In vivo Senior Research Associate – Genetic Diseases

Posted on May 25,

Orna is a venture-backed, Cambridge-based startup creating a pipeline of RNA-based therapies based on technology developed at MIT. Our mission is to address diseases not accessible by existing approaches with our best-in-class proprietary RNA expression and delivery platform. We are seeking an exceptional researcher to join our team as a Senior Research Associate to evaluate candidate therapies for the treatment of genetic diseases. The ideal candidate has at least a bachelor’s degree in a biology-related field with relevant in vivo laboratory experience. They will be able to quickly learn and integrate new protocols into existing workflows, possess strong oral and written communication capabilities, demonstrate excellent collaboration and interpersonal skills, and be adept at problem solving in a fast-paced environment.


  • Expand Orna’s therapeutic pipeline through evaluation of RNA encapsulated nanoparticle formulations in relevant animal models
  • Support design and execution of studies in relevant animal disease models
  • Collaborate with technical support services to facilitate study execution
  • Ability to solve technical problems in a practical and rational manner
  • Prepare tissue collection materials and documents related to in vivo studies
  • Effectively communicate experimental plans and data; present to cross-functional R&D teams
  • Maintain an up-to-date and accurate electronic notebook record of performed studies
  • Self-motivated, detail oriented, and able to effectively manage time to execute multiple parallel laboratory and in vivo activities
  • Contribute to a positive and exciting work environment; contribute to a strong entrepreneurial and creative culture


  • BS in biology, cellular biology, genetics, biochemistry, or related discipline with 3+ years of relevant in vivo experience
  • Significant hands-on experience with animal handling, anesthesia, and dosing (IV, IM) methods according to humane practices
  • Perform full necropsy and collection of tissues and blood, for downstream processing including protein isolation; Experience with related-molecular biology techniques such as Western Blotting or qPCR a plus
  • Highly organized individual that can manage the execution of multiple, parallel in vivo studies occurring at internal and external research facilities
  • Detail oriented and self-motivated, willingness to take on new challenges
  • Effective written and oral communication skills with experience working in cross-functional teams