Postdoctoral Position to Investigate the Molecular Mechanisms of Regulation of Alternative pre-mRNA Splicing

A postdoctoral position is available to work on a Wellcome Trust funded project to investigate the molecular mechanisms of regulation of alternative pre-mRNA splicing in the group of Prof. Chris Smith (

The position will be based in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge. The project focuses on the mechanisms by which regulatory RNA binding proteins, such as PTBP1 and RBPMS control splicing complex assembly at regulated splice sites, and builds upon our recent discovery of RBPMS as a master splicing regulator that acts in smooth muscle cells. It will involve a range of biochemical, molecular, proteomic, biophysical, structural and single-molecule techniques based in the PI’s and collaborators labs. Candidates should have experience in two or more of the following areas: structural biology, biophysical analyses of protein-protein or protein-nucleic acid assemblies, molecular cell biology, pre-mRNA splicing/RNA biology, and bioinformatics.

The successful candidate will work in a research team comprising further post-doctoral researchers and Ph.D. students. They will need to have the initiative to work independently and as part of a team. The research will involve interaction with collaborators groups so good communication and interpersonal skills are required. In addition to carrying out research they will be expected to present research findings, contribute to writing manuscripts and supervise students in the laboratory.

The successful candidate will have a PhD or has recently submitted for a PhD.

Fixed-term: The funds for this post are available for 5 years in the first instance.

To apply online for this vacancy and to view further information about the role, please visit: This will take you to the role on the University‚Äôs Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.

Interested candidates are welcome to make informal enquiries to

Any enquiries relating to the application process please contact the HR team –