RNA Editing and Genome Stability: Postdoctoral positions are available to study the biology of RNA editing and the functions of ADAR (adenosine deaminase acting on RNA) (Nishikura 2010 Annu Rev Biochem 79: 321; Nishikura 201. Nat Rev Mol Cell Biol 17: 83).
ADARs are involved in adenosine-to-inosine editing of coding- and non-coding RNAs as well as microRNAs in the nucleus (Kawahara et al. 2007 Science 315: 1137). In the cytoplasm, ADAR interacts with the RNAi mechanism (Ota et al 2103 Cell 153: 575) and regulates decay of a class of mRNAs required for stress response (Sakurai et al. 2017 Nat Struct Mol Biol 24: 534).
More recently we discovered that ADAR knockdown results in mitotic catastrophe, indicating that ADAR plays an important role in the maintenance of genome stability.
We are investigating the mechanism of this newly found ADAR function in regulation of genome stability and also its relation to the embryonic lethal phenotype of ADAR null mice.
Previous experience in molecular techniques, protein purification, fluorescent microscopy, bioinformatics as well as in the handling of gene knock-out mice is essential.
Persons who received their degree within the last two years and are able to take the position immediately and stay for at least 3 years are preferred.
Send a cover letter describing your research interests, curriculum vitae, and names of three references to: Dr. Kazuko Nishikura (https://wistar.org/our-scientists/kazuko-nishikura): The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104. E-mail: firstname.lastname@example.org.