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The Genome Sciences Centre within the British Columbia Cancer Agency in Vancouver, British Columbia, Canada has an immediate opening for a post-doctoral fellow in the laboratory of Dr. Gregg Morin, to study the mechanisms-of-action of pharmacological inhibition of proteins that regulate pre-mRNA splicing. The scientist will join a collaboration with Drs. Samuel Aparicio and Sohrab Shah that is using global genomic and proteomic technologies to identify changes in alternative splicing due to inhibition of several classes of enzymes that regulate spliceosome function. The objective is to investigate how these enzymes regulate genome-wide spliceosomal function and splice site choice.
The position will perform laboratory research to design and interpret experiments using biochemical, proteomic, molecular and genomic tools to investigate the functional mechanisms of enzyme inhibition on the spliceosome and its regulatory proteins in human cancer cells. The team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics. The candidate should have experience in ribonucleoprotein biochemistry, mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, RNAi, and a comprehensive understanding of splicing and spliceosome function.
All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Additional information can be obtained at www.bcgsc.ca.
Applicants should send a cover letter, curriculum vitae, and names of three referees by email to: Dr. Gregg B. Morin (firstname.lastname@example.org)
Duration: 1 year renewable
Postdoctoral scholar positions are available at the Nanobiotechnology Center of the University of Kentucky and the NCI Cancer Nanotechnology Platform Partnerships (CNPP) program directed by Dr. Peixuan Guo (http://nanobio.uky.edu/Guo/peixuanguo.html). Strong background in one of the areas of Molecular Biology, Biochemistry, Genetics, Cell Biology or RNA Chemistry is preferred. To apply, please contact Dr. Hui Zhang at email: email@example.com. The University of Kentucky is an Equal Opportunity and Affirmative Action Employer.
Seeking a motivated postdoc to investigate novel mechanisms of cap-independent translation via translation enhancing sequences located in the 3′ UTRs of plant viral RNAs.
Desired expertise: RNA-protein interactions, structural biology, computational modeling, good writing skills, ability to work independently and also be a team player in a collaborative lab environment. Experience in plants and/or viruses and/or translation is an advantage but not necessary. However, interest in working with, and learning about, all three is a must.
Can start immediately (March 2014), but we are willing to wait for the best candidate to complete Ph.D. or other commitments if necessary. Duration: 3 years depending on progress. This project is funded by a recently awarded NIH R01 grant.
Please mention this advertisement when applying for the position.
One postdoctoral research position is available in the laboratory of Regulation of Protein Synthesis led by Dr. Fátima Gebauer. The successful candidate will investigate the role of RNA binding proteins in cancer progression using cutting edge genomics technologies and molecular and cellular biology assays. The candidate will integrate on a team with interests in post-transcriptional regulation of gene expression and molecular mechanisms of translational control.
Requirements: Candidates must hold a PhD degree on Molecular Biology, Cellular Biology, Biochemistry or Biomedicine. Expertise in RNA and protein manipulation is required. Experience in Bioinformatics, Genomics, Proteomics and Cancer Biology will be valued. Personality: highly motivated, analytical, interactive and independent.
Duration: 3 years
Starting date: As soon as 1st of April 2014
Postdoctoral position in RNA Biotechnology in the Department of Biological Sciences at Columbia University. The candidate will develop mammalian cell vectors that promote high level monoclonal antibody production through improved post-transcriptional processing. The targets include realizing greater mRNA stability and translation initiation. Although the goals are in engineering., i.e., to create useful vectors, it is likely that interetsing information regarding the regualtion of mRNA stability and translation will be discovered as well. A second project involves genetic engineeering of CHO cells to facilitate gene amplification. Methods involve molecular genetic manipulation and RNA molecular biology; expertise in a range of recombinant DNA technologies is required. This position is industrially funded in a laboratory that is otherwise supported by the NIH to study pre-mRNA processing in mammalian cells. The postion is available immediately and has assured funding though April 2015 with a history of renewal. Email a cover letter and CV to Larry Chasin, firstname.lastname@example.org.
A postdoctoral position is available immediately for at least two years (renewable yearly). The ideal candicate will have a strong background in molecular biology and biochemistry and have experience in expression of recombinant proteins and protein purification.
H/ACA ribonucleoproteins (RNPs) are a large family of small RNA-protein particles that include snoRNPs and scaRNPs (responsible for the pseudouridylation of ribosomal RNAs and spliceosomal snRNAs, respectively), mammalian telomerase, intronic Alu RNA particles, and others. Some of the RNP core proteins and assembly factors of H/ACA RNPs are targets of inherited disease and cancer. We are studying the molecular mechanisms underlying these diseases. For more information see our home page:
Albert Einstein College of Medicine is a vibrant scientific community that caters to postdoctoral researchers through its postdoctoral association, the Belfer Institute. Postdoctoral housing is available. For more details check out the webpage of the Belfer Institute:
Send application letter, CV, and addresses of three references to: email@example.com
“Cellular mRNA decay and translation in response to Listeria monocytogenes infection”
A two-year post-doctoral position is available in the “Bacterial Infection and RNA Destiny” team lead by Alice Lebreton, in the Biology Institute of École Normale Supérieure, Paris, France, starting September 2014.
Invasion and proliferation of Listeria monocytogenes, the bacterial agent of listeriosis, in human cells is coupled with extensive reprogramming of gene expression and cell function.
Our team aims to unravel the post-transcriptional regulation that affects eukaryotic mRNA stability or translation during infection, its molecular mechanisms and its physio-pathological consequences. These studies should allow a better understanding of the mutual requirements for bacteria-host niche adaptation, the characterization of new virulence factors, and the exploration of eukaryotic translational control pathways.
We seek to recruit a highly motivated, open-minded and creative postdoctoral researcher to explore these novel aspects of the host-bacterial dialogue. The project relies on cutting-edge technologies for the analysis of mRNA fate, such as ribosome profiling and mRNA degradome, but also more classical approaches in cellular microbiology and biochemistry. The selected candidate will benefit from the very stimulating and multidisciplinary environment of IBENS, from exceptional opportunities to develop collaborations, and from the strong expertise of the group leader, both in the Listeria and RNA fields. Candidates should have a strong background in cell biology and biochemistry; previous experience with RNA biology, Hi-Seq and/or host-bacterial interactions would be an asset. Applicants interested in developing “dry lab” aspects of their research are also encouraged to apply.