. As a result, many neurodegenerative diseases result from conditions that alter responses to stress. Our lab is uncovering the molecular determinants of these pathways with an aim at treating disease.

We are actively hiring post-doctoral fellows to aid in the exploration of these topics, including:

  1. How is ribosomal RNA processing and modification altered during a stress response?
  2. How does alteration in ribosomal RNA processing/modification effect ribosome biogenesis or the production of specialized ribosomes?
  3. How do these alterations affect the phase-separated nature of the nucleolus?
  4. How do translation initiation factors promote non-canonical mechanisms of translation initiation during a stress response?
  5. How do non-canonical RNA structures drive cap-independent translation in response to stress?

For more information, visit our lab website: TheLyonsLab.com

Candidates with a background in RNA biology, biochemistry or cell biology are encouraged to apply. Approaches will utilize proteomics, high-throughput sequencing and CLIP, immunofluorescence and live imaging, classical biochemistry techniques, and any other techniques that the candidate can bring to the lab. The successful candidate will be encouraged to take on new challenges, learn new technologies, and promote their career by applying for fellowships to foster research independence for their future careers.

There are multiple positions available beginning on October 1st, although the start date is negotiable. Review of applications will begin immediately and continue until the positions are filled. Interested applicants should send a cover letter describing their interests and experience along with a C.V. to:

Shawn Lyons, Assistant Professor of Biochemistry, slyons1@nullbu.edu

Postdoctoral Position available, Institute of Genetics and Biotechnology, University of Warsaw, Poland

RNA biology Post-doc position in the in the RNA Metabolism Laboratory of Joanna Kufel to work on a project “Stress adaptation and regulation of gene expression in eukaryotic cells via alternative transcriptional and translational mechanisms”, carried out within the TEAM programme of the Foundation for Polish Science (4.4 SG OP).

Project description:

Global gene expression is subject to systematic reprogramming during cell cycle, development, metabolic changes, stress response and programmed cell death. These transitions, mediated at the transcriptional and postranscriptional levels, involve a massive flux of cellular RNAs and proteins. The major aim of this project is to establish connections between regulatory mechanisms that that use non-coding and coding properties of RNA molecules and orchestrate changes in gene expression programs during the response to physiological and stress-induced stimuli in eukaryotic cells. We focus on the following less-examined and alternative aspects of this regulation in a model eukaryotic organism yeast Saccharomyces cerevisiae: i) the impact of stress-induced antisense RNAs on transcription of genes encoding stress factors; ii) regulation of transcription and translation by stress-derived degradation products of stable structural RNAs; iii) the regulatory potential of short peptides encoded by stress-activated “non-coding” RNAs; iv) stress-induced changes in the expression of protein isoforms generated by non-canonical translation initiation. We will use both high-throughput (e.g. RNA-seq, ribosome profiling, peptidomics) and specific molecular biology approaches to analyse in detail the network of interactions between RNA molecules and proteins during the perception of aging and autophagy that integrate the response to nutrient deficiency

Requirements:

  • Recent Ph.D. degree in life sciences: molecular biology, genetics or related field (4 years or less after Ph.D.)
  • Prior experience in RNA and molecular biology techniques, inlcuding high-throughput approaches and/or proteomics
  • Competence in bio-informatics or aptitute to learn required skills
  • Good oral and written communication skills in English

Key responsibilities:

  • Planning and implementation of research in the designated part of the project
  • Data analysis and reporting
  • Presenting results at seminars and conferences
  • Writing scientific papers
  • Participation in laboratory everyday duties

The position is funded by the Foundation for Polish Science for 2.5-3 years, salary 115000 PLN pa.

Required documents:

  • CV with detailed description of research experience, list of publications and information about previous employment (if applicable)
  • Motivation letter
  • Copy of PhD diploma
  • Statement: “I give permission to the University of Warsaw, registered at the address of ul. Krakowskie Przedmieście 26/28, 00-927 Warszawa, to process my personal data for the purposes of carrying out the recruitment procedure, choosing the employee, and entering into an employment contract with the University of Warsaw, if applicable. I have been informed about my legal rights and obligations in relation to these actions. I acknowledge that providing the aforementioned personal data is done by me on a voluntary basis.” (can be added to the CV)
  • Contact details and e-mail addresses of two people willing to provide a reference letter on request

Application deadline 30th September 2019. Please apply via e-mail to kufel@nullibb.waw.pl. Informal inquiries and questions welcome.

Web pages:
www.igib.uw.edu.pl/index.php/start2/

www.biol.uw.edu.pl/pl/

Faculty Position, Dept of Biochemistry and Molecular Biology, Michigan State University

The Department of Biochemistry and Molecular Biology (http://bmb.natsci.msu.edu/) at Michigan State University seeks outstanding applicants for a tenure-track position at the Assistant/Associate level with expertise in cryo-electron microscopy (Cryo-EM) and the ability to develop a vigorous, externally funded research program that will complement existing strengths in the areas of structural, membrane protein, computational, biomedical, microbial, and plant biochemistry.  Michigan State University is building and committed to expand a state-of-the-art Cryo-EM facility.  We are currently operational with a Talos Arctica outfitted with a phase plate and Falcon 3 camera to support this research area. The successful candidates must hold a PhD, or equivalent, have a minimum of two years’ postdoctoral research experience, and will be expected to contribute to teaching at the undergraduate and/or graduate level.

Michigan State University is an affirmative action, equal-opportunity employer. The Department of Biochemistry and Molecular Biology and the University are committed to achieving excellence through diversity. The Department of Biochemistry and Molecular Biology and the University actively encourages applications from women, persons of color, veterans, and persons with disabilities. The University  endeavors to facilitate employment assistance for spouses or partners of candidates for faculty positions.

Candidates must hold a PhD, or equivalent, have a minimum of two years’ postdoctoral research experience, with expertise in cryo-electron microscopy (Cryo-EM)

Application materials should include a cover letter, curriculum vitae, statement of research accomplishments, a proposal for future research (up to five pages), a one-page teaching statement, and three letters of references. We request that letters from references are sent directly to BMB.Search@nullmsu.edu. The application materials should be combined into a single PDF file and must be uploaded electronically at http://careers.msu.edu/cw/en-us/job/497980/assistantassociate-professortenure-system.

Questions regarding the position may be directed to Dr. Charles Hoogstraten, hoogstr3@nullmsu.edu, or to Dr. Kristin Parent, Chair of the Search Committee (kparent@nullmsu.edu). Review of application materials will begin on October 1, 2019, and continue until the position has been filled.

Postdoctoral Position in Computational RNA Biology

A postdoctoral position is available for joint projects between the labs of Prof. Sally Assmann (sma3@nullpsu.edu) in Penn State’s Biology Department and Prof. Phil Bevilacqua (pcb5@nullpsu.edu) in Penn State’s Chemistry and Biochemistry and Molecular Biology Departments.

This position builds on the Structure-seq method that we developed to probe RNA structure genome-wide in vivo. We are applying Structure-seq and other genomic and transgenic methods to uncover RNA structure-function relationships in rice and Arabidopsis and their regulation by abiotic stressors. We seek an innovative computational post-doc who is proficient in coding (ideally in Python) and in the application of established bioinformatic tools for analysis of next-gen datasets. Candidates should have a background in either genomics or RNA structure. Experience in implementing machine learning algorithms would be a plus. Applicants should have a publication record in international peer-reviewed journals.

The successful candidate will have the opportunity to work creatively in a highly collaborative environment to develop new analytical tools for RNA structure analysis and will gain expertise in both biological and chemical aspects of RNA structure-function relationships. The successful candidate will be encouraged to apply for fellowships to foster research independence for their future career.

This position is available immediately, although the start date is negotiable. Interested applicants should send via e-mail a cover letter describing their interests and experience and a c.v., including names and e-mail addresses of three references, to:

Dr. Sally Assmann, Waller Professor of Biology, Penn State University (sma3@nullpsu.edu) or Dr. Phil Bevilacqua, Distinguished Professor of Chemistry (pcb5@nullpsu.edu). Review of applications will begin immediately and continue until the position is filled.

Penn State has large, vibrant, and collaborative groups of faculty in both plant and RNA biology. Penn State’s flagship University Park campus is situated in a community consistently rated as among the most livable small cities in the US.

More information on our research can be found in our publications and at our websites: http://www.personal.psu.edu/sma3/
https://sites.psu.edu/bevilacqua/

Su Z, Tang Y, Ritchey LE, Tack DC, Zhu M, Bevilacqua PC, Assmann SM. 2018. Genome-wide RNA structurome reprogramming by acute heat shock globally regulates mRNA abundance. PNAS. 115: 12170-12175. doi: 10.1073/pnas.1807988115

Tack DC, Tang Y, Ritchey LE, Assmann SM, Bevilacqua PC. 2018. StructureFold2: bringing chemical probing data into the computational fold of RNA structural analysis. Methods. pii: S1046-2023(17)30353-5. doi: 10.1016/j.ymeth.2018.01.018.

Bevilacqua PC, Ritchey L, Su Z, Assmann SM. 2016. Genome-wide analysis of RNA secondary structure. Annu. Rev. Genetics, 50: 235-266.

Tang Y, Bouvier E, Kwok CK, Ding Y, Nekrutenko A, Bevilacqua PC, Assmann SM. 2015. StructureFold: genome-wide RNA secondary structure mapping and reconstruction in vivo. Bioinformatics. pii: btv213.

Ding Y, Tang Y, Kwok CK, Zhang Y, Bevilacqua PC, Assmann SM. 2014. In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features. Nature. 505:696-700.

Research Assistant Position, Montreal Clinical Research Institute (IRCM)

The laboratory of Functional Genomics and Noncoding RNAs at the Montreal Clinical Research Institute (IRCM) is looking for a highly motivated and resourceful individual to fill the position of Research Assistant. The candidate will be part of a team studying noncoding regions of the genome to uncover new functional elements and understand how they contribute to human diseases. We are particularly interested in long noncoding RNAs (lncRNAs) and cis regulatory modules and use genome editing, genomics, molecular and bioinformatics approaches to characterize their function. The candidate will play a central role in the laboratory and help maintain a nurturing and stimulating environment.

Summary of Responsibilities

Under the direction of Dr. Martin Sauvageau, the candidate will be responsible to manage and help coordinate the day-to-day lab operations, order reagents, perform experiments and assist in training new lab members. The candidate will be expected to implement current technologies in ongoing research projects, adapt the technologies to new applications and ensure the quality of the data being produced. Additional tasks will be to carry out cloning, primary cell cultures, CRISPR genome editing, harvest tissues from animal models, help prepare samples and perform functional and biochemical assays, help identify and implement new approaches for solving relevant biological problems.

Major Responsibilities

  • Carry out molecular cloning, purification and expression of RNA and protein constructs
  • Work closely with Principal Investigator and Research Associate to help develop and carry out biochemical and functional assays to study RNA and protein function
  • Contribute to the development, implementation and optimization of lab protocols and organizational framework to create efficient lab workflows
  • Perform mouse genotyping and manage mouse colonies together with the mouse technician
  • Help with day-today lab operations (reagent preparation, instrument maintenance, ordering)
  • Maintain a detailed laboratory notebook
  • Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group
  • Help ensure and enforce lab safety standards
  • Perform miscellaneous job-related duties as assigned

 

Required Qualifications

  • MSc degree in the life sciences or BSc degree with at least 2-3 years of job-related experience
  • Strong molecular biology background
  • Experience in a molecular biology and/or biochemistry research lab
  • Experience in molecular cloning, RNA & Protein purification, cell culture
  • Knowledge/experience with standard biochemical and molecular biology assays. Experience with RNA-protein interactions is a plus
  • Knowledge/experience with quantitative analysis techniques for RNA and protein. Experience with next-generation sequencing and/or bioinformatic is a plus
  • Experience with mouse manipulation and experimental work is a plus
  • Excellent organizational and time management skills
  • Ability to multitask, set priorities, and thrive in a fast-paced environment
  • Excellent problem-solving skills
  • Effective communication skills
  • Critical thinking skills who excels at completing projects in an independent manner
  • Enthusiasm and is eager to acquire new knowledge and skills on a regular basis
  • Fluency in English (writing and speaking)

 

How to apply

Applicants should submit a one-page statement letter explaining why you’re interested in our work, a detailed CV and the names and contact information for 3 references to:

Dr. Martin Sauvageau

Director of the Functional Genomics and Noncoding RNA Laboratory

martin.sauvageau@nullircm.qc.ca

The applications will be examined as they are received, until the position is filled. Only those applicants selected for an interview will be contacted.

About IRCM

The Montreal Clinical Research Institute (IRCM) is an independent non-profit research institution with a dynamic and multi-disciplinary team of scientists working on a wide range of basic and clinical research subjects. Located in downtown Montreal, it is affiliated with the Université de Montréal and McGill University. The institute represents an excellent working environment, both in terms of the diversity of subjects and systems studied. The modern infrastructure of the IRCM houses state-of-the-art equipment and core facilities for a variety of applications in functional genomics, proteomics, imaging, flow cytometry, molecular biology and bioinformatics.

Positions Available – Postdoctoral Candidates with training/expertise in RNA/protein structural biology/biochemistry

The Messenger RNA Regulation and Decay Section, RNA Biology Laboratory (RBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), is seeking postdoctoral candidates with training/expertise in RNA/protein structural biology/biochemistry. Research experience in RNA biology or structural/biophysical techniques will be considered advantageous. Strong work ethic, excellent communication skills and ability to work in a multidisciplinary team are essential.

The focus of our research is to understand the mechanisms by which the function of messenger RNA is regulated. We are especially interested in exploring in molecular detail the processes of deadenylation and decapping as well as the connections in the metazoan 5´-to-3´ cytoplasmic degradation pathway. Recently, we have described the biochemical reconstitution of human CCR4-NOT deadenylation complex and uncovered new links between decay factors. The next stage will be to take structural approaches, especially high-resolution cryoEM, in combination with other biophysical techniques toward the study of the human mRNA decay machinery. Significant preliminary data has already been generated for several projects and candidates will join an established research program.

For high-resolution cryoEM, a Talos Arctica equipped with a K3 detector together with a Vitrobot plunger is available on site together with a Talos L120C for screening. Titan Krios microscopes are also locally accessible at dedicated facilities on the NIH campuses in Frederick and Bethesda. For crystallography, there is regular access to synchrotron beamlines at the Argonne National Laboratory. Automated crystallization platforms and automated imagers for crystal detection are available in the neighboring Structural Biophysics Laboratory. In addition, a biophysics core facility contains an array of instruments for biophysical characterization. High-performance computational resources including a GPU-enabled cluster are also provided. Further information about the core facilities can be found here: https://ostr.ccr.cancer.gov/resources/core.

For relevant recent publications please see: Raisch et al. (2019) Nature Communications, Chang et al. (2019) Nucleic Acids Research, Valkov et al. (2016) Nature Structural & Molecular Biology.

We are looking for enthusiastic, imaginative and dedicated scientists to join our research team working on exciting RNA structural biology projects. The NIH intramural program provides ample opportunities for advanced training to early-career scientists to develop valuable research and transferable skills. A vibrant and collegiate NIH community with diverse expertise in RNA, chemical and structural biology ensures a unique research environment with excellent collaborative opportunities. NIH offers a competitive salary and comprehensive health insurance as well as a host of other benefits. Candidates must have a doctoral degree or expect to receive their degree shortly. Appointments will be for one year initially and renewable for up to a maximum of 5 years.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation.

Applicants should send their CV and contact details for three references to Dr. Eugene Valkov: eugene.valkov@nullnih.gov. Informal inquiries are welcome. More information can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/eugene-valkov. The RNA Biology Laboratory is located on the Frederick campus of the National Cancer Institute in Maryland, U.S.A.

DHHS, NIH, and NCI are Equal Opportunity Employers

One Fellow Position for grad student in noncoding RNA-dependent control of adult neurogenesis

CB: 77386.

One Fellow position will be available from November 2019 in the “Neurobiology of miRNA” Research Line (https://www.iit.it/research/lines/neurobiology-of-mirna) to investigate the role of “noncoding RNAs in the regulation of adult neurogenesis. The project will focus on a novel class of small noncoding RNA with unknown function in mammalian neural stem cells in murine models.

Neurogenesis is the process of generation of new neurons from neural stem cells. This process results from the precise balance of quiescence/proliferation/differentiation. Proper regulation of this balance prevents tumor formation, allows brain development and maintains lifelong neurogenesis. Lab focus is the molecular control of neurogenesis in mammals focusing on small noncoding RNAs. Our research combines expertise in molecular and cellular biology, primary cultures of neurons, astrocytes and neural stem cells, animal models, imaging, behavior. We collaborate with the multidisciplinary staff of IIT (www.iit.it) having strong expertise on proteomics/metabolomics, bioinformatics, genomics, material science, imaging, neuro-pharmacology and neuro-electronics. Our lab is located in the IIT Central research labs in Genoa, Italy and provides state-of-the-art laboratory facilities.

Ideal candidate must be eligible to apply for a PhD (i.e., holding or being in the process of obtaining) a MSc in Biology, Biotechnology, Medicine or a related discipline; be highly motivated and creative individual who wants to work in a dynamic, multi-disciplinary research environment. Will be taken into consideration candidates with experience in the following techniques: Molecular biology/Biochemistry (e.g., RNA profiling and data analysis; Western blotting; RIP etc.) AND/OR Primary cell cultures preparation (including Nerve cells and iPSCs); AND/OR Histology/immunohistochemistry; AND/OR Imaging; AND/OR Handling/manipulation in vivo small lab animal models.

Prior experience in neuroscience is highly recommended. A good knowledge of the English language is a requisite. Successful applicants should also be willing to learn a variety of complementary techniques ranging from the transgene expression via genetic or acute manipulations (e.g., virus injection or electroporation), to Behavior.

Applications, including detailed Curriculum Vitae, publication list, research interest statement and name and contacts of 2 referees, has to be submitted using the online form.

Deadline: September 15, 2019

Link to the form: https://iit.taleo.net/careersection/ex/jobdetail.ftl?lang=en&job=1900000J

Istituto Italiano di Tecnologia, with its headquarters in Genoa, Italy, is a non-profit institution with the primary goal of creating and disseminating scientific knowledge and strengthening Italy’s technological competitiveness. IIT’s research endeavour focuses on high-tech and innovation, representing the forefront of technology with possible application from medicine to industry, computer science, robotics, life sciences and nanobiotechnologies.

Istituto Italiano di Tecnologia is an Equal Opportunity Employer that actively seeks diversity in the workforce.

Please note that the data that you provide will be used exclusively for the purpose of  professional profiles’ evaluation and selection, and in order to meet the requirements of Istituto Italiano di Tecnologia.

Your data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.

Please also note that, pursuant to articles 15 et. seq. of European Regulation no. 679/2016 (General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone +39 010 71781 – email: dpo[at]iit.it)

Scientist/Senior Scientist – Cell & Molecular Biology

Apply: https://bit.ly/31Ml8hI

Mission:
Flagship Labs 63 Inc. (FL63) is a privately held, well-funded, early-stage platform biotechnology company that is leveraging emerging insights in RNA biology to develop novel human therapeutics with a focus on mRNA translation and post-transcriptional RNA modifications.

FL63 was founded by Flagship Pioneering, an innovation enterprise that conceives, resources and grows first-in-category life science companies. The firm’s institutional innovation foundry, Flagship VentureLabs, is where teams of scientific entrepreneurs systematically evolve ideas and turn previously undiscovered areas of science into real-world ventures. Flagship manages >$2.4B in funds and has applied its hypothesis-driven innovation process to foster 75 scientific enterprises. These companies represent >$19B in aggregate value, have been issued 500+ patents, and have conducted >50 clinical trials for novel therapeutic agents. Flagship’s portfolio companies include Seres Therapeutics, Rubius Therapeutics, Moderna, Syros Pharmaceuticals, Axcella Health, Evelo Biosciences and Indigo Agriculture.

FL63 is a highly dynamic, entrepreneurial and innovation-driven organization seeking to hire an exceptional scientist to join our growing team. A successful candidate will have a Ph.D. in cell/molecular biology (or equivalent), an additional 3-5 years of relevant experience, and a proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. The candidate’s career goals, laboratory skills, and core competencies should be aligned with the description below.

Key Outcomes:
1. Design, execute, and interpret multiple experimental workflows including human cellular and molecular biology assays.
2. Internalize and develop novel technologies related to the company’s mission.
3. Continually cultivate scientific/technical expertise through critical review of the scientific literature, attending external conferences, and developing relationships with key opinion leaders.
4. Work effectively with a cross-functional biology, technology, and chemistry team to contribute to the vision, strategy, and tactics of the organization.
5. Willing to work hands-on in the wet lab for the first 1-3 years and to recruit/develop a team in 2-5 years.

Required Skills:
1. Strong cell biology background, especially the cultivation of suspension and adherent human cell lines.
2. Experience with quantitative cell analysis including cell viability, proliferation, cell cycle, migration/invasion, differentiation, colony formation, and cell signaling.
3. Background in the design and construction of mammalian expression constructs, transient transfection of plasmids/small RNAs, lentiviral packaging/transduction, and stable cell line production.
4. Knowledge of cell separation techniques (e.g FACS) and cell imaging techniques (e.g. immunofluorescence/FISH) using wide-field fluorescence and confocal microscopy.
5. Quantitation of protein and RNA levels using traditional (e.g. Western/northern blots, IP) and plate-based technologies (e.g. ELISA, qPCR)

Preferred Skills:
1. Exposure to complex cellular systems including primary cells, human ESC/iPSC-derived models, and 3D organoids.
2. Experience with viability- and FACS-based pooled shRNA/CRISPR screening and other massively parallel assay formats.
3. Hands-on experience with RNA-seq and Ribo-seq using the Illumina and/or Nanopore platforms as appropriate.
4. Knowledge of modern statistics-based experimental design methods including Design of Experiments (DoE) models.
5. Expertise in the field of RNA biology.

Core Competencies:
1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
3. Critical thinking and innovation. Learns quickly. Demonstrates ability to proficiently understand new information. Able to structure and process qualitative/quantitative data and draw insightful conclusions. Generates new and innovative approaches to problems.
4. Teamwork. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills.
5. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities.

Postdoctoral Position Available, Single Molecule Imaging Group, Professor David Rueda, at the MRC, London

The Single Molecule Imaging Group, led by Professor David Rueda, at the MRC London Institute of Medical Sciences (LMS), and the Department of Medicine at Imperial College London, is offering a 3-year Postdoctoral Position in Sigle Molecule Cell Biophysics.

We have recently developed a fluorgenic RNA (Mango) aptamer-based approach to image individual RNA molecules in live cells (Autour et al 2018 Nature Communications and Cawte et al 2019 in revision). We now seek a postdoctoral researcher to further exploit this technique to image various RNA processing mechanisms, such as gene expression, RNA splicing, RNA localization and RNA decay in live mammalian cells. Using this approach, we aim to elucidate the mechanisms regulating these RNA processing steps.

You must have a PhD (or equivalent experience), with a strong background in biophysics, quantitative biology or related disciplines. Candidates should be familiar with several of the following techniques: fluorescence microscopy, mammalian tissue culture, RNA transcription and processing, programming (e.g., python, Matlab, Labview, etc), image analysis (e.g. ImageJ) and quantitative data analysis. Equally important are outstanding creativity and enthusiasm for interdisciplinary science. Excellent English communication skills (spoken and in writing) are required.

Interestged individuals must apply online:

https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/1275

mRNA Biochemist (EU funded position) at Sixfold Bioscience, London (UK)

About us

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of Cell and Gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.

The opportunity

As an mRNA Biochemist you’ll have the opportunity to build a radically different approach to how we deliver mRNA in vivo. You’ll be applying your knowledge of RNA biochemistry to design and synthesise mRNA that works in harmony with Sixfold’s proprietary drug delivery systems. You’ll be utilising intra- and extra-cellular systems to ‘hack’ biology for more effective therapeutic potential.

We know this is a big challenge, which is why you’ll be working in close collaboration with our multidisciplinary team of chemists, biologists and computational scientists. You’ll become familiar with areas of science and preclinical research you might not be typically exposed to. As we work towards our common goal you’ll see how teams function as part of a rapidly growing startup.

Your work will make invaluable contributions to the scientific and strategic direction of the company, which is why we will give you all the support to help achieve your goals. Oh, and being funded by a prestigious Horizon 2020 Innovation Associate grant from the European Commission means you’ll gain access to additional financial support to develop your skills and build your network!

During the first year, you’ll

  • Lead the development and optimisation of mRNA for therapeutic use including considerations of stability and translational efficiency.
  • Establish innovative chemistries for increasing the potential of Sixfold’d drug delivery systems for mRNA delivery.
  • Design and execute robust experiments, interpret data, communicate findings, and maintain high-quality records.
  • [Optional] Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).

Who you are

You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who is:

  • Awarded or soon-to-be-awarded with a PhD degree in RNA (Bio)chemistry or equivalent scientific discipline.
  • Strong background in mRNA translational control and RNA processing.

Perks

  • €58,000-62,000 gross annual salary.
  • 12 month full-time position.
  • €4,000 relocation package (e.g. removals, travel costs, family travel costs, visa costs).
  • €5,500 for training and conferences.
  • Participation at a European Commission kick-off meeting in Brussels

Other perks

  • Possibility of full time employment following the 1 year Horizon 2020 Innovation Associate program, including employee stock options.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • Inclusive company culture.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Team-wide social events.
  • 25 days paid vacation (not including bank holidays)

Application process

The application process consists of the following:

  1. September 1st at 11:59pm: Applications close.
  2. September 2nd: Shortlisted candidates notified.
  3. September 2-5th: Skills-based challenge for Shortlisted candidates (remote).
  4. September 6th: Candidates invited to interview.
  5. September 9-11th: Interviews (via Skype).
  6. October 15th: Start date.

Eligibility

  • Awarded or soon-to-be-awarded with a PhD
  • To have resided or carried out your main activity in the UK for no more than 12 months in the previous 3 years.

Further Information

Should you have any questions, please email careers@nullsixfold.bio

Apply here: http://bit.ly/H2020-RNA

Visit our website: https://www.sixfold.bio/

 

 

 

Computational Engineering of Nucleic Acid Nanostructures (EU funded position) at Sixfold Bioscience, London (UK)

About Sixfold Bioscience

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of Cell and Gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.

The opportunity

As an RNA nanotechnologist you’ll have the opportunity to radically improve how we deliver Cell and Gene therapeutics. You’ll learn how to use computational methods to build advanced functionalities into our drug delivery systems to improve both safety and efficacy. You’ll be working in-sync with intra- and extra-cellular systems to ‘hack’ biology for more effective RNA based therapeutics.

We know this is a big challenge, which is why you’ll be working in close collaboration with our multidisciplinary team of chemists, biologists and computational scientists. You’ll become familiar with areas of science you might not be typically exposed to. As we work towards our common goal you’ll see how teams function as part of a rapidly growing startup.

Your work will make invaluable contributions to the scientific and strategic direction of the company, which is why we will give you all the support to help achieve your goals. Oh, and being funded by a prestigious Horizon 2020 Innovation Associate grant from the European Commission means you’ll gain access to additional financial support to develop your skills and build your network!

During the first year, you’ll

  • Apply computational techniques to adapt and optimize Sixfold’s proprietary oligonucleotide delivery systems for therapeutic cargo.
  • Utilise your computational background for the modelling and simulation of RNA.
  • Work in collaboration with our chemistry and computational teams to improve the speed and accuracy of RNA software.
  • [Optional] Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).

Who you are

You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who is:

  • Awarded or soon-to-be-awarded with a PhD degree in either Biophysics, RNA Nanotechnology, DNA nanotechnology, Computational (Bio)Chemistry or equivalent scientific discipline.
  • Familiar with RNA nanotechnology software, such as: Murlet, RNAbuild, Revolvr, Ligate, Trace, Nupack, RiboSketch, Hyperfold, MPGAfold, KNetFold, NanoTiler, RNA2D3D and StructureLab.

Perks

  • €58-62,000 gross annual salary.
  • 12 month full-time position.
  • €4,000 relocation package (e.g. removals, travel costs, family travel costs, visa costs).
  • €5,500 for training and conferences.
  • Participation at a European Commission kick-off meeting in Brussels

Other perks

  • Possibility of full time employment following the 1 year Horizon 2020 Innovation Associate program, including employee stock options.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Team-wide social events.
  • 25 days paid vacation (not including bank holidays)

Application process

The application process consists of the following:

  1. September 1st at 11:59pm: Applications close.
  2. September 2nd: Shortlisted candidates notified.
  3. September 2-5th: Skills-based challenge for Shortlisted candidates (remote).
  4. September 6th: Candidates invited to interview.
  5. September 9-11th: Interviews (via Skype).
  6. October 15th: Start date.

Eligibility

  • Awarded or soon-to-be-awarded with a PhD
  • To have resided or carried out your main activity in the UK for no more than 12 months in the previous 3 years.
  • Be able to relocate to London.

Further Information

Should you have any questions, please email careers@nullsixfold.bio

Apply here: http://bit.ly/H2020-RNA

Visit our website: https://www.sixfold.bio/

Postdoctoral Position Available, Newly Established Group of Dr Lovorka Stojic, London

A postdoctoral position is available in a newly established group of Dr Lovorka Stojic at the Barts Cancer Institute in London to work on the role of long noncoding RNAs (lncRNAs) in genome stability and cancer.

The project is aimed at identifying mechanisms by which specific lncRNAs safeguard genome integrity and determine the contribution of lncRNA dysregulation to genome instability in cancer. Using cutting-edge quantitative proteomics, genomics and imaging, we aim to functionally dissect a subset of lncRNA genes, in order to identify lncRNA molecular interactors and examine their functional relevance in pathways governing genome stability.

This project is based on our prevoius work, mainly: Stojic et al., NAR, 2018; Stojic et al., bioRxiv, 2019.

For more information about the lab, please visit stojiclab.com.

Skils required: PhD in biology or related life science field. Significant laboratory experience in cell and molecular biology is essential. Experience in the field of RNA biology, genomics and bioinformatics is strongly desired.

Interested candidates should send their CV, cover letter and the names of three referees to

lovorka.stojic@nullcruk.cam.ac.uk

Deadline: 31st September 2019.

Earliest start date: 1st November 2019.

Duration: 3 years

About the Institute please visit www.bartscancer.london and www.bci.qmul.ac.uk

 

Research Technician / Research Associate Position Available, University of Delaware

Research Technician / Research Associate position available to study RNA-protein interactions and mechanism, University of Delaware

The Mugridge Lab (mugridgelab.org) in the Department of Chemistry & Biochemistry at the University of Delaware is seeking a full-time Research Associate I to join our team. We are a new lab at UD focused on a mechanistic understanding of enzymes that control RNA function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development.

Under the general direction of the Principal Investigator, the Research Associate I will carry out cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein interactions, and contribute to lab maintenance and organization. This is an exciting opportunity for a motivated BS or MS level scientist to help build a new lab, generate data for publication, and take on diverse techniques and roles.

MAJOR RESPONSIBILITIES:

  • Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.
  • Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.
  • Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.
  • Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).
  • Maintain a detailed laboratory notebook.
  • Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.
  • Help ensure general lab safety standards.
  • Perform miscellaneous job-related duties as assigned.

QUALIFICATIONS:

  • Bachelor’s degree and two years of job-related experience or equivalent combination of education and experience. Degree in Biochemistry, Chemistry, Molecular Biology, Bioengineering, or related field preferred.
  • Experience in a biochemical research laboratory.
  • Experience with molecular cloning and protein expression and purification methods. Experience with AKTA FPLC is a plus.
  • Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.
  • Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.
  • Ability to work both independently and as part of a team.
  • Enthusiasm to learn new techniques and take on new roles.
  • Excellent communication and organizational skills.

Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references.

APPLY HERE: https://careers.udel.edu/cw/en-us/job/494198/research-associate-i-chemistry-biochemistry

Postdoctoral Fellow Position Available, RNA Modification and Function, University of Delaware

Postdoctoral Fellow position available to develop new tools to study RNA modification and function, University of Delaware

The Mugridge lab (mugridgelab.org) in the Department of Chemistry & Biochemistry at the University of Delaware is seeking a postdoctoral fellow to join our team. We are a new lab focused on a mechanistic understanding of enzymes that control RNA function and impact human disease. In particular, we are interested in understanding how diverse chemical modifications on RNA, which affect RNA structure, processing, translation, and stability, regulate gene expression. We are looking for an enthusiastic, self-motivated postdoc to engage in a project developing new tools to study RNA modification biology and RNA-modifying enzymes.

The ideal candidate will have a PhD in chemistry, biochemistry, synthetic biology, or a related field, and have experience with protein engineering, in vitro aptamer selection, or chemical biology approaches. Candidates with experience in structural biology or molecular biology with interests in protein-nucleic acid interactions and/or RNA modification biology are also encouraged to apply. The successful applicant will have a strong scientific record, excellent communication skills, ability to work independently and as part of team, and willingness to help mentor junior scientists. This is an exciting opportunity to develop new tools to study RNA biology, apply these tools to study RNA function and/or RNA-modifying enzymes, and contribute to growing and steering the scientific directions of a new lab.

Applications should consist one page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references.

APPLY HERE: https://careers.udel.edu/cw/en-us/job/494158/post-doctoral-fellow-chemistry-biochemistry

Two Post-Doc Positions Available, The Ke Lab, Jackson Laboratory

The Ke Lab at The Jackson Laboratory with two Post-doc postings online:

1) Computational Biology Postdoc:

https://careers-jax.icims.com/jobs/25557/postdoctoral-associate—ke-lab/job

2) RNA Biology Postdoc:

https://careers-jax.icims.com/jobs/25230/postdoctoral-associate—ke-lab/job

The Laboratory of Dr. Shengdong Ke has two postdoctoral associate openings (one in RNA biology, and the other in computational biology) at The Jackson Laboratory in Bar Harbor, Maine. The Ke Lab focuses on RNA, a central node of genetic information flow from DNA to protein (https://www.jax.org/research-and-faculty/faculty/shengdong-ke). Malfunction of RNAs leads to many human diseases, including neurological diseases and cancer. To thoroughly address fundamental molecular mechanisms of RNA genomics, the Ke lab utilizes multidisciplinary approaches, including computational biology, biochemistry, innovative biotechnologies, genetics and molecular biology. We are especially interested in the fundamental mechanism of m6A RNA genomics; and regulation of m6A RNA genomics in neurological disease and cancer, using mouse and human iPS models. (References: 1] Ke, S. et al. m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover, Genes & Development 2017, 31: 990-1006; 2] Ke, S. et al. A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation, Genes & Development 2015, 29:2037-53.)

Requirements for Computational Biology Postdoc:

The successful candidate will develop and apply computational methods for genomic data analyses, have novel opportunities at the intersection of algorithms, data interpretation, and experimental design in close collaboration with the experimental team in the lab.  A good publication record and excellent communication skills are essential. A PhD. in a quantitative area is required: computational biology, computer science, statistics, physics and/or applied math.  Programming in Python, Perl, R or C++ is desired, as well as experience in genomic dataset analysis and integration.

Requirements for RNA Biology Postdoc:

Qualified candidates will be self-motivated and career oriented individuals, have a genuine interest in addressing complex biological questions, and have a Ph.D. or MD. degree with background in one of the following areas, including biochemistry, molecular biology, biotechnology, neurosciences, immunology, stem cell, cancer biology or computational biology. Biochemistry and/or computational background and interest is a plus.

The Jackson Laboratory (http://www.jax.org) in Bar Harbor, Maine, USA is a world leader in mammalian genetics.  JAX is passionate about its mission of discovering precise genomic solutions for disease and empowering the global biomedical community in the shared quest to improve human health. JAX is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.

Research/Laboratory Manager, Research Group of Steven Brenner, University of California, Berkeley

About Berkeley

The University of California, Berkeley, is one of the world’s most iconic teaching and research institutions. Since 1868, Berkeley has fueled a perpetual renaissance, generating unparalleled intellectual, economic and social value in California, the United States and the world. Berkeley’s culture of openness, freedom and acceptance—academic and artistic, political and cultural—make it a very special place for students, faculty and staff.

Berkeley is committed to hiring and developing staff who want to work in a high performing culture that supports the outstanding work of our faculty and students. In deciding whether to apply for a staff position at Berkeley, candidates are strongly encouraged to consider the alignment of the Berkeley Workplace Culture with their potential for success at http://jobs.berkeley.edu/why-berkeley.html.

Application Review Date

The First Review Date for this job is: July 30, 2019

Position will remain open until filled.

Departmental Overview

The Brenner research group is an interdisciplinary research group, at the University of California, Berkeley. Our research has implications for diseases from cancer to Crohn’s Disease, and the future of personalized medicine for all people. We have a dozen members ranging from undergraduates to senior researchers and the research group provides a dynamic, occasionally demanding, flexible, and supportive work environment. We are associated with the Department of Plant and Microbial Biology, the Department of Molecular and Cell Biology, the Department of Bioengineering, the Center for Computational Biology, and the Institute for Quantitative Bioscience at the University of California Berkeley. We are also affiliated with Lawrence Berkeley National Lab and the University of California, San Francisco. We have collaborations with researchers worldwide.

Responsibilities

The Brenner computational genomics research group is seeking a Research / Laboratory Manager. The Research / Laboratory Manager will play a key role in facilitating effective laboratory operations and research efforts for a cutting-edge genomics, computational biology, and bioinformatics research group.

*   Day-to-day management and requisition of laboratory materials and supplies, organization and maintenance of chemical and lab equipment inventories, and upkeep of the common laboratory including space safety procedures/protocols including for collaborative programs.

*   Routine information management, interfacing with department and service structures, outreach and website production, calendar maintenance, travel coordination, management of correspondence, and meeting schedules and retreats, including for collaborative programs.

*   Learn and employ standard laboratory and program management tasks including procurement and reimbursement, personnel appointments, and budget and grant preparation, management, review and reporting including for collaborative programs.

*   Production of weekly reports and recording of information in standardized forms.

*   Supervision of one or more undergraduate assistant(s) to perform routine tasks.

*   Depending on skills, preparation of reagents and buffers; equipment maintenance; scientific software development and graphics; editing of research papers and grant proposals.

Required Qualifications

*   Excellent facility with all components of the Microsoft Office family and Adobe Creative Suite.

*   Able to work effectively with and respond to collaborators and other lab members and meet their needs.

*   Excellent organizational skills and attention to detail.

*   Ability to prioritize tasks and work independently.

*   Demonstrated fluent and facile command of written and spoken English.

*   Overtime may be required for this position; limited travel might be required.

Preferred Qualifications

*   Previous experience using and maintaining standard molecular biology equipment such as PCR machines, microplate readers, and chemical inventories.

*   Previous experience with scientific data analysis and/or visualization, software development, script writing and web site development.

*   Authorship of published scientific papers, and scientific poster presentation experience.

Salary & Benefits

For information on the comprehensive benefits package offered by the University visit:

http://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

How to Apply

Please submit your cover letter and resume as a single attachment through the UC Berkeley job site: https://jobsprod.is.berkeley.edu/psp/jobsprod/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_CE.GBL?Page=HRS_CE_JOB_DTL&Action=A&JobOpeningId=27300&SiteId=1&PostingSeq=1

Equal Employment Opportunity

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see: http://www.eeoc.gov/employers/upload/poster_screen_reader_optimized.pdf

For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct