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Post-doctoral Position, Group of Dr. Giulia Palermo University of California Riverside (UCR)

Post-doctoral position is available in the group of Dr. Giulia Palermo at the University of California Riverside (UCR) in computational biophysics.

Research in the Palermo lab focuses on applying and developing novel computational methods to unravel the function and improve applications of key macromolecular complexes responsible of gene regulation, DNA cleavage and replication, RNA transcription and in translation. The appointee will apply a variety of computational methods, spanning from conventional Moleuclar Dynamics (MD) simulations, enhanced sampling methods, ab-initio MD and emerging cryo-electron microscopy (cryo-EM) refinement/processing methods. As well, she/he will have the opportunity to join ongoing collaborations with leading experimental scientists at UCR, UC Berkeley and at UC San Diego.

We are seeking a postdoctoral fellow with the following research background and interests:

1) MD simulations of protein and nucleic acid systems, including but not limited to DNA/RNA dynamics, protein-protein interactions, and ion-protein interactions. Experiences with enhanced sampling and unconventional analysis methods, including but not limited to the dimensionality reduction methods, correlation analysis and Markov state modeling is preferred.

2) Knowledge of QM/MM approaches based on ab-initio methods (such as the Born-Oppenheimer and Car-Parrinello approaches) is preferred but not strictly required.

3)  Applicants should hold a PhD in physics, chemistry, computational sciences or related fieds. Motivation in learning and developing unconventional computational approaches during the appointment will be key for the successful applicant.

The University of California Riverside is a public research University belonging to the University of California system, located in the vibrant research area of southern California. The appointee will be employed in the Department of Bioengineering, receiving competitive salary and benefits, in agreement with the UC salary scale.

To apply, please email your CV and contact information for 2-3 references to gpalermo@nullengr.ucr.edu

More information: https://palermolab.com

 

Cancer Postdoctoral Fellowship Position, National Cancer Institute

The Protein-Nucleic Acid Interaction Section in Structural Biophysics Laboratory, National Cancer Institute, invites applications for a Cancer Postdoctoral Fellowship position.  Applicants should have training/expertise in RNA biology and biochemistry.  The postdoctoral fellow recruited for the position will work on exciting RNA biotechnology and cancer immunotherapy projects and have opportunities to train and learn multiple techniques for the research projects.  We seek an enthusiastic, creative and dedicated scientist to join our team.

The position is open until a qualified candidate is identified.  NIH offers a competitive stipend and comprehensive health insurance.  The appointment will be one year initially and renewable up to a total of 5 years based on performance.  The NIH is dedicated to building a diverse community in its training and employment programs.  This position is subject to a background investigation.  To apply, please send a cover letter and a curriculum vitae.  In addition, please arrange three reference letters to be sent to wangyunx@nullmail.nih.gov on behalf of applicants.

DHHS, NIH, and NCI are Equal Opportunity Employers

Faculty Positions Available, Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative

The newly founded Center for RNA Biomedicine, funded by the $150M University of Michigan Biosciences Initiative, solicits applications for faculty positions at the assistant professor level, but appointment at a more senior level is possible for applicants with suitable experience. The faculty position will be tenure track or tenured with a university year appointment starting September 1, 2019 or January 1, 2020.

Candidates must have the following qualifications:

  • A PhD, MD, or other terminal degree
  • Evidence of superlative scientific accomplishment and scholarly promise
  • Depending on field, evidence of teaching excellence

Primary school and departmental affiliation(s) will be determined by the applicant’s qualifications and preferences, and by relevance of the applicant’s research program to departmental initiatives and themes. We welcome applications from outstanding scientists in any area of RNA research complementary to existing expertise at Michigan, with particular emphasis on RNA drug targeting or as medicine, structural biology of RNA nanomachines, RNA structural in vivo profiling, RNA protein interaction profiling, and in vivo analysis of long non-coding RNA function. For further information about the Center for RNA Biomedicine’s current research areas, please visit https://www.umichrna.org.

All applications must be submitted online at https://rna.lsa.umich.edu/facRecruiting/application.php. You will be asked to upload the following materials: a cover letter, a curriculum vitae, a brief summary of recent research accomplishments and statement of future research plans, and a statement of teaching interests and philosophy. Candidates for appointment as an assistant professor should provide names and contact information for at least three references, as instructed in the on-line application form. To ensure full consideration, all materials should be received by January 15, 2019.

Women and underrepresented minorities are encouraged to apply. The University of Michigan is supportive of the needs of dual career couples and is an equal opportunity/affirmative action employer.

For more information, contact us directly at mjerant@nullumich.edu or 734-615-8213

Learn more about the Biosciences Initiative at University of Michigan: biosciences.umich.edu

RNA Biochemist position(s), Sixfold Bioscience, London

Job summary

Utilise RNA in innovative ways to cure disease.

At Sixfold we’re building a better way to deliver cures. We see the huge potential of gene therapies being limited to how effectively they can be systemically delivered in people. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic.

We’re seeking a highly motivated and independent researcher to join our team. Specifically, we are looking for skilled scientists that are passionate about utilising nucleic acids in innovative and transformative ways to cure disease. As a rapidly growing start-up, your work will make invaluable contributions to the scientific and strategic direction of the company.

Requirements

  • PhD with specialisation in RNA Biochemistry/Biophysics, Molecular Biology, Chemical Engineering, Nanotechnology or equivalent scientific discipline.

Extra credit

  • Hands-on experience in RNA synthesis, purification, characterisation formulation, and stability testing.
  • mRNA translational control and RNA processing.
  • Expertise in analytical techniques including HPLC, LC-MS GC-MS.
  • Cell biology expertise in mammalian cell culture and cell visualisation using techniques such as confocal microscopy and flow cytometry.

Who you are

  • Use creativity and scientific intuition for designing and undertaking experiments.
  • Can work in a highly collaborative research environment.
  • Drive innovative research through the internalisation of new techniques and technology, as well as forming internal and external collaborations.
  • Have a desire to work in a dynamic and fast-paced environment.

What you’ll do

  • Lead the development and optimisation of RNA for therapeutic use.
  • Design and execute robust laboratory experiments, interpret data, communicate findings, and maintain high-quality records.
  • Support and contribute to publishing and grant writing efforts.

Perks

  • Highly competitive salary based on experience.
  • Equity based remuneration.
  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • Inclusive company culture.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Opportunities for personal, professional and scientific development.
  • Team-wide social events.

About us
Who we are Located in London, Sixfold is a YCombinator and venture-backed startup. Founded by researchers from the University of Cambridge and the Francis Crick Institute, we’re dedicated to expanding the potential of gene therapies, so that ultimately we can cure more diseases in more people. It’s why we started Sixfold — to make a difference. We work at the cutting edge of science by fostering collaborations with the world’s best institutions and the sharpest minds. If you want to help cure the incurable, you belong with us.

It’s important to mention that although disease affects us all, our industry still displays a huge lack of diversity — this needs to change. Our founding team is comprised of different nationalities and is 2/3rds female founders. Our goal is to create a company culture that promotes ideas and the inclusion of scientist and engineers from all backgrounds.

Find out more

 

  

 

Postdoctoral Fellow Position Available, Department of Biomedicine in the group of Professor Ruth Brenk

At the Faculty of Medicine, Department of Biomedicine in the group of Professor Ruth Brenk (http://www.uib.no/en/rg/brenk ) a full-time (100 %) position as Postdoctoral Fellow is available for a period of 3 years. The position is part of the project “Exploration of the TPP riboswitch as a new target for antibiotics” financed by The Research Council of Norway under the Joint Programming Initiative on Antimicrobial Resistance(JPIAMR) initiative.

The main focus of the project will be hit discovery and optimization for the TPP riboswitch which is a target for new antibiotics (https://www.jpiamr.eu/wp-content/uploads/2018/11/Summary_Explore.pdf). The role of this postdoc will be high-throughput screening (HTS) assay development, hit validation (using binding assays and X-ray crystallography) and structure-based ligand design.

More information can be found here: https://www.jobbnorge.no/ledige-stillinger/stilling/161277/postdoctoral-fellow-3-years-for-hit-discovery-for-riboswitches

Ph.D. Studentships, Dept of Molecular Genetics, University of Groningen (the Netherlands)

Applications are invited for two 4-year Ph.D. studentships, starting April 2019, in the newly established research group of Dr. Danny Incarnato (embedded in the department of Molecular Genetics, headed by Prof. Dr. Oscar Kuipers) at the University of Groningen (the Netherlands), to study in vivo RNA folding dynamics.

What

The successful applicants will work on a multidisciplinary project aimed at understanding the mechanistic aspects underlying in vivo RNA structure formation. Particularly, they will:

–        study the role of different factors, such as macromolecular crowding, RNA binding proteins (RBPs) and RNA post-transcriptional modifications (PTMs), in regulating RNA folding (and their crosstalk)

–        develop novel approaches for the accurate interrogation on a transcriptome-wide scale of RNA structures and PTMs

–        integrate the wet-lab work with a substantial component of bioinformatics analyses (developing novel analysis tools where needed)

Ph.D. candidates will receive excellent training through cutting-edge research projects, advanced courses and training opportunities, complemented by workshops on generic research, transferable skills and teaching. Ph.D. candidates are committed to conduct independent and original scientific research, to report on this research in international publications and presentations, and to present the results of the research in a Ph.D. dissertation, to be completed within 4 years. Moreover, Ph.D. candidates are expected to contribute 10% of their overall workload to teaching.

Who

The ideal candidates must be highly motivated, hard-working, ambitious, creative, really enthusiastic about RNA and interested in doing both wet-lab and bioinformatics. They must hold a Diploma or Master’s degree in the field of life sciences (molecular biology, biochemistry, or related disciplines) and have at least 6 months of lab experience (ideally with a focus on RNA biology and/or Next-Generation Sequencing). Strong communication skills and the ability to work efficiently, independently as well as in a team, are required. An excellent written and oral fluency in English is essential. Prior knowledge of UNIX/Linux computing environments and of a programming language (Perl, Python, Ruby, C++) is not required but is a plus.

How

Our lab uses both prokaryotic and eukaryotic cellular models and exploits (or develops where needed) cutting-edge Next-Generation Sequencing approaches (Incarnato et al., 2017 [PMID: 28934475]; Incarnato et al., 2017 [PMID: 28180324]; Incarnato et al., 2014 [PMID: 25323333]) and bioinformatics analysis tools (Incarnato et al., 2018 [PMID: 29893890]; Incarnato et al., 2016 [PMID: 26487736]; Incarnato et al., 2013 [PMID: 23863844]), complemented by traditional molecular genetics and biochemistry techniques.

Where

Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative center of higher education offering high-quality teaching and research. Flexible study programmes and academic career opportunities in a wide variety of disciplines encourage the 30,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge.

The “RNA Folding Dynamics” lab is hosted in the prestigious Groningen Biomolecular Sciences and Biotechnology Institute (GBB), located in the Zernike Campus, at the northern edge of the city of Groningen.

The GBB is one of the larger institutes of the Faculty of Science and Engineering (FSE) and provides an excellent environment for top-notch research in the field of biomolecular sciences. Twelve vibrant research groups with strong roots in biophysics, biochemistry & molecular biology, cell biology, chemistry, computational biology, microbiology or genetics are organized in two focal areas: ‘Molecular Mechanisms of Biological Processes’ and ‘Physiology and Systems Biology’.

When

The preferred starting date is April 1st, 2019.

Conditions of employment

The University of Groningen offers a salary of € 2,325 gross per month in the first year to a maximum of € 2,972 gross per month in the final year (salary scale Dutch Universities), based on a full-time position (1.0 FTE) excluding an 8% holiday allowance and an 8.3% end of the year bonus.

The position offered is for four years. Each successful candidate will first be offered a temporary position of one year with the option of renewal for another three years. Prolongation of the contract is contingent on sufficient progress in the first year to indicate that a successful completion of the PhD thesis within the contract period is to be expected. A Ph.D. training programme is part of the agreement and the successful candidate will be enrolled in the Graduate School Science and Engineering of the Faculty.

How to apply

Applications should consist of:

–        a cover letter with background and motivation to apply for this position

–        a curriculum vitae, including details of bachelor and master degrees, labwork experience and a publication list, if applicable

–        detailed (1-2 pages) description of previous research experience, such as the bachelor/master research projects

–        contact details of 2 academic references who can provide information on candidate’s suitability for the position

Interviews are scheduled to take place in February 2019, in Groningen.

Please refer to the official job announcement of the University of Groningen with further details on the appointment and remuneration and apply online at:

https://www.rug.nl/about-us/work-with-us/job-opportunities/overview?details=00347-02S0006PLP

Deadline

Applications for this position can be sent until January 30 23:59 h / before January 31, 2019 (Dutch local time) by means of the online application form (click on “Apply” below on the advertisement on the University website).

Information

Question regarding the open positions and the objectives of the research can be obtained by contacting: Dr. Danny Incarnato (E-mail: dincarnato@nullincarnatolab.com; Skype: incarnatolab).

Additional information on the university, faculty, institute, research groups and the city:

–        University of Groningen: https://www.rug.nl/

–        Groningen Biomolecular Science and Biotechnology Institute (GBB): https://www.rug.nl/research/gbb/

–        RNA Folding Dynamics research group: http://www.incarnatolab.com

–        The conditions of employment: https://www.rug.nl/about-us/work-with-us/

–           The city of Groningen: http://www.rug.nl/about-us/who-are-we/discover-groningen/

Seeking an Experienced RNA Computational Biologist with a strong RNA biology background

Panorama Medicine is seeking an experienced RNA Computational Biologist with a strong RNA biology background to analyze large-scale RNA data at their Philadelphia office.

Responsibilities:

  • Analyze large-scale RNA-seq data.
  • Discover underlying mechanisms of observed data results.
  • Closely work with molecular biologist for target validation.

Minimum Qualifications:

  • All applicants must have a PhD in genetics, biology, bioinformatics, or closely related fields. Post-doctoral experience is preferred.
  • Excellent understanding of RNA biology. Exposure to rare disease research and a strong record of publication is preferred.
  • Good programming and scripting abilities in languages, such as R, Python. Familiar with Linux/Unix systems.
  • Familiar with public genomics databases, such as TCGA, GTEx, LINCS, ENCODE, OMIM, etc.
  • Strong knowledge of statistics and machine learning algorithms.
  • Strong writing skills for scientific reports. Experience in grant application is preferred.
  • Excellent problem-solving, teamwork, organization, and communication skills.
  • US citizen or permanent resident only.

About Panorama Medicine:

Panorama Medicine is a VC-backed startup founded by a multidisciplinary team of world-renowned computational and experimental RNA biologists. Our mission is to use genomics and computing to accelerate drug discovery. Panorama is young and fast-growing, offering rewarding career development opportunities.

Benefits:

Panorama strives to build a Google-like work environment, creative, fun, hardworking, and highly productive. We offer a strong compensation package that includes competitive salary, generous stock options, and a comprehensive health benefits package. Flexible time off, productivity perks, paid parental leave, company sponsored learning and development opportunities.

Panorama is an Equal Opportunity Employer and Prohibits Discrimination and Harassment of Any Kind.

Interested applicants should send a cover letter and a CV to hr@nullpanoramamedicine.com.

Postdoctoral position at the Very High Field NMR Center (CRMN) in Lyon

Project: The work will focus on visualizing RNA conformational dynamics and interactions at very high resolution using NMR spectroscopy. This position is provided in the context of a recently accepted ERC project and will be centered on the development of new RNA synthesis to obtain uniquely informative RNA for NMR spectroscopy. By accessing those RNA it will become possible to study highly flexible non-coding RNA at atomic resolution and understand the role of RNA complex conformational dynamics in the biological function.

Requirements: Candidates should hold a PhD in chemistry, molecular biology, biophysics or related field. Skills in RNA biochemistry and spectroscopy are highly desirable. The candidate will be working in an international, collaborative environment and is expected to demonstrate good creative thinking and communication skills.

Lab: The CRMN is a worldwide unique interdisciplinary NMR center (up to 1GHz spectrometers, liquid/solid/DNP). It hosts leading NMR research groups, provides excellent working conditions and is located in Lyon, one of the most dynamic French city, internationally recognized for its life quality.

Application: Interested candidates are welcome to contact me for further information. Application should be submitted via the web interface: http://bit.ly/2BaYm8t and include a cover letter and a CV with a publication list and three references.

Postdoctoral Research Fellow in Cardiac RNA Biology (University of Illinois at Chicago)

A postdoctoral position is immediately available in the laboratory of Dr. Sang-Ging Ong in the Department of Pharmacology and the Center for Stem Cell and Regenerative Medicine at the University of Illinois at Chicago. The Ong lab is stably funded by the National Heart, Lung, and Blood Institute and institutional funding.

Using mouse models, patients’ samples, and patient-specific induced pluripotent stem cells, the Ong lab seeks to understand the molecular and biological mechanisms underlying various cardiovascular diseases through cellular, genetic, and biochemical approaches. We are currently seeking a candidate to lead a new research program on how post-transcriptional regulation of RNA including RNA modifications lead to metabolic changes in the heart under both physiological and pathological conditions. We are also interested in studying how non-coding RNAs regulate the response of cardiac cells during stress.

Qualifications: Recent or upcoming PhD or MD/PhD degree (must be within 3 years of obtaining PhD) and a strong record of peer-reviewed publications with at least one first-author manuscript (IF>5) in RNA biology, is essential. Ideal candidates should have experience working in two or more of the following areas: 1) stem cell biology/chemical biology, 2) epigenetics/epitranscriptomics, 3) sequencing techniques e.g. ChIP-Seq, MeRIP-seq, and CLIP-seq, 4) RNA biology, genomics or bioinformatics, and 5) gene-editing techniques including CRISPR.

Interested candidates should submit a CV with the names of three referees to Dr. Sang-Ging Ong (sangging@nulluic.edu). The position is open immediately until filled.

The University of Illinois at Chicago is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply. The University of Illinois may conduct background checks on all job candidates upon acceptance of a contingent offer. Background checks will be performed in compliance with the Fair Credit Reporting Act.

Lab Manager, University of Michigan

Our laboratory studies basic mechanisms in RNA biology and RNA defects in neurologic diseases.  We are particularly interested in how RNA structure and sequence regulate cell function.

Applicants with at least 5 years of work experience in a molecular biology laboratory and familiarity with bioinformatics are required.  Candidates should have a Ph.D. or M.D.  S/he must be able to work independently and has excellent communication skills.  Besides designing and carrying out experimental and analytical work, the position will include lab management.  Experience with RNA sequencing and analysis is highly desired.  The position provides opportunities for growth and independent research.  The position is ideal for someone with deep interests in mechanistic aspects of RNA biology but does not wish to be concerned with grant writing.

Please send a cover letter, curriculum vitae, including names and contact information for at least three references to:

Vivian G. Cheung, MD
HHMI/ University of Michigan
vgcheung@nullumich.edu

Postdoc Position: Bioinformatics of Long Noncoding RNA Functional Elements

The “Genomics of Long Non-Coding RNAs in Disease” Laboratory (GOLD Lab) at the University of Bern has an opportunity for a Bioinformatics Postdoc.

The Project: Understanding how long noncoding RNA (lncRNA) functions are encoded in their sequence is a great challenge in biology. Our goal is to discover, classify and characterise lncRNA functional elements by means of an integrative bioinformatic / experimental approach. You will lead the bioinformatic component to develop novel methods for identifying lncRNA elements and predicting their functions. In collaboration our experimental team, you will have ample opportunities for experimental validation of in silico-generated hypotheses.

The Group: We are an international and interdisciplinary group of researchers with a passion for lncRNA research. We foster an open and collaborative working environment. Our work is funded by the Swiss National Center for Competence in Research (NCCR) “RNA & Disease” (nccr-rna-and-disease.ch), and we participate in the GENCODE project and International Cancer Genome Consortium (ICGC). We also have excellent biomedical links at the University Hospital of Bern. For more information about us: gold-lab.org / twitter.com/goldlab_bern

The City: Bern, the capital of Switzerland, has a vibrant international community, numerous outdoors and cultural activities, and ranks among the best cities worldwide for quality of life (https://tinyurl.com/y9vrtb7d).

The Person: We seek a dedicated and dynamic colleague to integrate into our diverse team. You should have strong background in bioinformatics or computer science, and specifically some/all of: Unix environment, R, perl/python, analysis of NGS data, webservers/databases. Experience in lncRNAs, CRISPR-Cas9 is a plus.

Details: Ideal start date will be Q1 of 2019. Project is fully funded for 4 years. Salary is according to (generous) University of Bern scales.

Recent publications:

Carlevaro-Fita et al. Biorxiv https://www.biorxiv.org/content/early/2017/10/23/189753

Uszczynska-Ratajczak B et al. Nat Rev Genet. 2018 Sep;19(9):535-548. doi: 10.1038/s41576-018-0017-y.

Lagarde J et al. Nat Genet. 2017 Dec;49(12):1731-1740. doi: 10.1038/ng.3988.

To apply: Please send a motivation letter, publications list, list of references, and CV to rory.johnson@nulldbmr.unibe.ch with subject title: “Job application Bioinformatics Postdoc”. Informal enquiries are also welcome.

Postdoctoral Position, Dr. Zhipeng Lu lab at USC School of Pharmacy, Dept of Pharmacology and Pharmaceutical Sciences

A postdoctoral position is immediately available in Dr. Zhipeng Lu lab at USC School of Pharmacy, Department of Pharmacology and Pharmaceutical Sciences. Our research is focused on “RNA machines” in living cells. We develop and apply novel technologies to understand the structures and functions of RNA molecules in basic cellular processes, with the ultimate goal of targeting human diseases, including genetic disorders, cancers and viral infections.

We have recently developed a powerful new technology, PARIS (Psoralen Analysis of RNA Interactions and Structures), a crosslinking based method for high throughput mapping of RNA duplexes in living cells at single-molecule level with near base-pair resolution (Lu et al. 2016 Cell). These unique strengths allow direct determination of alternative conformations, long-range and complex structures and RNA-RNA interactions across the transcriptome. This work was featured on the cover of Cell and a video abstract “Get an Eye-full (Eiffel)” (https://www.youtube.com/watch?v=1GXibPeUUGQ). A more complete description of our science can be found at http://zhipenglulab.org.

Current projects in the lab span the development of new computational and chemical tools for the analysis of RNA structures and interactions, and application of these technologies to important problems in the RNA field. The questions that we are interested in include structural basis of mRNAs and noncoding RNAs in post-transcriptional regulation of gene expression, roles of RNA structures and interactions in human diseases, such as neurological disorders and cancers. We also welcome and support novel and unconventional ideas that are related to the current work in the lab.

Research in the Lu lab is highly interdisciplinary and collaborative. Postdocs are exposed to research questions and techniques in the forefront of various fields centered around RNA. This training environment is exceptionally valuable for individuals who are interested in pursuing careers in academia or scientific leadership positions in the pharmaceutical industry. The PI is fully committed to empowering trainees with the capabilities to fulfill their ambitions.

USC School of Pharmacy is located in Health Sciences Campus, immediately adjacent to the USC Keck School of Medicine and Caltech. This rich scientific environment provides unique research training opportunities, such as research seminars given by leaders in science from throughout the U.S. and abroad, opportunities for collaborations, exposure to diverse research programs, and highly sophisticated core facilities.

Candidates should have a Ph.D. and/or an M.D. and less than three years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, genetics, biochemistry, or chemical biology, as evidenced by publications. Experience in computational biology is highly valued. Starting date is flexible from December 2018, and funding is guaranteed for at least three years.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to zhipengl@nullusc.edu.

Postdoctoral position to study RNA-protein complexes and non-coding RNA in New York

Postdoctoral positions are available immediately in the laboratory of Dr. Alexander Serganov at New York University School of Medicine. We are looking for enthusiastic, highly motivated and creative individuals with a strong interest in applying multidisciplinary approach and cutting-edge methodology to study RNA-mediated gene expression control. We are presently focusing our efforts on RNA-protein complexes and non-coding RNAs from bacteria and mammals, using structural (cryo-EM and X-ray), biochemical (including genome-wide) and biophysical methods. Research topics include transcriptional and translational control, mRNA modification, RNA degradation, and RNA-protein complexes in human diseases.

Candidates should hold a Ph.D. degree in structural biology, biochemistry, molecular biology, or related fields. Qualified candidates should have strong background in routine molecular biology techniques and protein purification. Good communication in English is expected.

The first position requires prior experience in genome-wide methods (RNAseq, CLIP, etc) or in vitro RNA studies. Projects will be primarily focused on genome-wide and in vitro characterization of RNA-protein interactions, with less emphasis on structural methods.

The second position requires experience in X-ray crystallography or cryo-EM and will primarily involve structural studies.

The Serganov laboratory (www.serganovlab.com) is located on the NYU Langone campus at 31st Street and First Avenue in midtown Manhattan, New York, USA. Postdocs will benefit from the vibrant scientific environment and the outstanding School infrastructure that supports the most advanced technologies including robotic X-ray facility, cryo-EM facility with Titan Krios, genome center and over 20 other facilities. Postdocs will be involved in collaboration with leading groups and receive a competitive salary, excellent benefits, and subsidized housing.

Interested applicants should submit a detailed CV, brief statement of research interests with description of previous research experience and contact information (email addresses and telephone numbers) of three references to Dr. Alexander Serganov at alexander.serganov@nullNYUMC.org. Consideration of submitted applications will start immediately and continue until positions are filled.

Postdoctoral Position, Lab of Dr. Marcos Morgan, National Institute of Environmental Health Sciences

A position will be available in the laboratory of Dr Marcos Morgan at the National Institute of Environmental Health Sciences (NIEHS) part of the National Institutes of Health (NIH), in North Carolina, USA. The candidate will lead a research program on post-transcriptional regulation of gene expression mediated by RNA modifications in the male germ line. To this end, the candidate will use novel mouse models and develop advanced methods to measure RNA modifications in vivo.

The selected individual must be able to work independently and as a proactive member of a team and should have a passion for automating processes, setting metrics and achieving goals on time. Qualified applicants are advanced graduate students that already submitted a manuscript to an international journal as first author, or currently hold a PhD. Ideally, they should have worked in one or more of the following areas: Mouse development, reproductive biology or RNA biology. Candidates should have experience in molecular biology techniques, tissue culture, preparation of next-generation sequencing libraries, handling of mouse colonies and bioinformatics.

The institute offers excellent opportunities for training and state of the art facilities with a strong emphasis on mouse model research. The competitive stipend and benefits offered are regulated by the institute’s intramural funding policies and can be found at https://www.training.nih.gov/postdoctoral_irta_stipend_ranges

The starting date of the Job is June 2019. The position is for at least one year.

Candidates interested in the opportunity should send a CV, including a list of publications and contact details for three references together with a cover letter indicating research interests and career goals to Dr Marcos Morgan. (marcosmorgan@nullgmail.com).

As an institution committed to diversity, NIH encourages candidates from underrepresented groups to apply.

NCI intramural-funded Postdoctoral position, available immediately (duration: 1-5 years).

A postdoctoral research position is available in the laboratory of Dr. Natasha Caplen in the Genetics Branch, National Cancer Institute, Center for Cancer Research, Bethesda, MD. Dr. Caplen’s Laboratory conducts multidisciplinary and interdisciplinary research that uses RNAi and other DNA or RNA-based functional genomic technologies to interrogate specific aspects of the genetic, transcriptional, and cell-signaling alterations observed in cancer cells.

Our current research focuses on the development of new treatment strategies for cancers driven by a fusion oncogene. Since only tumor cells express and depend on the products of fusion or chimeric oncogenes, a fusion transcript or protein represents an ideal molecular target. We hypothesize that proteins needed for the expression of fusion oncogenes will reveal new therapeutic targets for tumors dependent on their oncogenic activity and potentially other cancers. Using functional genetic approaches coupled with molecular, biochemical, and cell biology-based methods our specific aims are to discover and characterize proteins required for the post-transcriptional regulation of fusion oncogenes. Our recent studies have demonstrated that the splicing of the fusion transcript EWS-FLI1 encoding the oncoprotein responsible for the development of the pediatric tumor Ewing sarcoma represents a significant vulnerability. We are seeking candidates for a postdoctoral position that will focus on further investigating how cancer cells adapt to process a fusion RNA molecule. We anticipate that this project will include the development and application of several next-generation sequencing approaches, including long-range transcript-specific RNA-Seq and methods that analyze the expression of nascent RNA.

We are seeking self-motivated candidates with a recent Ph.D. or M.D. degree (within two years of graduating), or equivalent, in molecular/cell biology or biochemistry, or related disciplines, ideally with additional training in the computational analysis of large-scale genome and transcriptome data. The candidate must have excellent verbal and written communication skills. The initial appointment will be for one year, renewable for up to five years.

The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.

Contact:
Natasha Caplen
Email: ncaplen@nullmail.nih.gov
https://ccr.cancer.gov/Genetics-Branch/natasha-j-caplen

 

PhD student in RNA structure and transcriptome Bioinformatics

The Bioinformatics Group of  Prof. I. Meyer at the BIMSB and MDC in Berlin is seeking to recruit a post-doctoral researcher in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/phd-position-bioinformatics and https://www.mdc-berlin.de/meyer#t-news

N.B. The application deadline is Friday, 30. November 2018.

Post-doc in RNA structure and transcriptome Bioinformatics

The Bioinformatics Group of  Prof. I. Meyer at the BIMSB and MDC in Berlin is seeking to recruit a post-doctoral researcher in Bioinformatics. Our goal is to discover new mechanisms of transcriptome regulation in diverse biological settings with a particular emphasis on mechanisms involving RNA-structures or trans RNA-RNA interactions. To this end, we develop new computational methods and algorithms to analyze large-scale transcriptome data (e.g. RNA-seq). Our methods employ a variety of machine learning techniques and new probabilistic models. We work in close collaboration with several experimental research groups to investigate a diverse range of exciting biological systems.

For the details on the position and how to apply, please see https://www.mdc-berlin.de/career/jobs/post-doc-position-bioinformatics and https://www.mdc-berlin.de/meyer#t-news

N.B. The application deadline is Friday, 30. November 2018.

Postdoctoral Researcher (Molecular Biology), Flinders University, AUSTRALIA

We are seeking a highly motivated early-mid career postdoctoral researcher with very strong molecular biology and cell biology skills to take the lead and perform experiments on an NHMRC-funded project grant investigating circular RNAs in human disease.

The applicant must bring a unique skillset for studying RNA interactions and have demonstrated experience with contemporary RNA profiling technologies. A strong team ethos and experience with supervising research technicians, higher degree students and working with mouse models of disease are all distinct advantages.

This postdoctoral position is for 3 years, full-time, commencing from Jan 2019. Saalary is from $72k-100k. International applicants are strongly encouraged.

Applications close November 5th 2018.

More details of the position can be found at Nature Careers (https://www.nature.com/naturecareers/job?id=656823) or by email (simon.conn@nullflinders.edu.au).

Assistant Professor Positions, Columbia University, Department of Biochemistry and Molecular Biophysics

The Department of Biochemistry and Molecular Biophysics at Vagelos College of Physicians and Surgeons invites outstanding candidates to apply for TENURE-TRACK faculty positions at the level of Assistant Professor. The department seeks individuals with exceptional accomplishments and abilities in Biochemistry and Molecular Biophysics. Areas of particular interest are RNA Biology, Chromosome Structure and Function, and Computational Structural Biology, but exceptional candidates in other areas are strongly encouraged to apply. Examples of such areas include, but are not limited to: single molecule studies and live imaging; phase transitions and granules; and biophysical studies of cellular phenomena.  We seek colleagues committed to scientific excellence, collaboration, and collegiality.

Applicants should provide a summary of their scientific accomplishments and a description of their scientific vision, emphasizing one or more major unsolved problems in their field and how they plan to solve them (no more than three pages).

The Department of Biochemistry and Molecular Biophysics offers a rigorous and stimulating environment for conducting research. Faculty use the full spectrum of contemporary biophysical, biochemical, molecular biological, and cellular techniques to study developmental biology; gene expression, regulation and signal transduction; macromolecular structure, function and dynamics; and molecular neurobiology. The Department has a rich history of excellence in molecular and structural biology and molecular neuroscience. Cross-appointment with other departments or centers is also possible.

Essential Qualifications

All applicants must have a Ph.D., M.D., or equivalent degree. In addition, applicants must have a very strong record of research productivity and demonstrated ability to develop a rigorous research program.

Completed applications, including the research statement, curriculum vitae, PDF copies or links for three reprints (which may be uploaded as a single PDF file), and contact information for three references must be submitted online via the following website:

http://pa334.peopleadmin.com/postings/1616

Consideration of completed applications will begin in November, 2018 and continue until the positions are filled.

Columbia University is an equal opportunity/affirmative action employer. Women and minorities are especially encouraged to apply.

Assistant or Associate Professor Positions in Genome-to-Phenome Biology

The Department of Biological Sciences at the University at Buffalo, The State University of New York (http://biology.buffalo.edu) invites applications for two 10-month tenure-track assistant or associate professor-level positions (rank negotiable based on experience) from individuals who study the complex relationships between genotype and phenotype, and are committed to establishing robust, extramurally-funded research programs. Specifically, this hiring initiative focuses on understanding the relationships linking genome to phenome at all levels of life. In this round of recruitment, the Department seeks to hire: (1) an assistant or associate professor in the area of gene regulation at several different levels, including the epigenetic, and (2) an assistant or associate professor studying how cells or organisms alter their genomes (i.e., post-genomic biology) to adapt to their environments.

The University at Buffalo (UB) has a tradition of research excellence in biology. UB is the largest and most comprehensive campus in the State University of New York system. The Department of Biological Sciences is the major focal point for interdisciplinary research and education in life sciences at the University at Buffalo. The Department Biological Sciences’ strengths include the biochemistry of gene expression, molecular evolution and genomics, and sensory transduction and development. In addition to the advertised positions, an active, ongoing search for a neurogeneticist will bolster and extend departmental strengths (refer to: https://www.ubjobs.buffalo.edu/postings/16479). Opportunities for interdisciplinary interactions among UB, Roswell Park Comprehensive Cancer Center, and the NYSCenter of Excellence in Bioinformatics and Life Sciences are available. The positions will provide a 10-month, state-supported salary plus a competitive startup package.

With backing from the College of Arts and Sciences, the Department aims to achieve disciplinary excellence in addressing “the large genome” challenge of understanding the genetic control of phenotype. The successful candidate is expected to: (1) develop a nationally-recognized, externally-funded research program; 2) participate in research laboratory training of baccalaureate, masters and doctoral students; and 3) teach undergraduate and graduate level courses. Applicants must have a doctoral or equivalent degree in an appropriate field, relevant postdoctoral experience, documented evidence of high-quality research productivity, and a solid commitment to excellence in both research and teaching.

To apply, submit electronic versions of a cover letter, a curriculum vitae, a summary of research accomplishments and future plans, and a statement of teaching interests and philosophy to UBJobs at: http://www.ubjobs.buffalo.edu/postings/16805

Please include the names of three colleagues who could be contacted for letters of recommendation.

Completed applications will be reviewed beginning December 10, 2018, and will continue until the position is filled. Please consult our website: http://biology.buffalo.edu for information about UB, our department and our community.

University at Buffalo is an affirmative action/equal opportunity employer and, in keeping with our commitment, welcomes all to apply including veterans and individuals with disabilities.