We seek a motivated scientist with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to annotate and functionally elucidate small RNA pathways, mRNA processing pathways, and neural transcription factor networks.
The candidate will work on two projects. First is to elucidate mechanisms that regulate alternative polyadenylation in the nervous system. Second is to study the post-transcriptional regulation of miRNA processing. These projects will involve molecular and biochemical approaches, towards the goal of understanding mechanisms and discovering relevant substrates across the transcriptome.
Relevant candidates will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods.
Postdoctoral fellows or well-qualified MS level candidates seeking experience before graduate school will be considered. Please send letter of inquiry, CV and references to [email protected]. Position is available immediately.
Recent Selected References
Dai, Q., A. Ren, J. O. Westholm, A. Serganov, D. J. Patel and E. C. Lai (2013). The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes and Development 27: 602-14.
Miura, P., S. Shenker, J. O. Westholm, C. Andreu-Agullo and E. C. Lai (2013). Widespread and extensive lengthening of 3′ UTRs in the mammalian brain. Genome Research 23: 812-825.
Okamura K., E. Ladewig, L. Zhou and E. C. Lai (2013). Regulatory RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes and Development 27: 778-792.
Smibert, P., J.-S. Yang, G. Azzam, J.-L. Liu and E. C. Lai (2013). Homeostatic control of Argonaute stability by microRNAs. Nature Structural and Molecular Biology 20: 789-795.
Mohammed, J., D. Bortolamiol-Becet, A. S. Flynt, I. Gronau, A. Siepel and E. C. Lai (2014). Adaptive evolution of testis-specific, recently-evolved, clustered miRNAs in Drosophila. RNA 20: 1195-1209.
Garaulet, D. L., M. Castellanos, F. Bejarano, P. Sanfilippo, D. M. Tyler, D. Allan, E. Sanchez-Herrero and E. C. Lai (2014). Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system. Developmental Cell 29: 635-48.
Wen, J., J. Mohammed, D. Bortolamiol-Becet, H. Tsai, N. Robine, J. O. Westholm, E. Ladewig, Q. Dai, K. Okamura, A. S. Flynt, D. Zhang, J. Andrews, L. Cherbas, T. C. Kaufman, P. Cherbas, A. Siepel, and Eric C. Lai (2014). Diversity of miRNAs, siRNAs and piRNAs across 25 Drosophila cell lines. Genome Research 24: 1236-50.