Employment Opportunities

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Postdoctoral Scholar Positions

Postdoctoral scholar positions are available at the Nanobiotechnology Center of the University of Kentucky and the NCI Cancer Nanotechnology Platform Partnerships (CNPP) program directed by Dr. Peixuan Guo (http://nanobio.uky.edu/Guo/peixuanguo.html). Strong background in RNA chemistry, RNA conjugation, Genetics, or Cell Biology is preferred.

To apply, please contact Dr. Hui Zhang at email: [email protected]. The University of Kentucky is an Equal Opportunity and Affirmative Action Employer.

H3 Biomedicine Postdoctoral Program

The H3 Biomedicine Postdoctoral Program provides an environment for scientists to undertake innovative academic-focused research projects in a biotech industry setting. H3 Biomedicine offers a framework for scientists to design and execute their research plans and provide appropriate training with a goal to present research at major scientific conferences and publication of results in leading peer-reviewed journals.

We seek highly motivated and enthusiastic individuals to join the H3 Biomedicine Postdoctoral Program based at our facility in Cambridge, Massachusetts. Individuals will interact with a team of scientists working towards understanding the role of RNA splicing in cancer and identifying novel therapeutic approaches for the treatment of targeted patient populations. H3 Biomedicine provides a state-of-the-art research facility and interactions with scientists from multiple disciplines including bioinformatics and genomics, target discovery, structural biology, enzymology, drug discovery and chemistry.

Research Areas

H3 Biomedicine has built a world-class research effort that applies cancer genomics and next generation chemistry geared towards the identification of novel cancer medicines. A major area of research at H3 Biomedicine is in RNA biology and RNA splicing in cancer. We have pioneered methods to drug the spliceosome and apply this knowledge to modulating deregulated cancer-specific splice events. Our ultimate goal is the discovery and development of novel therapies for the treatment of genomically-defined cancer patients.

We seek to attract postdoctoral candidates interested in pursuing research in the following three areas:

•        Exploring the disease mechanisms of spliceosome mutations in cancer (e.g. SF3B1, U2AF1, SRSF2) and nodes for therapeutic intervention with small molecule splicing modulators
•        The structural basis for splicing modulation approaches and aberrant splicing in SF3B1 mutant cancers.
•        Discovery and validation of driver RNA splicing alterations in cancer and identification of target modulation strategies to enable precision medicine.

Program Highlights

•        Regular interactions with mentor, and academic external advisor as appropriate, to formulate and execute research plans
•        Regular presentations at Scientific Founders Meeting to the H3 Biomedicine senior scientists and our academic founders Stuart Schreiber, PhD and Todd Golub, MD.
•        Presentation/publication of research at major scientific conferences/journals
•        Potential for transition into full-time employment should appropriate positions be available at the end of the postdoctoral position

Qualifications

The applicant must have completed, or is anticipated to complete within the next 3 months, a Ph.D. in Biology, Cancer Biology, Molecular Biology, Structural Biology, Biochemistry or a related field. Previous research experience in the area of RNA biology/splicing, cancer biology or structural biology/crystallography is desirable. Candidates should have displayed an ability to produce high quality research in peer-reviewed journals

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs

Interested candidates may forward a CV to [email protected]

www.h3biomedicine.com

Postdoctoral Position Studying the Molecular Mechanisms of RNA Quality Control

A postdoctoral position studying the molecular mechanisms of RNA quality control is immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. The laboratory is an RNA biochemistry and molecular biology research group established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The research of the group and its members is supported by the collaborative and interdisciplinary NIH intramural program and state-of-the-art proteomics, high-throughput sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse transgenic, and other core facilities.

The laboratory is focused on using biochemical methods to study the assembly and functions of viral and cellular messenger ribonucleoprotein complexes. A major tool in these efforts is a novel system for RNA hairpin tag-based affinity purification of messenger ribonucleoproteins from human cells followed by mass spectrometry. This approach led to the identification of a mechanism by which the key NMD factor Upf1 is able to directly sense 3′UTR length in the process of decay target discrimination (see Hogg and Goff, Cell, 143, 379-89 for more details). The lab is now pursuing several projects designed to understand the molecular mechanisms underlying 3’UTR length sensing by Upf1 and subversion of this process by retroviral RNA elements. These efforts require a combination of molecular, cell biological, biochemical, and proteomic techniques in mammalian cell culture and in vitro systems. More information is available at http://www.nhlbi.nih.gov/research/intramural/researchers/pi/hogg-robert/.

Requirements:

Interested candidates must have received a Ph.D. or M.D. within the past five years in molecular biology, cell biology, biochemistry, genetics or a related discipline and be highly motivated to participate in and design innovative research programs.  The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.

To apply:

Please email a cover letter indicating preferred start date and research area, CV, summary of research accomplishments, and names and contact information for at least three references to:

Dr. J. Robert Hogg
Email: [email protected]

The NIH is dedicated to building a diverse community in its training and employment programs.

DHHS/NIH is an Equal Opportunity Employer

Postdoctoral Fellow in Computational RNA Genomics

A Postdoctoral Fellow position in Computational RNA Genomics is available at the Genome Center and the Biomedical Engineering Department of the University of California, Davis. The postdoc will be working as part of a newly forming team in the Aviran lab (www.bme.ucdavis.edu/aviranlab) and will be developing probabilistic models and statistical inference algorithms for genomic big data analysis. Of particular interest is research relevant to our NIH-funded projects in RNA genomics and in structural RNA biology. The developed methods will be applied to problems in RNA systems and synthetic biology.

Required Qualifications

We are looking for a highly motivated, creative, and enthusiastic individual, with interest in RNA genomics, folding dynamics, or rational design. Candidates should have a PhD in bioinformatics, statistics, applied math, electrical engineering, computer science, biophysics, or a related field. Preference will be given to candidates with experience in probabilistic modeling and computational statistics or machine learning. Specific skills that are strongly preferred include proficiency in programming and scripting (using, e.g., Python, R, Matlab, or C/C++) and in hands-on genomic data analysis. Excellent writing and communication skills in English are required.

Interested candidates should submit a cover letter stating their interest in our research directions and why they are interested in joining, a CV with list of publications, and contact information for three references. Please combine all information into a single PDF and send to Dr. Aviran (saviran at ucdavis dot edu). Applications will be accepted immediately, with a proposed start date of Summer 2014. Duration: 3 years, depending on performance. NIH funding for this project has been recently granted through a K99-R00 award.

Review of applications will continue until an outstanding candidate has filled the position. The successful candidate will join a young, vibrant, and rapidly growing Biomedical Engineering department, a large and active Genome Center, and collaborative genomics and computational biology communities at UC Davis. For more information, please visit www.bme.ucdavis.edu/aviranlab/positions/.

Regulation of Cancer Genes by RNA Binding Proteins and Non-Coding RNAs

A post-doctoral research position is available in the laboratory of Dr. Aaron Goldstrohm in the Department of Biological Chemistry at the University of Michigan Medical School. The research project focuses on regulation of cancer genes by RNA binding proteins and non-coding RNAs. Candidates should hold a Ph.D. in biochemistry, genetics, cellular or molecular biology or related field. They should have strong interests in gene regulation and RNA biology and be skilled in molecular and cellular biology techniques.

The University of Michigan and the Goldstrohm Lab provide an outstanding training environment. In addition to abundant scientific and intellectual resources, the post-doctoral fellow well benefit from career and professional development opportunites.

To apply, candidates should submit curriculum vitae with publication record and contact information for three references. Please include a cover letter describing career goals, research experience and interests.

To learn more about our lab and research, please visit: http://www.biochem.med.umich.edu/?q=agoldstrohm

Study Protein-RNA Complexes Involved in HIV Alternative Splicing

A postdoctoral position is available to study protein-RNA complexes involved in HIV alternative splicing in the Department of Chemistry at Case Western Reserve University. The goal of this NIH funded project is to understand the structural and biophysical basis of how host proteins recognize HIV RNA elements to control the balance of viral splicing events. The position will require the elucidation of several high-resolution structures of isolated RNA elements and protein-RNA complexes as well as determining physicochemical parameters associated with these molecules.

The environment for RNA and protein structural biophysics at Case Western Reserve University is outstanding, with state-of-the art NMR spectrometers equipped with cryogenic probes (every field strength 500-900 MHz), instruments for X-ray crystallography, cryo-electron microscopy and other biophysical instrumentation. Major biophysical and biochemical instrumentation available in the PI’s personal lab include titration and scanning calorimeters (Microcal), two AKTA FPLC instruments, two Innova tissue culture incubators and several computer workstations for data analysis and structure calculations.

In addition to the strong instrumentation, the intellectual environment at CWRU is exceptional where barriers to collaborations are low. The PI maintains active collaborations with members of the Center for AIDS Research and interacts routinely with members of the Center for RNA Molecular Biology, Departments of Biochemistry, Pharmacology and Microbiology. Moreover, Cleveland offers a pleasant cultural setting for work and home life.

The ideal candidate will have a recent PhD in Biochemistry or Biophysics, a strong academic record, proven experience in biomolecular NMR spectroscopy or X-ray crystallography and fluent English language skills. Previous experience with RNA biochemistry is preferred.

To apply, please email a statement of research interests, CV and the names and contact information for three references to Dr. Blanton S. Tolbert ([email protected]). Informal inquiries are also welcome.

Diversity Statement:

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Reasonable Accommodations:

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Postdoctoral Position to Investigate RNA-mediated Meiotic Regulation in Fission Yeast

Available immediately, term of appointment up to 3 years

The Wise lab in the Center for RNA Molecular Biology at Case Western Reserve University is inviting applications for a postdoctoral scientist to spearhead our efforts to understand the molecular basis of changes in RNA metabolism during the transition from proliferative growth and at successive stages of meiotic differentiation in fission yeast.  Previous work has elucidated two unusual regulatory strategies that come into play as this simple developmental pathway unfolds:

  • Increased accumulation of early meiotic mRNAs, driven by enhanced stability due to modulation of RNA binding by a protein that senses methylation of adenosine residues
  • Increased accumulation of middle meiotic mRNAs, driven by enhanced co-transcriptional RNA processing mediated by a meiosis-specific transcription factor

The project will utilize a combination of genome-wide and traditional molecular genetic approaches to dissect the cascade of events through which these sequential but interconnected regulatory mechanisms ensure proper temporal control of gene expression.  As counterparts of factors implicated in fission yeast meiotic regulation have recently been uncovered in budding yeast, flies and mammals, it may be illuminating to extend our studies through collaborations with RNA Center colleagues.  The Center for RNA Molecular Biology provides a stimulating and highly interactive research environment in which trainees benefit from the high concentration of faculty, students and postdocs with relevant expertise.

The ideal candidate will hold a recently (or soon to be) awarded Ph.D. in Molecular Biology, Biochemistry or a related discipline and have laboratory experience working with RNA.  A strong track record of self-directed research and excellent technical and communication skills are also essential.  Expertise in bioinformatics and/or genetic manipulation is highly desirable.  Salary support (NSF-funded) will be provided at a level commensurate with experience.

Interested individuals should send a cover letter including a description of research interests and career goals, as well as a detailed CV and the names of three references (with e-mail addresses and phone numbers) to Jo Ann Wise, preferably via e-mail ([email protected]).

Postdoctoral Position in the Laboratory of Dr. Pedro Miura

A postdoctoral position is available starting September 1st, 2014 in the laboratory of Dr. Pedro Miura, Assistant Professor in functional genomics at the University of Nevada, Reno, Department of Biology. Projects will focus on the regulatory mechanisms governing extended 3’UTR and circular RNA formation, and their functional impact in the nervous system. Drosophila, mice and mammalian tissue culture will used as model systems. High-throughput sequencing and CRISPR/Cas mediated genome engineering approaches will be employed.

Qualifications include a PhD in the biological sciences and a strong publication record. Previous experience in bioinformatics, molecular biology, mouse genetics and/or fly genetics is preferred, but not required.

Candidates should send their CV, letter of introduction, statement of career plan/goals, and contact information for 3 references to:

Dr. Pedro Miura ([email protected])

Lab website: http://www.post-transcriptional.com