An 18-month post-doctoral position is available immediately at the University of Edinburgh to establish whether mammalian RNA-binding proteins (approx. 1500 in human) can be regulated via “histone-code” like switches, where specific lysine modification regulates competing protein-protein interactions. Such a switch would provide unique insight into the basis of the multi-functionality of many RNA-binding proteins. This BBSRC funded work builds upon work by three collaborating Edinburgh labs (Matt Brook’s newly-formed lab [Twitter: @BrookLab3] and the established labs of Nicola Gray and Atlanta Cook) and involves collaborating labs in Liverpool, Dundee and Birmingham. The post-holder will determine the modification-dependent effects on post-transcriptional gene regulation (mRNA translation and stability), primarily through mammalian cell line-based and/or cell-free reporter assays, quantify modification stoichiometry under specific cellular conditions and investigate the effector enzymes involved. They will work closely with another post-doctoral scientist who focuses on the biophysical and structural consequences of these modifications on protein-protein interactions. Applicants with a proven track record in studying RNA-binding protein-mediated regulation of mRNA translation and stability, and/or the interrogation of lysine acetylation/methylation pathways are particularly welcomed. The post is particularly suitable for candidates with relevant post-doctoral experience but those with strong, relevant, publication records from their PhD would also be considered. The post involves short periods of work at other locations (e.g. Liverpool) leveraging specialised collaborative expertise/training (e.g. quantitative mass spectrometry).
For full details of the vacancy and to apply, please visit: https://www.vacancies.ed.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.display_form