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Postdoctoral position at Institut Curie (Paris area, France) – Alternative polyadenylation in anticancer drug resistance.
Polyadenylation, Splicing, Cancer, Chemotherapy, DNA damage, RNA-seq, CLIP-seq.
We are seeking a highly motivated postdoc to study the role of alternative polyadenylation in the context of cancer cell resistance to genotoxic anticancer agents. The project will involve the use of genome-wide approaches (RNA-seq and CLIP-seq) to analyse specific RNA-binding proteins involved in this process. The project is based on our previous studies (Dutertre et al., Nat Struct Mol Biol 2010; Decorsière et al., Genes Dev 2011; Dutertre et al., Nat Commun 2014; Dutertre et al., TIBS 2014).
Lab and institute:
The team (“RNA biology linked to DNA damage”, head Stephan VAGNER) includes 2 researchers, 3 engineers, 3 postdocs and 2 PhD students (5 nationalities). The general interest of the team is in RNA regulations in the contexts of DNA damage response and cancer. The lab is located in the Paris area (France) and is part of Institut Curie, an internationally renowned foundation devoted to cancer care and clinical, transfer and basic research (from physics to biology). The research institute has various technology platforms (genomics/ NGS, proteomics, bioinformatics, imaging, cell screening, in vivo and preclinical investigation, chemical library, tumor collections, etc.). With more than 80 nationalities at Institut Curie, English is the commonly used language in the lab and in the institute.
The candidate must hold a PhD and be the first author of at least one accepted publication. Skills in molecular biology are required; skills in RNA biology are strongly desired.
Start date: January 2016.
Duration: 36 months.
3-year salary is available but the selected candidate will be encouraged to apply for a postdoctoral fellowship.
Project supervisor: Martin DUTERTRE (PhD, permanent researcher)
Send CV, motivation letter and 2 letters of support to [email protected]
A postdoctoral position is available in the laboratory of Dr. Julia Salzman at Stanford University. The lab focuses on studying the mechanism of biogenesis and decay of circular RNA and their function. The successful candidate will be involved in either molecular/genetic or statistical/bioinformatics approaches to answer the above questions.
We are looking for an engaged, inquisitive and highly motivated individual who will make a positive contribution to the collaborative atmosphere of the lab. See med.stanford.edu/salzmanlab.html for more details about the lab.
Please contact Julia Salzman ([email protected]) with your curriculum vitae and description of your interest in the lab’s research as well as previous experience. In addition, please submit three letters of recommendation.
Postdoctoral and graduate studentship positions in RNA synthetic biology at the Alberta RNA Research and Training Institute (ARRTI)
The newly-established research group of Dr. Nehal Thakor is currently accepting applications for a postdoctoral fellow and graduate studentship positions in the research area of RNA synthetic biology. Applicants will ideally have experience in SELEX, RNA chemical probing, and RNA structure function analysis. Experience with RNA-seq and RNA bioinformatics will be an asset. The postdoctoral position is tenable for a period of one year, and may be extended depending on funding and performance.
Dr. Thakor is a Campus Alberta Innovates Program research chair in Synthetic Biology and RNA-based system. The Thakor lab (http://www.uleth.ca/artsci/biochemistry/thakor-group) is focused on RNA synthetic biology and protein translation regulation.
Interested applicants are encouraged to apply by contacting Dr. Nehal Thakor at [email protected].
Positions will remain open until filled.
A NIH-funded postdoctoral position for a highly self-motivated scientist is available in the ZZ lab at Carnegie Institution of Science, Department of Embryology. Research in our lab focuses on the impact of transposons during animal development, disease, and aging processes. We build tools to quantify the transposon activities and uncover the mechanisms that control transposons. The candidate will join a young and highly energetic family. Current research directions in our lab include:
1. Studying piRNA biogenesis and transposon silencing in animal (mouse and fly) germline.
2. Building transposition reporter system to probe transposition events.
3. Uncovering transposon control mechanisms in somatic cells.
4. Establishing genome-wide sequencing method to quantify DNA breaks.
Job requirements: Applicants should be creative individuals who are willing to ask big questions and challenge established dogmas.
I am seeking a qualified and motivated candidate to study the role of DEAD-box proteins in messenger RNA regulation in E. coli. The focus of the lab is on prokaryotic RNA metabolism, with particular emphasis on the cellular roles of DEAD-box proteins and ribonucleases. Candidates with a recent Ph.D. degree and a background studying any aspects of RNA metabolism in prokaryotes are welcome to apply. Applicants should send by e-mail (as a single PDF) a cover letter, CV, summary of research experience and contact information of three references.
Email: [email protected]
A postdoctoral position is available in the laboratory of Dr. Ryuya Fukunaga at Johns Hopkins University School of Medicine. The laboratory is focused on understanding the molecular mechanisms of biogenesis and function of small silencing RNAs such as miRNAs, siRNAs, and piRNAs. We are also interested in post-transcriptional RNA regulation. We employ a wide range of approaches that include biochemistry, Drosophila genetics, cell culture system, deep-sequencing, and X-ray crystallography. We are looking for a highly motivated and enthusiastic new member of the lab. Candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, biochemistry, genetics, cell biology, structural biology, or a related discipline. Candidates with strong background in biochemical, molecular, cellular, and genetic analyses in RNA research are encouraged to apply.
More information is available at: http://biolchem.bs.jhmi.edu/Pages/facultydetail.aspx?FID=755
Please email a cover letter, CV, a brief summary of research interests, accomplishments, and career goals, and contact information of at least three references to Dr. Ryuya Fukunaga at [email protected]
The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research and is an Equal Opportunity Employer.
Postdoctoral position to study the structure and function of catalytic ribonucleoproteins, Penn State University
A postdoctoral position is available in the laboratory of Dr. Andrey Krasilnikov at Penn State University. The succesful candidate will be involved in NIH-funded study of the structure and function of catalytic RNPs with the focus on the enzymes of the RNase P/MRP family. Research involves a broad spectrum of approaches ranging from biochemistry and molecular biology to X-ray crystallography.
We are looking for a highly motivated and enthusiastic new member of the lab. Considerable experience in protein purification and/or RNA work is highly desirable; experience in X-ray crystallography is a plus, but not required (the succesful applicant will have a chance to learn it if desired). Please submit your letter of intent, a short description of previous interests and achievements, your curriculum vitae, and contact information for three references to Andrey Krasilnikov ([email protected]).
New position for NCI Laboratory Chief, similar to Department Chair. The Chief will have stable funding, renovated lab space and resources to hire two new faculty, each with their own space and funding. The Chief will also have the opportunity to incorporate existing CCR/NCI PIs into the new Laboratory/Department.
Contact: [email protected]
Highly motivated postdoctoral candidates are invited to lead several new projects to address fundamental questions in Nucleic Acid Biology. Current directions in the lab include novel functions of DNA/RNA of unconventional structures, microRNA processing, and general RNA and protein homeostasis. Candidates with a strong background in biochemical, molecular, and cellular analyses of nucleic acids are encouraged to apply.
The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research. Our lab is affiliated with the Department of Biochemistry and Molecular Biology of the Bloomberg School of Public Health and the Department of Neuroscience of the School of Medicine. The Baltimore/Washington D.C. area also offers rich professional and living opportunities.
Candidates should have a doctoral degree and strong research background. Please send a statement of research experience and career goals, a copy of Curriculum Vitae, and contact information of at least one reference to Dr. Jiou Wang at [email protected].
More information available at: http://www.jhsph.edu/faculty/directory/profile/5049/Wang/Jiou. The Johns Hopkins University is an Equal Opportunity Employer.
A postdoctoral position is currently available in the laboratory of Carson Thoreen in the Department of Cellular and Molecular Physiology at Yale School of Medicine. The laboratory is focused on understanding the molecular functions and physiologic roles of mechanisms that control the translation of mRNAs in response to cellular signals, especially those that are deregulated in human diseases such as cancer. We employ a wide range of approaches that include deep-sequencing (eg. ribosome profiling), bioinformatic and classical biochemical strategies. Creative individuals with a PhD or MD, and preferably a strong background in biochemistry and/or cell biology and a quantitative bent, are encouraged to apply. Applicants should send a current CV to [email protected].
Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Ribonucleoprotein Complexes.
A postdoctoral position is available starting in the Fall of 2015 in Dr. Jinwei Zhang’s group as part of the Laboratory of Molecular Biology (LMB) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in the National Institutes of Health (NIH)’s vibrant main campus in Bethesda, MD just outside of Washington DC. More details will become available at http://www-mslmb.niddk.nih.gov/
The laboratory aims to address a widening gap between the exponential growth of genome-wide discovery and functional description of the noncoding transcriptome, and a significant lack of three-dimensional structural information and mechanistic understanding of such complex noncoding RNAs. Initial projects include gene-regulatory riboswitches, stress-sensing Gcn2 kinase system, HIV and other viral RNA and RNPs.
The laboratory is established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/trans-nih-scientific-recruitments/stadtman-tenure-track-investigators). The research of the group is supported by the collaborative and interdisciplinary NIH intramural program consisting of more than 1100 labs and state-of-the-art equipment in structural biology (X-ray crystallography, Cryo-EM, SAXS, etc), biochemistry and biophysics core facilities with hands-on training provided by PhD-level support staff, genomics (RNA-seq), proteomics, and bioinformatics cores, flow cytometry and microscopy, etc. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees in many aspects such as numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES), as well as intramural career transition funding (K grants) opportunities.
Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, cell biology, or a related discipline, have excellent oral and written communication skills, and be strongly self-motivated to participate in and design innovative and rigorous research programs.
To apply: Please email a cover letter indicating preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: [email protected]. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer.
Establish the Role of RNA Stability and Editing in Bone and Cartilage Tissue Homeostasis and Disease
A postdoctoral position is currently available in the laboratory of Drs. Michael Zuscik and Reyad Elbarbary in the Center for Musculoskeletal Research at the University of Rochester Medical Center (URMC). The primary focus of the research for this position is to establish the role of RNA stability and editing in bone and cartilage tissue homeostasis and disease. A second project will be related to our group’s ongoing study of the pathogenesis of osteoarthritis and the associated development of chondroregenerative therapeutic approaches. Candidates with expertise and/or interest in the musculoskeletal and RNA biology fields are encouraged to apply. Experience in mouse genetics, husbandry, genotyping and surgery, nucleic acid analysis, IP/ Western blotting, histologic methods and immunohistochemistry and cell culture is desired. Please send a current CV and a brief personal statement describing your career plans to Michael Zuscik ([email protected]) and Reyad Elbarbary ([email protected]).