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Postdoc Position: Bioinformatics of Long Noncoding RNA Functional Elements

The “Genomics of Long Non-Coding RNAs in Disease” Laboratory (GOLD Lab) at the University of Bern has an opportunity for a Bioinformatics Postdoc.

The Project: Understanding how long noncoding RNA (lncRNA) functions are encoded in their sequence is a great challenge in biology. Our goal is to discover, classify and characterise lncRNA functional elements by means of an integrative bioinformatic / experimental approach. You will lead the bioinformatic component to develop novel methods for identifying lncRNA elements and predicting their functions. In collaboration our experimental team, you will have ample opportunities for experimental validation of in silico-generated hypotheses.

The Group: We are an international and interdisciplinary group of researchers with a passion for lncRNA research. We foster an open and collaborative working environment. Our work is funded by the Swiss National Center for Competence in Research (NCCR) “RNA & Disease” (nccr-rna-and-disease.ch), and we participate in the GENCODE project and International Cancer Genome Consortium (ICGC). We also have excellent biomedical links at the University Hospital of Bern. For more information about us: gold-lab.org / twitter.com/goldlab_bern

The City: Bern, the capital of Switzerland, has a vibrant international community, numerous outdoors and cultural activities, and ranks among the best cities worldwide for quality of life (https://tinyurl.com/y9vrtb7d).

The Person: We seek a dedicated and dynamic colleague to integrate into our diverse team. You should have strong background in bioinformatics or computer science, and specifically some/all of: Unix environment, R, perl/python, analysis of NGS data, webservers/databases. Experience in lncRNAs, CRISPR-Cas9 is a plus.

Details: Ideal start date will be Q1 of 2019. Project is fully funded for 4 years. Salary is according to (generous) University of Bern scales.

Recent publications:

Carlevaro-Fita et al. Biorxiv https://www.biorxiv.org/content/early/2017/10/23/189753

Uszczynska-Ratajczak B et al. Nat Rev Genet. 2018 Sep;19(9):535-548. doi: 10.1038/s41576-018-0017-y.

Lagarde J et al. Nat Genet. 2017 Dec;49(12):1731-1740. doi: 10.1038/ng.3988.

To apply: Please send a motivation letter, publications list, list of references, and CV to rory.johnson@nulldbmr.unibe.ch with subject title: “Job application Bioinformatics Postdoc”. Informal enquiries are also welcome.

Postdoctoral Position, Dr. Zhipeng Lu lab at USC School of Pharmacy, Dept of Pharmacology and Pharmaceutical Sciences

A postdoctoral position is immediately available in Dr. Zhipeng Lu lab at USC School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences. Our research is focused on “RNA machines” in living cells. We develop and apply novel technologies to understand the structures and functions of RNA molecules in basic cellular processes, with the ultimate goal of targeting human diseases, including genetic disorders, cancers and viral infections.

We have recently developed a powerful new technology, PARIS (Psoralen Analysis of RNA Interactions and Structures), a crosslinking based method for high throughput mapping of RNA duplexes in living cells at single-molecule level with near base-pair resolution (Lu et al. 2016 Cell). These unique strengths allow direct determination of alternative conformations, long-range and complex structures and RNA-RNA interactions across the transcriptome. This work was featured on the cover of Cell and a video abstract “Get an Eye-full (Eiffel)” (https://www.youtube.com/watch?v=1GXibPeUUGQ). A more complete description of our science can be found at http://zhipenglulab.org.

Current projects in the lab span the development of new computational and chemical tools for the analysis of RNA structures and interactions, and application of these technologies to important problems in the RNA field. The questions that we are interested in include structural basis of mRNAs and noncoding RNAs in post-transcriptional regulation of gene expression, roles of RNA structures and interactions in human diseases, such as neurological disorders and cancers. We also welcome and support novel and unconventional ideas that are related to the current work in the lab.

Research in the Lu lab is highly interdisciplinary and collaborative. Postdocs are exposed to research questions and techniques in the forefront of various fields centered around RNA. This training environment is exceptionally valuable for individuals who are interested in pursuing careers in academia or scientific leadership positions in the pharmaceutical industry. The PI is fully committed to empowering trainees with the capabilities to fulfill their ambitions.

USC School of Pharmacy is located in Health Sciences Campus, immediately adjacent to the USC Keck School of Medicine and Caltech. This rich scientific environment provides unique research training opportunities, such as research seminars given by leaders in science from throughout the U.S. and abroad, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities.

Candidates should have a Ph.D. and/or an M.D. and less than three years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics, biochemistry, or chemical biology, as evidenced by publications. Experience in computational biology is highly valued. Starting date is flexible from December 2018, and funding is guaranteed for at least three years.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to zhipengl@nullusc.edu.

Postdoctoral position to study RNA-protein complexes and non-coding RNA in New York

Postdoctoral positions are available immediately in the laboratory of Dr. Alexander Serganov at New York University School of Medicine. We are looking for enthusiastic, highly motivated and creative individuals with a strong interest in applying multidisciplinary approach and cutting-edge methodology to study RNA-mediated gene expression control. We are presently focusing our efforts on RNA-protein complexes and non-coding RNAs from bacteria and mammals, using structural (cryo-EM and X-ray), biochemical (including genome-wide) and biophysical methods. Research topics include transcriptional and translational control, mRNA modification, RNA degradation, and RNA-protein complexes in human diseases.

Candidates should hold a Ph.D. degree in structural biology, biochemistry, molecular biology, or related fields. Qualified candidates should have strong background in routine molecular biology techniques and protein purification. Good communication in English is expected.

The first position requires prior experience in genome-wide methods (RNAseq, CLIP, etc) or in vitro RNA studies. Projects will be primarily focused on genome-wide and in vitro characterization of RNA-protein interactions, with less emphasis on structural methods.

The second position requires experience in X-ray crystallography or cryo-EM and will primarily involve structural studies.

The Serganov laboratory (www.serganovlab.com) is located on the NYU Langone campus at 31st Street and First Avenue in midtown Manhattan, New York, USA. Postdocs will benefit from the vibrant scientific environment and the outstanding School infrastructure that supports the most advanced technologies including robotic X-ray facility, cryo-EM facility with Titan Krios, genome center and over 20 other facilities. Postdocs will be involved in collaboration with leading groups and receive a competitive salary, excellent benefits, and subsidized housing.

Interested applicants should submit a detailed CV, brief statement of research interests with description of previous research experience and contact information (email addresses and telephone numbers) of three references to Dr. Alexander Serganov at alexander.serganov@nullNYUMC.org. Consideration of submitted applications will start immediately and continue until positions are filled.

Postdoctoral Position, Lab of Dr. Marcos Morgan, National Institute of Environmental Health Sciences

A position will be available in the laboratory of Dr Marcos Morgan at the National Institute of Environmental Health Sciences (NIEHS) part of the National Institutes of Health (NIH), in North Carolina, USA. The candidate will lead a research program on post-transcriptional regulation of gene expression mediated by RNA modifications in the male germ line. To this end, the candidate will use novel mouse models and develop advanced methods to measure RNA modifications in vivo.

The selected individual must be able to work independently and as a proactive member of a team and should have a passion for automating processes, setting metrics and achieving goals on time. Qualified applicants are advanced graduate students that already submitted a manuscript to an international journal as first author, or currently hold a PhD. Ideally, they should have worked in one or more of the following areas: Mouse development, reproductive biology or RNA biology. Candidates should have experience in molecular biology techniques, tissue culture, preparation of next-generation sequencing libraries, handling of mouse colonies and bioinformatics.

The institute offers excellent opportunities for training and state of the art facilities with a strong emphasis on mouse model research. The competitive stipend and benefits offered are regulated by the institute’s intramural funding policies and can be found at https://www.training.nih.gov/postdoctoral_irta_stipend_ranges

The starting date of the Job is June 2019. The position is for at least one year.

Candidates interested in the opportunity should send a CV, including a list of publications and contact details for three references together with a cover letter indicating research interests and career goals to Dr Marcos Morgan. (marcosmorgan@nullgmail.com).

As an institution committed to diversity, NIH encourages candidates from underrepresented groups to apply.

NCI intramural-funded Postdoctoral position, available immediately (duration: 1-5 years).

A postdoctoral research position is available in the laboratory of Dr. Natasha Caplen in the Genetics Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD. Dr. Caplen’s Laboratory conducts multidisciplinary and interdisciplinary research that uses RNAi and other DNA or RNA-based functional genomic technologies to interrogate specific aspects of the genetic, transcriptional, and cell-signaling alterations observed in cancer cells.

Our current research focuses on the development of new treatment strategies for cancers driven by a fusion oncogene. Since only tumor cells express and depend on the products of fusion or chimeric oncogenes, a fusion transcript or protein represents an ideal molecular target. We hypothesize that proteins needed for the expression of fusion oncogenes will reveal new therapeutic targets for tumors dependent on their oncogenic activity and potentially other cancers. Using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods our specific aims are to discover and characterize proteins required for the post-transcriptional regulation of fusion oncogenes. Our recent studies have demonstrated that the splicing of the fusion transcript EWS-FLI1 encoding the oncoprotein responsible for the development of the pediatric tumor Ewing sarcoma represents a significant vulnerability. We are seeking candidates for a postdoctoral position that will focus on further investigating how cancer cells adapt to process a fusion RNA molecule. We anticipate that this project will include the development and application of several next-generation sequencing approaches, including long-range transcript-specific RNA-Seq and methods that analyze the expression of nascent RNA.

We are seeking self-motivated candidates with a recent Ph.D. or M.D. degree (within two years of graduating), or equivalent, in molecular/cell biology or biochemistry, or related disciplines, ideally with additional training in the computational analysis of large-scale genome and transcriptome data. The candidate must have excellent verbal and written communication skills. The initial appointment will be for one year, renewable for up to five years.

The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.

Contact:
Natasha Caplen
Email: ncaplen@nullmail.nih.gov
https://ccr.cancer.gov/Genetics-Branch/natasha-j-caplen

 

PhD student in RNA structure and transcriptome Bioinformatics

The Bioinformatics Group of  Prof. I. Meyer at the BIMSB and MDC in Berlin is seeking to recruit a post-doctoral researcher in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/phd-position-bioinformatics and https://www.mdc-berlin.de/meyer#t-news

N.B. The application deadline is Friday, 30. November 2018.

Post-doc in RNA structure and transcriptome Bioinformatics

The Bioinformatics Group of  Prof. I. Meyer at the BIMSB and MDC in Berlin is seeking to recruit a post-doctoral researcher in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/post-doc-position-bioinformatics and https://www.mdc-berlin.de/meyer#t-news

N.B. The application deadline is Friday, 30. November 2018.

Postdoctoral Researcher (Molecular Biology), Flinders University, AUSTRALIA

We are seeking a highly motivated early-mid career postdoctoral researcher with very strong molecular biology and cell biology skills to take the lead and perform experiments on an NHMRC-funded project grant investigating circular RNAs in human disease.

The applicant must bring a unique skillset for studying RNA interactions and have demonstrated experience with contemporary RNA profiling technologies. A strong team ethos and experience with supervising research technicians, higher degree students and working with mouse models of disease are all distinct advantages.

This postdoctoral position is for 3 years, full-time, commencing from Jan 2019. Saalary is from $72k-100k. International applicants are strongly encouraged.

Applications close November 5th 2018.

More details of the position can be found at Nature Careers (https://www.nature.com/naturecareers/job?id=656823) or by email (simon.conn@nullflinders.edu.au).

Assistant Professor Positions, Columbia University, Department of Biochemistry and Molecular Biophysics

The Department of Biochemistry and Molecular Biophysics at Vagelos College of Physicians and Surgeons invites outstanding candidates to apply for TENURE-TRACK faculty positions at the level of Assistant Professor. The department seeks individuals with exceptional accomplishments and abilities in Biochemistry and Molecular Biophysics. Areas of particular interest are RNA Biology, Chromosome Structure and Function, and Computational Structural Biology, but exceptional candidates in other areas are strongly encouraged to apply. Examples of such areas include, but are not limited to: single molecule studies and live imaging; phase transitions and granules; and biophysical studies of cellular phenomena.  We seek colleagues committed to scientific excellence, collaboration, and collegiality.

Applicants should provide a summary of their scientific accomplishments and a description of their scientific vision, emphasizing one or more major unsolved problems in their field and how they plan to solve them (no more than three pages).

The Department of Biochemistry and Molecular Biophysics offers a rigorous and stimulating environment for conducting research. Faculty use the full spectrum of contemporary biophysical, biochemical, molecular biological, and cellular techniques to study developmental biology; gene expression, regulation and signal transduction; macromolecular structure, function and dynamics; and molecular neurobiology. The Department has a rich history of excellence in molecular and structural biology and molecular neuroscience. Cross-appointment with other departments or centers is also possible.

Essential Qualifications

All applicants must have a Ph.D., M.D., or equivalent degree. In addition, applicants must have a very strong record of research productivity and demonstrated ability to develop a rigorous research program.

Completed applications, including the research statement, curriculum vitae, PDF copies or links for three reprints (which may be uploaded as a single PDF file), and contact information for three references must be submitted online via the following website:

http://pa334.peopleadmin.com/postings/1616

Consideration of completed applications will begin in November, 2018 and continue until the positions are filled.

Columbia University is an equal opportunity/affirmative action employer. Women and minorities are especially encouraged to apply.

Assistant or Associate Professor Positions in Genome-to-Phenome Biology

The Department of Biological Sciences at the University at Buffalo, The State University of New York (http://biology.buffalo.edu) invites applications for two 10-month tenure-track assistant or associate professor-level positions (rank negotiable based on experience) from individuals who study the complex relationships between genotype and phenotype, and are committed to establishing robust, extramurally-funded research programs. Specifically, this hiring initiative focuses on understanding the relationships linking genome to phenome at all levels of life. In this round of recruitment, the Department seeks to hire: (1) an assistant or associate professor in the area of gene regulation at several different levels, including the epigenetic, and (2) an assistant or associate professor studying how cells or organisms alter their genomes (i.e., post-genomic biology) to adapt to their environments.

The University at Buffalo (UB) has a tradition of research excellence in biology. UB is the largest and most comprehensive campus in the State University of New York system. The Department of Biological Sciences is the major focal point for interdisciplinary research and education in life sciences at the University at Buffalo. The Department Biological Sciences’ strengths include the biochemistry of gene expression, molecular evolution and genomics, and sensory transduction and development. In addition to the advertised positions, an active, ongoing search for a neurogeneticist will bolster and extend departmental strengths (refer to: https://www.ubjobs.buffalo.edu/postings/16479). Opportunities for interdisciplinary interactions among UB, Roswell Park Comprehensive Cancer Center, and the NYSCenter of Excellence in Bioinformatics and Life Sciences are available. The positions will provide a 10-month, state-supported salary plus a competitive startup package.

With backing from the College of Arts and Sciences, the Department aims to achieve disciplinary excellence in addressing “the large genome” challenge of understanding the genetic control of phenotype. The successful candidate is expected to: (1) develop a nationally-recognized, externally-funded research program; 2) participate in research laboratory training of baccalaureate, masters and doctoral students; and 3) teach undergraduate and graduate level courses. Applicants must have a doctoral or equivalent degree in an appropriate field, relevant postdoctoral experience, documented evidence of high-quality research productivity, and a solid commitment to excellence in both research and teaching.

To apply, submit electronic versions of a cover letter, a curriculum vitae, a summary of research accomplishments and future plans, and a statement of teaching interests and philosophy to UBJobs at: http://www.ubjobs.buffalo.edu/postings/16805

Please include the names of three colleagues who could be contacted for letters of recommendation.

Completed applications will be reviewed beginning December 10, 2018, and will continue until the position is filled. Please consult our website: http://biology.buffalo.edu for information about UB, our department and our community.

University at Buffalo is an affirmative action/equal opportunity employer and, in keeping with our commitment, welcomes all to apply including veterans and individuals with disabilities.

NIH-funded Postdoctoral Fellowship Position, to begin as early as June 2019 (duration: 2-5 yrs).

NIH-funded Postdoctoral Fellowship in RNA Metabolism in Innate Immunity

National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to cytoplasmic RNA polymeradse III (cyto-Pol III)-mediated innate immune mRNA induction and metabolism. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience.  Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation.  The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.

Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.

  • Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:

Richard J. Maraia, M.D.

Email: maraiar@nullmail.nih.gov

Post-doctoral Research Associate, University College London, Research Dept of Structural & Molecular Biology

We are recruiting a post-doctoral Research Associate to investigate the interactions between the RNA binding proteins regulating local mRNA translation in neurons and their RNA and protein partners – and relate these interactions to the mRNA transport, stability and translation functions of the proteins. The Research Associate will use single molecule Microscopy, together with Cell and Molecular Biology methods and transcriptome wide analysis of in cell interactions (e.g. iCLIP) to define the key regulatory principles of the proteins in Neurons at the molecular level. The Research Associate will work in close collaboration with a Structural Biologist within the RNA Regulation Laboratory and with collaborating teams in the UK and US.

The position is available in principle from the 1st of January 2019 to 31st of December 2020, in first instance for two years with the possibility of extension.

The successful candidate will have a PhD (or about to submit) in Cellular and Molecular Biology. The S/he must have skills in cell culture, basic cellular and molecular assays and basic bioinformatics and data analysis. S/he must have experience in RNA Biology. Experience in the iCLIP and equivalent techniques is desirable.

Please see also  https://www.nature.com/naturecareers/job?id=653569

Postdoctoral Associate Position in Single-Cell Ribosome Translation and Microbial Pathogenesis-University of Maryland, College Park

A postdoctoral position is immediately available in the laboratory of Dr. Jiqiang (Lanny) Ling at The University of Maryland, College Park to study single-cell ribosomal translation, microbial pathogenesis, and antibiotic resistance. The Ling lab is interested in combining state-of-the-art single-cell, microbiology, biochemical, genetic, genomic, and proteomic approaches to understand the mechanisms and disease connections of the protein synthesis machinery. Recent work from the Ling lab has been published in leading journals such as Molecular Cell, New England Journal of Medicine, and American Journal of Human Genetics. For more information please visit Dr. Ling’s website: https://cbmg.umd.edu/faculty/lanny-ling/

UMD is a vibrant place to work, home to three Nobel laureates, five Pulitzer Prize recipients, and more than 40 members of the most prestigious national academies. The 1,250-acre campus is centrally located on the Baltimore, Annapolis and Washington, D.C. corridor. The postdoctoral position will be supported by NIH funding with a competitive salary. Highly motivated candidates with bacteriology, yeast biology, and microscopy expertise are particularly encouraged to apply. If interested, please contact Dr. Ling at jling12@nullumd.edu and include a brief description of research interests, career goals, and a detailed CV.

Job requirement: Ph.D. with at least 3 years of research experience in RNA biology or microbiology.

Job duration: Initial appointment of 1 years with possible extension.

Postdoctoral Researcher Position, Lab of Dr. Mingyi Xie, Dept. of Biochemistry & Molecular Biology, Cancer Center, University of Florida

Postdoctoral Researcher position available immediately in the Laboratory of Dr. Mingyi Xie (Assistant Professor, Department of Biochemistry and Molecular Biology, Cancer Center, University of Florida) to study the Function and biogenesis of alternatively-processed microRNAs and Integrator complex-mediated RNA processing. Postdoc salary starts at $47,476 per year.

Applicants should submit the following to mingyi.xie@nullufl.edu:

1)      Cover letter stating: laboratory experience in RNA/protein biochemistry and bioinformatics; your long-term career goals; date of availability to begin postdoc research

2)      Curriculum vitae (including publications and awards/honors)

3)      List of at least three references

Dr. Mingyi Xie was trained in the laboratory of Dr. Joan Steitz at Yale University (2010-2016), where he documented two surprising microRNA (miRNA) biogenesis pathways:

  • Herpesvirus saimiri (HVS)-miRNAs are processed by the host Integrator complex, a 14-subunit complex best known for executing the 3′-end cleavage of cellular small nuclear RNAs (snRNAs) (Cazalla, Xie and Steitz-Molecular Cell-2011; Xie et al.,-Genes & Development-2015).
  • Mammalian m7G-capped precursor miRNAs are generated from RNA polymerase (Pol) II transcription initiation sites. Whereas the nuclear-cytoplasmic export of capped pre-miRNAs is mediated by Exportin-1 (Xie et al.,-Cell-2013; Xie and Steitz-RNA Biology-2014).

The Xie lab’s immediate research goal is to further delineate the unique modes of miRNA production (Sheng et. al.-Nucleic Acids Res.-2018, Miller et. al.-RNA-2018), including Integrator-mediated RNA metabolism, and understand the functions of these special miRNAs in herpesviruses and their hosts. Such research will allow the design of therapies for related oncogenic herpesviruses and cancers.

Visit Xie lab website: xie.biochem.med.ufl.edu for more information.

Postdoctoral Fellow Position, Alberta RNA Research & Training Institute, University of Lethbridge, Medicinal Biophysics Laboratory

A postdoctoral researcher position is available at the Medicinal Biophysics Laboratory,
led by Dr. Trushar Patel, to study the RNA-protein and protein-protein interactions that
play crucial roles in cell signaling. The candidate will perform cell biology and mass
spectrometry assays and validate the results using biophysical methods. This is a 1-year
position with the possibility of extension for a second year and builds on the expertise in
the Patel laboratory in studying structure-function relationships of RNA and protein
molecules. We employ a variety of cell biology, biochemical and structural-biophysical
approaches.

Highly motivated researchers with a recent Ph.D. in biochemistry, molecular biology,
cellular biology or a similar discipline are encouraged to apply. It is expected that the
candidate will have proven their research accomplishments by peer-reviewed
publications. Mass Spectrometry experience is highly desirable. Interested candidates
should send a CV including the names of at least three referees, a motivation letter and
links to publications by email to Dr. Trushar Patel (trushar.patel@nulluleth.ca).
Lethbridge is located in Southern Alberta, not far from the Rocky Mountains, the city of
Lethbridge enjoys a sunny, dry climate that is surprisingly mild, has excellent cultural
and recreational amenities, and offers attractive economic conditions. The University is
situated on the west side of Lethbridge and stretches across the coulees, with a great view
of the Oldman River valley.

Postdoctoral Fellow Position, Karolinska Institute, Medical Biochemistry & Biophysics Dept.

Background:

Possibly more than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these cellular functions are largely unknown.

Our research group is interested in understanding how RNAs adopt their structures in order to select specific functions in a pool if RNAs. We employ different biochemical and biophysical techniques (e.g. EMSA, NMR, UV melting experiments), to investigate the molecular mechanism of RNA function (Nature 2012 & 2015).

Project:

(A) The Postdoc will work on a collaborative project together with the Lab from E.R. Andersson (andersonlab.com) and will therefore be working on an interface from molecular biology to biophysical/biochemical methods.

(B) The Postdoc will work on a project to study RNA biophysics in cellular conditions. Therefore the Postdoc will establish and develop biophysical, biochemistry and molecular biology methods for this task.

You will work in a team together with other lab members and regularly present your research work in lab-meetings, seminars and at international conferences.

We are looking for a highly motivated Postdoc that will work in Katja Petzold’s group at the Division of Molecular Structural Biology.

Eligibility:

To apply for the position, the applicant must have a PhD degree not older than 4 years. Scholarships for carrying out postdoctoral research may be granted to persons living in other countries who come to Sweden with the intention of only staying in Sweden for all or part of their postdoctoral education at KI. Persons who are resident in Sweden and/or have carried out all or part of their academic education at KI or some other educational institution in Sweden cannot be considered for scholarships from KI. This educational scholarship is tax-exempt.

To qualify, the applicant should have a background in biochemistry and biophysics of RNA with an interest in inter-disciplinary research. Of advantage are knowledge in NMR and/or molecular biology, but not required.

We are looking for a highly motivated, well organized, driven and enthusiastic person interested in our area of research, who is ready to explore new avenues in science. The candidate should have a high degree of independence but should also show a collaborative approach to research and be able to work productively in a team. Fluency in English is a requirement (written and oral).

Start-date upon agreement.

Contact: Katja Petzold
Email: katja.petzold@nullki.se
Apply: https://ki.mynetworkglobal.com/se/what:job/jobID:230326/type:job/where:4/apply:1

Faculty Position in the Biology of RNA and Chromatin Regulation

The Therapeutic Innovation Center (THINC) at Baylor College of Medicine (BCM) invites applications for a tenure-track Assistant Professor, Associate Professor, or Professor position for colleagues studying the biology of gene control, especially RNA or chromatin regulation.  Applicants’ research programs may focus on the basic mechanisms of gene control and/or therapeutics targeting this area of biology.  Diverse research programs studying gene control are welcome, including genetics and epigenetics, computational biology, chemical biology, structural biology, biochemistry, and genomics.  Experience in studying or developing therapeutics is encouraged but not required.

THINC (thincbcm.org) is a center of excellence at BCM that seeks to discover fundamental mechanisms of gene control, especially RNA and chromatin regulation, and to translate these discoveries into early therapeutic development.  THINC brings together colleagues across BCM and the Texas Medical Center who study gene regulation from multiple disciplines and are leveraging these discoveries in diseases of aberrant gene control including cancer, neurodegeneration, and infectious disease.

BCM is the premier medical school of Texas and has the top-ranked Genetics and Cell Biology Departments in the U.S. based on NIH funding.  BCM has internationally recognized strengths in structural biology and biochemistry, a long-standing NIH human genome sequencing center, cutting edge Advanced Technology Cores, exceptional Ph.D. graduate programs, a commitment to technology transfer for faculty discoveries, and a rich history of translating basic science into clinical implementation. BCM is also home to the NCI-designated Dan L. Duncan Comprehensive Cancer Center (bcm.edu/centers/cancer-center) and centered in Texas Medical Center, the world’s largest biomedical research complex.

THINC and BCM offer premier recruitment packages and resources to enhance the candidate’s research program.  Applicants should email a PDF of their curriculum vitae, a 4-page research statement, and a cover letter stating the position to which they are applying to THINC-communications@nullbcm.edu. Applicants should also request 3 letters of reference to be emailed directly from recommenders to THINC-communications@nullbcm.edu.  All materials should be received by October 22, 2018.

Postdoctoral Fellowship in Epigenetics and RNA Biology

Postdoctoral fellowship in epigenetics and RNA biology at the Department of Medical Biosciences and Wallenberg Centre for Molecular Medicine, Umeå University (Sweden)

A funded postdoctoral position (2 years) is available in the Aguilo laboratory (www.aguilolab.com) at Umeå University for a highly talented and motivated candidate willing to address fundamental questions in post-transcriptional regulation of RNA in connection with epigenetic regulation in breast cancer.

Project description

The research group investigates how changes epigenetic changes and aberrant RNA modification contribute to breast cancer progression as well as drug resistance. The successful applicant will combine cellular biology with state-of-the-art molecular biology approaches, including ChIP-seq, RNA-seq, MeRiP-seq, CLIP-seq and other large-scale epigenomic and epitranscriptomic analyses, including single-cell RNA-seq. In addition, 2D and 3D cell culture models, patient samples as well as mouse transgenic models will be used to study the central RNA-based regulatory circuitry in breast tumorigenesis.

Application

The application should include the following:

  • A cover letter (max two A4 pages) with a summary of research interests and accomplishments
  • Curriculum vitae (CV)
  • Copies of relevant degree certificates and PhD thesis
  • Contact information (name, address, telephone and e-mail) for three referees

Your complete application should be sent electronically (PDF format) to Dr. Francesca Aguilo francesca.aguilo@nullumu.se with subject POSTDOC_2018 no later than 30 November, 2019

 

 

Scientist, RNAi Discovery/Bioinformatics

Dicerna Pharmaceuticals is looking for a PhD scientist to help in its drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. Responsibilities will entail a combination of bioinformatics and drug discovery work. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

Key Responsibilities

  • Computational Biology analyses (e.g. RNA-seq data analysis); development and implementation of novel algorithmic tools for drug candidate screening
  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR

Qualifications

  • PhD in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting.
  • Experience in informatics is required (e.g. next-gen sequencing data analysis; informatics tool development; data mining; with expertise in R and R:Bioconductor suite, Python, PERL and/or PHP preferred).
  • Expertise in statistical analysis is strongly preferred.
  • Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
  • Experience with RNAi is preferred.
  • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment.
  • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected.

Contact: Maire Osborn
Email: mosborn@nulldicerna.com

Research Associate, RNAi Discovery

Dicerna Pharmaceuticals is looking for a BS/MS scientist to help in its drug discovery efforts. This is a hands-on research position that requires strong expertise in molecular and cellular methodologies. This is a full-time position. Dicerna offers an exciting work environment and strong team culture. Our company has a competitive benefits package and bonus incentive program.

Key Responsibilities

  • siRNA drug candidate screening, hit identification, and lead optimization
  • Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; PCR
  • In vivo drug candidate testing (e.g. mouse dosing; sample analysis)

Qualifications

  • BS/MS in a relevant field and 0-5 year’s postgraduate experience, preferably in drug discovery and in an industry setting (junior or senior candidates considered, with level and compensation commensurate with experience)
  • Expertise in cellular and molecular biology is essential (e.g., mammalian cell culture; cell-based assays; quantitative real-time PCR)
  • Experience with RNAi is preferred; experience with in vitro screening is preferred.
  • Experience with in vivo methodologies is desirable (e.g. mouse handling; dosing; sample analysis; histology).
  • The individual should have strong oral and written communication skills and a demonstrated ability to contribute effectively to group projects in a team-oriented environment.
  • Ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected.

Contact: Maire Osborn
Email: mosborn@nulldicerna.com