Biochemist on Condensate Biology at Johns Hopkins University

Posted on May 17,

We are looking for a postdoctoral fellow or research associate to join the Leung Lab at Hopkins. We will dissect the biochemistry of biomolecular condensate through the lens of RNA and poly(ADP-ribose) biology. Recent news piece on our work can be found here.

Poly(ADP-ribose) is a therapeutically important protein modification as evidenced by the FDA approval of poly(ADP-ribose) polymerase inhibitor for treating cancers. Here, we will investigate the condensate biology, specifically RNA-enriched granules, in viral infection and/or neurodegeneration. Our ultimate goal is to translate basic scientific discovery to biomarkers or therapeutic targets.

The ideal candidate should have prior experiences in biochemistry using various affinity purification techniques and protein purification techniques. Experiences with proteomics, post-translational modifications, nucleic acid chemistry, or relevant disease biology are a plus.

About us: We are a team from diverse backgrounds, with expertise in molecular biology, cell biology, biochemistry, proteomics, chemistry, and informatics. Over the years, our team has developed novel techniques to investigate poly(ADP-ribose) and discovered its roles in controlling condensate formation, disassembly, and composition. Therefore, these insights provide us a unique edge in exploring the science and developing the candidate for their next career move.

Environment:The Johns Hopkins University provides an excellent and stimulating scientific environment for collaboration and exchange of ideas to pursue the research goals. We enjoy a rich diversity of faculty research programs in the following departments that apply basic molecular, cellular and biochemical approaches to fundamental issues in public health and medicine:

Seminars, journal clubs, and research colloquia where individual laboratories present their latest research are held over the academic years, thus providing a strong environment for candidates to pursue innovative projects.

Instructions for applying:
Interested candidates should send a cover letter briefly describing their career goals/research interests (0.5 page) and accomplishments (0.5 page) to Anthony. The candidate’s CV and contact information for 3 references should also be provided for consideration.