mRNA Biologist (RNA processing) — London At London Biotech Startup

Posted on December 3,

Summary

  • Challenge: use your experience in RNA biology to improve, characterise and design assays for our radically differentiated approach to mRNA delivery
  • Required:
    • Experience in mRNA biology/biochemistry, RNA-protein interactions and/or RNA processing
    • PhD in relevant area OR MSc with >2 yrs experience in a fast growth biotech
  • Useful, but not required:
    • Knowledge of mRNA or RNA therapeutics more broadly
  • Who: work as part of a project team OR have the ability to lead it
  • Location: London, UK
  • Start-date: ASAP or ~Jan 2022
  • Contract: Full-Time/Permanent

The opportunity

Sixfold Bioscience is a VC backed team of 20+ researchers and operators looking to change how we treat disease.  We see the huge potential of RNA being limited by how safely and effectively it can be systemically delivered in people.

We’re engineering a radically different approach to mRNA, one that defies traditional thinking. This approach will make a significant impact to the mRNA field and patients across the globe.

You’ll be given support from the VC investment, grant funding and our growing mRNA team to apply your knowledge in RNA processing to design, characterise, and test our delivery and therapeutic platform.

This is an extremely exciting opportunity to join us as we enter a promising phase of team growth and R&D expansion. You’ll join a highly collaborative, multi-disciplinary and dynamic team environment: a passionate group of coders, chemists, biochemists and biologists looking to make a difference (and have fun doing it!).  You’ll be exposed to advanced technical and scientific skills that are in high demand in the rapidly growing field of RNA therapeutics.

During your time with us, you’ll

Be driving the biological development of our mRNA delivery and therapeutics platform:

  • Design: brainstorm, collaborate and scan for novel innovations to expand the applicability of our Mergo® platform
  • Test: Planning, conducting and analysing experiments to test the stability (serum/shelf) and translation of mRNA
  • Observe: Develop in vitro and in vivo assays to test the efficacy of mRNA therapeutics
  • Collaborate: work in a tight-knit and multidisciplinary team of chemists, coders and biologists looking to expand the potential of mRNA

You’ll also:

  • Be regularly involved in discussions with the executive team, senior management and the implementation of any actions arising
  • Supervise junior researchers and placement students (optional)
  • Work in a highly collaborative team environment
  • Be involved in Sixfolds many grant projects with leading industrial and academic institutions, such as Imperial College, Pharmidex and the Medicines Discovery Catapult.
  • Support and contribute to publishing, patenting and grant writing efforts

Who you are

You’ll need extensive experience in intracellular RNA processing or RNA protein interactions. We are not looking for the finished article, you can be fresh out of grad school or an industry vet, what we want to see are the raw ingredients that will allow you to hit what we expect, then go beyond that. We look for people who are highly motivated and independent individuals, infinite learners, who are comfortable working collaboratively as part of a multidisciplinary team.

Specifically, you should be someone who:

  • Has a PhD in RNA/DNA Biochemistry, Biophysics, Nanotechnology, Molecular biology, drug delivery, pharmacology or equivalent scientific discipline (or MSc with >2 yrs experience in a fast growth biotech, in a relevant area)
  • Experience working with RNA therapeutics, RNA-Protein interactions, RNA processing or mRNA.

Our team is what makes Sixfold. We look for people with:

  • Good humour, friendly and plenty of energy
  • A passion for science and learning
  • Team oriented
  • The ability to work under pressure and prioritise workload

We’re looking for someone with this skill set to join the mRNA team who will either be happy, 1) working as part of a research project team, or 2) with the ability and desire to lead it in a senior capacity.

For a leadership position, please indicate on your application form. We’ll look for the ability to lead and/or experience leading junior team members.

Not required, but helpful

None of the below are required, especially if you are highly experienced in other areas, but any of the following could add a little stardust to your application:

  • Experience in RNA therapeutics, including mRNA, RNAi, ASO, etc.
  • In vitro transcription of mRNA
  • DNA and RNA molecular techniques, including: PCR, agarose and acrylamide gel electrophoresis, plasmid processing, purifications, etc.

Perks

  • Share Scheme
  • Pension
  • Flexible hours
  • Highly collaborative, inclusive and friendly team environment
  • The chance to see your ideas make an impact
  • Bi-/Weekly team social events
  • Minimum 5 days paid training
  • 25 days paid holiday (not including bank holidays)
  • Cycle to work scheme
  • Free fruit :)
  • Sickness and bereavement pay
  • Attractive maternity and paternity pay

About us

We founded Sixfold to tackle the biggest challenge in healthcare: how to safely deliver RNA to diseased cells. We saw the huge potential of RNA therapies being limited to how safely and effectively they can be systemically delivered in people.  Our scientists are creative and iterate fast because they want to see what they do in the lab make a difference in the clinic.

Diversity and inclusion

It’s important to mention that although disease affects us all, our industry still displays a huge lack of diversity — this needs to change. Our team is composed of many different nationalities, cultures and genders. Our goal is to create a company culture that promotes ideas and the inclusion of team members from all backgrounds.

That means we have no judgement when it comes to any one of the things that make you who you are — your gender, race, sexuality, religion or your secret aversion to cucumber water.

The proof in the pudding: our board is 66% female, and at last count team Sixfold came from 9 nationalities, 3 continents, multiple races and ethnicities. As one of our team recently put it: “Sixfold is a great example of diversity [...] and I am sure many more diversities that I am not even aware of! The beauty of the fold-diversity ”

We actively encourage members of disadvantaged, minority and underrepresented groups to apply.

Further Info/ Apply

Should you have any questions, please email careers[@]sixfold.bio
Apply here: https://jobs.lever.co/SixfoldBioscience/12717a3e-08ad-4bdc-acbb-6b223c7e0851
Visit our website: https://www.sixfold.bio/