Two Post-Doctoral Positions Available, The UK:Brazil Joint Centre Partnership

The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL; funded by the MRC/FAPESP) offers two Postdoctoral Positions

PROJECT: Epigenetic regulation of Leishmania gene expression

Two Post-Doctoral Positions are available to work on the project “Epigenetic regulation of

Leishmania gene expression” in the laboratories of molecular parasitology under the supervision

of Angela K. Cruz (University of São Paulo, Ribeirão Preto, Brazil) and Drs. Pegine Walrad and Michael Plevin (York Biomedical Research Institute, Dept of Biology, University of York, UK) as part of the UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL); 12 collaborative research groups from the UK and Brazil. Appointed postdoctoral fellows will study the putative regulatory role of novel non-coding RNAs at the Brazilian laboratory and identify and characterise RBPs which bind and regulate these ncRNAs in the UK laboratory.

Summary: Leishmania gene expression control occurs mainly at the posttranscriptional
level. At the centre of the regulatory complexes are cis- and transregulatory elements, mainly represented by mRNA elements (cis-elements) and RNA binding proteins (RBPs) which may well bind an unexplored content of noncoding transcripts (ncRNAs), recently detected in these parasites. Cruz and co-workers have demonstrated that ncRNAs appear a common feature of Leishmania transcriptomes and hundreds of putative ncRNAs were identified as differentially expressed (DE) transcripts. Such DE L. braziliensis ncRNAs and interacting RBPs will be functionally investigated. The post-doctoral fellows will use state of the art technologies for genome editing to generate knockout (KO) of DE ncRNAs in L. braziliensis and to endogenously tag these ncRNAs to evaluate phenotypic changes and identify interacting partners. The Brazilian post-doctoral fellow will engage in the complementary study  developed in the UK, under the guidance of Drs. Pegine Walrad and Michael Plevin for two 6-months visits.

Applicants must have a Ph.D. in Parasitology, Biochemistry, Genetics, Molecular Biology or related fields. Preference will be given to highly motivated individuals with proven expertise in molecular parasitology/microbiology/ncRNAs. Candidates should be creative, personally motivated, have excellent oral and written communication skills and a sense of teamwork. It is mandatory that all applicants are fluent in English. Applicants for the USP post should have previous experience with both in vivo and in vitro infection procedures.

The Brazilian post is available for a period of up to 36 months full time, with formal review after the first year. Interested individuals should contact Angela K. Cruz by email at akcruz@nullfmrp.usp.br using “PostDoc_Leishmania_ncRNAs” in the subject line with the following documents attached: 1) Letter of intent stating the candidate’s motivations and qualifications for the position; 2) A short version of Curriculum Vitae containing a list of publications and professional experience; 3) Two letters of recommendation from previous mentors/ supervisors of the applicant should be sent to the same email address.

Candidates meeting the requirements will be contacted and interviewed (in-person or via Skype).

The UK post is available for a period of up to 18 months full time, within the salary range £32,817 – £40,322 per annum (Grade 6 of the University of York salary scales). Targetted start date is December 1st, 2019. Informal enquiries for the UK post are encouraged and may be made to Dr. Pegine Walrad, (email: pegine.walrad@nullyork.ac.uk, tel: +44 (0)1904 328918).

Applications should be made directly at http://jobs.york.ac.uk.