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Faculty Position at Department of Cell and Molecular Physiology at Loyola University Chicago

The Department of Cell and Molecular Physiology at Loyola University Chicago, Health Sciences Division seeks applicants for tenure-track positions at the ASSISTANT PROFESSOR, ASSOCIATE PROFESSOR and PROFESSOR level. We seek colleagues that will contribute to existing strengths in molecular neuroscience, cardiac physiology and biophysics. Our faculty are actively engaged in research in diverse areas including membrane transport mechanisms, molecular neuroendocrinology, neuronal excitability, neurobiological effects of alcohol abuse, and RNA/epigenetic regulation in health and disease. Applicants using proteomic and genomic tools to address fundamental questions in molecular neuroscience are strongly encouraged to apply. Departmental infrastructure includes resources in mass spectrometry, fluorescence microscopy, electrophysiology, animal facilities – including a small animal VIVO 2100 ultrasound, echocardiography instruments and surgical suites, viral vector core, molecular dynamics simulation, single molecule biophysics and biophysical spectroscopy. Other instrumentation and University core facilities are described here: (http://www.stritch.luc.edu/depts/physio). Laboratory space will be located in the new Center for Translational Research and Education. The faculty applicant will be expected to sustain an independent, externally funded research program. In addition, the applicant must have evidence of teaching experience and will be expected to contribute to graduate and medical education. Candidates must have a doctoral degree and postdoctoral experience; senior applicants should have a strong record of research productivity and extramural support. Review of applications will commence immediately and applications will be accepted until the position is filled. Apply directly at http://www.careers.luc.edu/applicants/Central?quickFind=57760
Equal Opportunity Employer: Minorities/Women/Veterans/Disabled

NIH-funded Postdoctoral Fellowship Position

NIH-funded Postdoctoral Fellowship Position, to begin Oct 1, 2015 or later (duration: 2-5 yrs).
NIH-funded Postdoctoral Fellowship Position in Eukaryotic RNA Metabolism
National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to eukaryotic gene expression. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation. The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Richard J. Maraia, M.D.
Email: [email protected]

Maraia lab current interests
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation and disease.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.

Postdoctoral Research Fellow Position at the University of California, San Francisco

A postdoctoral research fellow position is available at the University of California, San Francisco at the new Helen Diller Comprehensive Cancer Center (Mission Bay Campus) (http://pub.ucsf.edu/missionbay/tour/; http://cancer.ucsf.edu/news/20031028b.php), to study the molecular mechanisms by which impairments in accurate control of mRNA translation, cell growth, and overall cellular protein synthesis rates lead to cancer. The potential candidate will utilize the first mouse models for components of the translation machinery in combination with novel proteomics and pharmacological strategies to study the dynamics of translation control in gene expression, cancer, and disease. Highly motivated individuals with a recent Ph.D., M.D. or M.D./Ph.D. and a background in mouse genetics, biochemistry, or cellular and molecular biology are encouraged to apply. Evidence of scientific accomplishment is required and bioinformatics skills are desirable. Requests should be addressed to: [email protected] and [email protected].

Please visit our webpage at ruggerolab.ucsf.edu.

Explore the Role of mRNA Expression and Distribution in Cancers Caused by Genetic Re-arrangements

One position is available immediately to explore the role of mRNA expression and distribution in cancers caused by genetic re-arrangements. This is accomplished using single molecule florescent in situ hybridization, commercially called “Stellaris probes”. Studies involve working with cancer cell lines and patient samples, in situ hybridization, fluorescence microscopy and image analysis and interpretation using MATLAB software. The project is supported by an early independence award from NIH (2012-2017)

Job requirements: Recent Ph.D. in Life science or basic science. The candidate should be self-motivated and hard working with a strong background in molecular biology. Hands on working experience in basic molecular biology techniques like cloning, culture of immortalized and primary cells, microscopy and image analysis is desired. Candidate will be responsible for designing, performing experiments, compiling and analyzing data and providing necessary help in preparation of materials for publications and grant proposals. Ability to write and submit proposals for fellowships will be a plus.
Interested candidates who are willing to join immediately, should email their CVs and contact information of three references to Mona Batish, Ph.D. Assistant Professor, Email: [email protected]

2 Postdoctoral positions available in RNA NMR at Karolinska Institute (Stockholm)

Background:
More than 50% of the human genome codes for non-coding RNA. These RNAs are ubiquitous among all life forms and the mechanisms how non-coding RNAs regulate these cellular functions are largely unknown.
Our research group is interested in understanding how RNAs change their structures in order to perform function. We employ liquid-state Nuclear Magnetic Resonance (NMR) and other biophysical and biochemical techniques, to investigate the molecular mechanism of RNA function ( Nature 2012 & 2015). When function of these molecular machines becomes apparent, it also provides a variety of unique new drug targets. The lab also develops methods in NMR and RNA biochemistry to address these questions.

Projects (each one year with possibility to extend another year):
One Postdoc will work on development of NMR experiments and/or simulations for RNA dynamics parameters. The second Postdoc will develop biochemical methods to produce larger RNAs or RNAs in environment of larger proteins (e.g. partial labeling, specific modifications). Both postdocs will work on RNAs addressing biological questions studied in the lab (microRNAs and ribosomal RNAs). You will work in a team together with other lab members and regularly present the research work in lab-meetings, seminars and at international conferences.

The projects will be supervised by Dr. Katja Petzold, deadline 31st of January 2015. Please apply directly via the netrecruiter system:
https://ki.mynetworkglobal.com/en/what:job/jobID:48803/where:/
Fore more information please visit the website:
http://www.nature.com/naturejobs/science/jobs/480937-two-highly-motivated-postdocs-for-research-projects-in-rna-structural-biology-using-nmr

Investigate the Mechanisms and Regulation of Pre-mRNA Processing by the U12-dependent Spliceosome

The RNA splicing group at the Institute of Biotechnology, University of Helsinki, Finland is looking for a post-doctoral researcher in a project that investigates the mechanisms and regulation of pre-mRNA processing by the U12-dependent spliceosome.
A successful candidate has a PhD and strong background in molecular biology, cell biology or in a related field as shown by solid publication record in international peer-reviewed journals. Good communication skills and fluency in spoken and written English are required. An experience in RNA biology/biochemistry, bioinformatics/high throughput sequencing, and/or genome editing is an asset.
The specific projects will depend on the previous experience and the qualifications of the successful applicant but is likely include mammalian genome editing with CRISPR/CAS system combined with high-throughput sequencing to investigate the regulatory aspects of the U12-type intron splicing.
Application:
Further information of the research group and the research topic and the application form can be found from the group web site http://www.biocenter.helsinki.fi/bi/SPLICING/index.html.
In addition to the application form, the application should include a motivation letter, a CV and a list of publications (max. 1 page), all combined to a single pdf that should be attached to the application form. The deadline for applications is January 15th, 2015. The position is available immediately.
The funded position is initially for 2 to 3 years, depending on the start date.
For further information please contact Mikko.Frilander(at)Helsinki.Fi

Recent publications:
Niemelä, E.H., Oghabian, A., Staals, R.H.J., Pruijn, G.J.M., and Frilander, M.J. (2014). Global analysis of the nuclear processing of unspliced U12-type introns by the exosome. Nucleic Acids Res 42, 7358-7369.
Argente, J., Flores, R., Gutiérrez-Arumí, A., Verma, B., Martos-Moreno, G.A., Cuscó, I., Oghabian, A., Chowen, J.A., Frilander, M.J., and Pérez-Jurado, L.A. (2014). Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency. EMBO Mol Med 6, 299–306.
Turunen, J.J., Niemelä, E.H., Verma, B., and Frilander, M.J. (2013). The significant other: splicing by the minor spliceosome. Wiley Interdiscip Rev RNA 4, 61–76.
Turunen, J.J., Verma, B., Nyman, T.A., and Frilander, M.J. (2013). HnRNPH1/H2, U1 snRNP and U11 snRNP co-operate to regulate the stability of the U11-48K pre-mRNA. RNA 19, 380-389.
Pessa, H.K.J., and Frilander, M.J. (2011). Minor splicing, disrupted. Science 332, 184-185.
Verbeeren, J., Niemelä, E.H., Turunen, J.J., Will, C.L., Ravantti, J.J., Lührmann, R., and Frilander, M.J. (2010). An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing. Mol Cell 37, 821-833

Postdoctoral Position Available from Spring 2015 in the Yap Lab

A postdoctoral position is available from Spring 2015 in the Yap Lab (biochem.slu.edu/faculty/yap) at the Edward A. Doisy Department of Biochemistry and Molecular Biology at Saint Louis University School of Medicine. The research project will focus on the mechanism by which ribosome undergoes translational stalling in response to ribosomal antibiotics and arrest peptides. A variety of experimental methods will be employed, including genome-wide sequencing, molecular genetics and fluorescence-based biophysical and biochemical analyses.

The candidate must have a Ph.D. in Microbiology, Biochemistry, Bioinformatics, or related field from an accredited college or university. The ideal candidate also must have a deep interest and demonstrated capability in microbial genetics and biochemistry.

Please apply online at https://jobs.slu.edu(Requisition number 20140877) or send your CV and the names and contact of three referees to Frances at [email protected].

PhD Students in Molecular Biology or Bioinformatics

The Faculty of Biology of Adam Mickiewicz University in Poznań, Poland, is looking for 6 PhD students to participate in research projects of the international PhD program of the KNOW RNA Research Centre in Poznań. The research topics are focused on the molecular biology and bioinformatics of ribonucleic acids. The detailed descriptions of the individual projects and information about how to apply are available at the webpage http://know-rna.amu.edu.pl/konkursy/. The applications should be send to [email protected] by January 15th 2015.

Group Leader for Young Investigator Program

The Research Center for Infectious Diseases (ZINF) at the University of Würzburg seeks a new group leader for its young investigator program. We are looking to recruit a researcher with outstanding postdoctoral experience and international recognition in the general fields of microbiology, cell biology, mycology, parasitology, immunology, RNA biology, single cell analysis, or host-pathogen interactions. Candidates using emerging technologies to study new aspects of pathogenesis are preferred, but all outstanding scientists are encouraged to apply.

The appointment will be for a period of 5+2 years. Salary (E14/15) will be commensurate with training and experience. The position includes laboratory operating expenses and salaries for additional personnel (postdoc, graduate student, and technician), and laboratory space in a new 9,000 m2 state-of-the-art research building with bio-containment, molecular imaging, high-throughput genomics, and animal facilities. The building is specifically designed to foster collaborative research, and is home to nine additional young investigator groups as well as laboratories run by faculty members. See www.imib-wuerzburg.de for more information. Informal inquiries can be made to Prof. Jörg Vogel ([email protected]).

Interested individuals should send a one-page description of their research interests and future directions, CV and publication list, and the names of three academic references by January 31st, 2015. We may request that short-listed candidates provide a more detailed research proposal at a later date. Preference will be given to people with disabilities in the case of otherwise equal aptitude. The University aims to increase the proportion of female employees, therefore applications from qualified women are particularly welcome. Applications should be sent as a single pdf.file via email to Dr. Stan Gorski ([email protected]), and addressed to the Spokesperson of ZINF, Prof. Jörg Vogel.

The University of Texas at Houston Medical School – Assistant Professor in the field of Bioinformatics/Genomics

The University of Texas at Houston Medical School invites applications for a full-time, tenure-track faculty position at the Assistant Professor level at the Department of Biochemistry & Molecular Biology. The Department seeks candidates who use genomic, bioinformatic and systems biology approaches to understand gene regulation and other contemporary problems in biomedical sciences. Of particular interest are those with expertise in analyzing next-generation sequencing data to make novel biological discoveries.

Candidates must hold a Ph.D. and/or M.D. and have extensive experience in Bioinformatics, Genomics, or Computational Biology and a track record of scientific excellence. The successful candidate will collaborate with experimental biologists in the Department who generate large-scale genomic datasets. An experimental component to the candidate’s research program would be viewed as a positive but is not necessary.

The Department offers a highly collegial and interactive research environment and robust graduate programs for training Ph.D. and M.D./Ph.D. students. Researchers have the opportunity to interact with biomedical, clinical, and computational researchers across the UT Health Science Center as well as the Texas Medical Center at Houston, the largest biomedical and health research center in the U.S. An adjunct appointment in the School of Biomedical Informatics at the UT Health Science Center at Houston can be arranged for the successful candidate. Please visit our website (https://med.uth.edu/bmb) for additional information about the Department.

Applicants should prepare a single PDF file that includes a cover letter, CV, two-page summary of research accomplishments and plans and names/contact information of at least three individuals who agree to write a supporting letter. Please email the PDF file directly to Dr. Ann-Bin Shyu, Chair of the Search Committee, at [email protected] Review of complete applications will begin in January, 2015 and will continue until the position is filled.

Salary is commensurate with experience.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, genetics, disability, age, or any other basis prohibited by law. EOE/M/F/Disabled/Vet.