Are you an ambitious researcher looking for your next challenge? Do you have an established background in either mRNA translation or cryo-EM? Are you keen to develop new skills in a range of approaches? Do you want to further your career in one of the UKs leading research intensive Universities?
Applications are invited for a BBSRC-funded postdoctoral research fellow position, to dissect the function and structure of specialised ribosomes. This exciting, timely and transformative research project has the potential to provide a step-change in our understanding of protein synthesis. Together we will characterise the composition, function and structure of specialised ribosomes in the Drosophila testis. This research project is a collaboration between two experts in the fields of mRNA translation/initiation (Dr Julie Aspden) and cryo-EM (Dr Juan Fontana), combining genetic, biochemical, genomic and structural approaches to tackle an important, outstanding question on the structure-function relationship of specialised ribosomes. We have already obtained evidence by mass spectrometry of the existence specialised ribosomes in different tissues from Drosophila melanogaster, and we have obtained cryo-EM averages of these ribosomes at ~4Å resolution. Therefore this is an active project that requires someone to drive it forward. You will join a vibrant research community within the Faculty of Biological Sciences at Leeds, including LeedsOmics and The Astbury Centre for Structural Molecular Biology.
We are looking for someone who will have;
- A PhD (or close to completion) in RNA and/or structural biology or a closely allied discipline;
- Experience in mRNA translation and/or cryo-EM of macro-molecular complexes;
- Drive to pursue cutting-edge research in the field of mRNA translation using a range of approaches (biochemical, genetic, genomic and structural);
- Aptitude for computational analysis e.g. NGS and/or cryo-EM data analysis;
You may also have:
- Experience in biochemical purification of translation complexes, Drosophila melanogaster husbandry and genetics, analysis of RNA-Seq or similar data, structural biology, genomics, CRISPR or RNAi;
- Evidence of pursuing external funding to support research;
- Experience in public engagement and/or outreach.