Molecular & Cell Biology Research Scientist 12 MTH FTC

Posted on October 18,

Vertex Pharmaceuticals (Oxford, United Kingdom)

General Summary:

Our Human Disease Modelling group is seeking an innovative and dynamic Research Scientist with extensive knowledge and skills on RNA biology to play a pivotal role in expanding our capabilities to tackle novel drug targets at the Oxford Research site. Successful candidates would help to utilize a range of technologies to build disease models that can be leveraged to test therapeutic hypotheses, discover novel target biology, and characterize potential drug candidates. This position will involve working in close collaboration with other researchers and across drug discovery disciplines to ensure the delivery of medicines that treat the underlying cause of serious diseases and provide transformative benefit for our patients.

Education and Experience:

  • Recent Ph.D. (or equivalent degree) in molecular biology, cell biology or biochemistry (preferably in the RNA field)
  • Extensive experience in developing assays to interrogate RNA biology, such as RNA folding and stability, RNA-protein interactions, and translation/transcriptional regulation
  • Versatile molecular biology experience including qPCR, mRNA in vitro transcription, in vitro translation, RNA FISH, RNA Scope, Western Blot, ELISA, IHC and other cellular and molecular assays
  • Experience with mammalian cell culture systems  
  • Proven track record for solving complex scientific problems and delivering high quality results, as demonstrated through an excellent publication history, supported by evidence of major individual contributions
  • Very strong verbal and written communication and team working skills
  • Motivated and curious; happy to work across a broad range of biological subjects and projects in order to identify the molecular drivers of disease

Key responsibilities:

  • Ability to design and execute complex experiments, including target identification, validation, and mechanistic investigation in disease-relevant contexts.
  • Champion and leverage cutting edge molecular cell biology techniques and technologies for in vitro disease modelling
  • Effectively distil complex, multi-dimensional data and results into concise concepts and clearly propose strategic and experimental actions 
  • Proactively communicate and work highly effectively within and between teams
  • Collaborate extensively and work on shared projects with other scientific colleagues and cross-functional teams, including others in the Biology Dept and beyond