Employment Opportunities

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NIH-funded Postdoctoral Fellowship Position

NIH-funded Postdoctoral Fellowship Position, to begin Oct 1, 2015 or later (duration: 2-5 yrs).
NIH-funded Postdoctoral Fellowship Position in Eukaryotic RNA Metabolism
National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to eukaryotic gene expression. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation. The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Richard J. Maraia, M.D.
Email: maraiar@nullmail.nih.gov

Maraia lab current interests
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation and disease.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.

Postdoctoral Research Fellow Position at the University of California, San Francisco

A postdoctoral research fellow position is available at the University of California, San Francisco at the new Helen Diller Comprehensive Cancer Center (Mission Bay Campus) (http://pub.ucsf.edu/missionbay/tour/; http://cancer.ucsf.edu/news/20031028b.php), to study the molecular mechanisms by which impairments in accurate control of mRNA translation, cell growth, and overall cellular protein synthesis rates lead to cancer. The potential candidate will utilize the first mouse models for components of the translation machinery in combination with novel proteomics and pharmacological strategies to study the dynamics of translation control in gene expression, cancer, and disease. Highly motivated individuals with a recent Ph.D., M.D. or M.D./Ph.D. and a background in mouse genetics, biochemistry, or cellular and molecular biology are encouraged to apply. Evidence of scientific accomplishment is required and bioinformatics skills are desirable. Requests should be addressed to: davide.ruggero@nullucsf.edu and christine.milentis@nullucsf.edu.

Please visit our webpage at ruggerolab.ucsf.edu.

Explore the Role of mRNA Expression and Distribution in Cancers Caused by Genetic Re-arrangements

One position is available immediately to explore the role of mRNA expression and distribution in cancers caused by genetic re-arrangements. This is accomplished using single molecule florescent in situ hybridization, commercially called “Stellaris probes”. Studies involve working with cancer cell lines and patient samples, in situ hybridization, fluorescence microscopy and image analysis and interpretation using MATLAB software. The project is supported by an early independence award from NIH (2012-2017)

Job requirements: Recent Ph.D. in Life science or basic science. The candidate should be self-motivated and hard working with a strong background in molecular biology. Hands on working experience in basic molecular biology techniques like cloning, culture of immortalized and primary cells, microscopy and image analysis is desired. Candidate will be responsible for designing, performing experiments, compiling and analyzing data and providing necessary help in preparation of materials for publications and grant proposals. Ability to write and submit proposals for fellowships will be a plus.
Interested candidates who are willing to join immediately, should email their CVs and contact information of three references to Mona Batish, Ph.D. Assistant Professor, Email: batishmo@nullnjms.rutgers.edu

2 Postdoctoral positions available in RNA NMR at Karolinska Institute (Stockholm)

Background:
More than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these cellular functions are largely unknown.
Our research group is interested in understanding how RNAs change their structures in order to perform function. We employ liquid-state Nuclear Magnetic Resonance (NMR) and other biophysical and biochemical techniques, to investigate the molecular mechanism of RNA function ( Nature 2012 & 2015). When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab also develops methods in NMR and RNA biochemistry to address these questions.

Projects (each one year with possibility to extend another year):
One Postdoc will work on development of NMR experiments and/or simulations for RNA dynamics parameters. The second Postdoc will develop biochemical methods to produce larger RNAs or RNAs in environment of larger proteins (e.g. partial labeling, specific modifications). Both postdocs will work on RNAs addressing biological questions studied in the lab (microRNAs and ribosomal RNAs). You will work in a team together with other lab members and regularly present the research work in lab-meetings, seminars and at international conferences.

The projects will be supervised by Dr. Katja Petzold, deadline 31st of January 2015. Please apply directly via the netrecruiter system:
https://ki.mynetworkglobal.com/en/what:job/jobID:48803/where:/
Fore more information please visit the website:
http://www.nature.com/naturejobs/science/jobs/480937-two-highly-motivated-postdocs-for-research-projects-in-rna-structural-biology-using-nmr

Investigate the Mechanisms and Regulation of Pre-mRNA Processing by the U12-dependent Spliceosome

The RNA splicing group at the Institute of Biotechnology, University of Helsinki, Finland is looking for a post-doctoral researcher in a project that investigates the mechanisms and regulation of pre-mRNA processing by the U12-dependent spliceosome.
A successful candidate has a PhD and strong background in molecular biology, cell biology or in a related field as shown by solid publication record in international peer-reviewed journals. Good communication skills and fluency in spoken and written English are required. An experience in RNA biology/biochemistry, bioinformatics/high throughput sequencing, and/or genome editing is an asset.
The specific projects will depend on the previous experience and the qualifications of the successful applicant but is likely include mammalian genome editing with CRISPR/CAS system combined with high-throughput sequencing to investigate the regulatory aspects of the U12-type intron splicing.
Application:
Further information of the research group and the research topic and the application form can be found from the group web site http://www.biocenter.helsinki.fi/bi/SPLICING/index.html.
In addition to the application form, the application should include a motivation letter, a CV and a list of publications (max. 1 page), all combined to a single pdf that should be attached to the application form. The deadline for applications is January 15th, 2015. The position is available immediately.
The funded position is initially for 2 to 3 years, depending on the start date.
For further information please contact Mikko.Frilander(at)Helsinki.Fi

Recent publications:
Niemelä, E.H., Oghabian, A., Staals, R.H.J., Pruijn, G.J.M., and Frilander, M.J. (2014). Global analysis of the nuclear processing of unspliced U12-type introns by the exosome. Nucleic Acids Res 42, 7358-7369.
Argente, J., Flores, R., Gutiérrez-Arumí, A., Verma, B., Martos-Moreno, G.A., Cuscó, I., Oghabian, A., Chowen, J.A., Frilander, M.J., and Pérez-Jurado, L.A. (2014). Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. EMBO Mol Med 6, 299–306.
Turunen, J.J., Niemelä, E.H., Verma, B., and Frilander, M.J. (2013). The significant other: splicing by the minor spliceosome. Wiley Interdiscip Rev RNA 4, 61–76.
Turunen, J.J., Verma, B., Nyman, T.A., and Frilander, M.J. (2013). HnRNPH1/H2, U1 snRNP and U11 snRNP co-operate to regulate the stability of the U11-48K pre-mRNA. RNA 19, 380-389.
Pessa, H.K.J., and Frilander, M.J. (2011). Minor splicing, disrupted. Science 332, 184-185.
Verbeeren, J., Niemelä, E.H., Turunen, J.J., Will, C.L., Ravantti, J.J., Lührmann, R., and Frilander, M.J. (2010). An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Mol Cell 37, 821-833

Postdoctoral Position Available from Spring 2015 in the Yap Lab

A postdoctoral position is available from Spring 2015 in the Yap Lab (biochem.slu.edu/faculty/yap) at the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University School of Medicine. The research project will focus on the mechanism by which ribosome undergoes translational stalling in response to ribosomal antibiotics and arrest peptides. A variety of experimental methods will be employed, including genome-wide sequencing, molecular genetics and fluorescence-based biophysical and biochemical analyses.

The candidate must have a Ph.D. in Microbiology, Biochemistry, Bioinformatics, or related field from an accredited college or university. The ideal candidate also must have a deep interest and demonstrated capability in microbial genetics and biochemistry.

Please apply online at https://jobs.slu.edu(Requisition number 20140877) or send your CV and the names and contact of three referees to Frances at myap1@nullslu.edu.

Postdoctoral Position in the Laboratory of Dr. Xin Li, Assistant Professor at the University of Rochester Center for RNA Biology

A postdoctoral position is available starting from Feb 15, 2015 in the laboratory of Dr. Xin Li, Assistant Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics. Research in the Li Lab (www.zhaohuashan.com) is at the interface of reproductive and RNA biology. We thrive to understand how information is perpetuated and diversified through generations from an RNA perspective.

Some RNAs complex with PIWI proteins to become piRNAs essential for fertility. Yet, the mechanism(s) that determine which RNAs make piRNAs is unknown. We are looking for a creative individual, driven by scientific curiosity, to lead an inter-disciplinary project focused on answering the question “what defines a piRNA?”. This project is funded by NIH and will employ high-throughput sequencing, biochemistry, molecular biology, mouse genetics, and microscopy.

Being one of the founding members of the lab, the position will have the unique opportunity to work side by side with the PI, and help direct development and application of high-throughput sequencing methodologies. Ideas and data generated by the “dry” component of the lab will be tested rapidly and efficiently by “wet” bench members, and vice versa.

REQUIRED QUALIFICATIONS:

A recent Ph.D. or equivalent experience
At least one first-author publication
Good communication and organization skills
A background on reproductive biology or RNA biology

Please provide a cover letter describing your past projects and career goals. Please also describe what you hope to get out of this position and what you hope to bring to the Lab. Enclose your detailed CV with names and contacts of three referees to Xin_Li@nullURMC.Rochester.edu.

Rochester Center for RNA Biology is a mecca for RNA researchers, with a long history of nurturing RNA biologists and discoveries. The University of Rochester was ranked one of the top 15 institutions in the nation for scientists to work according to The Scientist magazine’s annual survey of “Best Places to Work for Scientists in Academia”. It should be noted that the University of Rochester outranked every other research institution in New York State. The environment is very collaborative and congenial and has an infrastructure that allows me and others to recruit outstanding lab members. Moreover, the city of Rochester is safe, beautiful and affordable.

PhD Students in Molecular Biology or Bioinformatics

The Faculty of Biology of Adam Mickiewicz University in Poznań, Poland, is looking for 6 PhD students to participate in research projects of the international PhD program of the KNOW RNA Research Centre in Poznań. The research topics are focused on the molecular biology and bioinformatics of ribonucleic acids. The detailed descriptions of the individual projects and information about how to apply are available at the webpage http://know-rna.amu.edu.pl/konkursy/. The applications should be send to rnaschool@nullamu.edu.pl by January 15th 2015.

Group Leader for Young Investigator Program

The Research Center for Infectious Diseases (ZINF) at the University of Würzburg seeks a new group leader for its young investigator program. We are looking to recruit a researcher with outstanding postdoctoral experience and international recognition in the general fields of microbiology, cell biology, mycology, parasitology, immunology, RNA biology, single cell analysis, or host-pathogen interactions. Candidates using emerging technologies to study new aspects of pathogenesis are preferred, but all outstanding scientists are encouraged to apply.

The appointment will be for a period of 5+2 years. Salary (E14/15) will be commensurate with training and experience. The position includes laboratory operating expenses and salaries for additional personnel (postdoc, graduate student, and technician), and laboratory space in a new 9,000 m2 state-of-the-art research building with bio-containment, molecular imaging, high-throughput genomics, and animal facilities. The building is specifically designed to foster collaborative research, and is home to nine additional young investigator groups as well as laboratories run by faculty members. See www.imib-wuerzburg.de for more information. Informal inquiries can be made to Prof. Jörg Vogel (joerg.vogel@nulluni-wuerzburg.de).

Interested individuals should send a one-page description of their research interests and future directions, CV and publication list, and the names of three academic references by January 31st, 2015. We may request that short-listed candidates provide a more detailed research proposal at a later date. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Applications should be sent as a single pdf.file via email to Dr. Stan Gorski (stan.gorski@nulluni-wuerzburg.de), and addressed to the Spokesperson of ZINF, Prof. Jörg Vogel.

The University of Texas at Houston Medical School – Assistant Professor in the field of Bioinformatics/Genomics

The University of Texas at Houston Medical School invites applications for a full-time, tenure-track faculty position at the Assistant Professor level at the Department of Biochemistry & Molecular Biology. The Department seeks candidates who use genomic, bioinformatic and systems biology approaches to understand gene regulation and other contemporary problems in biomedical sciences. Of particular interest are those with expertise in analyzing next-generation sequencing data to make novel biological discoveries.

Candidates must hold a Ph.D. and/or M.D. and have extensive experience in Bioinformatics, Genomics, or Computational Biology and a track record of scientific excellence. The successful candidate will collaborate with experimental biologists in the Department who generate large-scale genomic datasets. An experimental component to the candidate’s research program would be viewed as a positive but is not necessary.

The Department offers a highly collegial and interactive research environment and robust graduate programs for training Ph.D. and M.D./Ph.D. students. Researchers have the opportunity to interact with biomedical, clinical, and computational researchers across the UT Health Science Center as well as the Texas Medical Center at Houston, the largest biomedical and health research center in the U.S. An adjunct appointment in the School of Biomedical Informatics at the UT Health Science Center at Houston can be arranged for the successful candidate. Please visit our website (https://med.uth.edu/bmb) for additional information about the Department.

Applicants should prepare a single PDF file that includes a cover letter, CV, two-page summary of research accomplishments and plans and names/contact information of at least three individuals who agree to write a supporting letter. Please email the PDF file directly to Dr. Ann-Bin Shyu, Chair of the Search Committee, at BMB.Search@nulluth.tmc.edu. Review of complete applications will begin in January, 2015 and will continue until the position is filled.

Salary is commensurate with experience.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, genetics, disability, age, or any other basis prohibited by law. EOE/M/F/Disabled/Vet.

Department Head – Department of Biochemistry at Purdue University

The Department of Biochemistry at Purdue University invites applications and nominations for the position of Department Head. We are looking for a dynamic individual with a creative and inspiring vision for biochemistry research and education. Our forward-thinking, diverse, and internationally recognized department has 20 full-time faculty members with active research programs funded by the NIH, NSF, DOE, and ACS, as well as industry. These research programs encompass a wide variety of topics including metabolic and natural product biochemistry, cancer biochemistry, epigenetics and gene expression, proteomics and metabolomics, structural biology and macromolecular complexes. The majority of our faculty are members of the NCI designated Purdue University Center for Cancer Research and/or play key roles in Purdue’s Plant Sciences and Biofuels initiatives. The Department is dedicated to providing an exceptional undergraduate education that emphasizes experiential learning. Excellence in graduate education is a central goal of the department and is evidenced by a well-established graduate program; many biochemistry faculty also participate in the University-wide interdisciplinary life science graduate program (PULSe). Purdue University is committed to continued promotion of excellence in biochemistry research, and educational and scientific innovation. A competitive package for recruitment and resources is available for the successful candidate. More detailed information about the Department is available at: http://www.biochem.purdue.edu.

Qualifications: The successful candidate will have an outstanding record of scholarly achievement including an extramurally-funded research program and a forward-thinking, strategic vision for all levels of education. Successful candidates will also have demonstrated intellectual leadership necessary to further promote our department in an exciting period of growth. An appreciation of mentoring at all levels, service to the department and the greater scientific community, and an ability to inspire leadership in others is critical. Strong interpersonal, communication, and decision-making abilities are required. Administrative leadership experience is essential. Candidates must have a doctoral degree in biochemistry, biophysics, genetics, chemistry, computational biology or other related field, and be eligible for tenure at the rank of full professor.

The College: The Department of Biochemistry is an integral part of the College of Agriculture, one of the world’s leading colleges of agricultural, food, life, and natural resource sciences and ranked number 8 globally in the 2014 QS World University Rankings. The College is deeply committed to the three land-grant missions (teaching, research, and extension), to international activities and perspectives that span all missions, and to supporting a diverse and inclusive environment focused on excellence in all we do. Purdue is an ADVANCE institution – www.purdue.edu/dp/advance. The College has 11 academic departments and includes 330 faculty, 2710 undergraduate students, and 685 graduate students. The College’s strategic plan can be accessed at https://www2.ag.purdue.edu/Pages/strategicplan.aspx.

Application Procedure: Qualified persons are requested to submit the following: a letter of application, statements of research, teaching, and leadership philosophy, complete curriculum vitae, including the names of five references. Initial nominations and inquiries will be kept confidential; references will be contacted only upon the applicant’s approval. Nominations of potential candidates for the position are welcome. A background check is required for employment in this position.

Applications, nominations, and inquiries should be addressed to: Professor Rebecca Doerge, Chair of the Department of Biochemistry Head Search Committee, Purdue University, 615 W. State Street, West Lafayette IN 47907-2053. Electronic submission is preferred and should be sent to rdr@nullpurdue.edu. Screening of applicants will begin January 11, 2015, and will continue until a suitable candidate is identified. Questions regarding the position may be sent to Professor Rebecca Doerge at (765) 494-3141 (doerge@nullpurdue.edu).

Purdue University is an EEO/AA employer fully committed to achieving a diverse workforce. All individuals, including minorities, women, individuals with disabilities, and protected veterans are encouraged to apply.

Postdoctoral Research Position in the Lab of Dr. Aaron Goldstrohm

A postdoctoral research position is available immediately in the lab of Dr. Aaron Goldstrohm in the Department of Biological Chemistry at the University of Michigan Medical School.

Dr. Goldstrohm seeks a highly motivated postdoctoral candidate to perform research on the roles of RNA binding proteins, microRNAs, and long non-coding RNAs in cancer biology. Candidates should hold a Ph.D. in biochemistry, genetics, cellular and molecular biology or related field. They should have strong interests in cancer biology, gene regulation, RNA biology, and genetics. Individuals with experience in cancer research and molecular and cellular biology techniques are preferred. Candidates must have independent research skills including designing and executing experiments, interpreting data, and the ability to communicate results, as demonstrated by previous publications and presentations.

Initial support for the postdoctoral scientist will be provided by the American Cancer Society. Candidates will also be expected to apply for fellowships. Dr. Goldstrohm will provide guidance in developing fellowship proposals.

The University of Michigan and the Goldstrohm Lab provide an outstanding training environment with state-of-the-art facilities and instrumentation. The training environment is enhanced by participation in the multidisciplinary RNA Supergroup consisting of 17 labs from across the campus. In addition to abundant scientific and intellectual resources, the post-doctoral fellow will benefit from career and professional development opportunities. Compensation will correspond with the NIH NRSA payscale, commensurate with experience, and will include health care benefits.

The University of Michigan is located in Ann Arbor, a vibrant, affordable university town located in southeastern Michigan.

To apply, candidates should submit their curriculum vitae with publication record and contact information for three references to Dr. Aaron C. Goldstrohm at acgold@nullmed.umich.edu.

Please include a cover letter describing career goals, research experience, accomplishments, and interests. To learn more about the Goldstrohm lab and research, please visit: http://medicine.umich.edu/dept/biochem/aaron-goldstrohm-phd