Marie Sklowdowska-Curie PhD studentship – Understanding the role of riboregulation in virus infection

Posted on November 14,

Vacancy Ref: 102328
Salary: Approx. £35,000 - £45,000 per annum.
Researchers will receive an additional mobility allowance and, depending on personal circumstances, a family allowance.

We have an exciting opportunity to appoint a Marie Sklowdowska-Curie Early Stage Researcher to carry out research at the School of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR) relevant to the EU-funded PhD project investigating the importance of RNA-binding proteins in virus infection (RNA ReguNet).

RNA is a central molecule in RNA virus biology that functions not only as messenger (m)RNA, but also as genome. Recent studies lead by Prof Alfredo Castello and his Group have shown that viral RNAs engage with hundreds of cellular proteins including a wide range of enzymes, including kinases, E3 ubiquitin ligases, metabolic enzymes, and autophagy factors. The hypothesis is that these protein-RNA interactions may help recruiting critical host factors to the viral RNA to drive crucial changes in the microenvironment of the viral replication centres. The project will also test if the enzymatic activities of these RNA-binding proteins are altered upon interaction with RNA, in analogy to the protein kinase R (PKR) that activates upon binding to double stranded RNA. In such scenario, RNA would function as an allosteric switch that turns on/off these enzymes in the right place and at the right time. This project will elucidate the mechanisms underpinning these important host-virus interactions in the viral life cycle.

The School of Infection and Immunity is one of eight Schools in the College of Medical, Veterinary and Life Sciences which is the largest of the University’s four Colleges. The School comprises scientists and clinicians working together to promote and develop research, drug discovery and improvements in patient care. It is committed to excellence in graduate and post-graduate teaching and developing the next generation of researchers.

We welcome applications from candidates who hold a Good (equivalent to first class or upper second) BSc or equivalent undergraduate degree in Molecular Biology, Biochemistry, Microbiology or related area.

All applicants are advised to visit the following website to obtain further details of the eligibility requirements for Marie Skłodowska-Curie actions, see particularly pages 80-81 to assess your eligibility before making an application: - http://ec.europa.eu/research/participants/data/ref/h2020/wp/2018-2020/main/h2020-wp1820-msca_en.pdf

This post is full time and fixed term for 3 years.

Visit our website for further information on The University of Glasgow’s School of Infection & Immunity, https://www.gla.ac.uk/schools/infectionimmunity/

Informal Enquiries should be directed to Professor Alfredo.Castello, [email protected]

Apply online at: https://my.corehr.com/pls/uogrecruit/erq_jobspec_version_4.jobspec?p_id=102328