ERC-funded postdoctoral position in Bioinformatics (f/m/d) at the Helmholtz Institute for RNA-based Infection Research (HIRI)

Posted on February 28,

The Munschauer lab at HIRI is recruiting a postdoc to work on an innovative ERC-funded research project. The project is centered on the systematic functional dissection of RNA-binding proteins at the virus-host interface and will bring together experimental and computational scientists. The Munschauer lab takes an RNA-centric approach to study how RNA viruses interface with their hosts and how host cells respond to infection. We make extensive use of mass spectrometry-based proteomics and next-generation sequencing methods to dissect how RNA and protein interact and how these interactions shape infection outcomes. The successful applicant will work with a young and dynamic team of scientists, and will have unique opportunities to develop and apply computational methods to analyze and integrate transcriptomic and proteomic data to improve our understanding of virus-host interactions.

Your responsibilities

  • Analyze and interpret multi-omics data
  • Build analysis pipelines for pooled CRISPR perturbation screens in combination with single-cell RNA-sequencing (Perturb-seq, CROP-sec, etc.)
  • Develop analysis and data integration approaches for high-throughput sequencing data (e.g. RNA-seq, Ribo-seq, SLAM-seq, CLIP-seq, etc.)
  • Collaborate with wet lab scientists and bioinformaticians

Requirements

  • PhD or equivalent qualification in Computational Biology, Bioinformatics, Genomics, or a related field in the computational or natural sciences
  • Experience with the analysis and integration of high-throughput sequencing data, in particular transcriptomics
  • Experience handling large data sets in a high performance computing environment
  • Experience with relevant programming languages (e.g. Python, R, Perl, etc.) and packages (e.g. Bioconductor)
  • Strong written and spoken English language communication skills
  • Highly motivated, organized, collaborative and independent

Desired (non-essential)

  • Experience with mass-spectrometry-based proteomics data analysis
  • Statistics or machine learning background is a plus

We offer
We offer state-of-the-art infrastructure and cutting-edge technologies to promote scientific progress and interdisciplinary collaboration. We focus on a close integration of research and management and strive for excellence inside and outside the laboratory. Promoting equal opportunities and competencies for our employees and celebrating diversity are a matter of course for us. To ensure a good work-life balance, we have created a family-friendly atmosphere with flexible working hours and part-time models, a parent-child room and regular social activities.

Employment is through the Helmholtz Centre for Infection Research (Helmholtz-Zentrum für Infektionsforschung GmbH / HZI) in Braunschweig. The place of work is Würzburg. The position is suitable for part-time work. The HZI strives for professional equality between women and men. Therefore, women are especially encouraged to apply. People with severe disabilities and equivalent professional qualifications who are suitable for the position are given preference. In order to protect your rights, we ask you to provide us with a clearly recognizable reference to the existence of a degree of severe disability in your cover letter or resume.

Starting date:                          As early as immediately. The contract will initially run for five years. However, a longer-term commitment is aspired regardless of full- or part-time.
Salary:                                      E 14 TVöD Bund
Working time:                          39 hours per week
Place of work:                          Würzburg
Probation period:                     6 months

How to apply
We look forward to receiving your complete application including a cover letter, CV, and a brief research statement. Please send your application quoting the reference number 34/2022 to the Helmholtz Centre for Infection Research GmbH, Human Resources Department, Inhoffenstr. 7, 38124 Braunschweig, Germany or by email to [email protected]. If you send your application in electronic form, please provide a summary in one single (1) pdf document. For further information please contact Jun. Prof. Dr. Mathias Munschauer, email: [email protected].

When sending us your application documents, please confirm that you have read our privacy policy and that you agree to the processing of your personal data. Please use the text module in our privacy policy for this purpose. Without these declarations we cannot consider or process your application and will immediately delete any application documents already received after the application deadline. 

About the HIRI
The Helmholtz Institute for RNA-based Infection Research (HIRI) is the first institution worldwide to combine ribonucleic acid (RNA) research with infection biology. Based on novel findings from our strong basic research program, our long-term goal is to develop innovative therapeutic approaches to better diagnose and treat human infections. HIRI is a joint venture of the Helmholtz Center for Infection Research (HZI) in Braunschweig and the Julius Maximilians University of Würzburg (JMU) and is located on the Würzburg Medical Campus.

More information at www.helmholtz-hiri.de.