RNA biology of circadian clocks molecular mechanisms, physiological functions, implications for disease

Our group is seeking to recruit two new colleagues, a PhD student and a Postdoc, to investigate how regulatory mechanisms occurring at the RNA level impact on rhythmic gene expression, physiology and behaviour regulated by the circadian clock. We recently started to cover this broad topic with work on miRNAs (Du et al., eLife 2014) and on translation (Janich et al., Genome Research 2015; Castelo-Szekely et al., bioRxiv 060368) using mice and cultured cells as our experimental models.

The proposed projects will build on findings that we made in our work on rhythmic protein translation. They will entail a multidisciplinary mix of molecular biological, cellular and mouse genetics/behavioural approaches, in combination with state-of-the-art genomics (ribosome profiling) and bioinformatics techniques. Briefly, one of the projects will address how circadian rhythms are regulated by “upstream open reading frames” (uORFs), an emerging high-interest class of regulatory elements. The other project aims to unravel molecular mechanisms and physiological functions of rhythmic translation in the liver. Of note, we are also open to new research ideas that collaborators wish to bring into the lab.

The Gatfield lab is hosted at the Center for Integrative Genomics (CIG) at the University of Lausanne (UNIL), a vibrant, well-funded institute with a focus on functional genomics and equipped with modern core facilities (see www.unil.ch/cig). It is embedded in the broader Lausanne research environment that includes two universities (UNIL, EPFL), the Swiss Institute of Bioinformatics, Ludwig Center for Cancer Research, university hospital, and a cluster of biotech companies flourishing in the larger lake Geneva area.
Through the Gatfield lab’s membership in the National Centre of Competence in Research RNA & Disease (http://www.nccr-rna-and-disease.ch), lab members benefit from networking and training opportunities throughout Switzerland, with access to other leading RNA research labs in Zürich, Bern, Basel and Geneva.
Full funding for the positions is available (max. 5 years), although application to personal, international fellowship programs will be encouraged. Envisaged start date: negotiable (earliest April 1st, 2017).

To apply, please send – as a single PDF file – a motivation letter describing why you are interested in joining our group, a CV (potential PhD students should include their Bachelors/Masters grades; post-docs should list their scientific publications), and contact details for 2 or more referees to david.gatfield@nullunil.ch

Lab homepage: http://www.unil.ch/cig/gatfield