Biochemistry and Structural Biology of RNA/protein Complexes

Posted on January 31,

A postdoctoral research position is available in the laboratory of Yunsun Nam, in the Department of Biochemistry at the University of Texas Southwestern Medical Center in Dallas, to study the mechanisms underlying RNA-protein complexes important for gene regulation. Our laboratory works on exciting projects dissecting how chemistry and structure contribute to assembling specific RNA-protein complex architectures important for normal gene expression. More specifically, we investigate the core and regulatory mechanisms that govern RNA processing (eg. microRNA maturation), modification (eg. methylation), and folding (eg. RNA helicases) that impact the RNA function in the cell. To study how proteins and RNAs recognize each other, we use biochemical and biophysical methods. The RNA-protein complexes we study are relevant for normal development as well as diseases. Thus, as we unravel how dysregulated RNA-protein complexes derail gene expression and cause cancer, we use our mechanistic understanding to identify novel therapeutic avenues.

Postdoctoral scholars will have many opportunities to learn the newest methods in protein and nucleic acid biochemistry and biophysics, in addition to working in an exciting, fast-evolving field in biomedical sciences. We use various approaches, including cryo-electron microscopy (cryo-EM), X-ray crystallography, NMR spectroscopy, molecular biology, nucleic acid and protein biochemistry, genomics with next-generation sequencing, high-throughput screening for drug discovery, and cancer cell biology. The postdoctoral fellow will have ready access to the top-of-the-line equipment and resources necessary for the above approaches.

Candidates must hold a Ph.D. and/or M.D. degree. Experience in biochemistry and structural biology leading to publication in peer-reviewed journals is recommended.

Information on our postdoctoral training program, benefits, and a virtual tour can be found on the postdoc website.  

Interested individuals should send a CV, a statement of interest, and a list of three references as a single pdf file to:

Yunsun Nam, Ph.D.
Associate Professor
UT Southwestern Medical Center
5323 Harry Hines Blvd.
Dallas, TX 75390-9038
[email protected]
Lab Website:
University Profile Page

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