PhD Project on Splice sites recognition in normal and cancer cells. Paris-Saclay University, France

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The Paris-Saclay University is looking for a candidate for a doctoral program on functional analyzes of splicing regulators. The successful candidate will be hosted by the SABNP laboratory  which is dedicated at studying networks of RNA binding proteins using integrative approaches combining biochemical, structural and functional analyses.

Scientific project: Defects in RNA splicing have dramatic consequences on protein expression. Indeed, genetic diseases are often associated with mutations in RNA sequences recognized by splicing factors. In addition, mutations or abnormal expression of the spliceosome proteins are involved in tumorigenesis. However a detailed knowledge of the  mechanisms that allow the precise recognition of splice sites is still lacking. In this context, our laboratory focuses on interaction networks between factors involved in the recognition of splice sites [1].

The thesis project aims, by combining biochemistry, cell biology and bioinformatics approaches, to characterize the biochemical and functional interactions between two of these splicing factors and the importance of this interaction in the context of tumorigenesis and anti-cancer therapy targeting these proteins.

1. Tari M, Manceau V, de Matha Salone J, Kobayashi A, Pastré D, Maucuer A (2019) U2AF65 assemblies drive sequence-specific splice site recognition. EMBO reports.

Host laboratory and context:

The successful candidate will be funded by the University of Evry and will perform his research in the SABNP laboratory (INSERM research unit UMR1204) at Evry University (closed to Paris), part of the Genopole biocluster for biotechnologies.

Candidate profile: Candidates must hold a master degree (or equivalent) in cellular biology, molecular biology or bioinformatics, be rigorous, highly motivated by research work and interested in RNA biology, data processing, protein-protein and RNA-protein interactions.

Application deadline: April 30th 2020
Start date: October 2020. 

Contact and application: For further information, please contact Alexandre Maucuer at [email protected] . For application, please provide a full CV, a cover letter and a copy of the grades obtained during the master degree and please mention the RNA society announcement.