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Faculty position in molecular and cellular biology

The University of California, Riverside is searching for a new faculty member at the ASSISTANT PROFESSOR level in the area of Molecular and Cellular Biology. Areas of interest could involve nuclear dynamics, histone modifications, noncoding RNAs in chromatin remodeling and genome stability, RNA transport, stability, and translation, RNAi and microRNAs, and RNA/protein trafficking within and between cells. Candidates working in molecular and cellular biology with any state-of-the-art model systems are encouraged to apply. Candidates who incorporate systems biology approaches, large-scale genomics, next generation sequencing, bioinformatics and/or visual microscopy to their research programs are preferred.

The successful candidate will join an innovative and multidisciplinary Institute for Integrative Genome Biology (IIGB) that connects theoretical and experimental researchers from different departments in Life, Physical and Mathematical Sciences, Medicine, Engineering and various campus based Centers. The IIGB is organized around a 10,000 sq.ft. suite of Instrumentation Facilities that serve as a centralized, shared-use resource for faculty, staff and students, offering advanced tools in bioinformatics, microscopy and imaging, proteomics and genomics. The University of California, Riverside also just completed construction of the School of Medicine Research Building adjacent to the Genomics Building, which will be developing research and health care delivery programs to medically underserved populations in California. A modern vivarium and two BSL3 facilities are located close to the Genomics and School of Medicine Research Buildings.

Review of applications will begin December 1, 2014. Interested individuals should: (1) submit a curriculum vitae, (2) provide a statement of research and teaching interests, and (3) arrange to have three letters of reference sent on their behalf through the recruitment website https://aprecruit.ucr.edu.

Tenure-Track Positions, RNA Therapeutics Institute, University of Massachusetts Medical School

The RNA Therapeutics Institute (RTI) at the University of Massachusetts Medical School, co-directed by Victor Ambros, Craig C. Mello, Melissa J. Moore, and Phillip D. Zamore, invites applications for tenure-track faculty positions. Successful candidates will conduct innovative research to understand normal physiology and development, disease mechanisms, and/or will develop novel diagnostics or therapies. Candidates need not necessarily conduct research directly focused on RNA chemistry, biology, formulations or therapeutics development, but should indicate how their research will synergize with ongoing research within the RTI and the greater UMass Medical School community.

Research areas of interest include, but are not limited to 1) Nucleic acid chemistry and formulation; 2) oligonucleotide delivery; 3) chemical biology; 4) human genetics and pathophysiology with a focus on oligonucleotide therapeutics; 5) chemistry of epigenetic regulation. Synthetic chemists, bioengineers, and materials scientists all are encouraged to apply. Also desired are scientists with significant industrial experience who wish to return to academia.

The RTI is housed in a new, state-of-the-art research building and is central to a campus-wide interdisciplinary initiative in RNA therapeutics, stem cell biology and gene therapy designed to facilitate collaboration among basic scientists, preclinical investigators and clinicians. As a recipient of a Clinical and Translational Science Award (CTSA) from the National Institutes of Health, UMass Medical School seeks to build an environment in which basic, applied and clinical researchers collaborate to inform our understanding of human disease and accelerate development of novel diagnostics and therapies. To further encourage collaboration, all RTI investigators hold joint appointments in other departments on campus.

Applicants should submit a cover letter, curriculum vitae, a two-page statement of research interests, and contact information for three references to https://academicjobsonline.org/ajo/jobs/4674. Applications will be reviewed expeditiously, with interviews commencing in November. Inquiries (but not application materials) may be directed to Mary Beth Dziewietin at MaryBeth.Dziewietin@nullumassmed.edu. Applications at the Assistant, Associate and Full Professor levels will be considered.

As an equal opportunity and affirmative action employer, the University of Massachusetts Medical School recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds.

Postdoctoral position in RNA regulation at Sloan-Kettering, New York City

We seek a motivated scientist with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to annotate and functionally elucidate small RNA pathways, mRNA processing pathways, and neural transcription factor networks.

The candidate will work on two projects. First is to elucidate mechanisms that regulate alternative polyadenylation in the nervous system. Second is to study the post-transcriptional regulation of miRNA processing. These projects will involve molecular and biochemical approaches, towards the goal of understanding mechanisms and discovering relevant substrates across the transcriptome.

Relevant candidates will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods.

Postdoctoral fellows or well-qualified MS level candidates seeking experience before graduate school will be considered. Please send letter of inquiry, CV and references to laie@nullmskcc.org. Position is available immediately.

Recent Selected References
Dai, Q., A. Ren, J. O. Westholm, A. Serganov, D. J. Patel and E. C. Lai (2013). The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes and Development 27: 602-14.

Miura, P., S. Shenker, J. O. Westholm, C. Andreu-Agullo and E. C. Lai (2013). Widespread and extensive lengthening of 3′ UTRs in the mammalian brain. Genome Research 23: 812-825.

Okamura K., E. Ladewig, L. Zhou and E. C. Lai (2013). Regulatory RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes and Development 27: 778-792.

Smibert, P., J.-S. Yang, G. Azzam, J.-L. Liu and E. C. Lai (2013). Homeostatic control of Argonaute stability by microRNAs. Nature Structural and Molecular Biology 20: 789-795.

Mohammed, J., D. Bortolamiol-Becet, A. S. Flynt, I. Gronau, A. Siepel and E. C. Lai (2014). Adaptive evolution of testis-specific, recently-evolved, clustered miRNAs in Drosophila. RNA 20: 1195-1209.

Garaulet, D. L., M. Castellanos, F. Bejarano, P. Sanfilippo, D. M. Tyler, D. Allan, E. Sanchez-Herrero and E. C. Lai (2014). Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system. Developmental Cell 29: 635-48.

Wen, J., J. Mohammed, D. Bortolamiol-Becet, H. Tsai, N. Robine, J. O. Westholm, E. Ladewig, Q. Dai, K. Okamura, A. S. Flynt, D. Zhang, J. Andrews, L. Cherbas, T. C. Kaufman, P. Cherbas, A. Siepel, and Eric C. Lai (2014). Diversity of miRNAs, siRNAs and piRNAs across 25 Drosophila cell lines. Genome Research 24: 1236-50.

Faculty Position in Cell, Molecular and Developmental Biology

The Department of Biology at the University of Rochester invites applications for a tenure-track faculty position in cell, molecular and developmental biology. We are seeking outstanding candidates whose research programs address fundamental biological problems and who have demonstrated excellence, originality, and productivity in research. Our multidisciplinary biology department affords opportunities for intellectual interactions across diverse research disciplines, with faculty working in the areas of chromatin, DNA repair, aging, intracellular transport, proteomics, transposable elements, ribosome biogenesis, developmental and evolutionary biology.

Our research and graduate programs are integrated into a world-class life sciences research campus that provides ample opportunities for interactions and collaborations with the adjacent University of Rochester Medical Center. Faculty research is supported by University initiatives including the Institute for Data Science, Rochester Aging Research Center, Stem Cell Institute, and Cancer Center. Research activities across the University are supported by core facilities featuring Imaging, Proteomics, Functional Genomics, Small Molecule Screening, and Flow Cytometry.

Application materials should be uploaded at www.rochester.edu/faculty-recruiting/apply/bio . Complete applications should include: a cover letter; curriculum vitae including publication list; statement of research accomplishments and future plans; statement of teaching experience and interests. Also provide copies of three papers. Instructions for supplying three letters of recommendation are on the application website. Applicant screening will start October 1 and continue until the position is filled.

The University of Rochester is an Equal Opportunity Employer, has a strong commitment to diversity and actively encourages applications of candidates from groups underrepresented in higher education.

Postdoc in Regulatory sRNAs

A postdoctoral position is available in the laboratory of Associate Professor Birgitte H. Kallipolitis at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. The position is for two years, starting 1 January 2015 or soon thereafter. Application deadline: 02/11/2014

The laboratory of Birgitte H. Kallipolitis investigates the biological function and mechanism of action of small, regulatory RNAs (sRNAs) in bacteria. The research project will focus on gene regulatory networks comprising multiple homologous sRNAs in the human pathogen Listeria monocytogenes (for more details, see Sievers et al., 2014, Nucleic Acids Res. 42(14):9383-98). A variety of experimental methods will be employed, including RNA-seq, molecular genetics and biochemical analyses.

We seek a highly motivated and enthusiastic candidate with a PhD degree obtained within the last three years in Molecular Biology, Biochemistry, Microbiology or a related discipline. Previous research experience in RNA biochemistry and molecular microbiology is desirable. The ideal candidate should have displayed an ability to produce high quality research in peer-reviewed journals.

For further details, please contact Associate Professor Birgitte H. Kallipolitis (bhk@nullbmb.sdu.dk).

Applications must be submitted electronically using the link provided on the SDU Webpage: http://www.sdu.dk/en/servicenavigation/right/ledige_stillinger.

Bioinformatics position available at Sloan-Kettering, New York City

We seek a motivated bioinformatician to be involved in our studies of gene regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines computational and experimental approaches to annotate and functionally elucidate small RNA pathways (e.g. miRNAs, siRNAs and piRNAs), mRNA processing pathways (e.g. alternative polyadenylation and circularization), and transcription factor networks (mostly regarding neural specification). Towards this end, we produce a great deal of small RNA, RNA-seq and ChIP-seq data, and analyze these with respect to the rich comparative genomic data available for Drosophila and mammals. There is a close exchange of ideas between dry and wet lab members to generate and test biologically-based hypotheses. Questions of ongoing interest include the mechanics of small RNA biogenesis, the evolution of small RNA genes and their function, the control of 3′UTR formation, how RNA circularization occurs and is regulated, and the mRNA/miRNA networks downstream of key neural transcription factors. We were also a core group of the NHGRI modENCODE consortium (http://www.modencode.org/) and continue with integrative analysis with other largescale datasets produced by consortium members.

Relevant candidates should have proficiency in a programming language (e.g. Java or C/C++) and a scripting language (e.g. Perl or Python), and experience with R and database systems. Strong experience with deep-sequencing data (e.g. Illumina, SOLiD, and/or third-generation methods) is essential. Postdoctoral fellows or BA/MS level candidates seeking experience before graduate school will be considered. Please send letter of inquiry, CV and references to laie@nullmskcc.org. Position is available immediately.

Recent Selected References

Dai, Q., A. Ren, J. O. Westholm, A. Serganov, D. J. Patel and E. C. Lai (2013). The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes and Development 27: 602-14.

Miura, P., S. Shenker, J. O. Westholm, C. Andreu-Agullo and E. C. Lai (2013). Widespread and extensive lengthening of 3′ UTRs in the mammalian brain. Genome Research 23: 812-825.

Okamura K., E. Ladewig, L. Zhou and E. C. Lai (2013). Regulatory RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes and Development 27: 778-792.

Smibert, P., J.-S. Yang, G. Azzam, J.-L. Liu and E. C. Lai (2013). Homeostatic control of Argonaute stability by microRNAs. Nature Structural and Molecular Biology 20: 789-795.

Mohammed, J., D. Bortolamiol-Becet, A. S. Flynt, I. Gronau, A. Siepel and E. C. Lai (2014). Adaptive evolution of testis-specific, recently-evolved, clustered miRNAs in Drosophila. RNA 20: 1195-1209.

Garaulet, D. L., M. Castellanos, F. Bejarano, P. Sanfilippo, D. M. Tyler, D. Allan, E. Sanchez-Herrero and E. C. Lai (2014). Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system. Developmental Cell 29: 635-48.

Wen, J., J. Mohammed, D. Bortolamiol-Becet, H. Tsai, N. Robine, J. O. Westholm, E. Ladewig, Q. Dai, K. Okamura, A. S. Flynt, D. Zhang, J. Andrews, L. Cherbas, T. C. Kaufman, P. Cherbas, A. Siepel, and Eric C. Lai (2014). Diversity of miRNAs, siRNAs and piRNAs across 25 Drosophila cell lines. Genome Research 24: 1236-50.

University Professor of BIOCHEMISTRY

The University of Innsbruck invites applications for the position of an University Professor of BIOCHEMISTRY at the Institute of Biochemistry of the Faculty of Chemistry and Pharmacy. The position will be based on a permanent civil-law employment contract with the University.

Responsibilities include
• Representing the subject of “Biochemistry” both in experimental research and teaching with a main research focus on “Cellular Regulation”, for instance in the area of regulatory RNA.
• Offering a broad spectrum of courses in Biochemistry.
• Participating in the University’s research programme entitled “Molecular Biosciences”.

Eligibility requirements include a pertinent degree in higher education, a pertinent habilitation or equivalent qualification, publications in leading international peer-reviewed journals, involvement in international research.

The University of Innsbruck is committed to increase the percentage of female employees, especially in leading positions and therefore explicitly invites women to apply. In the case of equivalent qualifications, women will be given preference.

Applications must reach us at the latest by October 30th, 2014 and should include the usual documentation (esp. curriculum vitae, publication list, and description of current and intended research, samples of the five most important works). All documents have to be submitted in digital form (CD-ROM, e-mail, etc.). Hardcopy (paper) is optional. Please send the documents to: Leopold-Franzens-Universität Innsbruck, Fakultäten Servicestelle, Standort Innrain 52f, A-6020 Innsbruck (fss-innrain52f@nulluibk.ac.at)

The basic salary is set down in the collective bargaining agreement for university employees. Profes-sors are in the remuneration group A 1. For the position the monthly salary is 4.697,80 Euro/month (14 x). Depending on qualification and experience a higher salary can be a topic in the negotiations with the rector. Beyond that the university offers attractive additional benefits (http://www.uibk.ac.at/universitaet/zusatzleistungen/).

The full, authoritative text in German (published in the official bulletin of the University of Innsbruck of August 6th, 2014) as well as additional information on the current status of the application process may be found at: http://www.uibk.ac.at/fakultaeten-servicestelle/standorte/innrain52f/berufungen_habilitationen/berufungen_index_2010.html

Postdoctoral Fellow in Computational Biology at Boston University Medical Center

We are looking for a post-doctoral fellow in Computational Biology and Transcriptome Analysis to lead a joint project between laboratories of Dr. Ruslan Afasizhev at the Department of Molecular and Cell Biology and Dr. Stefano Monti in the Section of Computational Biomedicine at the BU School of Medicine. The candidate will have the opportunity to work in a unique computationally-oriented environment backed by an advanced molecular biology laboratory and substantial resources within the Boston University Medical Campus and collaborators at Harvard Medical School and the Broad Institute. The NIH-funded project involves de novo sequencing, assembly and functional studies of mitochondrial genomes from trypanosomatids, which are unicellular parasites causing a wide spectrum of human diseases. In this context, the candidate’s role will be to develop and apply methods to analyze High-Throughput Sequencing (Pac Bio and Illumina platforms, DNA and primarily coding and non-coding RNA-sequencing) data for the identification and characterization of the molecular pathways contributing to mitochondrial gene expression, and their perturbation in various loss-of-function genetic backgrounds. The ideal candidate will have: an interdisciplinary background in bioinformatics & computational biology; advanced expertise in the analysis and interpretation of sequencing data and its integration with other “omics” data sources; good programming skills; and advanced knowledge of statistical and machine learning methods. The position would be for a minimum of two years.

Requirements: Qualified candidates should have:
• A Ph.D. in computational biology, bioinformatics, computer science, engineering, mathematics, physics, or related field.
• Ability to program in Python and R, with knowledge of MATLAB and/or Java a plus.
• Familiarity with Unix systems.
• Demonstrated applied bioinformatics/computational proficiency as evidenced by relevant publications in peer-reviewed journals.

Cotnact: ruslana@nullbu.edu

Post-doctoral position in the Lambowitz lab at the University of Texas at Austin

A post-doctoral position is available in the Lambowitz lab at the University of Texas at Austin to carry out biochemical and structural analysis of thermostable group II intron reverse transcriptases. Thermostable group II intron reverse transcriptases are novel enzymes with beneficial properties and novel activities that open new methods for next-generation RNA sequencing, RNA structure analysis, and analysis of non-coding RNAs. The focus will be on analyzing structure-function relationships in these enzymes by combining in vitro mutagenesis and directed evolution with biochemical analysis and X-ray crystallography. Experience in protein purification and X-ray crystallography is desirable. Applications now until position filled.

Mohr, S., Ghanem, E., Smith, W., Sheeter, D., Qin, Y., King, O., Polioudakis, D., Iyer, V.R., Hunicke-Smith, S. Swamy, S., Kuersten, S., and Lambowitz, A.M. Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing. RNA, 19, 958-970, 2013.

Collins, K. and Nilsen, T. Enzyme engineering through evolution: thermostable recombinant group II intron reverse transcriptases provide new tools for RNA research and biotechnology. RNA 19, 1017-1018, 2013.

Enyeart, P.J., Mohr, G., Ellington, A.D., and Lambowitz A.M. Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis. Mobile DNA 5:2, 2014.

Katibah, G.E., Qin, Y., Sidote, D.J., Yao, J., Lambowitz, A.M. and Collins, K. Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5. Proc. Natl. Acad. Sci., USA, doi/10.1073.1412842111, 2014.

Eamil: lambowitz@nullaustin.utexas.edu

Seeking a highly motivated and independent individual interested in working in one of two areas

We are seeking a highly motivated and independent individual interested in working in one of two areas: 1) advanced single-molecule techniques to study RNA structure, or 2) programmable biosensors for RNA detection and purification. Successful candidate is to start this Fall and no later than December 2014 The single-molecule projects are more engineering based, and involve further development and testing of the recently invented Centrifuge Force Microscope (CFM) to probe the structure of individual RNA molecules with the application of force. The biosensor project is more biochemistry based, and involves adapting a recently developed DNA nanoswitch platform to RNA applications including detection and purification.

Minimum Qualifications: Ph.D. in Biomedical Engineering, Biophysics, Biochemistry or related field from a college or university accredited by USDOE or an internationally recognized accrediting organization

Preferred Qualifications (depending on area of interest): Experience in single-molecule biophysics (optical tweezers, AFM, etc.); Hands-on engineering and prototyping experience; Experience with optics, image analysis, or programming; Experience in DNA nanotechnology.

The RNA institute is a vibrant new establishment focused on the RNA sciences and interdisciplinary approaches. We have an extremely collaborative and friendly culture, facilitating scientific and social interactions. To apply, please send a cover letter, a CV, and contact info for 3 references to: khalvorsen@nullalbany.edu.

Postdoctoral position in systems biology

Principal Investigator / Institute:
Christine Vogel, Center for Genomics and Systems Biology, NYU Department of Biology

We are looking for a postdoctoral researcher to join our lab at the earliest convenience. Our lab uses system-wide approaches to investigate protein expression regulation in response to environmental stress. Our primary model organisms are yeast and mammalian cell lines. We emphasize interdisciplinary work, combining wet- and dry-lab approaches, as well as large-scale and targeted small-scale experiments.

The position is tied to a specific project, but work on own ideas and new directions are always welcome and part of our every day research life. The proposed project involves work with mammalian cell lines, several large-scale techniques (e.g. mass spectrometry based proteomics, next-generation sequencing), computational data analysis, and close interaction with our statistics collaborators. Expertise in one or more of the above areas is desirable.

Our lab is positioned at the Center for Genomics and Systems Biology. We are the primary users of an LTQ Orbitrap Velos mass spectrometer and have access to state-of-the-art sequencing, robotics, and microscopy facilities. The Center for Genomics and Systems Biology is part of the NYU Department of Biology with close links to the NYU Medical School, the Courant Institute, and other well-known universities in the city – offering a rich and active scientific environment. The Center is located in the heart of Manhattan near Washington Square Park – one of the most historical, cultural and liveliest areas in the big city.

Benefits such as medical/dental/retirement/tuition remission are available to qualified applicants, see http://www.nyu.edu/employees/benefit/ (code 103). Funding is available for at least two years. NYU provides visa support and (limited) post-doctoral housing.

To apply for this position, please send your CV and contact details of your references via email. Please also include a letter of interest describing your background, your career, and research interests. We are looking for someone to enrich our lab with scientific creativity and new skills.

Requirements: PhD in a biological discipline, preferably experience with tissue culture and large-scale data analysis
Job location: New York, NY
Info: https://sites.google.com/a/nyu.edu/vogel-lab/home
Contact: cvogel@nullnyu.edu
Application: Now until position is filled