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Research Scientist I, New England Biolabs Inc.

The RNA Research Division at New England Biolabs (NEB) is seeking a motivated, energetic, and scientifically rigorous individual to join a team engaged in research and development of new and innovative tools for synthesizing, manipulating, and analyzing RNA. Projects are part of a basic research program that focusses on understanding, improvising, and discovering enzymes for RNA synthesis platforms. Research will be undertaken in a highly collaborative and fast-paced environment. The successful candidate will utilize a variety of techniques to identify new and improved enzymes for research, diagnostic, and therapeutic applications.

Primary responsibilities:

  • Carry out basic and applied research on enzymes for RNA synthesis.
  • Develop analytics for characterizing and studying in vitro synthesized RNA.
  • Characterize enzymes for RNA synthesis and modification.
  • Effectively communicate findings to the scientific community through publications and presentations.
  • Interact and collaborate with members of other research divisions to further program and division goals.

Required qualifications:

  • Ph.D. in RNA Biology, Biochemistry, or Molecular Biology with 0-3 years post-Ph.D. experience in a related field.
  • Proven track record in RNA biochemistry and biology, protein analyses, and standard molecular biology techniques.
  • Attention to detail with a demonstrated track record of producing high-quality work in the form of peer-reviewed publications.
  • Excellent written and verbal communication skills.
  • Ability to generate and maintain detailed lab records and to make recommendations based on research outcomes.
  • A strong work ethic, with an emphasis on both efficiency and quality of work.

Preferred qualifications:

  • Experience with analysis of large datasets and high-throughput sequencing.
  • Experience in structural analyses of RNA and/or in tools to optimize RNA structure and expression.
  • Familiarity with high-throughput experimental design and analyses will be a plus.
  • The ability to multi-task effectively while working independently, and/or to contribute to team goals while working in a fast-paced environment.
  • A commitment to research excellence, strong analytical and problem-solving skills, and enthusiasm to learn and develop new techniques.

This position offers exciting opportunities for broad research training, collaboration with academic institutions, publishing in peer-reviewed journals and participation in meetings and conferences.

New England Biolabs, Inc. is an Equal Opportunity/Affirmative Action Employer of Minorities, Females, Disabled and Protected Veterans and a participating employer in the Employment Verification (E-Verify) program.

For more information, please contact broy@nullneb.com (https://www.neb.com/research/researcher-profiles#RNA)

Postdoctoral Position Immediately Available, Lab of Dr. Anastasios Vourekas, Dept of Biological Sciences Louisiana State University Baton Rouge,

A postdoctoral position is immediately available in the laboratory of Dr. Anastasios Vourekas, at the Department of Biological Sciences Louisiana State University Baton Rouge, to study fundamental RNA regulatory mechanisms with a high relevance to human health.

Several exciting projects are available, including small RNA regulation of spermatogenesis, the role of RNA helicases in RNP granule formation and function, stress related RNA regulation, and the study of mechanism of function of novel small RNAs including tRNA fragments. The postdoctoral fellow will have the opportunity to be trained on and further expand on high throughput sequencing methodologies (CLIP-Seq, RNA-Seq) and also classic biochemistry approaches for the study of RNA-protein complexes, in vitro and using cell culture systems.

For a more detailed description and a list of publications related to our work, visit our lab’s website:

https://faculty.lsu.edu/avourekas/index.php

Candidates must hold a Ph.D. degree in the general fields of biochemistry/molecular biology/cell biology; candidates with experience in RNA biology, protein biochemistry, NGS techniques and/or genetic models are particularly encouraged to apply.

Please send a CV, a letter stating research interests with reference to our work, and contact information for three referees to:

Anastasios Vourekas, PhD

Assistant Professor, Department of Biological Sciences

Louisiana State University

202 Life Sciences Building

Baton Rouge, LA 70803

225 578 1737

avourekas@nulllsu.edu 

Or apply online here: https://lnkd.in/dWJmkzY

Postdoc Position – Bioinformatics

We are seeking an innovative and enthusiastic bioinformatician to work with a team of researchers headed by Doctor Ulf Schmitz, in the areas of transcriptomics, RNA biology and cancer. Building on the recent discoveries we are currently investigating the roles of alternative splicing and microRNA-mediated gene regulation in diverse human and mouse cells and tissues. We are also expanding our study to define the interplay between aberrant epigenetic modifications that contribute to splicing abnormalities relevant to cancers. We are committed to support and mentor young investigators to become group leaders in the future.

Your main role will be to conduct bioinformatics analyses in collaboration with a team of wet lab researchers for a fixed term, while participating in the activities of Centenary.

We are looking for exceptional candidates with:

  • A recent PhD (preferably within the last 1-2 years) or about to be awarded a PhD in the relevant areas of computational biology/ bioinformatics, however more experience investigators will also be considered;
  • Extensive experience in NGS data analysis, pipeline development and algorithm implementation/development;
  • Solid research experience, including first author publications in top journals;
  • Ability to write/contribute to journal articles, grants and keep meticulous notes;
  • Strong interpersonal, written and oral communication skills with an ability to liaise with a diverse range of people
  • A strong team focus; and
  • A demonstrated commitment to Occupational Health and Safety.

Desirable:

  • A strong background in statistics and/or application of statistics for data analysis;
  • Familiar with blood cell development and related malignancies, or breast cancers;
  • Experience with systems biology and/or systems medicine workflows
  • A demonstrated ability to supervise junior staff and students.

To apply for the role: please email your application to recruitment@nullcentenary.org.au

Applications must include:

  • A cover letter addressing the essential skills,
  • A detailed curriculum vitae (CV) including academic transcript, and
  • The full contact details of at least three recent professional referees.

Applications close: 28 February 2020

Centenary Institute of Cancer Medicine And Cell Biology is a centre of excellence in medical research affiliated with the Royal Prince Alfred Hospital and the University of Sydney located at Camperdown.

For more information about Centenary please visit our website www.centenary.org.au

The Centenary Institute supports Equal Employment Opportunity. We value diversity and encourage applications from women, Aboriginal and Torres Strait Islanders, people with disability, LGBTIQ individuals and applicants of diverse cultures and ages.

Postdoctoral position at the University of Pittsburgh

A postdoctoral position is available in the laboratory of Dr. Nara Lee at the University of Pittsburgh. Our research is focused on uncovering the molecular mechanisms of Epstein-Barr virus expressed non-coding RNAs. We apply cutting-edge technologies entailing next-generation sequencing to study RNA-RNA, RNA-protein, and RNA-chromatin interactions. Please visit mmg.pitt.edu/person/nara-lee for further information.

We are looking for a highly motivated candidate with a PhD in RNA biology or a related discipline. Ideally, the candidate will have expertise in bioinformatic analysis of deep-sequencing data.

The start date for this position is summer/fall 2020. Funding is available for two years with the possibility of extension.

To apply: Please email a cover letter describing your motivation for this position and CV to Dr. Nara Lee at nara.lee@nullpitt.edu.

 

Post-doctoral Positions Open Immediately, Burns Lab, Dept. of Oncologic Pathology, Dana-Farber Cancer Institute

Retrotransposons

Post-doctoral positions are open immediately to join the Burns laboratory in the Department of Oncologic Pathology at Dana-Farber Cancer Institute. Our group studies high copy number repeats in the human genome, and the biology of the retrotransposons and endogenous retroviruses that generate these sequences. We and others have shown that subsets of these normally silenced elements are expressed as a hallmark of human cancers, and that this results in somatically-acquired retrotransposon insertions in cancer genomes. We aim to more fully characterize this phenomenon; to probe its consequences for cancer biology using models of cancer growth and tumor immunology; and to leverage our understandings to inform cancer detection and treatment.

The lab is moving from Johns Hopkins School of Medicine, and the successful candidates will be one of the first to establish the group in Boston. Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute will together offer a preeminent research environment for their work. Incoming fellows will have an outsized influence in setting the tone for an intellectually engaging, rigorous, productive, and positive environment. Each will be provided with significant intellectual freedom, substantial technical support, and ample opportunities to form collaborations and develop a national and international reputation in this potentially impactful and understudied field.

Accomplished and motivated candidates with a recent Ph.D. or M.D./Ph.D. in biomedical sciences and significant experience in molecular biology and cell biology are encouraged to apply. A background in transposable elements and repetitive sequences is not required and can be ‘learned on the job’. Rather, projects will lie at the interface of this field with another area of expertise brought by the successful candidates. These areas of expertise may include, but are not limited to: RNA expression and epigenetics; cellular interferon responses; RNP formation and function; and protein translation.

Several peer-reviewed, NIH-funded projects are available to work on, and funding will initially be provided by the laboratory; new fellows will be expected to apply for research support.

More permanent staff scientist positions can be made available, please contact the PI (kburns@nulljhmi.edu) or apply through the link below.

https://careers-dfci.icims.com/jobs/18185/research-fellow—burns-lab/job

Senior Scientist Position Available, Ionis Pharmaceuticals, Inc., Carlsbad CA (North San Diego County)

Ionis Pharmaceuticals, Inc., located in the North San Diego County city of Carlsbad, was founded in 1989 and was purposely designed to create a better, more efficient drug discovery platform, establish a new innovation-centered business model, and maximize the value of every medicine created and get it to the people who need it most as quickly and as efficiently as possible.

With the RNA molecule as the basis of our novel drug discovery platform, we are targeting an unprecedented range of therapeutic areas. Our antisense therapies are disrupting diseases and changing their course—from the rarest of conditions, to those that impact millions of people. We currently have three commercial products and more than 40 potentially transformative medicines in our pipeline designed to treat a broad range of diseases.

Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you develop and expand your career.

SENIOR SCIENTIST

We are seeking a highly qualified and motivated individual to perform basic research to increase our understand on how ASOs target RNA to modulate the expression of genes. The position offers the opportunity to do groundbreaking science and make discoveries that will create the next generation of ASO medicines. The selected candidate will become an integral part of an interdisciplinary and energetic team of scientists in the Ionis functional genomics group.

REQUIREMENTS:

  • Ph.D. in biochemistry, molecular biology or cell biology
  • Post-doctoral research in the RNA field with a proven track record of innovative research, including publications in top tier scientific journals
  • Candidates will be considered that have studied RNA biology in cell free systems or in cultured cells
  • Proven track record of performing advanced laboratory techniques frequently used in RNA research including ChIP-seq, RNA-seq, CLIP-seq, ChiRP, FISH, SHAPE, and CRISPR editingis preferred
  • Self-starter who is a critical thinker, has a strong work ethic and is not afraid to take risks
  • Outstanding organizational, communication and team skills
  • Ability to be productive and successful in an intense work environment

Excellent salary and benefits package offered.

Please visit our website, www.ionispharma.com, for more information about Ionis and to apply for this position; reference requisition # IONIS02148

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

PhD Position, Investigating Regulation of the RNA Modifying Enzyme ADAR1, Masaryk University | CEITEC | Brno | Czech Republic

Investigating the regulation of the RNA modifying enzyme ADAR1 and how it regulates other biological pathways and diseases

Professor Mary O’Connell

Masaryk University | CEITEC | Brno | Czech Republic

Project Description

The ADAR enzymes convert adenosine into inosine in dsRNA. Inosine is one of the most abundant and best studied modifications found in different classes of RNA. Hundreds of millions of positions have been identified within the human transcriptome where inosine can occur. The fact that levels of inosine have been found to increase in the RNAs of many cancers has sparked huge interest in this field. The levels of inosine in RNA have also been shown to profoundly affect activation of innate immunity in cancer, infection, and autoimmune diseases. The goal of this PhD project is to understand how ADAR1 is regulated and it in turn regulates different cellular processes. The methods used will include basis molecular biology techniques such as immune-blotting, RNA isolation, qPCR, cell culture etc. The candidate will have to be proficient in English, both spoken and written, be experienced in molecular biology or immunology. How to apply: Register for this call using the registration form at http://ls-phd.ceitec.cz/http-ls-phd-ceitec-cz/ and submit required documents to receive support with the preparation of the application and all formalities. Your application package will be forwarded to Professor O’Connell. Applicants who wish to pursue a degree at the CEITEC PhD program must hold the equivalent of a Master’s degree (MSc). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

Informal inquiries can be made to mary.oconnell@nullceitec.muni.cz

References

  1. Mannion, N. M. et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep 9, 1482-1494, doi:10.1016/j.celrep.2014.10.041 (2014). 2. Rice, G. I. et al. Mutations in ADAR1 cause Aicardi-Goutieres syndrome associated with a type I interferon signature. Nature genetics 44, 1243-1248 (2012). 3. M. A. O’Connell, et al. The Epitranscriptome and Innate Immunity. PLoS Genet 11, e1005687 (2015).

Closing date: 20th February

Postdoctoral Research Fellow position: Biochemistry and Structural Biology of Functional RNAs

UT Southwestern Medical Center

A postdoctoral training position is available in the laboratory of Yunsun Nam, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study the mechanisms of RNAs that regulate gene expression. Our laboratory has several exciting projects related to how RNA shape changes the destiny of the RNA by altering its function and specific interactions with proteins. The goal is to determine how macromolecular recognition and enzymatic regulation are accomplished, using biochemistry, structural biology, and molecular biology. The functional noncoding RNAs we study are relevant for normal development as well as diseases such as cancer, making our mechanistic work also valuable for therapeutics research. Postdoctoral scholars will have many opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast evolving field in biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, cryo-electron microscopy (cryo-EM), molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, drug discovery, and mammalian cell-based studies. Information on the UT Southwestern postdoctoral training program and benefits can be found in the Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry (protein or nucleic acids), cell biology, genomics, and/or structural biology leading to publication in peer-reviewed journals is recommended. The position is open immediately and available for > 3 years.

Interested individuals should send a CV, statement of interests, and a list of three references to:
Yunsun Nam, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8511
Yunsun.Nam@nullutsouthwestern.edu
www.ynamlab.org

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.

Postdoctoral position at the University of Pittsburgh

A postdoctoral position is available in the laboratory of Dr. Nara Lee at the University of Pittsburgh. Our research is focused on uncovering the molecular mechanisms of Epstein-Barr virus expressed non-coding RNAs. We apply cutting-edge technologies entailing next-generation sequencing to study RNA-RNA, RNA-protein, and RNA-chromatin interactions. Please visit mmg.pitt.edu/person/nara-lee for further information.

We are looking for a highly motivated candidate with a PhD in RNA biology or a related discipline. Ideally, the candidate will have expertise in bioinformatic analysis of deep-sequencing data.

The start date for this position is summer/fall 2020. Funding is available for two years with the possibility of extension.

To apply: Please email a cover letter describing your motivation for this position and CV to Dr. Nara Lee at .

 

Postdoctoral Research Fellow Position Available

Postdoctoral Research Fellow position:
Biochemistry and Structural Biology of Functional RNAs

UT Southwestern Medical Center

A postdoctoral training position is available in the laboratory of Yunsun Nam, in the Cecil H. and Ida Green Center for Reproductive Biology Sciences at UT Southwestern Medical Center to study the mechanisms of RNAs that regulate gene expression. Our laboratory has several exciting projects related to how RNA shape changes the destiny of the RNA by altering its function and specific interactions with proteins. The goal is to determine how macromolecular recognition and enzymatic regulation are accomplished, using biochemistry, structural biology, and molecular biology. The functional noncoding RNAs we study are relevant for normal development as well as diseases such as cancer, making our mechanistic work also valuable for therapeutics research. Postdoctoral scholars will have many opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast evolving field in biomedical sciences. We use various approaches, including X-ray crystallography, NMR spectroscopy, cryo-electron microscopy (cryo-EM), molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, drug discovery, and mammalian cell-based studies. Information on the UT Southwestern postdoctoral training program and benefits can be found in the Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry (protein or nucleic acids), cell biology, genomics, and/or structural biology leading to publication in peer-reviewed journals is recommended. The position is open immediately and available for > 3 years.

Interested individuals should send a CV, statement of interests, and a list of three references to:
Yunsun Nam, Ph.D.
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-8511
Yunsun.Nam@nullutsouthwestern.edu
www.ynamlab.org

UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.

Nucleic Acid Chemist, Sixfold Bioscience, London

Summary

  • Challenge: use your nucleic acid chemistry experience to build a radically different approach to drug delivery
  • Required: RNA and/or DNA synthesis experience
  • Start-date: spring 2020
  • Salary: £35–50,000 per year, depending on experience
  • Position: Full-time/ permanent

About us

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.

The opportunity

As an RNA Chemist you’ll have the opportunity to build a radically different approach to how we deliver RNA therapeutics in vivo. You’ll be applying your knowledge of nucleic acid chemistry to design and synthesise oligos that enhance our proprietary drug delivery systems. You’ll be utilising intra- and extra-cellular systems to ‘hack’ biology for more effective therapeutic potential.

During the first year, you’ll

  • Lead the development and optimisation of RNA for therapeutic use including considerations of stability.
  • Establish innovative chemistries for increasing the potential of Sixfold’d drug delivery systems.
  • Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).

Who you are

You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who has a strong background in RNA and/or DNA chemistry and synthesis.

Perks

  • Regular team-wide social events
  • Pension
  • Equity based remuneration
  • Inclusive company culture
  • See your ideas and research make an impact in a fast-growing start-up
  • 25 days paid vacation (+ bank holidays)

Further Information

Should you have any questions, please email careers@nullsixfold.bio

 

 

Postdoctoral Researcher or Staff Scientist Position Available, Lab of Dr. Xin Li, University of Rochester Center for RNA Biology, Genome Therapeutics, Dept Biochemistry

A postdoctoral researcher position or staff scientist position is available in the laboratory of Dr. Xin Li, Associate Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics and Department of Urology, NIEHS Environmental Health Sciences Center (zhaohua.urmc.rochester.edu).

Germ cells are the only cell type whose lifespan is not limited as they are reprogrammed with totipotency in the next generation. We want to understand the basic principles in germ cells that ensures the sustainability of a species from two unique angles. DNA is not the only information carrier. The first is through an RNA biology oriented approach. We strive to understand how various germ-line RNAs prepare and shape epigenetic information flowing across generations. The second focuses on comparative biology. We have established alternative model organisms, such as chickens and lizards, for studying germ cell biology.

We are adopting an interdisciplinary approach that includes genetics, epigenetics, cell biology, RNA biochemistry, reproductive biology, early embryology, evolutionary biology, and bioinformatics. Currently, our ongoing projects are centered on two related topics: PIWI-interacting RNAs (piRNAs) and sperm RNAs. piRNAs are a recently discovered type of small RNA that offers great promise in advancing our understanding of germ cell biology, whereas sperm RNAs may offer important insight into the transgenerational flow of epigenetic information. Finally, beyond infertility and contraception, what we have learned in germ cells can be applied to other cell types to promote regeneration or anti-aging. At the same time, understanding the mis-activation of some germline properties can offer insight into some diseases, such as cancer.

REQUIRED QUALIFICATIONS:

• A genuine interest in our research
• A Ph.D. or equivalent experience

The University of Rochester Medical Center ranks 36th nationally in medical research and 23rd in primary care, based on the 2020 US News and World Report. The University of Rochester was ranked one of the top 15 institutions in the nation for scientists to work at, according to The Scientist magazine’s annual survey of “Best Places to Work for Scientists in Academia”. Our Center for RNA Biology is a mecca for RNA researchers, with a long history of nurturing RNA biologists and discoveries. We offer a very collaborative, collegial environment that allows us to recruit the very best RNA researchers. Moreover, the city of Rochester is safe, beautiful, and affordable.

Please provide a cover letter describing your past projects and career goals. Please also describe what you hope to get out of this position and what you hope to bring to the Lab. Enclose your detailed CV with names and contacts of three references to Xin_Li@nullURMC.Rochester.edu.

Postdoc Position Available, Dept of Cellular, Computational and Integrative Biology – CIBIO of the University of Trento

The laboratory of Dr Emilio Cusanelli at the Department of Cellular, Computational and Integrative Biology – CIBIO of the University of Trento is currently seeking a motivated postdoc with expertise in molecular biology and cell biology and a strong interest in the telomere and noncoding RNA fields. The successful candidate will conduct a project aimed at investigating the function of the telomeric noncoding RNA TERRA in the activation of ALT mechanisms in human cancer cells. The project will combine live cell imaging, molecular biology and cell biology approaches and benefit from the multidisciplinary and collaborative environment present at the CIBIO Department.

Background: Cancer cells achieve replicative immortality by expressing the enzyme telomerase that elongates telomeres or by activating alternative telomere lengthening mechanisms, known as ALT. One of the hallmarks of ALT is increased telomere transcription and induced expression of the telomeric noncoding RNA TERRA. TERRA molecules are important regulators of telomere biology and may represent novel therapeutic targets for impairing cancer cells immortality.

Project overview:

The main goals of the project are the following: i) Defining the dynamics and function of TERRA in ALT cancer cells ii) Exploiting TERRA depletion to impair ALT activation, ALT human cancer cells viability and sensitize cancer cells to chemotherapy. The successful candidate will be responsible of developing and implementing multiple integrated experimental approaches including gene knock down approaches to deplete TERRA molecules in cells, the CRISPR/Cas9 tool to generate cancer cell clones expressing single-telomere TERRA molecules tagged with MS2 sequences for live cell imaging analyses, CHIRT-seq and transcriptomic approaches to identify TERRA target genes.

Qualifications

The successful candidate will be a self-motivated and multitasking scientist with an excellent attitude to work in a team and the ability to work independently at both intellectual and technical levels. The successful candidate will have extensive experience in mammalian cell cultures, cell biology and molecular biology techniques and a strong interest in the telomere and the noncoding RNA fields. The ideal candidate will have previous experience in the telomere field and familiarity with the use of gene knock down approaches and imaging techniques.

Hosting Institution

The Department CIBIO is a cutting-edge and top-ranked institute in biomedicine and biotechnology of the University of Trento. CIBIO offers the possibility to work in a young, highly dynamic and stimulating research environment supported by cutting-edge research infrastructures. The department provides a high level of research services and Core Facilities, operated by highly skilled staff scientists, with all the state-of-the-art equipment and tools necessary in supporting biomedical research projects to be carried out with the required level of technological sophistication, specifically for: High-Throughput/High Content Screening, Next Generation Sequencing, Cell Analysis and Separation, Cell Technology, Advanced Imaging, Model Organisms, Mass Spectrometry, Protein Technology, Bioinformatics. More information regarding the department and the University of Trento can be found at the following links: https://www.cibio.unitn.it/; https://www.unitn.it/en.

The position is for 1 year renewable for up to 3 years. The net starting salary will be of 20.000 euro/year.

Highly motivated candidates with a strong interest in the research field are encouraged to apply by sending their cv along with the names of two scientists who can provide reference letters to emilio.cusanelli@nullunitn.it

PhD Project on RNA-binding Activity of glycolytic enzymes in melanoma (Stéphan VAGNER’s team, Institut Curie, FR)

PhD project on the RNA-binding activity of glycolytic enzymes in melanoma (Stéphan VAGNER’s team, Institut Curie, FR)

Stéphan VAGNER’s team focuses on the role RNA-binding proteins in cancer biology and anticancer therapies (genome instability and genotoxic chemotherapy, oncogenic signaling pathways and targeted therapies, cancer-immune cells cross-talk and immunotherapy). The team uses a combination of approaches (biochemical analyses of RNA, proteins and their interactions, genome-wide analyses of RNA regulation (RNA-seq, 3’seq, polysome profiling) and RNA-protein interactions (iCLIP), analyses of cancer cell phenotypes in cell culture, tumor biology in vivo and patients’ tumors).

PhD project: In spite of the recent progress in the field of metastatic melanoma treatment, this cancer remains with a dreadful prognosis because resistance occurs in the majority of patients. Given that cancer cells rely on aerobic glycolysis for energy production, several drugs have been developed to target cellular metabolism. However, targeting metabolism may also affect immune cells function, preventing their contribution to tumor elimination. The metabolic status of tumor cells, mediated by the effects of a cascade of glycolytic enzymes (GE), is a critical parameter of melanoma biology. Recent data demonstrated that some GE could bind to mRNAs and influence their translation level.

In addition, the team has contributed to the demonstration that regulation of mRNA translation is involved in cancer hallmarks. We propose to explore the impact of GE on mRNA translation, highlighting a different perspective by which GE may affect melanoma biology.

The project focuses on the non-canonical RNA binding activity of GE, with the primary aim to identify mRNAs regulated at the level of translation by direct binding to GE. It will evaluate the potential anti-tumor effect of disrupting these interactions.

Beyond defining the functions of GE-mRNA interactions and their significance in melanoma cells, it is expected that new targets for alternative therapeutic modalities for cancer are identified.

Applicants should have a strong desire to explore RNA-protein interaction with molecular biology tools and should show solid capacity for independent and creative thinking. Background in molecular biology and cancer biology is strongly recommended. Background in bioinformatics is a plus but not compulsory.

The start date of the position is September 2020 and funding is available for 3 years.

More information & application: training.institut-curie.org/eureca

Application deadline: January 13th, 2020 at 4pm (CET)

Postdoctoral Position, Available Immediately, Lab of Dr. Paul F. Agris, Duke University Dept of Medicine

A postdoctoral position is immediately available in the Lab of Dr. Paul F. Agris recently established at Duke University Department of Medicine. Applicants are sought with expertise in the following areas: cellular and molecular biology, genetics and biochemistry with experience in RNA and protein expression and mammalian cell culture. Applicants must provide a complete curriculum vitae with publication list, three names and contact information for references, and a cover letter summaring the experience with RNA molecular/cellular biology.

Apply through Duke at the link:

https://career4.successfactors.com/sfcareer/jobreqcareer?jobId=2226&company=dukeuniverP1&username=

Scientist I, Molecular Biology/Platform Development Skyhawk Therapeutics

Scientist I, Molecular Biology/Platform Development

Skyhawk Therapeutics is seeking a Scientist to join the talented, growing startup team in Waltham, MA.

Skyhawk is committed to discovering, developing and commercializing small molecule therapeutics that correct RNA splicing. We use our novel SkySTARTM platform (Skyhawk Small molecule Therapeutics for Alternative splicing of RNA) to develop drug candidates directed to targets for some of the world’s most intractable diseases including cancer, neurological conditions, and other “undruggable” targets against a wide range of conditions.

Position Overview

The successful candidate will be part of an interdisciplinary research team, working on an interface from molecular biology to biophysical and biochemical methods to help support the growth of the Skyhawk Platform to develop small molecules targeting RNA. They will develop molecular biology assays and tools to elucidate a novel mechanism of actions of drugs, develop novel screening tools, and work with NGS techniques. The work of the successful candidate will aid multiple drug research projects and teams; and collaborate with contract research organizations to develop additional tools.

Role and Responsibilities (include, but are not limited to):

  • Design and develop molecular biology assays and tools to characterize molecular interactions between RNA and proteins/small molecules. Establish workflows, SOPs and guidelines
  • Design and create minigene constructs and mutagenesis to aid target validation and hit-to-lead studies
  • Design and develop CRISPR-based assays
  • Prepare next-generation sequence (NGS) library and run NGS sequencer
  • Clearly and efficiently communicate with multidisciplinary teams to integrate activities with programs
  • Review technical publications, articles and abstracts in the fields of RNA biochemistry, and molecular biology
  • Participate in project lab, team or company meetings, and scientific discussions
  • Summarize/report data and generate presentation materials

Education/Skills/Experience Requirements:

  • PhD in Molecular Biology/Biochemistry and 1-2 years of practical experience in RNA biology with an understanding of drug discovery
  • Deep knowledge in biochemical and molecular biology techniques
  • Hands-on experience in expression and purification of proteins, functional analyses of protein/small molecule-RNA complexes, and site-directed mutagenesis
  • Demonstrated contributions in identification and validation of target and drug binding sites
  • Proven experience in working independently as well as in a team environment
  • Innovation in research/methodology, and excellent command of the research literature and databases
  • Demonstrated track record of scientific publications related to RNA processing
  • Proficiency in MS Office package and GraphPad prism
  • Excellent written and oral communication skills in English
  • Excellent interpersonal and team skills; track record of success working collaboratively across disciplines
  • Ability to think critically, make timely decisions, and manage deadlines and priorities
  • Flexible, efficient and able to work independently with a problem-solving attitude in a fast-paced small company environment

To Apply: Please send resume and cover letter to taesun@nullskyhawktx.com

A COVER LETTER IS REQUIRED. Please explain why this job is of interest to you. Detail your strengths and weaknesses as they pertain to the requirements and responsibilities of this position.

Lab Research Analyst, Available Immediately, Lab of Dr. Paul F. Agris, Duke University Dept of Medicine

A Lab Research Analyst 1 (LRA1) is sought immediately for the Lab of Dr. Paul F. Agris recently established at Duke University Department of Medicine.
Applicants should have significant expertise in the following areas: cellular and molecular biology/biochemistry with mammalian cell culture and microbiology experience; and experiential experience with RNA and protein expression.
The primary duties for this position are initially related to Dr. Agris research on Type II Diabetes. All of the LRA1’s time will be reserved for research activities. It is expected that the LRA1 will focus their research on:
– Insulin inducible, Cdkal1 knockout cells that will be tested for Cdkal1 and insulin production, compared to the parental cells
– Cdkal1 knockout cells will be rescued by transfection of the human Cdkal1 gene and Cdkal1 and insulin assayed, and compared to the parental cells
– tRNA will be isolated from the different cell cultures and HPLC-MS analysis will be determined, particularly for ms2t6A and t6A
The LRA1 will also actively participate in other projects, aid in writing papers/grants, and supervising students.
Applications should be entered through the Duke Human Resources website:
https://career4.successfactors.com/sfcareer/jobreqcareer?jobId=15001&company=dukeuniverP1&username=

The above statements describe the general nature and level of work being performed by individuals assigned to this classification. This is not intended to be an exhaustive list of all responsibilities and duties required of personnel so classified.
Education/Training: Work requires a bachelor’s degree in botany, biology, biochemistry, microbiology, biological chemistry, zoology, botany, psychology or other directly related scientific field. Work requires two years of research experience. A related master’s degree may offset required years of experience on a 1:1 basis, e.g., a two year master’s degree in lieu of two years of experience. OR AN EQUIVALENT COMBINATION OF RELEVANT EDUCATION AND/OR EXPERIENCE

Postdoctoral Training Program, Tufts University, Boston, Massachusetts

We would like to tell you about an exciting postdoctoral training program that is in place at Tufts University in Boston, Massachusetts. This program, called Tufts IRACDA (Institutional Research and Academic Career Development Awards Program), is funded by the IRACDA mechanism of NIH-NIGMS. Tufts IRACDA is designed to prepare talented young scientists for the multiple demands of an academic career in biomedical research. Scholars spend on average 75% of their time conducting bench research and 25% of their time in career development activities. Opportunities are available in a wide range of biomedical research disciplines. Teaching skills are developed through programs involving mentored classroom assignments at minority-serving institutions in the Boston area. The training is further supplemented by workshops on essential skills such as grant and manuscript writing, mentoring, lab management, and scientific presentations, as well as on teaching methods that encourage active learning. The training components are sequenced to allow scholars to balance the activities and to build on previous experiences. IRACDA scholars receive up to four years of salary support and a travel and supply allowance. They will complete our program ready to manage a successful research program and balance the multi-faceted demands inherent in a career as an academic scientist.  Annual salary levels match the NIH postdoctoral stipend levels.

Applicants must be U.S. citizens or permanent residents with no more than two years of postdoctoral training at the time of their appointment to the program. Commitment to the goals of the program, strong academic and research credentials and an interest in teaching, mentoring, and active citizenship will be important criteria used in the selection process.

The application deadline for positions beginning in the fall of 2020 is March 1, 2020. Later applications will be considered if positions are available. For additional information on the Tufts IRACDA Program and application procedures, please visit our website: https://gsbs.tufts.edu/academics/TuftsIRACDA.

 

Post Doc Position Available, Max Planck Institute, Leipzig, Germany

The Smerlak group at the Max Planck Institute for Mathematics in the Sciences (Leipzig, Germany) seeks a talented postdoc to join an international collaboration working on the origin of life.

The RNA world hypothesis posits that an early stage of life involved RNA acting as both information carrier and catalyst. Extant self-splicing introns (such as the Azoarcus ribozyme, which can catalyze its own self-assembly from ~50nt-long fragments) may provide a window into this ancient world.

The project aims to combine computational and experimental techniques to design RNA self-replicators from group I introns and test whether they can evolve in vitro.

 The collaboration partners are Philippe Nghe (ESPCI, Paris), Eric Hayden (Boise State University, USA) and Arati Ramesh (National Center for Biological Sciences, India) and their groups.

The ideal candidate will have some expertise in either bioinformatics, biophysics or machine learning and an ability to work creatively across disciplinary boundaries.

The position is for one year (renewable for up to three years). Start date preferably in the spring of 2020.

Funding is through HSFP Young Investigator Award RGY0077/2019.

Contact:
Matteo Smerlak
Email: smerlak@nullmis.mpg.de
URL: www.smerlak.group

Postdoctoral position at Johns Hopkins University

A postdoctoral position is available in the laboratory of Dr. Ryuya Fukunaga at Johns Hopkins University School of Medicine. The laboratory is focused on understanding RNA biology, including the molecular mechanisms of (1) biogenesis and function of small silencing RNAs such as miRNAs and siRNAs and (2) post-transcriptional gene regulation by RNA-binding proteins, RNases, RNA helicases, and RNA modification enzymes.

We employ a wide range of approaches that include biochemistry, Drosophila genetics, cell culture system, high-throughput sequencing, and structural analysis.

We are looking for a highly motivated and enthusiastic new member of the lab. Candidates must have received (or be expecting) a Ph.D. or M.D. within the past three years in molecular biology, biochemistry, genetics, cell biology, structural biology, or a related discipline. Candidates with strong background in biochemical, molecular, cellular, and genetic analyses in RNA biology and/or Drosophila genetics are encouraged to apply.

More information is available at:

https://sites.google.com/site/fukunagalabjhmi/

https://bcmb.bs.jhmi.edu/people/faculty/ryuya-fukunaga

Please email [1] cover letter, [2] CV, [3] a brief summary of research interests, accomplishments, and career goals, and [4] contact information of at least three references to Dr. Ryuya Fukunaga at fukunaga@nulljhmi.edu