The Wang laboratory is seeking a talented and motivated Postdoctoral Fellow to lead the project for understanding RNA splicing dysregulation (SF3B1 mutation, occurs in 20% chronic lymphocytic leukemia) and oncogenesis in blood malignancies. We are a young and NIH-funded lab, which is located near Los Angeles within the Beckman Research Institute of City of Hope. Our laboratory focuses on functional genomics in chronic lymphocytic leukemia (CLL) and systematically dissects genetic alterations contributing to the disease phenotype utilizing cutting-edge technologies including CRIPSR/Cas9 gene editing, single-cell sequencing, and integrated omics analysis (genomics, transcriptomics, and proteomics), coupling with murine models as well as clinical samples. The ultimate goal is to discover novel prognosis markers and design better therapeutic approaches for this heterogeneous disease. Candidates with strong background in RNA biology, cancer biology, and molecular biology are encouraged to apply.
Minimum Education and Skills Required for Consideration:
- Ph.D., or M.D./Ph.D. degree in molecular and cancer biology, or a related discipline is required
- Understanding fundamental mechanism of RNA biogenesis and oncogenesis, genomics and transcriptomic analysis is preferred
- Familiar with flow cytometry and genetic murine models is preferred
The Beckman Research Institute of City of Hope is a world renowned institute with specific focus on the translational research. The Department of Systems Biology includes 13 research faculty and 80 postdoctoral fellows, staff scientists and research associates and is supported by an annual budget of $7 million in research grants from the National Institutes of Health (NIH), The Leukemia & Lymphoma Society, the Howard Hughes Medical Institute and the California Institute for Regenerative Medicine (CIRM).
For consideration, please directly send a CV, a brief statement of scientific research interests and start date availability to: firstname.lastname@example.org. For detail laboratory information, please visit https://www.cityofhope.org/research/systems-biology/systems-biology-research-labs/lili-wang-lab.