Charting the Interface Between Metabolic States and Gene Regulation in Heart Disease

The John Curtin School of Medical Research, The Australian National University
is looking for a PhD student with strong talent and motivation to do first class basic research in a project entitled ‘Charting the interface between metabolic states and gene regulation in heart disease’.
Cells constantly respond to external challenges by changes in gene expression as well as metabolic state. How cells coordinate this interplay between metabolism and genes is a key challenge for future research. We investigate the novel concept of widespread interactions between major components of gene expression (RNA) and metabolism (Enzymes and Metabolites) to form coordinative REM networks. Perturbations of gene regulation as well as metabolism manifest themselves in serious and common diseases including diabetes and obesity, cancer or cardiac disease.
The PhD student will be based in the RNA Biology Group headed by T Preiss at The John Curtin School of Medical Research at ANU, Canberra, Australia and will participate in a collaborative project with MW Hentze at The European Molecular Biology Laboratory, Heidelberg, Germany, to tackle the relevance of REM networks in cardiac disease. Mass spectrometry will be employed to determine proteins in complex mixtures (proteomics). Similarly, next generation sequencing technology will be used to characterise gene regulation at the level of RNA.
You will:
• Work on an exciting scientific project with internationally renowned experts in the field 
• Receive scholarship funding for 3 – 3.5 years
• Enjoy the benefits of a state-of-the-art scientific research school with first-class facilities.
•Have opportunities to meet and collaborate with international academics and attend conferences. 
•Benefit from practical, academic and professional training at a world-class research-intensive university.
Australian BSc(Honours) at H1 standard or international equivalent in biology, biomedicine, or related science. Practical experience in the lab working on a scientific project. Excellent English language skills.

Expression of interest documents required
(1) Curriculum vitae 
(2) Summary of previous research (3) Copy of academic transcripts

More information about the program can be obtained from
Expression of interest deadline: 14th December