Fully funded postdoctoral positions are available in Sandra Wolin’s laboratory at the National Cancer Institute in Frederick Maryland. We are seeking candidates with expertise in molecular biology, biochemistry or structural biology to join one of our ongoing projects. A major interest of our laboratory is a class of noncoding RNA-protein complexes, called Ro60 RNPs, that are present in animal cells, bacteria and archaea. Our work revealed that the Ro60 protein is ring-shaped and binds defective RNAs in its central cavity and that noncoding RNAs called Y RNAs scaffold the interactions of Ro60 with other proteins such as nucleases. Our current studies are focused on characterizing ways in which Ro60 RNPs contribute to the biogenesis of other ncRNAs and to the surveillance of defective RNAs. We are also determining how defects in RNA surveillance pathways contribute to diseases such as cancer and autoimmunity. We use a wide variety of approaches, including mouse and bacterial genetics, biochemistry, molecular biology and structural biology. A more complete description of our science can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/sandra-l-wolin
Our group is part of the newly formed RNA Biology Laboratory in the Center for Cancer Research, National Cancer Institute, National Institutes of Health. We are part of the National Cancer Institute’s RNA Biology Initiative, which includes more than 50 laboratories spanning the Frederick and Bethesda campuses. The environment is highly collaborative, with the ability to interact with a wide range of scientists and clinicians. The extraordinary resources and opportunities available at the National Cancer Institute and the National Institutes of Health make these positions ideal for motivated candidates who are seeking additional training in RNA biology.
Candidates should have a Ph.D. and/or an M.D. and less than five years of postdoctoral experience. Candidates should also have significant experimental training in molecular biology, biochemistry or structural biology, as evidenced by publications.
To apply, please send a cover letter discussing your interests in the position, your CV, and contact information for three references to email@example.com
This position is subject to a background investigation. The NIH is dedicated to building a diverse community in its training and employment programs. The Department of Health and Human Services, NIH, and NCI are Equal Opportunity Employers.