Mechanisms and regulation of human nonsense-mediated mRNA decay

A postdoctoral position studying the molecular mechanisms of RNA quality control is
immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and
Blood Institute, National Institutes of Health, Bethesda, MD. Our laboratory investigates
multiple facets of the NMD pathway, including novel positive and negative regulators of
RNA decay.

We are seeking a postdoctoral fellow to extend our recent efforts to identify and
investigate new members of the human NMD pathway. In collaboration with colleagues
at NIH, we have recently used whole-genome siRNA screening to discover multiple
novel NMD factors, including ICE1, a protein that promotes the link between the exon
junction complex and the NMD machinery (see Baird et al., Elife, 2018). We are
currently working to understand the mechanism and regulation of ICE1 function in
NMD, in addition to using the siRNA screen to identify additional new NMD proteins.
The research of the group and its members is supported by the collaborative and
interdisciplinary NIH intramural program and state-of-the-art proteomics, highthroughput
sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse
transgenic, and other core facilities.

Interested candidates must have received a Ph.D. or M.D. within the past five years in
molecular biology, cell biology, biochemistry, genetics or a related discipline and be
highly motivated to participate in and design innovative research programs. Candidates
with expertise in bioinformatics are particularly encouraged to apply. The candidate will
be supported with an excellent intramural NIH fellowship in a stimulating and interactive
research environment at NIH.

To apply:
Please email a cover letter indicating preferred start date and research area, CV, summary
of research accomplishments, and names and contact information for at least three
references to:
Dr. J. Robert Hogg
Lab Website:
Employer Name: National Heart, Lung, and Blood Institute
Position Location: Bethesda, MD
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