Postdoctoral Researcher position available immediately in the Laboratory of Dr. Mingyi Xie (Assistant Professor, Department of Biochemistry and Molecular Biology, Cancer Center, University of Florida) to study the Function and biogenesis of alternatively-processed microRNAs and Integrator complex-mediated RNA processing. Postdoc salary starts at $47,476 per year.
Applicants should submit the following to email@example.com:
1) Cover letter stating: laboratory experience in RNA/protein biochemistry and bioinformatics; your long-term career goals; date of availability to begin postdoc research
2) Curriculum vitae (including publications and awards/honors)
3) List of at least three references
Dr. Mingyi Xie was trained in the laboratory of Dr. Joan Steitz at Yale University (2010-2016), where he documented two surprising microRNA (miRNA) biogenesis pathways:
- Herpesvirus saimiri (HVS)-miRNAs are processed by the host Integrator complex, a 14-subunit complex best known for executing the 3′-end cleavage of cellular small nuclear RNAs (snRNAs) (Cazalla, Xie and Steitz-Molecular Cell-2011; Xie et al.,-Genes & Development-2015).
- Mammalian m7G-capped precursor miRNAs are generated from RNA polymerase (Pol) II transcription initiation sites. Whereas the nuclear-cytoplasmic export of capped pre-miRNAs is mediated by Exportin-1 (Xie et al.,-Cell-2013; Xie and Steitz-RNA Biology-2014).
The Xie lab’s immediate research goal is to further delineate the unique modes of miRNA production (Sheng et. al.-Nucleic Acids Res.-in revision), including Integrator-mediated RNA metabolism, and understand the functions of these special miRNAs in herpesviruses and their hosts. Such research will allow the design of therapies for related oncogenic herpesviruses and cancers.
Visit Xie lab website: xie.biochem.med.ufl.edu for more information.
Dr. Xie will be attending 2018 RNA society meeting at UC Berkeley. Applicants are welcome to schedule a meeting with Dr. Xie during the conference.
Contact: Dr. Mingyi Xie