Post-Doctoral Candidates in Molecular and Cellular Biology with Bioinformatics Skills

Posted on May 3,

The research group of Dr Zbigniew Warkocki at the Polish Academy of Sciences (PAS) is looking for post-doctoral canditates in molecular and cellular biology with bioinformatics skills. A position is available and other options exist within the PASIFIC programme of the Polish Academy of Sciences that is directed at international post-doctoral candidates.

The Institute of Bioorganic Chemistry, PAS in Poznan, Poland is one of the leading scientific units in Poland. Its scientists conduct multi-faceted research at the interface of three sciences: chemistry, biology and informatics to solve questions about synthesis, structure and function of nucleic acids, proteins and metabolites, as well as their mutual interactions.

Research in the Department of RNA Metabolism concentrates on molecular mechanisms of RNA metabolism in human cells with special emphasis on post-transcriptional processes. These are essential processes to maintain cell homeostasis, viability and proper function and thus for human health.

In our studies we use human model cell lines and methods of molecular and cellular biology, biochemistry, proteomics and transcriptomics. The current project aims at investigation of routes of RNA metabolism regulation by terminal uridyltransferases, enzymes that add non-templated uridines to cellular RNA 3’ ends and on the molecular mechanisms of LINE-1 retrotransposons in health and disease 1,2,3.

More information about the open position: https://portal.ichb.pl/lib/hrpb7v/Konkurs_2020_005_sn_na_pracownika_naukowego_en-kna4volb.pdf

More information about the PASIFIC:

https://pasific.pan.pl/supervisors-from-institute-of-bioorganic-chemistry/

1.         Warkocki, Z., Terminal nucleotidyl transferases (TENTs) in mammalian RNA metabolism. Philos. Trans. R. Soc. B Biol. Sci. 373, 20180162 (2018) https://doi.org/10.1098/rstb.2018.0162.

2.         Warkocki, Z. et al. Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s. Cell 174, 1537-1548.e29 (2018) https://doi.org/10.1016/j.cell.2018.07.022.

3.         Łabno, A., Warkocki, Z., Kuliński, T., Krawczyk, P.S., Bijata, K., Tomecki, R., and Dziembowski, A.Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs. Nucleic Acids Research 44, 10437–10453. PMID: 27431325 (2016). https://doi.org/10.1093/nar/gkw649