Post-doctoral Training Fellow - RNA biology - mechanisms of alternative splicing  
Posted on September 9

The Institute of Cancer Research, London

The post-doctoral position is available in the laboratory of Vlad Pena, starting with November 15th. We are looking for a highly motivated and creative molecular biologist with a strong background in RNA biochemistry and cell biology, who wishes to expand his/her expertise in structural biology. The goal of the project is to understand how regulatory splicing factors act within spliceosomes to determine decisions in alternative splicing.

The successful candidate will reconstitute complexes relevant for splicing regulation and characterize their structure by single particle cryo-EM. The structures will be complemented with various functional assays, in vitro and in vivo.

Our lab is fully equipped for RNA and protein biochemistry, large scale mammalian cells cultivation, recombinant protein expression in baculovirus and bacteria. For structural studies, we provide routine access to facilities for electron microscopy (Tecnai T12 and F20, Glacios and Titan Krios with state of the art detectors), high performance GPU computing, mass-spectrometry, fluorescence microscopy and isolab.

Applicants should possess a PhD (or equivalent) in molecular biology or biochemistry, and have a strong expertise in RNA biology. Experience in methods of structural biology would be an advantage, although it is not mandatory.

For more details, please refer to the job description and person specification, following the link below:

https://icr.tal.net/vx/appcentre-ext/brand-0/candidate/so/pm/1/pl/1/opp/1105-Post-doctoral-Training-Fellow-RNA-biology-mechanisms-of-alternative-splicing/en-GB