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Area of research: ribosome biophysics
skill required: nucleic acid research experienence and basic molecular biology skills are desired but not required
starting date: immediately
duration: 4 years from NIH funding
The person will master a novel magnetic sensing-based force spectroscopy to study the chemical to mechanical energy transfer in the ribosome translation, and the mechanism/drug effects that control the viral frameshifting processes.
The projects are unique, cutting-edge, and challenging. The research environment is supportive, communicative, and open to individual innovation.
Candidates should have a Ph.D. in biophysics/biochemistry, physical chemistry, bioengineering, or a closely related field.
The University of Houston is an affirmative Action/Equal Opportunity employer. Minorities, women, veterans, and persons with disabilities are encouraged to apply. The compensation will be generous and competitive, including whole-family health insurance and appropriate retirement benefits. Personal/family needs will be considered
Postdoctoral position in Systems Biology of Bacterial ncRNA Regulation: Boston College, Chestnut Hill, MA
A postdoctoral position utilizing systems biology approaches to study the impacts of RNA regulators on bacterial fitness is available for a collaborative project between the Meyer and van Opijnen labs at the Biology Department at Boston College. The position will start between Jan. 1 and June 1, 2016 and is fully NIH funded for 3 years; yearly contracts will be issued.
The Meyer lab focuses on computational identification and experimental validation of novel ncRNA regulators, as well as understanding the evolutionary forces on ncRNA evolution in bacterial systems. The van Opijnen lab focuses on the application of genome-wide strategies to determine how microbial pathogens deal with and overcome stressors in their environment, and on the development of novel strategies to study bacterial pathogens. The labs are equipped with state-of-the-art technology including a robotics system, two massively parallel sequencers and a single cell analysis system, which are used in experiments that include high-throughput screens, full genome sequencing, RNA-seq, ChIP-seq and Tn-seq. For more information on each lab visit: bioinformatics.bc.edu/meyerlab/ and www.vanopijnenlab.com.
The candidate will preferentially perform both computational and experimental work (including mouse experiments) that focus on the systems biology of ncRNA regulation.
• Ability to conduct collaborative research.
• Excellent English communication skills both in written and oral form.
• A PhD in molecular or micro- biology, computer science, bioinformatics, biochemistry, biophysics or related discipline. NB. A strong willingness and ability to learn is considered more important than experience in the topics studied by the labs.
• A track record of publications in peer-reviewed journals.
• Experience with mouse experiments, NGS-techniques, and or in statistical methods, programming languages (e.g. Python, Perl), mathematical modeling, and/or analysis of large-scale sequencing data, RNA biology of biochemistry, is a plus.
How to apply
Please send a cover letter, a letter describing your professional interests and ambitions, a curriculum vitae and contact information for at least two references to Dr. Meyer email@example.com. Applications will be considered until the position is filled.
The college and department
Boston College is situated on a beautiful campus dating back to the beginning of the twentieth century and is closely located to downtown Boston and Cambridge. The Biology Department and the lab have strong ongoing collaborative efforts with surrounding institutes including Harvard, MIT, and Tufts University. The core faculty in the Biology Department conducts research in areas including HIV, SIV, Toxoplasma, the immune system, and microbial community structures.
Postdoctoral positions are available in the lab of Dr. Olga Anczuków at The Jackson Laboratory for Genomic Medicine in Farmington, CT. Our lab investigates how changes in RNA splicing contribute to breast and ovarian cancer progression as well as drug resistance. We utilize 3D organotypic cell culture models, as well as mouse orthotopic transplantation and PDX models, to decipher the role of alternative-splicing alterations in cancer with the goal of developing novel therapeutic strategies for precision medicine.
Preferred skills and experience: We are looking for talented candidates with interests in RNA biology and cancer research. Successful candidates should have a PhD and/or MD degree with a strong background in molecular biology, cell biology, biochemistry and/or genomics. Research experience in computational biology is also desirable. The candidate should be highly self-motivated, able to work in a team environment, able to acquire new skills rapidly, and have strong written and communication skills.
About The Jackson Laboratory for Genomic Medicine: The successful candidate will join a stimulating and collaborative working environment with eight decades of distinguished research in mammalian genetics and a promising future in genomic medicine. The Jackson Laboratory is recognized internationally for its excellence in research and educational activities, unparalleled genomic resources, and outstanding research support services. It is voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine.
The Jackson Laboratory for Genomic Medicine is part of a $1.1 billion venture between The Jackson Laboratory and the state of Connecticut. The laboratory collaborates with leading medical institutions, including the University of Connecticut Health Center, the Yale University School of Medicine, and the BIDMC Cancer Center. The institute is located in a new, dedicated, state-of-the-art research building, a 183,000 ft2 space incorporating a broad range of the most advanced research laboratories and supporting facilities. It is within 2-hour drive of both New York City and Boston. Nearby recreational activities include hiking, biking, shopping and sampling the offerings of local restaurants in West Hartford. The area offers affordable living and great schools districts. The Jackson Laboratory offers a comprehensive medical plan and other benefits.
To apply: Applications should submitted via the career section of www.jax.org and include a Cover Letter and CV, as well as a list of references. When candidates are otherwise equally qualified, JAX will give preference to the Connecticut resident.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.
A NIH-funded postdoctoral position in structural biology is open in Prof. Ailong Ke’s laboratory at Cornell University, Ithaca, NY, USA. Related research projects seek to understand the structure and function of RNA and RNA-protein complexes.The lab is interested in three main research areas: 1. Structure and function of RNA-protein complexes in CRISPR-Cas and other RNA-guided systems; 2. Structural enzymology of nuclease and helicase in DNA degradation and repair; 3. Structure and conformation dynamics of riboswitches and RNA-containing motors. For representative publications, please refer to Nature. 2016 Feb 25;530(7591):499-503.; Molecular Cell. 2015 Mar 19;57(6):1110-23; Nat Struct Mol Biol. 2014 Sep;21(9):771-7; Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3573-8; and Nat Struct Mol Biol. 2014 Jan;21(1):95-102.
Applicants are expected to hold (or expect) a Ph.D. or equivalent degree. Preferred prior experience in structural biology (crystallography or EM), nucleic acid biochemistry, single molecule biophysics, or molecular evolution. More additional information can be found at http://sites.google.com/site/kelaboratory/
To apply, please send CV and names of 3 references to: firstname.lastname@example.org
We are recruiting a Scientific programmer in Bioinformatics/Computational Biology
to join the Group Bioinformatics of RNA Structure and Transcriptome Regulation and the BIMSB Bioinformatics Platform .
The Berlin Institute for Medical Systems Biology (BIMSB) is the most recently established institute at the Max-Delbruck Centre for Molecular Medicine (MDC) in Berlin, Germany, which is one of the national research centres of the Helmholtz Association. Research at BIMSB combines state-of-the-art high-throughput technologies with Bioinformatics, molecular biology, biochemistry and engineering to gain a comprehensive and fundamental understanding of different biological systems. The successful applicant will join an international team of interdisciplinary scientists on a vibrant research campus in Berlin, Germany.
The newly established Bioinformatics research group of RNA Structure and Transcriptome regulation (Prof. Meyer) seek an experienced scientific programmer to support the research of the Meyer group and to coordinate work with the BIMSB Bioinformatics Platform (Dr. Akalin).
|Responsibilities||– support the research program of the Meyer group and coordinate
sys admin work with the BIMSB Bioinformatics Platform
particular for analysing large scale data sets) as well as new
computational analysis pipelines integrating various data sources and
software packages for Linux distributions, e.g. for official release and
for use on the high-performance multi-user compute cluster
presentations on work
– strong interest in Bioinformatics research and the scientific mission of
as effectively as part of a team
– excellent programming skills in C++, Java, R and basic knowledge of
– excellent programming skills of a scripting language (Perl and/or Python)
(e.g.Guix) and packaging software from source (.rpm, .deb)
high-performance cluster environment (Sun Grid Engine)
automated system deployment and linux configuration management (e.g.
high-throughput sequencing data
employing computational methods
|Salary||Re-numeration according to German TVoeD (Bund/Ost) E13, depending on qualification and experience.|
|Application Deadline||Friday, 3. June 2016|
|Start Date||as soon as possible|
|Limitation||The position is initially offered for 3 years, with the possibility for further extension beyond the initial 3-year contract.|
Meyer group (www.mdc-berlin.de/45451098)
Akalin group (www.mdc-berlin.de/20902467)
How to apply:
Please submit your complete application as a single pdf-file by email to Ms. Sabine Froese (email@example.com) including
• letter of motivation (1 page max)
• CV including relevant experience
• university and other relevant certificates
• contact details of 2 or more referees
• N.B.: Please get 2 or more letters of recommendation to be sent directly to Ms. Sabine Froese (firstname.lastname@example.org) by the application deadline.
The MDC is an equal opportunity employer and supports gender equality
A postdoctoral position is available in the laboratory of Dr. Xin Li, Assistant Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics. Research in the Li Lab (zhaohua.urmc.rochester.edu) is at the interface of reproductive and RNA biology. We thrive to understand how information is perpetuated and diversified through generations from an RNA perspective. The current known RNA-regulations in germ lines just represent the tip of the iceberg. We are looking for a highly motivated individual to uncover new mechanism together.
There are several ongoing projects in the lab: including the biogenesis and function of piRNAs, the translation regulation in germ-line development, the RNA structure and modification in testis, the cause and the consequence of germ-line aging. We are adopting an interdisciplinary approach including genetics, biochemistry, bioinformatics and cell biology, and testing our finding across different model organisms including humans, mice and chickens .
Being one of the founding members of the lab, the position will have the unique opportunity to work side by side with the PI. Ideas and data generated by the “dry” component of the lab will be tested rapidly and efficiently by “wet” bench members, and vice versa. You will attend our joint group meeting with Drs. Lynne Maquat and Yitao Yu and interact with other RNA biologists. We also have close interactions with the reproduction groups at Cornell University, including Drs. John Schimenti and Paula Cohen.
• A recent Ph.D. or equivalent experience
• One first-author publication
• Good communication and organization skills
• Awareness of details
• Preferred background on bioinformatics, reproduction, avian biology or RNA biology
Rochester Center for RNA Biology is a mecca for RNA researchers, with a long history of nurturing RNA biologists and discoveries. The University of Rochester was ranked one of the top 15 institutions in the nation for scientists to work according to The Scientist magazine’s annual survey of “Best Places to Work for Scientists in Academia”. It should be noted that the University of Rochester outranked every other research institution in New York State. The environment is very collaborative and congenial and has an infrastructure that allows me and others to recruit outstanding lab members. Moreover, the city of Rochester is safe, beautiful and affordable.
Please provide a cover letter describing your past projects and career goals. Please also describe what you hope to get out of this position and what you hope to bring to the Lab. Enclose your detailed CV with names and contacts of three referees to Xin_Li@nullURMC.Rochester.edu.
A NIH funded postdoctoral position is available in the Cifuentes laboratory at Boston University School of Medicine for a talented and extremely motivated candidate willing to address fundamental questions of embryonic reprogramming using zebrafish as a model system.
The long-term goals of the laboratory and the available projects involve:
i) to uncover the RNA-protein interactions that occur during early embryogenesis using iCLIP and CRISPR mutagenesis, ii) to understand how do these interactions regulate RNA processing during developent and finally, iii) to integrate mRNA methylation and epitranscriptomics into this regulatory framework.
To address these goals, the lab combines zebrafish microinjection together with powerful genetic, genomic, and proteomic approaches. We are located in a renovated lab space at Boston University School of Medicine in the Department of Biochemistry, with close access to scientific core facilities and immersed in the lively city of Boston.
Candidates should have a PhD, MD, or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important is their motivation to learn and adapt to scientific challenges and become positive members of the lab. The position is funded for at least three years, contingent on performance. Additional information can be found at: http://www.bumc.bu.edu/biochemistry/people/faculty/daniel-cifuentes/
To apply please send to Dr. Cifuentes a cover letter stating research interests and accomplishments, CV, and contact information for three references in a single PDF
We are looking for a postdoc in the field of RNA –protein interactions.
The project will likely start early next year and should have a focus on the identification of drug targets. The candidate will have an important role in the final design of the project.
Applicants should have relevant experience in RNA biochemistry and ideally in “Omics” approaches.
The project is planned as a collaboration between Cellzome and the EMBL, and the position will be based at the EMBL campus in Heidelberg.
Informal enquiries can be made to me via phone or email. Please contact:
Dr. Paola Grandi
Group Leader Chemical Genomics
Cellzome GmbH, a GSK company
69117 Heidelberg, Germany
phone: +49 6221 137 57 323
The University of Copenhagen seeks to appoint a Postdoc to the Department of Immunology and Microbiology to work at Copenhagen Hepatitis C Program (CO-HEP) to commence as soon as possible.
During your postdoc, you will be working on RNA biology associated with different viral infections using and developing state-of-the-art methodology. Your studies will be part of establishing a platform in RNA and systems virology under the supervision of Associate Professor Troels Scheel. As part of CO-HEP, a highly active and competitive program headed by Professor Jens Bukh, you will be working in a dynamic, international environment with 25 other researchers including Senior Investigators, Postdoctoral Fellows, PhD and Master’s Students, Research Assistants, and Technicians. CO-HEP is affiliated with the University of Copenhagen and with Copenhagen University Hospital, Hvidovre.
RNA viruses are responsible for significant morbidity and mortality worldwide. Pathogens of our interest include hepatitis viruses, flaviviruses (e.g. dengue, yellow fever, zika), picornaviruses (e.g. polio, coxsackie) and alphaviruses (e.g. sindbis, chikungunya). RNA interactions and dynamics during viral infection are becoming increasingly important, and some, such as that of hepatitis C virus and miR-122, are emerging as therapeutic targets. Much, however, remains to be understood on RNA interactions during infection. During the project, you will apply high throughput methodology, such as RNA-seq, crosslinking immunoprecipitation (CLIP) and RNA antisense purification (RAP) as well as standard virology methods to study RNA interactions during infection. You will be expected to actively participate in method development and development of the project.
The successful applicant should have:
•A PhD in virology, molecular biology, cellular biology, systems biology or related fields.
•Experience with virology, RNA biology, cell biology, systems biology or related fields.
•Interest in RNA viruses, molecular biology and novel deep sequencing methods.
•Research qualifications including experience with cell culture and molecular biology. Experience with virology, microbiology or immunology is an advantage but not a requirement.
•First author publications in high quality internationally recognized journals.
Copenhagen is a modern and international city with a high living standard.
For further information and to apply: http://employment.ku.dk/faculty/?show=817079
Further details can also be obtained by contacting Troels Scheel: email@example.com
The University of Copenhagen encourages all interested applicants to apply for this position. The closing date for applications is 23.59pm, Sunday 8 May 2016. Only online applications will be accepted.
We seek motivated scientists with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to discover and functionally elucidate small RNA biogenesis, mRNA processing, and regulatory networks that govern neural specification and function.
Three major projects are available, each with substantial unpublished molecular and genetic data that the candidate can take advantage of. These projects include:
(1) Molecular genetic analysis of endo-siRNA systems across Drosophila species. This follows on recent work from the lab regarding hpRNA function in D. melanogaster (e.g. Wen et al, Molecular Cell 2015), and exploits our current annotation of rapidly evolving hpRNA systems across 12 fly species, and our ability to genetically manipulate other Drosophilid species yielding unexpected phenotypes. This work reveals adaptive function of the RNAi pathway in the testis and surprising biology of RNAi in other species.
(2) Elucidation of mechanism and biology of small RNA tailing and trimming pathways in Drosophila. This follows on recent work from the lab regarding the mirtron tailing enzyme Tailor (e.g. Bortolamiol-Becet, Molecular Cell 2015), and exploits our current generation of novel mutants and biochemical data on Tailor-associated factors and novel tailing enzymes. This work reveals new mechanistic insights into the regulation of small RNA modification, and its consequences on gonadal biology.
(3) Genetic analysis of neural miRNA mutants. Our laboratory has a rich background in elucidating miRNA biology, and our recent work explores neural development and behavior (e.g. Garaulet, Developmental Cell 2014; Sun, PLoS Genetics 2015; Garaulet Journal of Neuroscience 2016). Our current work reveals a panel of Drosophila neural miRNA mutants that exhibit profound defects, including in established and novel behavioral paradigms. This work reveals fundamental biology of miRNA regulation in vivo, and provides access into unexplored behavioral circuits.
We have openings for 2 highly motivated postdoctoral fellows with broad interest in integrative strategies to join our team. Relevant candidates for the first two projects will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods. Relevant candidates for the third project will have strong background in Drosophila genetics and neurobiological methods. Positions are available immediately and are funded for at least three years, contingent on performance. Please send letter of inquiry, CV and references to firstname.lastname@example.org.
Post-doctoral positions are available in the Department of Biophysics at the Johns Hopkins University to study the dynamics of protein-RNA interactions during ribosome assembly and during regulation by small non-coding RNAs. Projects involve the integration of RNA biochemistry with intracellular X-ray footprinting, single molecule FRET, small angle X-ray scattering or mass spectrometry. Trainees benefit from extensive collaborations with laboratories at Johns Hopkins, the NIH, and the University of Maryland. The positions require self-motivated candidates comfortable with quantitative data analysis and methods development. Expertise in RNA biochemistry, single molecule biophysics, small angle scattering or high-throughput sequencing is helpful. Please send a CV and names of 3 references by e-mail to Professor Sarah Woodson email@example.com.
Postdoctoral positions are available in the lab of Dr. Nathan Baird at the University of the Sciences in Philadelphia. The Baird lab combines emerging research in RNA biology with high-throughput chemical screening to advance RNA-targeted drug discovery. Additionally, research projects focus on structure-function analyses of novel RNA-ligand interactions.
Highly motivated candidates possessing skills in RNA biochemistry/biophysics or high-throughput screening are encouraged to apply. Additional skills in the analysis and management of large data sets, including a basic knowledge of computer scripting languages, are desirable though not required. Qualified candidates must have a Ph.D. in biochemistry, biophysics, or chemical biology related to RNA.
Research in the Baird lab is supported by a Career Transition Award (K22) from NIH. Extensive opportunities for collaborative and innovative science are a hallmark of the Baird lab, including existing collaborations with groups at NIH and Temple University. For more information, visit www.bairdlabusci.com. Candidates are requested to send a statement of interest, curriculum vitae, and contact information for 3 references to firstname.lastname@example.org
USciences is located in the University City District of Philadelphia in close proximity to a number of excellent neighboring universities, biotechnology companies, and large pharmaceutical companies.
The RNA Bioscience Initiative is a major new interdepartmental effort to expand basic and clinical RNA biology research and education at the University of Colorado Anschutz Medical Campus. We anticipate hiring 5 new faculty members as well as additional personnel to develop RNA bioinformatics technology. In the first phase of recruitment, we invite applications for faculty positions in the areas of RNA technology and bioinformatics. Highly qualified applications at the Assistant Professor and more senior levels will be considered. The ideal candidates are developing novel experimental and computational technologies to investigate questions relevant to RNA biology in normal and diseased cells.
New recruits will join a highly interactive and interdisciplinary group of faculty (http://rnabio.CO), students, and postdoctoral fellows, and will enjoy access to state-of-the-art equipment and facilities on the new Anschutz Medical Campus. Candidates must hold a PhD (or equivalent) degree and have a strong record of research accomplishments.
Applicants should submit a cover letter, curriculum vitae, a brief description of research plans (2 pages), and the contact information for 3 people who will provide letters of reference.
Materials should be submitted at http://jobs.sciencecareers.org/job/401006/faculty-positions-university-of-colorado-anschutz-medical-campus-rna-bioscience-initiative/.
We will begin reviewing applications May 15, 2016 and the search will remain open until the positions are filled.
NIH-funded Postdoctoral Fellowship in Developmental Biology of Formation of RNA: interaction with DNA
Postdoctoral Fellowship Position, to begin June 1, – August 15, 2016 (duration: 2-5 yrs).
NIH-funded Postdoctoral Fellowship Position in National Institutes of Health (NIH), Bethesda, Maryland
The Fellow will examine how RNases H find their substrates and how, when these enzymes are defective, do the substrates cause severe neurological disorders using mouse models. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in mouse development, molecular biology, genetics and/or biochemistry is required. The successful candidate will confer regularly with the principal investigator on a mutually establish area of research. During the candidate’s tenure, creating new projects, development of technical skills, presentation, and communication skills will be strongly supported by the PI and other members of the laboratory.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Crouch lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Robert J. Crouch
Crouch lab current interests
• Role RNases H1and H2 in preventing genome instability
• Development of innate and adaptive immune responses
• Contribution of RNA/DNA hybrids and R-loops to genome integrity
•.Mitochondrial DNA replication and disorders
• Roles of ribonucleotides incorporated during DNA replication
Two Postdoctoral Fellow/Research Associate Positions in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine
Two Postdoctoral Fellow/Research Associate positions are immediately available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine.
The project is to elucidate molecular mechanisms of diseases caused by mutations in splicing factors. Its aim is to provide new, important insights into mechanisms that contribute to normal development and prevent carcinogenesis. All of the projects in the laboratory relate to aspects of mammalian pre-mRNA transcription and processing. The realization of these projects will involve state-of-the-art approaches in biochemistry, cell and molecular biology including genomics, genome engineering, and the development of cell culture models of disease.
The successful candidate will demonstrate dedication to pursue a research career in molecular genetics. The candidate will have a Ph.D. in biochemistry, molecular biology, genetics, developmental or cell biology, and will have first-author publications in top-tier, peer-reviewed journals. In addition, the candidate must have excellent skills in written and spoken English. Positions are supported by NIH grants for at least three years.
Please email your curriculum vitae, a brief description of research accomplishments and career objectives as well as contact information for 3 references to email@example.com.
Two Postdoc Positions Available to Study microRNAs and Translational Regulation in the Immune System
Postdoctoral positions are available in the Department of Immunology and Microbial Science at The Scripps Research Institute to study the functions and molecular mechanisms of microRNA and translational control in immune tolerance, immune responses, autoimmune disease, lymphoma, virus infection, and cancer immunotherapy. For more information, see Cell (2007) PMID: 17923094, Nature Immunology (2008) PMID: 18327259, Cell (2009) PMID: 19135886, Nature Immunology (2013) PMID: 23812097, EMBO J (2013) PMID: 23921550, Nature Immunology (2016) PMID: 26901150.
Highly motivated PhD, MD, or MD/PhD with a solid background in immunology. Working experience in the following areas is desired: the mouse immune system; immune tolerance; germinal center reaction; mouse models of autoimmune diseases or lymphoma; cancer immunotherapy, lentiviral or retroviral systems for gene expression; bone marrow reconstitution; Crispr/Cas9 gene editing, mouse genetics.
Highly motivated PhD, MD, or MD/PhD with a solid background in studying RNA, RNA-binding protein, and/or translational regulation in mammalian systems. The following expertise is desired: ribosome profiling, polysome profiling, CLIP, and bioinformatic skills.
Please e-mail application including cover letter indicating current and future research interests and expected availability date, CV, selected reprints of publications, names and contact information of three references to:
Changchun Xiao, Associate Professor, Department of Immunology and Microbial Science, The Scripps Research Institute, firstname.lastname@example.org.