Employment Opportunities

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Post Doc Opportunities, Ditlev E. Brodersen Lab, Aarhus University, Denmark

Post doc opportunities are available in the Ditlev E. Brodersen lab at Aarhus University, Denmark, to work on structural and functional aspects of microbial defence mechanisms, including ribonuclease toxins, transcriptional regulation og toxin-antitoxin modules, and the interplay between toxin-antitoxin modules and CRISPR-Cas in bacteria and archaea. Candidates must have previous hands-on experience with either x-ray crystallography or cryo-electron microscopy.

Start date: 1 Oct 2018, or later as agreed.

Duration: Initially 1 year, but with possibility of extension

To apply, send a cover letter with your motivation and include a CV to Ditlev Brodersen (deb@nullmbg.au.dk).

Postdoctoral Associate Position in RNA Biology

The Kiledjian laboratory in the Dept. Cell Biology & Neuroscience at Rutgers University is seeking outstanding postdoctoral associates to study the regulation of RNA turnover in the control of gene expression. The laboratory is interested in understanding the molecular mechanism by which 5´ end cap epitranscriptomic modifications such as a nicotinamide adenine diphosphate (NAD) cap (see Jiao et al., 2017 Cell) or m6Am cap (see Mauer et al., 2017 Nature) regulate RNA levels and gene expression. Other areas of investigation include the role of decapping proteins in human cognitive disability. Please refer to the Kiledjian Lab web page (https://cbn.rutgers.edu/kiledjian-lab-home) for more information on research areas of interest in the lab.

We are seeking highly motivated candidates with a Ph.D. in molecular/cellular biology or a related discipline with good communications skills and a publication track record in peer reviewed journals.  Preference will be given to applicants with research experience in the areas of post-transcriptional gene regulation, RNA metabolism and computational biology.

Interested individuals should apply be email (Kiledjian@nullbiology.rutgers.edu) to Mike Kiledjian, Ph.D., and include a cover letter describing interests and past accomplishments, a current curriculum vitae, and contact information for three references.

Postdoc position in Bioinformatic and transcriptomic analysis and detection of non-coding RNA in bacteria

A two-year Postdoc position is available in the bioinformatics group (http://ivh.ku.dk/bioinformatics), Center for non-coding RNA in Technology and Health (RTH), (http://rth.dk) at Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences at University of Copenhagen. The Postdoc position in Bioinformatic and transcriptomic analysis and detection of non-coding RNA in bacteria is available from 1 October 2018 or as soon as possible thereafter.

Information about the department can be found at http://ivh.ku.dk/english/.

As a team player working with great excitement you will be a key person in the project. The Postdoc position is part of the NextProd project (http://nextprod.dk), which aims to discover non-coding and structured RNA (ncRNA) that can affect the yield of cell factories. The NextProd project is supported by Innovation Fund Denmark.

Background

Cell factories are based on organisms, which have been carefully optimised to produce protein-based products such as enzymes and pharmaceutical proteins with the highest possible yield. However, current technology is saturated with respect to yield improvement although the theoretical maximum has not yet been reached. Within the NextProd project, the goal is to improve the yield by manipulating ncRNAs.

Job description

Transcriptomic data sets from relevant strains of the model cell-factory Bacillus subtilis will be used as outset for identification of ncRNAs, their expression, RNA structure and potential RNA-RNA interactions. An integrated workflow will be established including both known tools and tools developed on demand when relevant. The work involves interfacing and updating a genome browser framework with transcriptomics data, visualization results and gene associations. The work will be combined with further experimental analysis of candidates from the project collaborators.

Required qualifications and selection criteria

The applicant should hold the professional as well as personal skills and qualifications as stated below:

  • A completed PhD degree in bioinformatics, systems biology, computer science or in a similar area
  • General background knowledge of biological areas of genome structure and transcriptomes
  • Solid experience with transcriptome analysis
  • Experience with gene network and pathway analysis
  • Algorithmic insight broad and for RNA 2D structure and RNA-RNA interactions
  • Strong experience with script languages such as Perl or Python (or similar)
  • Strong experience with the Linux/Unix environment, command lines and shell scripting
  • Familiarity or experience in at least one of the following programming languages: C, C++ or Java
  • Good interpersonal skills
  • Excellent in English both in writing and speech

Candidates fulfilling one or more of the following qualifications will be prioritised:

  • Experience with transcriptomic data in bacteria
  • Strong experience in at least one of the following programming languages: C, C++ or Java

It is recommended that the applicant address the qualification requirements one by one in the cover letter.

Terms of employment

Salary and other terms and conditions of appointment are set in accordance with the Agreement between the Ministry of Finance and AC (Danish Confederation of Professional Associations) or other relevant professional organizations. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013.

The gross basic salary range for Postdoctoral Fellows is DKK 33,224 to DKK 34,980 per month (level 6 to 8). To the basic salary, a supplement could be negotiated, dependent on the candidate’s experience and qualifications. An additional 17.1 % monthly contribution to pension will be paid by the employer. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark for the last 10 years.

The position is limited to a two-year period.

Place of employment

RTH is located on the Frederiksberg Campus; however, as part of the NextProd project research visits with project partners or collaborators will be a part of the Postdoc employment. Our research environment is highly international and stimulating. We frequently organise seminars, workshops, PhD summer schools with international speakers and have retreats with our international collaborators.

Questions

For further information about the scientific content of the position please contact Professor Jan Gorodkin, email gorodkin@nullsund.ku.dk, phone +45 2337 5667 or for application procedure and formalities please contact HR, email sund-hr-ivh@nullsund.ku.dk.

Application procedure

Apply by going to the UCPH website: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=147905&DepartmentId=19008&MediaId=5

Please note that only online applications will be accepted.

Applications – in English – must include:

Cover letter detailing your motivation and background for applying for the specific Postdoc project

  •  CV
  • Diploma and detailed transcripts of records
  • Other information for consideration, e.g. list of publications, peer reviewed and other
  • Personal Recommendations (if any)
  • A maximum of 3 relevant scientific works which the applicant wishes to be included in the assessment

The deadline for applications is 17 September 2018. Any applications received after this time or incomplete will not be considered.

Receipts of the applications will be acknowledged, and the applicant will be kept continuously informed of the progress of the application.

The further process

Shortlist: After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself. You can read about the recruitment process at http://employment.ku.dk.

Assessment: The selected applications will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritised assessment of the academic qualifications and experience with respect to the mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Please note that the applicant will be contacted if the assessment committee requires further documentation.

All applications must be submitted via the University of Copenhagen’s website: https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1307&ProjectId=147905&DepartmentId=19008&MediaId=5

University of Colorado School of Medicine, Dept of Biochemistry and Molecular Genetics, Anschutz Medical Campus, Aurora, Colorado

The University of Colorado School of Medicine invites nominations and applications for the position of Chair of the Department of Biochemistry and Molecular Genetics.

The Department of Biochemistry and Molecular Genetics has 22 primary faculty located on the Anschutz Medical Campus in Aurora. The department has an international reputation for research excellence,  state-of-the art resources, a highly interactive and collaborative culture, and outstanding training programs.

The Department had an annual budget of $17.5 million, approximately 45 percent of which is derived from competitive extramural grants. Research in the department is built on a foundation of innovation and excellence, with strength in RNA biology, structural biology and biochemistry, cancer research, genomics, yeast genetics and molecular biology.   Department of Biochemistry and Molecular Genetics faculty participate extensively in medical and graduate student education and postdoctoral training.

The University of Colorado Anschutz Medical Campus, one of four campuses in the University of Colorado System, is the major academic medical center in the Rocky Mountain region, and one of the largest and most comprehensive biomedical research and clinical care centers in the western United States. The Anschutz Medical Campus is home to a NCI-designated Comprehensive Cancer Center as well as UCHealth’s University of Colorado Hospital, Children’s Hospital Colorado, and a new Veterans Affairs Hospital.

The CU School of Medicine has distinctive and highly productive research programs fueled by more than $421 million per year in grants, including more than $221 million from National Institutes of Health and other federal agencies. The School’s total annual clinical and research revenue exceeds $1.5 billion per year. The School of Medicine recently identified five focus areas for research investment, with one—RNA Biology—having extensive involvement of Biochemistry and Molecular Genetics faculty. In addition, the School has invested significant resources to establish a state-of-the-art core facility for structural biology that includes cryo-electron microscopy, x-ray crystallography, NMR, and proteomics and metabolomics. that is managed by the Biochemistry and Molecular Genetics Department.

The Chair reports to the Dean of the School of Medicine and serves on the School of Medicine’s Executive Committee. We are seeking a Chair with a strong track record of innovative scientific discovery who will maintain a well-funded research program.  She/he will have leadership skills commensurate with a world class research-focused department. The Chair will be responsible for leading growth in the Department’s research portfolio and for promoting collaborative research throughout the School of Medicine and the Anschutz Medical Campus. The Chair is expected to maintain and enhance diversity amongst the Department’s faculty, trainees and staff, enhance the Department’s educational programs, and assure transparency in the Department’s administration, management, budgetary planning and implementation.

Applications are accepted electronically at www.cu.edu/cu-careers/anschutz-medical-campus (click on “Search for Career Opportunities”; enter Job Number #14591).  First consideration will be given to applications received by October 15, 2018.  Questions regarding the search may be directed to Sarah.H.Miller@nullUCDenver.edu.

The University of Colorado is committed to diversity and equality in education and employment.

Nucleic Acid Technologies Intern

The Nucleic Acid Technologies Team at Bayer Crop Sciences (formerly Monsanto) seeks a motivated intern. The position will be located in Chesterfield, Missouri, reporting to our Customs Solutions Lead.

The intern will work with scientists that support a diverse set of next generation sequencing experiments related to the fields of genetics and genomics. You will conduct an approximate 3-month long project focused on providing data or solutions to a biological problem while working with next generation sequencing and/or automation approaches.

The intern will work closely with scientists in the Nucleic Acid Technologies group to understand, design and execute experiments but will also collaborate with and have opportunities to network with related teams such as bioinformatics and computational biology, trait discovery and design, gene expression, genotyping, etc. Networking opportunities will also be made available such that the intern has a broad overview of career opportunities within R&D at Bayer Crop Science (Formerly Monsanto).

The intern will be exposed to hands-on molecular biology laboratory techniques most likely related but not limited to nucleic acid purification, PCR, automation, and next-generation library preparations.
The internship will take place Mid-May to Mid-August 2019.
Required Skills/Experiences:
• Enrollment within a university in the US, pursuing a BS, MS or PhD degree in Biology, Molecular Biology, Biotechnology or related field
• Cumulative GPA >3.0
• Demonstrated interest and coursework in subjects related to genetics or genomics or molecular biology
• Curiosity and self-motivation to be exposed to and learn different molecular biology techniques and their applications.
• Proven ability to troubleshoot problems
• Ability to work within a team-based environment of other scientists
• Agility in the face of changing projects or demands
Desired Skills/Experiences:
• Lab experience outside of coursework, preferably nucleic acid techniques such as DNA or RNA extraction and PCR.
• Experience with documentation of scientific results.
• Written and oral communication skills.

Applications must be submitted through the web page:
https://jobs.monsanto.com/job/st-louis/nucleic-acid-technologies-intern/769/8930788

Postdoctoral positions are available in Dr. Xuebing Wu’s lab at Columbia University Medical Center, New York, NY

We develop integrated experimental and computational approaches to study RNA-based gene regulation in mammalian cells. Please visit wu-lab.net for more information.

We are looking for researchers passionate in RNA, CRISPR, and genomics to join our team. Start date is flexible. Applicants should have a recent (<2 years) Ph.D. in molecular biology or relevant field and have demonstrated research productivity through publications. Interested applicants should apply to xw2629@nullcumc.columbia.edu by sending (1) a cover letter summarizing research interests and accomplishments, (2) a complete CV with a publication list, and (3) contact information for three references.

Noncoding RNAs in Human Cancer

The Lauberth laboratory in the Division of Biological Sciences at the University of California San Diego welcomes applications for research positions at the postdoctoral level. The primary goal of the research in our laboratory is to study perturbations in gene regulation that lead to the development of human cancer. The open positions will focus on investigating the roles of noncoding enhancer RNAs (eRNAs) in human cancers that contain genetic alterations in p53, which are present in more than 50% of all human cancers. The recent and intriguing discovery that enhancers support transcription has raised a key question of whether eRNAs are functional molecules, or merely reflections of enhancer activation and thereby transcriptional noise. This question has gained considerable traction due to a number of recent studies that have started to unveil functions for at least a subset of eRNAs. We recently identified a class of enhancers that support eRNA production in a manner that is dependent on mutant p53 (Nature Communications 2017). The open positions will include research that is aimed to identify and characterize the functions of these eRNAs in gene regulation and cancer development. Also, the position will include exploring the feasibility of targeting this class of eRNAs as a means of silencing cancer-causing genes as a transformative approach in cancer treatment. These studies are of great significance, given the emerging field of functional eRNAs and the potential of using eRNAs as diagnostic markers and therapeutic targets for altering enhancer activities that are linked to human disease.

Candidates must have a strong background in biochemistry, molecular biology, and/or genomics and a first-author publication. The research will combine cell and molecular biology techniques, cell-free biochemical assays, and Next-Gen sequencing (ie. ChIP-seq, GRO-seq, ATAC-seq). We particularly value motivated, creative, and collaborative team members.

Interested applicants may start immediately and should send their cover letter containing a summary of their prior work and a short paragraph describing research interests and career plans, curriculum vitae, and the names of three references to Shannon Lauberth, PhD at slauberth@nullucsd.edu.

Inflammatory Tumor Microenvironment and Its Impact on Cancer Development

The Lauberth laboratory in the Division of Biological Sciences at the University of California San Diego welcomes applications for research positions at the postdoctoral level. The primary goal of the research in our laboratory is to study perturbations in gene regulation that lead to the development of human cancer. The open positions will focus on investigating the mechanisms that link the cancer-promoting effects of inflammation to genetic aberrations in the p53 gene, which are the most frequent alterations in human cancer. Using the stimulus-induced expression of inflammatory genes in human cancer cells as a model, the Lauberth lab has made important contributions in revealing mechanistic insights into how immune signaling drives alterations in the cancer cell transcriptome. Specifically, we have demonstrated a functional crosstalk between mutant p53 and the master proinflammatory regulator NFB that shapes an active enhancer landscape to reprogram the cancer cell transcriptome in response to chronic TNF signaling. These findings that have significant implications for understanding how p53 mutants impart transcriptional plasticity to a tumor in response to chronic immune signaling were published in Nature Communications 2017. To build upon these findings, the open positions will include leveraging mouse models and single-cell sequencing analyses to further explore the mechanisms underlying the roles of inflammatory cytokines in signaling between tumor and immune cells in the tumor microenvironment and to dissect the role of p53 mutants in modulating the composition and functions of the cell populations within a single tumor.

Candidates must have a strong background in biochemistry, molecular biology, and/or genomics and a first-author publication. The research will combine cell and molecular biology techniques, cell-free biochemical assays, and Next-Gen sequencing (ie. ChIP-seq, GRO-seq, ATAC-seq). We particularly value motivated, creative, and collaborative team members.

Interested applicants should send their cover letter containing a summary of their prior work and a short paragraph describing research interests and career plans, curriculum vitae, and the names of three references to Shannon Lauberth, PhD at slauberth@nullucsd.edu.

 

Postdoctoral Position Available, McJunkin Lab, NIH Main Campus, Bethesda MD

A fully-funded postdoc position is available in the McJunkin lab at the NIH main campus in Bethesda, Maryland. Our research has two major long-term goals: 1) to define the biological functions of miRNAs during embryogenesis and 2) to elucidate mechanisms of miRNA turnover. Using C. elegans as a model organism to address these questions, we are combining the strengths of classical forward genetics with CRISPR-Cas-9-mediated genome editing, next-generation sequencing, cell biology, and biochemical techniques. Because embryonically-expressed miRNAs exhibit a sharp decrease in abundance at the end of embryogenesis, our efforts to simultaneously study the biology of these miRNAs and the mechanisms of miRNA decay has the potential to uncover regulatory modules that couple miRNA decay to developmental timing.

The NIH main campus is a vibrant and collaborative research environment boasting over four hundred research groups and an active postdoc community. Bethesda, Maryland is part of the Washington, D.C. metropolitan area, and the NIH main campus is easily accessible by the Washington, D.C. subway system.

Applicants must have completed a Ph.D. and/or M.D. within the last three years. Expertise in molecular biology and strong verbal and written communication skills are required. Experience in either RNA biology or C. elegans research is desirable. International scientists and U.S. citizens are equally eligible for this fully-funded position. Ideal start date is spring or summer 2019, but this is very flexible.

For more information or to apply, email mcjunkin@nullnih.gov. To apply, please send a cover letter describing which aspect of our research program you are interested to pursue, a CV, and contact information for three references.

Contact: katherine.mcjunkin@nullnih.gov

Postdoctoral Position Available, Lab of Dr. Grace Chen, Immunobiology Dept., Yale University

A postdoctoral position is available in the laboratory of Dr. Grace Chen in the Immunobiology Department at Yale University. The Chen Laboratory is building a dynamic team of collaborative scientists motivated to understand the molecular mechanisms underlying circular RNA function and regulation. Interested candidates with backgrounds in molecular biology, biochemistry, chemical biology, or genomics should send a cover letter, CV, and contact information for three references to ye.grace.chen@nullyale.edu. Please visit www.yegracechen.com for more information.

Multiple Faculty Positions in RNA Biology at the NIH

The newly established RNA Biology Laboratory at the Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH) in Frederick, Maryland is recruiting Tenure-eligible or Tenure Track Investigators to join the Intramural Research Program’s mission of high impact, high reward science. These positions, which are supported with stable financial resources, are the equivalent of Assistant Professor/Associate Professor/Professor in an academic department. The RNA Biology Laboratory is looking for candidate(s) who will complement our current group of seven dynamic and collaborative principal investigators (https://ccr.cancer.gov/RNA-Biology-Laboratory). We encourage outstanding scientists investigating any area of RNA Biology to apply. Areas of interest include, but are not limited to, the roles of RNA-binding proteins, noncoding RNAs and nucleotide modifications in cell and organismal function; the ways in which alterations in RNA homeostasis result in diseases such as cancer, and the development of RNA therapeutics.

About NCI’s Center for Cancer Research

The Center for Cancer Research (CCR) is an intramural research component of the National Cancer Institute (NCI). CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, the world’s largest dedicated clinical research complex; provides extensive opportunities for collaboration; and allows scientists and clinicians to undertake high-impact laboratory- and clinic-based investigations.  Investigators are supported by a wide array of intellectual and technological and research resources, including animal facilities and dedicated, high quality technology cores in areas such as imaging/microscopy, including cryo-electron microscopy; chemistry/purification, mass spectrometry, flow cytometry, SAXS, genomics/DNA sequencing, transgenics and knock out mice, arrays/molecular profiling, and human genetics/bioinformatics.  For an overview of CCR, please visit http://ccr.cancer.gov/ .

Applicants should hold a Ph.D. and/or M.D. degree or equivalent doctoral degree, and should have at least three years of postdoctoral experience; a substantive record of publications, and the potential to develop an outstanding independent program in basic and/or translational RNA research.

Salary is commensurate with education and experience.  A full benefits package is available, including retirement, health insurance, life insurance, long-term care insurance, annual and sick leave, Thrift Savings Plan (401K equivalent).  This position is not restricted to U.S. citizens.

Interested applicants should submit:

  • The names and contact information of three references
  • A current curriculum vitae and complete bibliography
  • A two-page summary of research interests, goals, and future plans

The search will remain open until the positions are filled.  Review of applications will begin on or about October 1, 2018.  Applications must be submitted electronically to https://irp-positions.nih.gov/job/RBL

 

This position is subject to a background investigation.  The NIH is dedicated to building a diverse community in its training and employment programs.

Postdoctoral Research Fellow, Ghalei Lab at Emory University in Atlanta

Ghalei lab at Emory University in Atlanta, is seeking a creative and highly motivated postdoctoral research fellow. The lab uses a combination of techniques including RNA and protein biochemistry, X-ray crystallography, cryo-EM, and yeast genetics to answer fundamental questions about the molecular mechanisms underlying the assembly and turnover of snoRNPs.

The applicant has ideally just completed his/her Ph.D or is currently a Ph.D student in their final year in biochemistry, molecular biology, or any other related field. He/she will start on the ground of exciting novel preliminary data and work closely with members of a highly collaborative team in an interdisciplinary laboratory.

Interested individuals should apply to hghalei@nullemory.edu by sending: 1) a CV including the contact information of three academic references, and 2) a cover letter describing their research interests, accomplishments, and long-term career goal.

Contact: hghalei@nullemory.edu

Research Associate I/II – Translational Biology

Overview

Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

We are seeking a highly skilled scientist to lead mechanism of action and pharmacology studies on Dicerna’s GalXC therapeutics. Major responsibilities include conducting in vivo studies on our pre-clinical and clinical candidates, conducting hands-on research, and interacting closely with members of Translational Biology and Chemistry groups. You will apply your expertise on animal dosing and surgery and deep understanding of the molecular and cellular biology to study liver diseases, and play an important role in all phases of drug discovery and clinical development at Dicerna.

Key Responsibilities

  • Scientist will play a prominent role in guiding creative and rigorous biological research programs aimed at fully understanding the disease mechanism of Dicerna’s pipeline. He/she will be responsible for:

o       Conducting efficacy, pharmacokinetic, pharmacodynamics, structure-activity-relationship and mechanisms of action studies of drug candidates

o       Using appropriate in vivo models, perform research efforts to understand the mechanisms by which our drug candidates may contribute to adverse events in patients

o       Present working progress to other team members in group meeting

  • Work closely with all members of Dicerna’s research team to develop in vivo strategies to rapidly and effectively address key questions related to the safety and efficacy of our drugs, with actionable results
  • Efficiently review literature and provide insights to research directions, while predominantly also making hands-on contributions to the research

Qualifications

  • Bachelors Degree in Biology, Pharmacology, or a related field, with a minimum of 2-4 years of additional experience or a Masters Degree in Biology, Pharmacology, or a related field.
  • Previous experience on drug discovery is preferred
  • Proficient in animal handling, dosing and surgery. Proficient in techniques including but not limited to oral gavage, intravenous injection, subcutaneous injection, blood collection and basic surgery
  • In depth knowledge of, and hands-on experience with, in vitro and in vivo models used for mechanistic investigation with small molecule or RNAi therapeutics
  • Experience performing molecular and cellular biology techniques, including but not limited to RNA preparation, RT-qPCR, ELISA, immunohistochemistry, urine biomarker analysis, plasma biomarker analysis
  • Broad and deep understanding of signaling pathways and biological processes implicated in rare genetic liver diseases as well as the mechanism of action of RNAi therapies is desirable
  • Outstanding written and oral communication skills
  • An extremely high level of motivation and a sustained record of accomplishment throughout your career
  • The ability to work effectively as part of a team, in a fast-paced environment

Position Type
Full-Time/Regular

Contact:
Maire Osborn
Dicerna Pharmaceuticals Dept.
Address 87 Cambridgepark Drive
Cambridge, MA 02140
Tel. (617) 621-8097
E-mail mosborn@nulldicerna.com

Scientist I/II – Translational Biology

Dicerna is a biopharmaceutical company focused on the discovery and development of innovative treatments for rare diseases, chronic liver diseases, cardiovascular disease, and viral liver infectious diseases.  The Company is using its proprietary GalXC™ RNAi technology platform to build a broad pipeline in these therapeutic areas.

Overview

We are seeking a highly skilled scientist with experience investigating liver diseases to lead mechanism of action and pharmacology studies on Dicerna’s GalXC therapeutics. Major responsibilities include designing and managing in vivo studies on our pre-clinical and clinical candidates, conducting hands-on research, and interacting closely across functional groups. The candidate will apply his/her expertise and deep understanding of molecular and cellular biology to study liver diseases, and play a key role in all phases of drug discovery and clinical development at Dicerna.

Key Responsibilities

  • Scientist will play a prominent role in guiding creative and rigorous biological research programs aimed at fully understanding the disease mechanism of Dicerna’s pipeline. He/she will be responsible for:

o       Develop in vivo model systems and technologies to evaluate efficacy, pharmacodynamics, and mechanisms of action of drug candidates

o       Using appropriate in vivo models, lead internal and external research efforts to understand the mechanisms by which our drug candidates may contribute to adverse events in patients

o       Design and execute comprehensive in vivo and in vitro studies to understand disease mechanisms and therapeutic hypothesis.

o       Produce high quality technical reports and summaries for internal use and inclusion in key Regulatory documents (e.g. INDs and NDAs)

o       Regularly present work progress to rest of company

  • Work closely with all members of Dicerna’s research team, external collaborators, and contract research organizations (CROs) to develop in vivo strategies to rapidly and effectively address key questions related to the safety and efficacy of our drugs, with actionable results
  • Efficiently review literature and provide insights to research directions, while predominantly also making hands-on contributions to the research
  • Serve as a role model for compliant behavior that is consistent with the mission, vision and values of the Dicerna organization

Qualifications

  • PhD in Biology, Pharmacology, biochemistry, molecular biology or a related field, with 0-5 years of additional experience
  • Broad and deep understanding of signaling pathways and biological processes implicated in genetic diseases, and the mechanisms of action of RNAi therapies is preferred
  • In depth knowledge of, and hands-on experience with, in vitro and in vivo models used for mechanistic investigation of liver biology and toxicity, and identification of biomarkers
  • Experience performing molecular and cellular biology techniques including but not limited to RNA preparation, RT-qPCR, ELISA, immunohistochemistry, urine biomarker analysis, plasma biomarker analysis
  • Outstanding written and oral communication skills
  • An extremely high level of motivation and a sustained record of accomplishment throughout your career
  • Strong publication record
  • The ability to work effectively as part of a team, in a fast-paced environment
  • Experience managing direct reports would be beneficial

Position Type
Full-Time/Regular

Contact:
Maire Osborn
Dicerna Pharmaceuticals Dept.
Address 87 Cambridgepark Drive
Cambridge, MA 02140
Tel. (617) 621-8097
E-mail mosborn@nulldicerna.com

Postdoctoral Fellow Position, RNA Modification in Stem Cells and Cancer Development, Medical Discovery Institute, San Diego, California

We seek a highly motivated postdoctoral fellow to study the role of RNA modification in stem cells and cancer development. In analogous to DNA modification, post-transcriptional modification is also identified on RNA. Recently, messenger RNA modification, particularly methylation at the N6 position of adenosine or m6A, has emerged as an exciting research area in epigenetics and RNA biology. My lab identified a protein complex that governs m6A formation. Using loss-of-function studies, we discovered that m6A mRNA modification is essential for the proliferation and self-renewal of embryonic and neural stem cells. Mechanistically, we reported that m6A regulates gene expression via shortening the half-life of mRNAs or interacting with histone modifiers. Please refer to our publications for further information (Nature Cell Biology 16 (2): 191-8, Feb. 2014; Nature Neuroscience 21 (2): 195-206, Feb. 2018). Currently, we are digging deeper into the biological function and molecular mechanism of m6A in stem cells and cancer cells, using a combination of biochemistry, cell biology, and high throughout sequencing technologies. A highly motivated Ph.D. or M.D. graduate with background in RNA biology, cancer biology, and/or molecular biology is encouraged to apply.

For immediate consideration: Please submit a CV, 3 reference letters, and a cover letter to Dr. Crystal Zhao at czhao@nullsanfordburnham.org. Zhao lab located at Sanford Burnham Prebys (SBP) Medical Discovery Institute, San Diego, California. Please refer to the website ( https://www.sbpdiscovery.org ) to learn more about SBP.

IMMAGINA BioTechnology S.r.l. – Senior Research Scientist Position Available

IMMAGINA BioTechnology S.r.l. is looking for a senior research scientist to join the R&D/RNAseq team in collaboration with I.E.C.T. (http://www.iect.at/homepage/). We are seeking an experienced postdoctoral fellow who is energetic, enthusiastic, and enjoys collaborative and applied science. A strong background in molecular biology and cloning is required.
Skills: Experience in in molecular biology and cloning. • RNA-seq, cloning, genome editing and cell transfection • Proficiency in spoken and written English

Contact:
Massimiliano Clamer
Organization Immagina Biotechnology S.r.l. Dept.
Address: via alla cascata 56/c
City: Trento
State: Prv.
ZIP/Postal Code: 38123
Country Italy
Tel. 00390461312018
E-mail info@nullimmaginabiotech.com
URL www.immaginabiotech.com (optional)

Production Scientist (RNA Biology and Genome Editing)

New England Biolabs is inviting applicants for the position of Production Scientist. The individual in this position will be part of the Production Group for RNA Biology and Genome Editing.

Primary Responsibilities:

• Formulate enzymes, buffers and kit components as per defined procedures
• Perform quality control and functional tests on products prior to release
• Track and maintain inventory in collaboration with the Packaging group
• Fulfill OEM/Bulk custom orders
• Assist with setting up standard operating procedures (SOPs)
• Adhere to protocols and maintain proper documentation
• Gain expertise on product line and assist customers with technical inquiries
• Work in collaboration with Research and Applications & Product Development groups to develop new products for commercialization.

Qualifications and Experience:

• Bachelor’s degree in Biochemistry, Molecular Biology, Biotechnology or related field; advanced degree preferred
• Minimum 2 years’ experience in the life science industry
• Knowledge of RNA modifying enzymes, in vitro transcription required
• Knowledge of genome editing technology strongly preferred
• Experience in molecular biology techniques such as enzymatic assays, gel electrophoresis, in vitro transcription, DNA/RNA purification and radioactivity incorporation assays
• Experience in nucleic acid analysis using Bioanalyzer or Fragment analyzer
• Ability to be a team player in a fast-paced and dynamic environment
• Ability to multi-task and perform effectively under pressure; keen attention to detail required
• Excellent organizational and communication skills
• Proven “good hands” at the bench and the ability to perform careful and consistent experiments

New England Biolabs is an Equal Opportunity/ Affirmative Action Employer of Minorities, Females, Disabled and Protected Veterans

Apply online at: https://chk.tbe.taleo.net/chk05/ats/careers/requisition.jsp?org=NEB&cws=1&rid=353

For more information contact: jani@nullneb.com

Postdoctoral Position Available, Kansas State University

The Zinovyeva lab at Kansas State University invites applications for a postdoctoral position investigating miRNA-mediated gene regulation. Our laboratory uses a combination of genetic, genomic, molecular, and biochemical approaches to address questions related to miRNA biogenesis and function. The lab primarily uses C. elegans as a model system, expanding into tissue culture. The applicants should have a PhD or be in the process of completing their PhD. The successful candidate will have a record of productivity as demonstrated through research publications, excellent communication skills, and ability to work both independently and as part of a collaborative team. Strong molecular background/skills are essential. Start date and duration of the position are flexible.

Interested individuals should submit 1). a cover letter describing research interests and past training, 2). a detailed CV, and 3). contact information for three references. To apply for this position, please visit the Kansas State University Careers site at  http://careers.k-state.edu/cw/en-us/job/503228/fellow-post-doc. Requests for more information and questions about the position should be directed at zinovyeva@nullksu.edu, see also https://www.k-state.edu/biology/people/tenure/zinovyeva/

Kansas State University is located in Manhattan, a beautiful college town nestled against the Flint Hills in northeastern Kansas. Kansas State University has been rated by Business Insider to be in the Top 20 best college campuses in the nation. www.livability.com places Manhattan, KS as #2 in 2018 Top 100 Best Places to Live.

Postdoctoral Position Available Immediately, Lab of Dr. Rui Zhao, University of Colorado School of Medicine

I am seeking a motivated, independent, creative entry level post-doctoral researcher to join my laboratory at the University of Colorado School of Medicine. My lab is interested in understanding the molecular mechanism of pre-mRNA splicing and its role in disease processes, including cancer, as well as developing potential therapeutic approaches targeting splicing in these processes. We use a combination of structural (cryoEM and crystallography), biochemical, genetic, molecular biology, and cell biology approaches. Below are two examples of our recent publications:

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017; 8:1035. PMID 29051543.

Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017; 358:1278-1283. PMID 29146870.

The postdoc candidate can choose to focus on any one or more of the following projects depending on his/her interest and expertise:

Structural studies of spliceosome and related proteins/RNAs using cryoEM and crystallography;

Functional studies of spliceosomal proteins or RNAs and splicing mechanism using molecular biology, biochemistry, and high throughput sequencing;

The role of a splicing factor in Myc-driven cancer and drug discovery targeting the splicing factor.

My lab is located on the University of Colorado Denver Anschutz Medical Campus within the highly collegial Department of Biochemistry and Molecular Genetics and is part of the RNA BioScience Initiative. Denver is a great place to live and to do research. To apply, please send an email with a cover letter summarizing past research accomplishments, research interest, long term plans, and start date availability; CV; and contact information of three references to Rui.Zhao@nullucdenver.edu.

 

Mechanisms and regulation of human nonsense-mediated mRNA decay

A postdoctoral position studying the molecular mechanisms of RNA quality control is
immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and
Blood Institute, National Institutes of Health, Bethesda, MD. Our laboratory investigates
multiple facets of the NMD pathway, including novel positive and negative regulators of
RNA decay.

We are seeking a postdoctoral fellow to extend our recent efforts to identify and
investigate new members of the human NMD pathway. In collaboration with colleagues
at NIH, we have recently used whole-genome siRNA screening to discover multiple
novel NMD factors, including ICE1, a protein that promotes the link between the exon
junction complex and the NMD machinery (see Baird et al., Elife, 2018). We are
currently working to understand the mechanism and regulation of ICE1 function in
NMD, in addition to using the siRNA screen to identify additional new NMD proteins.
The research of the group and its members is supported by the collaborative and
interdisciplinary NIH intramural program and state-of-the-art proteomics, highthroughput
sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse
transgenic, and other core facilities.

Requirements:
Interested candidates must have received a Ph.D. or M.D. within the past five years in
molecular biology, cell biology, biochemistry, genetics or a related discipline and be
highly motivated to participate in and design innovative research programs. Candidates
with expertise in bioinformatics are particularly encouraged to apply. The candidate will
be supported with an excellent intramural NIH fellowship in a stimulating and interactive
research environment at NIH.

To apply:
Please email a cover letter indicating preferred start date and research area, CV, summary
of research accomplishments, and names and contact information for at least three
references to:
Dr. J. Robert Hogg
Email: j.hogg@nullnih.gov
Lab Website: http://www.nhlbi.nih.gov/research/intramural/researchers/pi/hogg-robert/
Employer Name: National Heart, Lung, and Blood Institute
Position Location: Bethesda, MD
The NIH is dedicated to building a diverse community in its training and employment
programs.