Post-doctoral positions are open immediately to join the Burns laboratory in the Department of Oncologic Pathology at Dana-Farber Cancer Institute. Our group studies high copy number repeats in the human genome, and the biology of the retrotransposons and endogenous retroviruses that generate these sequences. We and others have shown that subsets of these normally silenced elements are expressed as a hallmark of human cancers, and that this results in somatically-acquired retrotransposon insertions in cancer genomes. We aim to more fully characterize this phenomenon; to probe its consequences for cancer biology using models of cancer growth and tumor immunology; and to leverage our understandings to inform cancer detection and treatment.
The lab is moving from Johns Hopkins School of Medicine, and the successful candidates will be one of the first to establish the group in Boston. Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute will together offer a preeminent research environment for their work. Incoming fellows will have an outsized influence in setting the tone for an intellectually engaging, rigorous, productive, and positive environment. Each will be provided with significant intellectual freedom, substantial technical support, and ample opportunities to form collaborations and develop a national and international reputation in this potentially impactful and understudied field.
Accomplished and motivated candidates with a recent Ph.D. or M.D./Ph.D. in biomedical sciences and significant experience in molecular biology and cell biology are encouraged to apply. A background in transposable elements and repetitive sequences is not required and can be ‘learned on the job’. Rather, projects will lie at the interface of this field with another area of expertise brought by the successful candidates. These areas of expertise may include, but are not limited to: RNA expression and epigenetics; cellular interferon responses; RNP formation and function; and protein translation.
Several peer-reviewed, NIH-funded projects are available to work on, and funding will initially be provided by the laboratory; new fellows will be expected to apply for research support.
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