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I am anticipating one and possibly two post-doc positions in my lab beginning in spring 2014 with funding for up to four years We use a combination of molecular genetics, cell biology and biochemical techniques to study nuclear assembly and cytoplasmic maturation of eukaryotic ribosomes. Projects include: understanding the dissociation of U3 snoRNA and the SSU processome from the pre-40S subunit in the nucleus and the mechanisms of quality control that test newly assembled 60S subunits in the cytoplasm. I am looking for a highly motivated person with strong experimental training in molecular or cell biology with a strong publication record. Prior experience in protein purification and biochemistry and/or in vivo and in vitro RNA work are essential. Interested candidates should email a cover letter, CV, and contact information for three references to Dr Arlen Johnson at email@example.com.
UT Austin has a vibrant research community and Austin is a great place to live. Check
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The Centre for Genomic Regulation (CRG, www.crg.eu), a leading Institute in life science and biomedical research, is recruiting two junior group leaders,
Junior Group Leader at the CRG-EMBL Systems Biology Partnership Unit, ideally with a focus on systems biology approaches to multicellular biology of tissues and organs . This could include new model systems (in vitro tissue/organ culture, tissue engineering, regeneration, immunology, etc.), or other interesting systems, and would preferably include both experimental and computational approaches.
Junior Group Leader at the Gene Regulation, Stem Cells and Cancer Program, to develop innovative approaches to study any aspect of gene regulation and/or cell differentiation/ reprogramming, including (but not restricted to) the molecular and cellular basis of human pathologies .
Candidates for these positions should have an outstanding pre and postdoctoral record, an ambitious project for their future group and a keen interest to interact scientifically with their future colleagues at the CRG. We offer a competitive salary with a 5-year contract extendable to a total of 9 years depending on external evaluation. The offer includes equipped lab space for up to 6-8 people, special equipment if needed, and core funding that covers salaries and consumables for three additional positions for the entire duration at the CRG. Candidates should send a CV with list of publications, a brief research proposal and the addresses of at least 3 references to: firstname.lastname@example.org indicating the reference in the subject line (ref. GL-BS-GRSCC-1013). The CRG aims to increase the number of female group leaders and strongly encourages women to apply.
A postdoctoral fellow position is available in the laboratory of David Weinberg at UCSF (http://weinberglab.ucsf.edu) to study mechanisms of translational control. The Weinberg lab is taking a multidisciplinary approach to identify the molecular determinants of translational efficiency, which varies widely between endogenous mRNAs for largely unknown reasons. We are particularly interested in understanding how the closed-loop structure of translating mRNPs is formed and how this structure affects mRNA translation and decay. We have recently developed the first genome-wide assay to detect the closed loop in vivo in yeast and human cells. By combining this assay with accurate measurements of translational efficiency, we have identified a critical role for the closed-loop structure in enhancing translational efficiency in vivo (Weinberg & Bartel, in preparation). Building on these findings, the successful candidate will characterize the mechanism by which mRNA circularization enhances translational efficiency while also extending our studies of the closed loop to mRNA degradation. Specific focus will be on combining classical biochemistry techniques with high-throughput sequencing to study endogenous mRNPs in yeast and human cells. A variety of additional experimental and computational projects are available, including genetic analysis of the closed-loop structure, biochemical reconstitution of translational efficiency, and computational identification of determinants of translational efficiency.
The position is fully funded for up to 5 years and is available immediately. Required qualifications include a PhD in Molecular Biology, Biochemistry, Computational Biology, or a related field. Our lab is located in the Genentech Hall building at the Mission Bay campus of the University of California, San Francisco. Genentech Hall houses state-of-the-art research facilities and with the adjoining Byers Hall comprises a highly collaborative scientific community.
Interested individuals should send an application file (consisting of a cover letter, CV, and three references; together as a single PDF document) by email to David.Weinberg [at] ucsf.edu.
A computational postdoctoral fellow position in regulatory RNAs is available immediately in Ye Ding’s RNA Bioinformatics group (http://sfold.wadsworth.org).
A major ongoing research activity is high throughput data analysis and modeling for functional elucidation of regulatory RNAs in gene regulation. Specific research topics include microRNAs and SNPs, circular RNAs, bacterial small RNAs and lncRNAs, with potential applications to stem cells, cancer and other human diseases.
Candidates must have solid understanding of statistical methods, preferably including Bayesian data analysis and modeling. Experience with R is expected. Understanding of molecular biology, training in Bioinformatics and familiarity with Perl or C are pluses.
A Ph.D. in Statistics or related field is required, and interest in statistical applications to molecular biology is essential.
Application including resume, a statement of research interests and names of three references should be sent to Ye Ding at email@example.com.
The position is located in Albany, the capital of New York State, with ready access to the Adirondacks, Berkshires, Boston, New York City, Montreal and Buffalo. The capital region is the home to the University at Albany of the State University of New York (SUNY), SUNY College of Nanoscale Science and Engineering (CNSE), Rensselaer Polytechnic Institute (RPI), Union College, General Electric (GE) Research and Development, GE Power Systems, and many New York state agencies.
A postdoctoral position is available to do research in the laboratory of Shalini Sharma, Ph.D. in regulation of pre-mRNA splicing in humans at the Department of Basic Medical Sciences, University of Arizona, College of Medicine-Phoenix. Specific focus will be on understanding mechanisms of splice site pairing and commitment to splicing. These are critical steps in formation of the spliceosome, which is a large RNA complex that catalyzes splicing. They are important for maintenance of splicing fidelity and for regulation of alternative splicing by splicing regulatory proteins. These studies will use a combination of conventional molecular biology and biochemistry techniques, and advanced high-throughput RNA-seq and proteomic techniques.
The University of Arizona, College of Medicine-Phoenix is located in downtown Phoenix in a new state-of-the-art research building with excellent core facilities. The College of Medicine-Phoenix fosters academic excellence and economic growth in the region. The environment fosters academic excellence and ample opportunity for collaborations with researchers at institutions such as Translational Genomics Research Institute (TGen), Arizona State University, The Biodesign Institute, the Arizona Cancer Center – an NCI-designated comprehensive cancer center, St. Joseph’s Hospital/Barrow Neurological Institute and the Scottsdale Mayo Clinic. For more information, please visit the website at http://bms.med.arizona.edu/.
The position is available immediately. Required qualifications include a Ph.D. in Biochemistry, Molecular Biology, or related field. Interested individuals should e-mail a cover letter describing their current research and future career goals along with a CV and contact information for three references to Shalini Sharma, Ph.D.- firstname.lastname@example.org.
A postdoctoral position is available in the ATIP-Avenir laboratory of Mathieu Gabut at the Cancer Research Centre of Lyon in France (http://www.crcl.fr/442-Diversite-du-transcriptome-des-cellules-souches.crcl.aspx?language=fr-FR) to study the role of alternative splicing for the control of embryonic stem cell (ESC) self-renewal and pluripotency. Building on our recent discoveries (Gabut et al Cell 2011; Han et al, Nature 2013), the successful candidate will characterize novel RNA binding proteins which coordinate alternative splicing networks in ESCs using cellular, molecular and high-throughput RNA analysis approaches.
The position is funded for 3 years and will be available early 2014. The salary is based on the applicant’s experience and on the National Institute for Health and Medical Research (INSERM) guidelines.
The CRCL is a research centre which provides state of the art research facilities in a collegial and collaborative environment for 19 principal investigators. It is located in downtown Lyon, in close vicinity of the Léon Bérard Cancer Centre, the General Hospital of Lyon and the Rockefeller Medical School of Lyon.
We would be glad to receive applications from motivated recent or future graduates with a strong expertise in molecular and RNA biology as evidenced by published papers. A background in RNA binding proteins, alternative splicing, UV crosslinking and immunoprecipitation (CLIP) and/or transcriptome bioinformatics is preferred. Excellent written and spoken English is necessary.
Please send a brief statement describing past and current research interests, an up-to-date CV and list of publications, and 3 references to Dr. Mathieu Gabut (email@example.com).
We are seeking an excellent candidate for research on regulation of mRNA expression, specifically the role of 5’ and 3’ UTR structures in regulation, interaction of these RNA regions with protein factors, and mechanisms of interaction and assembly. Our lab uses both molecular biology and biophysical techniques to address these questions (Ma et al. (2012) PNAS; 109:8417-22) in both mammalian and plant viral systems.
Qualifications: Recent Ph.D. with outstanding research productivity as evidenced by published papers. Experience in molecular biology/biochemistry with experience in RNA and protein expression.
Applicants should submit:
1.) complete resume
2.) names and contacts for three references
3.) brief description of RNA research experience that includes those techniques with which the applicant has extensive experience.
This position is for two years with possible extension for a third year. Please contact Dr. Goss: firstname.lastname@example.org
A postdoctoral position is available in the laboratory of Grace Pavlath at Emory University (http://www. pharm.emory.edu/gpavlath/) to study genetic models of Oculopharyngeal Muscular Dystrophy (OPMD) in mice. OPMD is an adult onset disease characterized primarily by eyelid drooping and difficulties in swallowing. The mutation responsible for the disease is found within the polyadenylate-binding protein nuclear 1 (PABPN1) gene. The ubiquitously expressed PABPN1 protein regulates post-transcriptional gene expression through modulating 3’-end formation including poly(A) tail length and 3’-end cleavage/polyadenylation site selection. The autosomal dominant form of OPMD, which is the most common form of the disease, is characterized by a polyalanine expansion in the N-terminal domain of PABPN1 from the normal 10 alanines to 12-17 alanines. Join a highly collegial and collaborative environment to identify mechanisms by which the polyalanine expansion in PABPN1 leads to muscle-specific pathology.
This position is funded for at least 2 years and is available immediately. Salary is based on qualifications and Emory University guidelines. This work is part of a collaborative project with Anita Corbett at Emory University (http://www.biochem.emory.edu/labs/acorbe2/) . Emory University provides state of the art research facilities in a collegial, collaborative environment. Atlanta is a vibrant, cosmopolitan city with easy access to a broad array of cultural and recreational activities.
Ph.D. within past 2 yrs with outstanding research productivity as evidenced by published papers. Experience in cell and molecular biology is required. A background in RNA biology, trinucleotide expansion diseases, bioinformatics is preferred. Must be able to work with mice. Excellent written and spoken English necessary.
Please send a brief statement describing past and current research interests and career objectives, CV including your contact information and publications, and contact information for 3 references to Grace Pavlath (email@example.com)