One postdoctoral position is available at the Nicoli Lab, Department of Genetics and Internal Medicine, Yale University, New Haven, CT USA.
The goal of our laboratory is to combine RNA-based mechanisms, genomics, and genetics in embryonic development to uncover new endothelial cell behaviors in vascular development and homeostasis. Our laboratory contributed to this research field with several publications available at nicolilab.com (most relevant for this job posting are Kasper bioRxiv 2019, Moro Nat. Cell Bio. 2019, Kasper Dev. Cell 2017, Narayanan Sci. Rep. 2016)
Area of interests in the Nicoli Lab:
1) Define RNA-based regulations occurring during mechanotransduction. The central question is to understand how translational and regulation of biomechanical genes control cell behaviors dictated by the extracellular matrix and/or blood flow-hemodynamics.
2) Define the functional effect of multigene miRNA families on developing vascular treats. The central question is to assign function to complex miRNA genes using an endothelial single cell phenotypic screening in zebrafish miRNAs knockouts.
3) Define Cis-regulatory RNAs that determine vascular cell behaviors. The central question is to decode sequences on the RNA that control common or tissue specific homeostatic endothelial cell behaviors.
Candidates with excellent molecular biology and/or microscopy skills will be considered. Computational skills are preferable but not necessary. Candidates are required to have strong interpersonal skills and outstanding written and spoken English to collaborate with a diverse team of scientists. Qualified candidates should have recently accomplished their Ph.D. degree (possibly no more than 1 year).
Candidates should send their Curriculum Vitae and a cover letter summarizing:
– A description of accomplishments.
– Research interests in RNA and/or Development and/or Vascular Biology.
– Contact information for three references to: Stefania Nicoli, Ph.D. firstname.lastname@example.org