The Messenger RNA Regulation and Decay Section, RNA Biology Laboratory (RBL), Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), is seeking postdoctoral candidates with training/expertise in RNA/protein structural biology/biochemistry. Research experience in RNA biology or structural/biophysical techniques will be considered advantageous. Strong work ethic, excellent communication skills and ability to work in a multidisciplinary team are essential.
The focus of our research is to understand the mechanisms by which the function of messenger RNA is regulated. We are especially interested in exploring in molecular detail the processes of deadenylation and decapping as well as the connections in the metazoan 5´-to-3´ cytoplasmic degradation pathway. Recently, we have described the biochemical reconstitution of human CCR4-NOT deadenylation complex and uncovered new links between decay factors. The next stage will be to take structural approaches, especially high-resolution cryoEM, in combination with other biophysical techniques toward the study of the human mRNA decay machinery. Significant preliminary data has already been generated for several projects and candidates will join an established research program.
For high-resolution cryoEM, a Talos Arctica equipped with a K3 detector together with a Vitrobot plunger is available on site together with a Talos L120C for screening. Titan Krios microscopes are also locally accessible at dedicated facilities on the NIH campuses in Frederick and Bethesda. For crystallography, there is regular access to synchrotron beamlines at the Argonne National Laboratory. Automated crystallization platforms and automated imagers for crystal detection are available in the neighboring Structural Biophysics Laboratory. In addition, a biophysics core facility contains an array of instruments for biophysical characterization. High-performance computational resources including a GPU-enabled cluster are also provided. Further information about the core facilities can be found here: https://ostr.ccr.cancer.gov/resources/core.
For relevant recent publications please see: Raisch et al. (2019) Nature Communications, Chang et al. (2019) Nucleic Acids Research, Valkov et al. (2016) Nature Structural & Molecular Biology.
We are looking for enthusiastic, imaginative and dedicated scientists to join our research team working on exciting RNA structural biology projects. The NIH intramural program provides ample opportunities for advanced training to early-career scientists to develop valuable research and transferable skills. A vibrant and collegiate NIH community with diverse expertise in RNA, chemical and structural biology ensures a unique research environment with excellent collaborative opportunities. NIH offers a competitive salary and comprehensive health insurance as well as a host of other benefits. Candidates must have a doctoral degree or expect to receive their degree shortly. Appointments will be for one year initially and renewable for up to a maximum of 5 years. The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation.
Applicants should send their CV and contact details for three references to Dr. Eugene Valkov: firstname.lastname@example.org. Informal inquiries are welcome. More information can be found at https://ccr.cancer.gov/RNA-Biology-Laboratory/eugene-valkov. The RNA Biology Laboratory is located on the Frederick campus of the National Cancer Institute in Maryland, U.S.A.
DHHS, NIH, and NCI are Equal Opportunity Employers