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Assistant Professor Positions, Columbia University, Department of Biochemistry and Molecular Biophysics

The Department of Biochemistry and Molecular Biophysics at Vagelos College of Physicians and Surgeons invites outstanding candidates to apply for TENURE-TRACK faculty positions at the level of Assistant Professor. The department seeks individuals with exceptional accomplishments and abilities in Biochemistry and Molecular Biophysics. Areas of particular interest are RNA Biology and Chromosome Structure and Function, but exceptional candidates in other areas are strongly encouraged to apply. Examples of such areas include, but are not limited to: single molecule studies and live imaging; phase transitions and granules; and biophysical studies of cellular phenomena. We seek colleagues committed to scientific excellence, collaboration, and collegiality.

The Department of Biochemistry and Molecular Biophysics offers a rigorous and stimulating environment for conducting research. Faculty use the full spectrum of contemporary biophysical, biochemical, molecular biological, and cellular techniques to study developmental biology; gene expression, regulation and signal transduction; macromolecular structure, function and dynamics; and molecular neurobiology. The Department has a rich history of excellence in molecular and structural biology and molecular neuroscience. Cross-appointment with other departments or centers is also possible.

Essential Qualifications

All applicants must have a Ph.D., M.D., or equivalent degree. In addition, applicants must have a very strong record of research productivity and demonstrated ability to develop a rigorous research program.

Applicants should provide a summary of their scientific accomplishments and a description of their scientific vision, emphasizing one or more major unsolved problems in their field and how they plan to solve them (no more than three pages).

Completed applications, including the research statement, curriculum vitae, PDF copies or links for three reprints (which may be uploaded as a single PDF file), and contact information for three references must be submitted online via the following website:

https://pa334.peopleadmin.com/hr/postings/4363

Consideration of completed applications will begin in November, 2019 and continue until the positions are filled.

Columbia University is an equal opportunity/affirmative action employer. Women and minorities are especially encouraged to apply.

POSTDOCTORAL RESEARCH FELLOW POSITION IN RNA BIOLOGY AND HEART DISEASE

Department of Biochemistry and Molecular Biology at University of Texas Medical Branch

A post-doctoral fellow position  is available immediately in the laboratory of Dr. Muge Kuyumcu-Martinez to study post-transcriptional gene regulation by RNA binding proteins in normal and diseased hearts. We utilize inter-disciplinary approaches that combine mouse genetics, cell biology, genome editing, biochemistry, and genome-wide analyses (e.g. RNA-seq, CLIP-Seq, PolyA seq and nanopore sequencing) to investigate molecular mechanisms that dictate post-transcriptional decisions in the heart.

We are looking for a highly motivated, bright and enthusiastic candidate with a background in RNA biology, heart development or cardiac physiology. The candidate should be to able to work as a team member, learn new skills rapidly, and have excellent communication skills. It is highly desirable that the applicant received his/her PhD within the last year.

University of Texas Medical Branch is a part of the Texas Medical Center, which is the largest medical complex in the world comprised of 54 highly collaborative and interactive medically oriented institutions including MD Anderson Cancer Center, Baylor College of Medicine, University of Texas Medical School at Houston, and Methodist Research Institute to name a few.

If you are interested, please provide your curriculum vitae, a statement of career interests (1 paragraph long), and contact information for three references to nmmartin@nullutmb.edu.

Postdoctoral Positions Available – Wolin Lab, National Cancer Institute, National Institutes of Health

Fully funded postdoctoral positions are available in Sandra Wolin’s laboratory at the National Cancer Institute in Frederick Maryland. We are seeking candidates with expertise in molecular biology, biochemistry or structural biology to join one of our ongoing projects. A major interest of our laboratory is a class of noncoding RNA-protein complexes, called Ro60 RNPs, that are present in animal cells, bacteria and archaea. Our work revealed that the Ro60 protein is ring-shaped and binds defective RNAs in its central cavity and that noncoding RNAs called Y RNAs scaffold the interactions of Ro60 with other proteins such as nucleases. Our current studies are focused on characterizing ways in which Ro60 RNPs contribute to the biogenesis of other ncRNAs and to the surveillance of defective RNAs. We are also determining how defects in RNA surveillance pathways contribute to diseases such as cancer and autoimmunity. We use a wide variety of approaches, including mouse and bacterial genetics, biochemistry, molecular biology and structural biology. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin

Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research, National Cancer Institute, National Institutes of Health. We are part of the National Cancer Institute’s RNA Biology Initiative, which includes more than 50 laboratories spanning the Frederick and Bethesda campuses. The environment is highly collaborative, with the ability to interact with a wide range of scientists and clinicians. The extraordinary resources and opportunities available at the National Cancer Institute and the National Institutes of Health make these positions ideal for motivated candidates who are seeking additional training in RNA biology.

Candidates should have a Ph.D. and/or an M.D. and less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, biochemistry or structural biology, as evidenced by publications.

To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to sandra.wolin@nullnih.gov

This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.

Postdoctoral Position Available Immediately, Lab of Sarah Keane, Departments of Biophysics & Chemistry, University of Michigan

A postdoctoral position is available immediately in the laboratory of Sarah Keane in the Departments of Biophysics and Chemistry at the University of Michigan. Our lab aims to investigate the structure and mechanism of functional noncoding RNAs. We utilize an array of biochemical and biophysical techniques to characterize RNA structure, RNA-RNA, RNA-protein, and RNA-small molecule interactions. We seek a highly motivated postdoc with experience in RNA biochemistry and/or RNA structural biology (biomolecular NMR spectroscopy, X-ray crystallography, small angle X-ray scattering, chemical probing). Successful applicants should hold (or will obtain shortly) a Ph.D. in: Biochemistry, Biophysics, Chemistry, Molecular Biology, or a related field. More information about the lab can be found on our website (http://sites.lsa.umich.edu/keane-lab/).

Postdocs in the Keane lab are expected to assume leadership of their projects and serve as mentors to both graduate and undergraduate students in the lab. Interested candidates should send a cover letter, their CV, and the names and contact information for three references via email (sckeane@nullumich.edu) with the subject POSTDOC APPLICATION. This position is a full-time, 12-month appointment with an opportunity for renewal based on performance and funding. The University of Michigan is an equal opportunity/affirmative action employer.

Informatics Fellows in the RNA Bioscience Initiative

The RNA Bioscience Initiative at the University of Colorado School of Medicine seeks to hire RNA Bioinformatics Fellows.

Two types of positions are currently available:

  1. Positions solely focused on informatic analysis and development
  2. Positions where time is spent both on wet-lab RNA method development and applications as well as informatic analysis and development

The Bioinformatics Fellowships are unique, semi-autonomous postdoctoral positions at the Senior Research Associate Level that provide informatics training with the goal of mastering the large skill set needed for RNA bioinformatics analysis. The Fellows (https://informatics-fellows.rnabio.co/) develop and apply software for the analysis of a variety of RNA sequencing and other experiments focused on:

  • in-depth analysis of single cell sequencing data from multiple modalities
  • characterizing mRNA isoforms generated by alternative splicing and polyadenylation
  • the stability and processing of mRNAs after transcription
  • identifying and characterizing the dynamics of RNA modifications
  • integrating RNA sequencing data with genetic data
  • ribosome profiling and the measurement of small and long non-coding RNAs

Wet-lab project may include:

  • Development of new single-cell sequencing methods
  • RNA-seq analysis of consequences of alterations in nonsense mediated RNA decay
  • RNA-seq approaches to complement ongoing efforts in antisense oligonucleotide therapy development

The fellows have the opportunity to interact with a variety of RNA informatics researchers on campus, and support informatics analysis for the recipients of seed grants provided by the RNA Bioscience Initiative.

The fellows develop and help teach curricula (e.g., graduate level classes and week-long short courses) that promote the use of RNA methods and informatics on the Anschutz campus. Our ideal candidates have a Ph.D. in biological or computer sciences, and wish to expand their training to become proficient in both disciplines. The positions will be for two years with the possibility to extend the fellowship for an additional year. Toward the end of their tenure, Fellows have the opportunity to develop collaborations with faculty in the School of Medicine and liaise with pharmaceutical and biotech companies to secure a stable long-term position in Informatics.

Applicants should submit a cover letter, curriculum vitae and the contact information for 3 people who will provide letters of reference.

Materials should be submitted through CU Careers, posting # 17661

We will begin reviewing applications immediately and the search will remain open until the positions are filled.

Qualifications:

Minimum Requirements:

  • PhD in biological or computational discipline, MS candidates will also be considered
  • Molecular or RNA biology experience for position that includes wet-lab
  • Preferred expertise in R, Python or C++
  • Working knowledge of computational and molecular biology, and high throughput DNA sequencing data analysis
  • Demonstrated ability to teach bioinformatics, computational Biology and/or genomics courses and workshops

Special Notices to Applicants:

The University of Colorado at Denver is committed to providing a safe and productive learning and living community.  To achieve that goal, we conduct background investigations for all final applicants being considered for employment.  Background investigations include a criminal history record check, and when appropriate, a financial and/or motor vehicle history.

The Immigration Reform and Control Act requires that verification of employment eligibility be documented for all new employees by the end of the third day of work. The University of Colorado strongly supports the principle of diversity. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. Alternative formats of this ad are available upon request for persons with disabilities.

Please be advised that the University does check references as part of the employment process, and selection committee members may choose to contact work references other than those listed in your application during the search process.

The University of Colorado is committed to diversity and equality in education and employment.

Jay Hesselberth
University of Colorado School of Medicine
Dept. Biochemistry and Molecular Genetics
E-mail jay.hesselberth@nullgmail.com

Post Doctoral Researcher Position Available, The University of Leeds, UK

Are you an ambitious researcher looking for your next challenge? Do you have an established background in RNA biology? Are you keen to develop new skills in both research approaches and group leadership? Do you want to further your career in one of the UKs leading research intensive Universities?

We are seeking an ambitious scientist to join a dynamic research group pursuing RNA research to address key questions in translational control and lncRNA functions. The position is to provide support for an academic lead taking maternity leave. In addition to RNA research this role involves mentoring of PhD students and some group management. This position would be an excellent career development opportunity for an outstanding RNA biologist to learn key skills on how to run a group with time and flexibility to write fellowships. The group use a combination of biochemical, genomic, genetic, and structural approaches to tackle important, outstanding questions in mRNA translation and lncRNA function. The successful applicant would help supervise the research group and will join a vibrant research community within the Faculty of Biological Sciences at Leeds, including LeedsOmics and the Astbury Centre for Structural Biology.

You should have a PhD in RNA biology with a strong background in mRNA translation, lncRNA biology or RNA-protein complexes. Experience in biochemical purification of RNA-protein complexes, Drosophila melanogaster husbandry and genetics, analysis of RNA-Seq or similar data, structural biology, genomics would be desirable.

The University of Leeds and the Faculty of Biological Sciences are committed to providing equal opportunities for all and offer a range of family friendly policies. The University is a charter member of Athena SWAN (the national body that promotes gender equality in higher education), and the Faculty of Biological Sciences was reawarded a Bronze award in 2017. We are proud to be an inclusive Faculty that values all staff, and are happy to consider job share applications and requests for flexible working arrangements from our employees. Our Athena SWAN webpage provides more information.

RNA biology: lncRNAs, RNA-protein interactions or mRNA translation.

Looking for an experienced postdoc who wants career development opportunity to help manage group as PI goes on maternity leave. Great opportunity for someone wanting to write fellowships. 1 year fixed term, available from 1st Dec 2019

To apply:
https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSMB1169

Post-Doctoral Researcher Position Available, Colorado School of Medicine

I am seeking a motivated, independent, creative entry level post-doctoral researcher to join my laboratory at the University of Colorado School of Medicine (position available immediately). My lab is interested in understanding the molecular mechanism of pre-mRNA splicing and its role in disease processes, using a combination of structural (cryoEM and crystallography), biochemical, molecular biology, and cell biology approaches. Below are examples of our recent publications:

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing. Nat Commun. 2017; 8:1035. PMID 29051543.

Structure of the yeast spliceosomal postcatalytic P complex. Science. 2017; 358:1278-1283. PMID 29146870.

A unified mechanism for intron and exon definition and back-splicing. Nature. 2019; 573: 375-380. PMID 31485080.

My lab is located on the University of Colorado Denver Anschutz Medical Campus within the highly collegial Department of Biochemistry and Molecular Genetics and is part of the RNA BioScience Initiative. Denver is a great place to live and to do research. To apply, please send an email with a cover letter summarizing past research accomplishments, research interest, long term plans, and start date availability; CV; and contact information of three references to Rui.Zhao@nullcuanschutz.edu.

Grant and Development Strategist for the RNA Bioscience Initiative at CU Anschutz

Job Overview. The RNA Bioscience Initiative (RBI; www.rockyrna.org) seeks to hire a Grant and Development Strategist. Through a $20 million dollar initiative at the University of Colorado Anschutz Medical Campus, the RBI has expanded and increased the excitement for RNA research through hiring of new RNA faculty and a RNA bioinformatics group, developing new research programs and approaches for data generation and analysis, funding seed projects focused on RNA science, and educating trainees at all levels in RNA biology. We seek a Grant and Development Strategist to capitalize on these accomplishments and co-ordinate the development of competitive PI-driven applications for large-scale funding from the NIH and other funding agencies, to lead the effort to liaise with researchers and clinicians on campus, and to work to develop strategic partnerships to secure long-term funding for our research and training mission.

 

Primary and initial responsibility will be to:

•        Facilitate and coordinate multi-PI grant submissions, including a program project grant, PREP R25, and T32 grants.

 

Over time, the Grant and Development Strategist is expected to:

•        Facilitate collaborations between RBI members and clinicians

•        Interface with CU Innovations and CU Office of Advancement for purposes of fundraising and strategic development

 

The ideal candidate will have a Ph.D. and/or post-doctoral research experience in Molecular Biology or a related field, and experience in the preparation and submission of NIH grant applications. Exceptional candidates without extensive Molecular Biology experience will be considered if they have a demonstrated track record in grant writing or development activities. The candidate must be self-motivated, organized, communicate effectively, be a team player, and have scientific maturity.

 

Qualifications

Minimum Requirements:

•        Ph.D. and/or post-doctoral research experience in Molecular Biology

•        Strong interpersonal and organizational skills.

•        Experience in grant writing

 Preferred Qualifications:

•        Track record of coordinating multi-PI grants

•        Experience in fundraising or other development activities

 

Instructions to Applicants 

Required materials:

1). A letter of application which specifically addresses the job requirements and outlines qualifications.

2). A current resume/CV.

3). List of 3-5 professional references. Please be advised that the University does check references as part of the employment process.

 

Please do not submit any of your application material (via email) to the job posting contact. Applications are accepted electronically at CU Careers, refer to requisition ID: 17526. 

Link: https://cu.taleo.net/careersection/2/jobdetail.ftl?job=17526&lang=en 

 

Salary and Benefits:

The hiring salary is negotiable and commensurate with skills and experience. 

RNA Chemist (Innovation Associate)

About us

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver therapeutics to diseased cells. We saw the huge potential of Cell and Gene therapies being limited to how safely and effectively they can be systemically delivered in people. Motivated by the impact our technology could make, we’ve been working hard in the lab and are now looking for scientists to help scale our preclinical research program. We’re proud of the company we’ve built and our team is Sixfold’s biggest competitive advantage. Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic. If you want to help cure the incurable, you belong with us.

The opportunity

As an RNA Chemist you’ll have the opportunity to build a radically different approach to how we deliver RNA therapeutics in vivo. You’ll be applying your knowledge of nucleic acid chemistry to design and synthesise RNA that enhances Sixfold’s proprietary drug delivery systems. You’ll be utilising intra- and extra-cellular systems to ‘hack’ biology for more effective therapeutic potential.

We know this is a big challenge, which is why you’ll be working in close collaboration with our multidisciplinary team of chemists, biologists and computational scientists. You’ll become familiar with areas of science and preclinical research you might not be typically exposed to. As we work towards our common goal you’ll see how teams function as part of a rapidly growing startup.

Your work will make invaluable contributions to the scientific and strategic direction of the company, which is why we will give you all the support to help achieve your goals. Oh, and being funded by a prestigious Horizon 2020 Innovation Associate grant from the European Commission means you’ll gain access to additional financial support to develop your skills and build your network!

During the first year, you’ll

  • Lead the development and optimisation of RNA for therapeutic use including considerations of stability and translational efficiency.
  • Establish innovative chemistries for increasing the potential of Sixfold’d drug delivery systems.
  • Design and execute robust experiments, interpret data and communicate findings.
  • Support and contribute to publishing, patenting and grant writing efforts; supervising of a junior researcher(s).

Who you are

You need to be passionate about utilising nucleic acids in innovative and transformative ways to cure disease. Specifically, you should be someone who is:

  • Awarded or soon-to-be-awarded with a PhD degree in RNA (Bio)chemistry or equivalent scientific discipline.
  • Strong background in RNA and/or DNA chemistry.

Perks

  • €58,000-62,000 gross annual salary.
  • €4,000 relocation package (e.g. removals, travel costs, family travel costs, visa costs).
  • €5,500 for training and conferences.
  • Three EU funded industrial innovation management training events in Belgium (2-3 days each).

Other perks

  • Working on world-changing technology with leaders in the field.
  • Dynamic, innovative, passionate, entrepreneurial team.
  • Inclusive company culture.
  • The chance to see your ideas and research make an impact in a fast-growing start-up.
  • Team-wide social events.
  • 25 days paid vacation (not including bank holidays)

Eligibility

  • PhD in (Bio)chemistry or equivalent scientific discipline.
  • To have resided or carried out your main activity in the UK for no more than 12 months in the previous 3 years.

Further Information

Should you have any questions, please email careers@nullsixfold.bio

 

 

PhD. Student/Predoctoral Fellow Position Available

The Research Group of Prof. Dr. Katja Sträßer, Institute of Biochemistry, Justus Liebig University, Giessen, German, invites applications for the position as a PhD. student / predoctoral fellow as part of the ERC-funded project “Nuclear mRNP packaging and mRNP architecture”.

The position is available from December 1st, 2019 until May 31st, 2023. The salary of the position is determined by payment group E 13 according to the collective labor agreement of the State of Hessia (TV-H).

We offer:

Participation in state-of-the-art research projects

Collaboration in an enthusiastic research team

Opportunities to develop strong research skills and a solid academic profile

Opportunity to obtain a doctoral degree

Key Responsibilities:

Investigation of nuclear mRNP biogenesis as part of the ERC-funded project “Nuclear mRNP Packaging and mRNP Architecture”.

For further information please contact Prof. Dr. Katja Sträßer (Katja.Straesser@nulluni-giessen.de)

Required Qualifications:

Completed academic studies in biology, biochemistry, human biology or a similar subject (Master’s degree or equivalent) with a focus on molecular biology, cell biology, biochemistry and/or genetics. Knowledge in RNA biology, the model organism S. cerevisiae and/or structural biology is advantageous.

The Justus Liebig University Giessen is seeking a larger percentrage of women in academia; therefore, qualified female researchers are esppecially encouraged to apply. The university sees itself as a family-friendly university. Applicants with children are most welcome.

Please send your application per Email as a single pdf file with all relevant documentation per Email to katja.straesser@nullchemie.bio.uni-giessen.de until the 8th of November 2019. Applications from disabled people of equal aptitude will be given preference.

Postdoc offer: Structural & Molecular Biology of Mitochondrial Ribosome Assembly

An ANR-funded postdoctoral position is available in UMR7156 – GMGM (University of Strasbourg, CNRS) for a research project on structural, molecular and biochemical aspects of two highly conserved mitochondrial ribosome assembly factors, involved in critical steps of mitoribosome maturation and associated with severe mitochondrial diseases in human.

Mitochondria inherited from their bacterial ancestors a set of essential proteins required for translation, but also acquired new, mitochondria-specific protein factors to accomplish the assembly of the highly divergent and complex mitochondrial ribosome. Our laboratory studies two such proteins, that turned out to be essential mitoribosome assembly factors with surprising biochemical and structural characteristics and still poorly understood molecular mechanisms. Their phylogenetic distribution suggests that they play critical roles in ribosome biogenesis in the majority of mitochondrial, chloroplast and even bacterial systems and represent promising drug targets in infection- but also cancer-related pathologies. Therefore, it is necessary to reach detailed structural and functional understanding of their activity in the context of ribosome maturation and beyond.

The position, which may start any time in the first half of 2020, is a standard 3-year postdoctoral contract with a net salary of ~2,400 €. A successful candidate is expected to be a highly motivated and autonomous researcher, fluent in English, have a strong background and experience in structural biology and/or biochemistry. Experience in mitochondrial or ribosome biology is not required but may be an asset.

Applications (an informal motivation letter and CV) will be sent directly to Dr Alexandre SMIRNOV and considered until the position is filled.

Email: alexandresmirnov@nullunistra.fr
URL https://www.researchgate.net/profile/Alexandre_Smirnov

A Postdoctoral Researcher and a Research Technician to study spliced leader trans-splicing, University of Aberdeen

The laboratory of Berndt Müller and Jonathan Pettitt at the Institute of Medical Sciences of the University of Aberdeen has open positions for a Postdoctoral Researcher with a strong interest in RNA biology and for a Research Technician.  These positions are supported by a BBSRC-funded project grant that aims to understand the molecular machinery critical for an essential, nematode-specific pre-mRNA maturation step termed spliced leader trans-splicing.

The project combines state-of-the-art nematode molecular genetics and RNA biochemistry, including genome editing, proteomics and RNA sequencing technologies to (1) determine the molecular composition of RNA-protein complexes critical for spliced leader trans-splicing; and (2) define the roles of newly identified protein factors. We have partnered with Prof Michael Sattler (Technical University of Munich), a leading expert in the structural biology of RNA-protein complexes, for the detailed analysis of molecular interactions and structures.  This comprehensive, multifaceted approach will provide crucial insights into nematode gene expression, with clear implications for the development of new treatments for parasitic nematode infections.

Lab website: https://www.aberdeenwormlab.org/

University staff websites:

https://www.abdn.ac.uk/people/b.mueller

https://www.abdn.ac.uk/ims/profiles/j.pettitt

The POSTDOCTORAL RESEARCHER will work in collaboration with the Research Technician to employ CRISPR-Cas9 genome engineering to generate transgenic animals that express fluorescently tagged trans-splicing factors for the analysis of protein expression and localisation, and the characterisation of RNA and protein complexes by immunoprecipitation followed by RNA-Seq analysis and proteomics, respectively. The role of identified factors will be determined by analysing the effect of their loss-of-function on spliced leader trans-splicing in vivo. Their detailed molecular functions will be determined using protein-protein and RNA-protein interaction assays, including UV cross-linking “CRAC” technologies, which will also allow us to measure the dynamics of these interactions in vivo. Molecular structures will be solved in collaboration with the group of our project partner Professor Michael Sattler (Technical University of Munich), which has an established, world-leading track record in biomolecular structure determination and with whom the successful candidate will work closely.

Candidates for the POSTDOCTORAL RESEARCHER position must have a PhD in a relevant discipline such as Molecular Biology, Biochemistry or Genetics, with experience of working with Caenorhabditis elegans or another genetically-tractable system, and a strong interest in RNA biology.

The ideal candidate would have extensive experience in molecular biology techniques, RNA analysis and the investigation of RNA-protein and protein-protein interactions. Experience with high-throughput sequencing, proteomics, confocal fluorescence microscopy or genome editing would be an advantage.

Targeted start date for this position is January 1, 2020.  Salary will be at the appropriate point on the Grade 6 University of Aberdeen salary scale (£33,797 – £36,914 per annum). The position will be available for a period of 36 months.

For more details about the POSTDOCTORAL RESEARCHER position and to apply go to:

https://www.abdn.ac.uk/research/jobs/IMS174R

The RESEARCH TECHNICIAN will work closely with the Postdoctoral Researcher and support other members of the laboratory working on related projects. This post also involves the management, organisation and operation of an expanding research laboratory and support of associated undergraduate and postgraduate research projects.

We are looking for a skilled, experienced and ambitious individual with good technical abilities in microbiology and molecular biology and experience in working with C. elegans or other genetically tractable model organisms.  A good BSc in Molecular Biology, Genetics, Microbiology or related area is desirable. Training will be given for specialised techniques.

Targeted start date for this position is January 1, 2020. Salary will be on Grade 5 of the University of Aberdeen salary scale (£28,332 per annum). The position will be available for a period of 36 months.

For more details about the RESEARCH TECHNICIAN position and to apply go to:

https://www.abdnjobs.co.uk/vacancy/research-technician-400353.html

Informal enquiries about both positions are very much encouraged and may be made to Dr Berndt Müller (b.mueller@nullabdn.ac.uk).

Postdoctoral Position Available, Kleiner Lab, Princeton University

The Kleiner Lab at Princeton University is looking for a postdoctoral candidate with strong bioinformatic/computational biology ability. In particular, candidates with expertise in the analysis of CLIP data, RNAseq, RNA modification sequencing, and proteomic datasets are encouraged to apply. Those with strong experimental skills in nucleic acid chemistry, biochemistry, and cell biology, are also desired. We are a multi-disciplinary chemical biology lab that studies epitranscriptomic RNA modifications. A PhD in Chemistry, Biology or a related field is required. The start date for the position is negotiable. Please send applications containing your CV, cover letter, and a list of 3 references to rkleiner@nullprinceton.edu.

Two Postdoctoral Researchers to Study MicroRNA Functions in Single Cells, Stockholm University

Research project

The postdoctoral positions are available in the Quantitative RNA Biology group headed by associate professor Marc Friedlander, part of MBW and located at the SciLifeLab. The group is part of a larger vibrant international collaborative environment and seeks to address fundamental questions in RNA biology, by applying quantitative approaches such as single-cell RNA sequencing, single-cell proteomics, various high-throughput screening methods and advanced computational biology.

Recent collaborations include paleotranscriptomic profiling of mammoth non-coding RNAs and study of the impact of space flight on the human transcriptome (NASA Twin study). The main focus of the group is to study microRNA functions in mammalian single cells, investigating the impact of microRNAs on target gene expression variation, covariation and on overall gene expression networks. This research direction is funded by an ERC Starting Grant (miRCell 758397).

The postdoctoral researchers will develop beyond-state-of-the-art methods to profile the variation of microRNA expression, interactions between microRNAs and their targets, and the impact of microRNAs on the transcriptome and proteome, in single cells. The post docs will interact with experimental and computational researchers from the group, and will participate in limited co-supervision of PhD students.

Lab website: www.friedlanderlab.org

Twitter: www.twitter/friedlanderlab

Recent pre-print on gene covariance: www.biorxiv.org/content/10.1101/771402v1

Recent pre-print on single-cell proteomics: www.biorxiv.org/content/10.1101/749473v3

Institutions

Science for Life Laboratory (SciLifeLab) is a collaboration between four universities in Stockholm and Uppsala: Stockholm University, the Karolinska Institute, the Royal Institute of Technology, and Uppsala University. The SciLifeLab is a national center for large-scale biosciences with a focus on high-throughput health and environmental research. The center combines advanced technical know-how and cutting-edge equipment with a broad knowledge in translational medicine and molecular biosciences. In particular, SciLifeLab has in the recent years become an international hub for research in single-cell and spatial transcriptomics.

Stockholm University is a leading European university offering a multicultural environment in one of the world’s most dynamic capital cities. With more than 60,000 students and 5,000 staff, the University facilitates individual and societal development by providing top quality education that is tightly linked to its internationally recognized research programs. The MBW department conducts experimental basic research in molecular cell biology, integrative biology and infection and immune biology.

Eligibility

Postdoctoral positions are appointed primarily for purposes of research. Applicants are expected to hold a Swedish doctoral degree or an equivalent degree from another country.

Selection criteria

In the appointment process, special attention will be given to research skills. We are looking for candidates that have extensive wet-lab experience with transcriptomic or proteomic methods, preferably in a single-cell context. Specific experience with single-molecule FISH, microfluidics, oligo-assisted proteomics, PEA or PLA constitutes an additional advantage. Familiarity with the microRNA field is not necessary, however the candidates must be highly motivated, creatively thinking and have a record of high-quality scientific publications. Excellent English language skills, both written and spoken, are a requisite.

Terms of Employment

This is a full-time position available immediately. The starting date is negotiable. The position is initially funded for two years, with a possibility of extension. The position constitutes full employment including all social benefits. Stockholm University strives to be a workplace free from discrimination and with equal opportunities for all.

Contact

Further information can be provided by associate professor Marc Friedlander, marc.friedlander@nullscilifelab.se

Application

Applications should be submitted using the Stockholm University web-based application system at: www.su.se/english/about/working-at-su/jobs

Click on the position “Postdoctoral Fellows to study microRNA functions in single cells (2)” and click the “Apply” button on this page.

The instructions for applicants are available at: Instructions – Applicants.

You are welcome to apply!

Stockholm University – our education and research produce results.

Assistant or Associate Professor Position Available, University at Buffalo, SUNY

Assistant or Associate Professor (10 month), Genome to Phenome Biology

The Department of Biological Sciences at the University at Buffalo, The State University of New York at Buffalo (http://biology.buffalo.edu) invites applications for an assistant or associate professor-level position (rank negotiable based on experience) from individuals who study the complex relationships between genotype and phenotype, and are committed to establishing robust, extramurally-funded research programs. Specifically, this hiring initiative focuses on understanding the relationships linking genome to phenome at all levels of life. In this round of recruitment, the Department seeks to hire an assistant or associate professor in the area of gene regulation at several different levels, including the epigenetic.

The University at Buffalo (UB) has a tradition of research excellence in biology. UB is the largest and most comprehensive campus in the State University of New York system. The Department of Biological Sciences is the major focal point for interdisciplinary research and education in life sciences at the University at Buffalo. The Department’s strengths include the biochemistry of gene expression, molecular evolution and genomics, and sensory transduction and development. As part of its ongoing strategic growth plan, the Department has recently hired faculty in neurogenetics studying development and connection patterns of diverse neural cell types, and in genome-to-phenome biology studying the genetic and molecular mechanisms responsible for phenotypic differences between species. Opportunities for interdisciplinary interactions among UB, Roswell Park Comprehensive Cancer Center, and the NYS Center of Excellence in Bioinformatics and Life Sciences are available. The position will provide a 10-month, state-supported salary plus a competitive startup package.

With backing from the College of Arts and Sciences, the Department aims to achieve disciplinary excellence in addressing “the large genome” challenge of understanding the genetic control of phenotype. The successful candidate is expected to: (1) develop a nationally-recognized, externally-funded research program; 2) participate in research laboratory training of baccalaureate, masters and doctoral students; and 3) teach undergraduate and graduate level courses. Applicants must have a doctoral or equivalent degree in an appropriate field, relevant postdoctoral experience, documented evidence of high-quality research productivity, and a solid commitment to excellence in both research and teaching.

To apply, submit electronic versions of a cover letter, a curriculum vitae, a summary of research accomplishments and future plans, and a statement of teaching interests and philosophy to UB Jobs at: http://www.ubjobs.buffalo.edu/postings/21704. Please include the names of three colleagues who could be contacted for letters of recommendation.

Completed applications will be reviewed beginning November 1, 2019, and will continue until the position is filled. Please consult our website: http://biology.buffalo.edu for information about UB, our department and our community.

University at Buffalo is an affirmative action equal opportunity employer and, in keeping with our commitment, welcomes all to apply including veterans and individuals with disabilities.

Minimum Qualifications:  PhD or equivalent

Preferred Qualifications:  Postdoctoral research experience; history of peer-reviewed publications and successful funding

Special Instructions to Applicants:  Review of applications will begin November 1, 2019. All application materials should be submitted via UB Jobs. Application materials submitted directly to the posting contact will not be acknowledged and cannot be considered.

Two Post-Doctoral Positions Available, The UK:Brazil Joint Centre Partnership

The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL; funded by the MRC/FAPESP) offers two Postdoctoral Positions

PROJECT: Epigenetic regulation of Leishmania gene expression

Two Post-Doctoral Positions are available to work on the project “Epigenetic regulation of

Leishmania gene expression” in the laboratories of molecular parasitology under the supervision

of Angela K. Cruz (University of São Paulo, Ribeirão Preto, Brazil) and Drs. Pegine Walrad and Michael Plevin (York Biomedical Research Institute, Dept of Biology, University of York, UK) as part of the UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL); 12 collaborative research groups from the UK and Brazil. Appointed postdoctoral fellows will study the putative regulatory role of novel non-coding RNAs at the Brazilian laboratory and identify and characterise RBPs which bind and regulate these ncRNAs in the UK laboratory.

Summary: Leishmania gene expression control occurs mainly at the posttranscriptional
level. At the centre of the regulatory complexes are cis- and transregulatory elements, mainly represented by mRNA elements (cis-elements) and RNA binding proteins (RBPs) which may well bind an unexplored content of noncoding transcripts (ncRNAs), recently detected in these parasites. Cruz and co-workers have demonstrated that ncRNAs appear a common feature of Leishmania transcriptomes and hundreds of putative ncRNAs were identified as differentially expressed (DE) transcripts. Such DE L. braziliensis ncRNAs and interacting RBPs will be functionally investigated. The post-doctoral fellows will use state of the art technologies for genome editing to generate knockout (KO) of DE ncRNAs in L. braziliensis and to endogenously tag these ncRNAs to evaluate phenotypic changes and identify interacting partners. The Brazilian post-doctoral fellow will engage in the complementary study  developed in the UK, under the guidance of Drs. Pegine Walrad and Michael Plevin for two 6-months visits.

Applicants must have a Ph.D. in Parasitology, Biochemistry, Genetics, Molecular Biology or related fields. Preference will be given to highly motivated individuals with proven expertise in molecular parasitology/microbiology/ncRNAs. Candidates should be creative, personally motivated, have excellent oral and written communication skills and a sense of teamwork. It is mandatory that all applicants are fluent in English. Applicants for the USP post should have previous experience with both in vivo and in vitro infection procedures.

The Brazilian post is available for a period of up to 36 months full time, with formal review after the first year. Interested individuals should contact Angela K. Cruz by email at akcruz@nullfmrp.usp.br using “PostDoc_Leishmania_ncRNAs” in the subject line with the following documents attached: 1) Letter of intent stating the candidate’s motivations and qualifications for the position; 2) A short version of Curriculum Vitae containing a list of publications and professional experience; 3) Two letters of recommendation from previous mentors/ supervisors of the applicant should be sent to the same email address.

Candidates meeting the requirements will be contacted and interviewed (in-person or via Skype).

The UK post is available for a period of up to 18 months full time, within the salary range £32,817 – £40,322 per annum (Grade 6 of the University of York salary scales). Targetted start date is December 1st, 2019. Informal enquiries for the UK post are encouraged and may be made to Dr. Pegine Walrad, (email: pegine.walrad@nullyork.ac.uk, tel: +44 (0)1904 328918).

Applications should be made directly at http://jobs.york.ac.uk.

Postdoctoral Position in the Gavis Lab at Princeton University

The Gavis Lab at Princeton University is seeking motivated post-doctoral candidates who are interested in working at the interface of RNA biology and developmental biology. We study post-transcriptional mechanisms that spatially control gene expression during development. Research opportunities are available to investigate the assembly of ribonucleoprotein granules and how they regulate the localization, translation, and stability of mRNAs for Drosophila germ cell and neuronal development. Approaches include high resolution microscopy, biochemistry, and genome level analyses, supported by the power of Drosophila genetics.

More information about current work in the Gavis Lab and our publications can be found at https://scholar.princeton.edu/gavislab.

Applicants must have a Ph.D., preferably with training in molecular biology, cell biology, biochemistry, or genetics. Candidates with computational biology skills are encouraged to apply.

Please submit a CV, a cover letter describing research interests and motivation for joining the lab, and contact information of three references to Liz Gavis at gavis@nullprinceton.edu.

Postdoctoral Fellow Position Available, Duke University Medical Center

POSTDOCTORAL FELLOW POSITION Starting JAN 1, 2020 to study RNA-protein and small molecule interactions, drug design and mechanism, Duke University Medical Center

The Agris Lab in the Department of Medicine at Duke University is seeking a full-time Postdoctoral fellow for research in antibiotic resistance, and type 2 diabetes. We are a new lab at Duke focused on a mechanistic understanding of RNAs that control function and impact human disease. The ideal candidate will have research laboratory experience in protein expression and purification as well as some experience with biochemical or biophysical assay development and RNA.

Under the general direction of the Principal Investigator, the Postdoctoral fellow will conduct cloning, expression, and purification of proteins and enzymes, help perform biochemical and structural studies to characterize RNA-protein and small molecule interactions, and contribute to lab maintenance and organization.

MAJOR RESPONSIBILITIES:

  • Carry out molecular cloning, expression, and purification to support protein biochemical and structural studies.
  • Work closely with Principal Investigator to help develop and carry out biochemical and biophysical assays to monitor enzyme kinetics and enzyme-substrate interactions.
  • Contribute to the development and implementation of lab protocols and organizational frameworks to create efficient lab workflows.
  • Help with day-to-day lab functions (e.g. instrument maintenance and reagent preparation).
  • Maintain a detailed laboratory notebook.
  • Present and discuss experimental findings and plans in meetings with the Principal Investigator and research group.
  • Help ensure general lab safety standards.
  • Perform miscellaneous job-related duties as assigned.

QUALIFICATIONS:

  • Bachelor’s degree and two years of job-related experience or equivalent combination of education and experience. Degree in Biochemistry, Chemistry, Molecular Biology, Bioengineering, or related field preferred.
  • Experience in a biochemical research laboratory.
  • Experience with molecular cloning and protein expression and purification methods. Experience with AKTA FPLC is a plus.
  • Knowledge of / experience with standard biochemical assays and/or assay development. Experience with enzymology is a plus.
  • Knowledge of / experience with quantitative analysis techniques for protein and small molecule samples. Experience with mass spectrometry is a plus.
  • Ability to work both independently and as part of a team.
  • Enthusiasm to learn new techniques and take on new roles.
  • Excellent communication and organizational skills.

Enthusiastic, imaginative and dedicated RNA scientists wishing to join our research team will find that the RNA community of Duke and UNC is dynamic, diverse and supportive with a history of the longest regional RNA community, seminars, monthly meetings, separate RNA modification group and annual Symposium (https://sites.duke.edu/ncrna2019/).

Applications should consist of a one-page cover letter and a CV including publication record, brief descriptions of previous research accomplishments and techniques, and the names and contact information for three references sent to Dr. Paul F. Agris (Paul.Agris@nullduke.edu). Informal inquires are welcome.

Full Professorship, RNA-based Infection Research, Germany

The Faculty of Medicine at the Julius Maximilians University of Würzburg and the Helmholtz Institute for RNA-based Infection Research (HIRI) jointly invite applications for a

Full Professorship (W3) in RNA-based Infection Research.

 The professorship is a permanent position to be filled at the earliest possible date. We seek to appoint a leading expert with an internationally visible research profile at the interface of RNA biology and infectious diseases research. At this point, we particularly welcome applications from experts on the function and dynamics of RNA molecules in the host or the pathogen during bacterial or viral infections, on RNA therapeutics approaches including the delivery of nucleic acids, and on RNA localization and RNA modification. In addition, we are interested in candidates who focus on emerging RNA-centric techniques such as single-cell RNA-seq.

The Helmholtz Institute for RNA-based Infection Research (HIRI) was established in May 2017 as joint venture between the Helmholtz Centre for Infection Research (HZI) Braunschweig and the Julius Maximilians University of Würzburg (JMU). Located on the Würzburg medical campus, it is the first research institution in the world to fully focus on the role of RNA in infection processes. HIRI also takes an integrative approach to exploit the vast potential of RNA as a diagnostic molecule, as a target or as a drug for new strategies to combat infectious diseases. The HIRI offers an international and vibrant scientific environment and state-of-the-art infrastructure for RNA and infection research. For further information, please visit www.helmholtz-hiri.de or send an email to Jörg Vogel, the founding director of the HIRI (joerg.vogel@nullhelmholtz-hiri.de).

The Helmholtz Society and the JMU seek to increase the number of women holding professorships and explicitly invite outstanding female scientists to apply.

Equally qualified applicants with disabilities will be given preference.

The legally binding German version of this announcement has been published in “DIE ZEIT” on August 29th, 2019. The advertisement is also available at www.med.uni-wuerzburg.de/fakultaet/berufungsverfahren/.

Please submit your application in English (or German) with the usual documentation (cover letter, signed curriculum vitae, copies of academic certificates and appointments, list of teaching activities including evaluations, list of publications, third-party funding) by October 1st, 2019. The application form can be downloaded at www.med.uniwuerzburg.de/fakultaet/berufungsverfahren/

Applications should be addressed to:

Professor Dr. M. Frosch
Dean of the Medical Faculty
University of Würzburg
Josef-Schneider-Straße 2 / Building D7
D-97080 Würzburg, Germany

NIH Funded Postdoc Position Available

NIH-funded postdoc position is available for two years with a strong possibility of extension, starting October 2019.

The laboratory represents two joined labs with diverse projects, a friendly and scientifically vibrant atmosphere, active staff and is ran by two young and active PIs:

https://som.rowan.edu/research/basicscience/cellbiology/facultybios/shcherbik.html

https://som.rowan.edu/research/basicscience/cellbiology/facultybios/pestov.html

Several lines of investigation are currently open to choose from:

1)      To understand the molecular alterations that occur on a ribosome during stress and to examine how modified ribosomes behave during translation in vitro and in cells. These projects might result in new supportive data on ribosome heterogeneity.

2)      To study effects of mitochondrial communication with translational apparatus (i.e. ribosomes) under different physiological settings.

3)      Co-translational protein quality control: does it work beyond 60S subunit?

4)      Investigation of ribosome degradation pathway.

Position requires a Ph.D. (or equivalent) in Molecular Biology or a related field. Preference will be given to candidates with the experience in yeast cell biology and/or biochemistry. Experience in high-throughput technologies (RNA-seq, ribosome profiling) is not necessary but highly desirable. The candidate must have a strong publication record, written and verbal communication skills, sound analytical and organizational skills, and ability to work independently as well as collaboratively.

The successful candidate will join an interactive environment of Rowan University School of Osteopathic Medicine (Rowan-SOM, the former University of Medicine and Dentistry of New Jersey, UMDNJ) with multiple laboratories investigating important questions in molecular/cellular biology utilizing yeast, worm and mammalian systems. The University offers state of the art facilities including Mass Spectroscopy, Next Generation sequencing, Microscopy facility. In addition, Rowan-SOM offers help in a future career planning/building, including teaching opportunities (if desirable), iJOBs seminars, Career Development Workshop and others.

Rowan-SOM is located in Stratford, a suburban south New Jersey community with an easy commute by train or car to Center City Philadelphia. This location combines and an affordable living environment, good school district, multiple child-care facilities. Due to close location to scientific hub of Philadelphia, Rowan-SOM gives the opportunity to collaborate with scientists at the University of Pennsylvania, Thomas Jefferson University, Temple University, Drexel University and the Fox Chase Cancer Center. To apply, please send a single pdf file, consisting of a one-page motivation letter, CV, publication list and the names and contact information of three references to Dr. Natalia Shcherbik at: shcherna@nullrowan.edu or nshcherb@nullgmail.com