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Department Head – Department of Biochemistry at Purdue University

The Department of Biochemistry at Purdue University invites applications and nominations for the position of Department Head. We are looking for a dynamic individual with a creative and inspiring vision for biochemistry research and education. Our forward-thinking, diverse, and internationally recognized department has 20 full-time faculty members with active research programs funded by the NIH, NSF, DOE, and ACS, as well as industry. These research programs encompass a wide variety of topics including metabolic and natural product biochemistry, cancer biochemistry, epigenetics and gene expression, proteomics and metabolomics, structural biology and macromolecular complexes. The majority of our faculty are members of the NCI designated Purdue University Center for Cancer Research and/or play key roles in Purdue’s Plant Sciences and Biofuels initiatives. The Department is dedicated to providing an exceptional undergraduate education that emphasizes experiential learning. Excellence in graduate education is a central goal of the department and is evidenced by a well-established graduate program; many biochemistry faculty also participate in the University-wide interdisciplinary life science graduate program (PULSe). Purdue University is committed to continued promotion of excellence in biochemistry research, and educational and scientific innovation. A competitive package for recruitment and resources is available for the successful candidate. More detailed information about the Department is available at: http://www.biochem.purdue.edu.

Qualifications: The successful candidate will have an outstanding record of scholarly achievement including an extramurally-funded research program and a forward-thinking, strategic vision for all levels of education. Successful candidates will also have demonstrated intellectual leadership necessary to further promote our department in an exciting period of growth. An appreciation of mentoring at all levels, service to the department and the greater scientific community, and an ability to inspire leadership in others is critical. Strong interpersonal, communication, and decision-making abilities are required. Administrative leadership experience is essential. Candidates must have a doctoral degree in biochemistry, biophysics, genetics, chemistry, computational biology or other related field, and be eligible for tenure at the rank of full professor.

The College: The Department of Biochemistry is an integral part of the College of Agriculture, one of the world’s leading colleges of agricultural, food, life, and natural resource sciences and ranked number 8 globally in the 2014 QS World University Rankings. The College is deeply committed to the three land-grant missions (teaching, research, and extension), to international activities and perspectives that span all missions, and to supporting a diverse and inclusive environment focused on excellence in all we do. Purdue is an ADVANCE institution – www.purdue.edu/dp/advance. The College has 11 academic departments and includes 330 faculty, 2710 undergraduate students, and 685 graduate students. The College’s strategic plan can be accessed at https://www2.ag.purdue.edu/Pages/strategicplan.aspx.

Application Procedure: Qualified persons are requested to submit the following: a letter of application, statements of research, teaching, and leadership philosophy, complete curriculum vitae, including the names of five references. Initial nominations and inquiries will be kept confidential; references will be contacted only upon the applicant’s approval. Nominations of potential candidates for the position are welcome. A background check is required for employment in this position.

Applications, nominations, and inquiries should be addressed to: Professor Rebecca Doerge, Chair of the Department of Biochemistry Head Search Committee, Purdue University, 615 W. State Street, West Lafayette IN 47907-2053. Electronic submission is preferred and should be sent to rdr@nullpurdue.edu. Screening of applicants will begin January 11, 2015, and will continue until a suitable candidate is identified. Questions regarding the position may be sent to Professor Rebecca Doerge at (765) 494-3141 (doerge@nullpurdue.edu).

Purdue University is an EEO/AA employer fully committed to achieving a diverse workforce. All individuals, including minorities, women, individuals with disabilities, and protected veterans are encouraged to apply.

Postdoctoral Research Position in the Lab of Dr. Aaron Goldstrohm

A postdoctoral research position is available immediately in the lab of Dr. Aaron Goldstrohm in the Department of Biological Chemistry at the University of Michigan Medical School.

Dr. Goldstrohm seeks a highly motivated postdoctoral candidate to perform research on the roles of RNA binding proteins, microRNAs, and long non-coding RNAs in cancer biology. Candidates should hold a Ph.D. in biochemistry, genetics, cellular and molecular biology or related field. They should have strong interests in cancer biology, gene regulation, RNA biology, and genetics. Individuals with experience in cancer research and molecular and cellular biology techniques are preferred. Candidates must have independent research skills including designing and executing experiments, interpreting data, and the ability to communicate results, as demonstrated by previous publications and presentations.

Initial support for the postdoctoral scientist will be provided by the American Cancer Society. Candidates will also be expected to apply for fellowships. Dr. Goldstrohm will provide guidance in developing fellowship proposals.

The University of Michigan and the Goldstrohm Lab provide an outstanding training environment with state-of-the-art facilities and instrumentation. The training environment is enhanced by participation in the multidisciplinary RNA Supergroup consisting of 17 labs from across the campus. In addition to abundant scientific and intellectual resources, the post-doctoral fellow will benefit from career and professional development opportunities. Compensation will correspond with the NIH NRSA payscale, commensurate with experience, and will include health care benefits.

The University of Michigan is located in Ann Arbor, a vibrant, affordable university town located in southeastern Michigan.

To apply, candidates should submit their curriculum vitae with publication record and contact information for three references to Dr. Aaron C. Goldstrohm at acgold@nullmed.umich.edu.

Please include a cover letter describing career goals, research experience, accomplishments, and interests. To learn more about the Goldstrohm lab and research, please visit: http://medicine.umich.edu/dept/biochem/aaron-goldstrohm-phd

Faculty position in molecular and cellular biology

The University of California, Riverside is searching for a new faculty member at the ASSISTANT PROFESSOR level in the area of Molecular and Cellular Biology. Areas of interest could involve nuclear dynamics, histone modifications, noncoding RNAs in chromatin remodeling and genome stability, RNA transport, stability, and translation, RNAi and microRNAs, and RNA/protein trafficking within and between cells. Candidates working in molecular and cellular biology with any state-of-the-art model systems are encouraged to apply. Candidates who incorporate systems biology approaches, large-scale genomics, next generation sequencing, bioinformatics and/or visual microscopy to their research programs are preferred.

The successful candidate will join an innovative and multidisciplinary Institute for Integrative Genome Biology (IIGB) that connects theoretical and experimental researchers from different departments in Life, Physical and Mathematical Sciences, Medicine, Engineering and various campus based Centers. The IIGB is organized around a 10,000 sq.ft. suite of Instrumentation Facilities that serve as a centralized, shared-use resource for faculty, staff and students, offering advanced tools in bioinformatics, microscopy and imaging, proteomics and genomics. The University of California, Riverside also just completed construction of the School of Medicine Research Building adjacent to the Genomics Building, which will be developing research and health care delivery programs to medically underserved populations in California. A modern vivarium and two BSL3 facilities are located close to the Genomics and School of Medicine Research Buildings.

Review of applications will begin December 1, 2014. Interested individuals should: (1) submit a curriculum vitae, (2) provide a statement of research and teaching interests, and (3) arrange to have three letters of reference sent on their behalf through the recruitment website https://aprecruit.ucr.edu.

Tenure-Track Positions, RNA Therapeutics Institute, University of Massachusetts Medical School

The RNA Therapeutics Institute (RTI) at the University of Massachusetts Medical School, co-directed by Victor Ambros, Craig C. Mello, Melissa J. Moore, and Phillip D. Zamore, invites applications for tenure-track faculty positions. Successful candidates will conduct innovative research to understand normal physiology and development, disease mechanisms, and/or will develop novel diagnostics or therapies. Candidates need not necessarily conduct research directly focused on RNA chemistry, biology, formulations or therapeutics development, but should indicate how their research will synergize with ongoing research within the RTI and the greater UMass Medical School community.

Research areas of interest include, but are not limited to 1) Nucleic acid chemistry and formulation; 2) oligonucleotide delivery; 3) chemical biology; 4) human genetics and pathophysiology with a focus on oligonucleotide therapeutics; 5) chemistry of epigenetic regulation. Synthetic chemists, bioengineers, and materials scientists all are encouraged to apply. Also desired are scientists with significant industrial experience who wish to return to academia.

The RTI is housed in a new, state-of-the-art research building and is central to a campus-wide interdisciplinary initiative in RNA therapeutics, stem cell biology and gene therapy designed to facilitate collaboration among basic scientists, preclinical investigators and clinicians. As a recipient of a Clinical and Translational Science Award (CTSA) from the National Institutes of Health, UMass Medical School seeks to build an environment in which basic, applied and clinical researchers collaborate to inform our understanding of human disease and accelerate development of novel diagnostics and therapies. To further encourage collaboration, all RTI investigators hold joint appointments in other departments on campus.

Applicants should submit a cover letter, curriculum vitae, a two-page statement of research interests, and contact information for three references to https://academicjobsonline.org/ajo/jobs/4674. Applications will be reviewed expeditiously, with interviews commencing in November. Inquiries (but not application materials) may be directed to Mary Beth Dziewietin at MaryBeth.Dziewietin@nullumassmed.edu. Applications at the Assistant, Associate and Full Professor levels will be considered.

As an equal opportunity and affirmative action employer, the University of Massachusetts Medical School recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives and backgrounds.

Postdoctoral position in RNA regulation at Sloan-Kettering, New York City

We seek a motivated scientist with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to annotate and functionally elucidate small RNA pathways, mRNA processing pathways, and neural transcription factor networks.

The candidate will work on two projects. First is to elucidate mechanisms that regulate alternative polyadenylation in the nervous system. Second is to study the post-transcriptional regulation of miRNA processing. These projects will involve molecular and biochemical approaches, towards the goal of understanding mechanisms and discovering relevant substrates across the transcriptome.

Relevant candidates will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods.

Postdoctoral fellows or well-qualified MS level candidates seeking experience before graduate school will be considered. Please send letter of inquiry, CV and references to laie@nullmskcc.org. Position is available immediately.

Recent Selected References
Dai, Q., A. Ren, J. O. Westholm, A. Serganov, D. J. Patel and E. C. Lai (2013). The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes and Development 27: 602-14.

Miura, P., S. Shenker, J. O. Westholm, C. Andreu-Agullo and E. C. Lai (2013). Widespread and extensive lengthening of 3′ UTRs in the mammalian brain. Genome Research 23: 812-825.

Okamura K., E. Ladewig, L. Zhou and E. C. Lai (2013). Regulatory RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes and Development 27: 778-792.

Smibert, P., J.-S. Yang, G. Azzam, J.-L. Liu and E. C. Lai (2013). Homeostatic control of Argonaute stability by microRNAs. Nature Structural and Molecular Biology 20: 789-795.

Mohammed, J., D. Bortolamiol-Becet, A. S. Flynt, I. Gronau, A. Siepel and E. C. Lai (2014). Adaptive evolution of testis-specific, recently-evolved, clustered miRNAs in Drosophila. RNA 20: 1195-1209.

Garaulet, D. L., M. Castellanos, F. Bejarano, P. Sanfilippo, D. M. Tyler, D. Allan, E. Sanchez-Herrero and E. C. Lai (2014). Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system. Developmental Cell 29: 635-48.

Wen, J., J. Mohammed, D. Bortolamiol-Becet, H. Tsai, N. Robine, J. O. Westholm, E. Ladewig, Q. Dai, K. Okamura, A. S. Flynt, D. Zhang, J. Andrews, L. Cherbas, T. C. Kaufman, P. Cherbas, A. Siepel, and Eric C. Lai (2014). Diversity of miRNAs, siRNAs and piRNAs across 25 Drosophila cell lines. Genome Research 24: 1236-50.

Faculty Position in Cell, Molecular and Developmental Biology

The Department of Biology at the University of Rochester invites applications for a tenure-track faculty position in cell, molecular and developmental biology. We are seeking outstanding candidates whose research programs address fundamental biological problems and who have demonstrated excellence, originality, and productivity in research. Our multidisciplinary biology department affords opportunities for intellectual interactions across diverse research disciplines, with faculty working in the areas of chromatin, DNA repair, aging, intracellular transport, proteomics, transposable elements, ribosome biogenesis, developmental and evolutionary biology.

Our research and graduate programs are integrated into a world-class life sciences research campus that provides ample opportunities for interactions and collaborations with the adjacent University of Rochester Medical Center. Faculty research is supported by University initiatives including the Institute for Data Science, Rochester Aging Research Center, Stem Cell Institute, and Cancer Center. Research activities across the University are supported by core facilities featuring Imaging, Proteomics, Functional Genomics, Small Molecule Screening, and Flow Cytometry.

Application materials should be uploaded at www.rochester.edu/faculty-recruiting/apply/bio . Complete applications should include: a cover letter; curriculum vitae including publication list; statement of research accomplishments and future plans; statement of teaching experience and interests. Also provide copies of three papers. Instructions for supplying three letters of recommendation are on the application website. Applicant screening will start October 1 and continue until the position is filled.

The University of Rochester is an Equal Opportunity Employer, has a strong commitment to diversity and actively encourages applications of candidates from groups underrepresented in higher education.

Postdoc in Regulatory sRNAs

A postdoctoral position is available in the laboratory of Associate Professor Birgitte H. Kallipolitis at the Department of Biochemistry and Molecular Biology, University of Southern Denmark. The position is for two years, starting 1 January 2015 or soon thereafter. Application deadline: 02/11/2014

The laboratory of Birgitte H. Kallipolitis investigates the biological function and mechanism of action of small, regulatory RNAs (sRNAs) in bacteria. The research project will focus on gene regulatory networks comprising multiple homologous sRNAs in the human pathogen Listeria monocytogenes (for more details, see Sievers et al., 2014, Nucleic Acids Res. 42(14):9383-98). A variety of experimental methods will be employed, including RNA-seq, molecular genetics and biochemical analyses.

We seek a highly motivated and enthusiastic candidate with a PhD degree obtained within the last three years in Molecular Biology, Biochemistry, Microbiology or a related discipline. Previous research experience in RNA biochemistry and molecular microbiology is desirable. The ideal candidate should have displayed an ability to produce high quality research in peer-reviewed journals.

For further details, please contact Associate Professor Birgitte H. Kallipolitis (bhk@nullbmb.sdu.dk).

Applications must be submitted electronically using the link provided on the SDU Webpage: http://www.sdu.dk/en/servicenavigation/right/ledige_stillinger.

Bioinformatics position available at Sloan-Kettering, New York City

We seek a motivated bioinformatician to be involved in our studies of gene regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines computational and experimental approaches to annotate and functionally elucidate small RNA pathways (e.g. miRNAs, siRNAs and piRNAs), mRNA processing pathways (e.g. alternative polyadenylation and circularization), and transcription factor networks (mostly regarding neural specification). Towards this end, we produce a great deal of small RNA, RNA-seq and ChIP-seq data, and analyze these with respect to the rich comparative genomic data available for Drosophila and mammals. There is a close exchange of ideas between dry and wet lab members to generate and test biologically-based hypotheses. Questions of ongoing interest include the mechanics of small RNA biogenesis, the evolution of small RNA genes and their function, the control of 3′UTR formation, how RNA circularization occurs and is regulated, and the mRNA/miRNA networks downstream of key neural transcription factors. We were also a core group of the NHGRI modENCODE consortium (http://www.modencode.org/) and continue with integrative analysis with other largescale datasets produced by consortium members.

Relevant candidates should have proficiency in a programming language (e.g. Java or C/C++) and a scripting language (e.g. Perl or Python), and experience with R and database systems. Strong experience with deep-sequencing data (e.g. Illumina, SOLiD, and/or third-generation methods) is essential. Postdoctoral fellows or BA/MS level candidates seeking experience before graduate school will be considered. Please send letter of inquiry, CV and references to laie@nullmskcc.org. Position is available immediately.

Recent Selected References

Dai, Q., A. Ren, J. O. Westholm, A. Serganov, D. J. Patel and E. C. Lai (2013). The BEN domain is a novel sequence-specific DNA binding domain conserved in neural transcriptional repressors. Genes and Development 27: 602-14.

Miura, P., S. Shenker, J. O. Westholm, C. Andreu-Agullo and E. C. Lai (2013). Widespread and extensive lengthening of 3′ UTRs in the mammalian brain. Genome Research 23: 812-825.

Okamura K., E. Ladewig, L. Zhou and E. C. Lai (2013). Regulatory RNAs are generated from select miRNA hairpin loops in flies and mammals. Genes and Development 27: 778-792.

Smibert, P., J.-S. Yang, G. Azzam, J.-L. Liu and E. C. Lai (2013). Homeostatic control of Argonaute stability by microRNAs. Nature Structural and Molecular Biology 20: 789-795.

Mohammed, J., D. Bortolamiol-Becet, A. S. Flynt, I. Gronau, A. Siepel and E. C. Lai (2014). Adaptive evolution of testis-specific, recently-evolved, clustered miRNAs in Drosophila. RNA 20: 1195-1209.

Garaulet, D. L., M. Castellanos, F. Bejarano, P. Sanfilippo, D. M. Tyler, D. Allan, E. Sanchez-Herrero and E. C. Lai (2014). Homeotic function of Drosophila Bithorax-Complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the central nervous system. Developmental Cell 29: 635-48.

Wen, J., J. Mohammed, D. Bortolamiol-Becet, H. Tsai, N. Robine, J. O. Westholm, E. Ladewig, Q. Dai, K. Okamura, A. S. Flynt, D. Zhang, J. Andrews, L. Cherbas, T. C. Kaufman, P. Cherbas, A. Siepel, and Eric C. Lai (2014). Diversity of miRNAs, siRNAs and piRNAs across 25 Drosophila cell lines. Genome Research 24: 1236-50.

Postdoctoral Fellow in Computational Biology at Boston University Medical Center

We are looking for a post-doctoral fellow in Computational Biology and Transcriptome Analysis to lead a joint project between laboratories of Dr. Ruslan Afasizhev at the Department of Molecular and Cell Biology and Dr. Stefano Monti in the Section of Computational Biomedicine at the BU School of Medicine. The candidate will have the opportunity to work in a unique computationally-oriented environment backed by an advanced molecular biology laboratory and substantial resources within the Boston University Medical Campus and collaborators at Harvard Medical School and the Broad Institute. The NIH-funded project involves de novo sequencing, assembly and functional studies of mitochondrial genomes from trypanosomatids, which are unicellular parasites causing a wide spectrum of human diseases. In this context, the candidate’s role will be to develop and apply methods to analyze High-Throughput Sequencing (Pac Bio and Illumina platforms, DNA and primarily coding and non-coding RNA-sequencing) data for the identification and characterization of the molecular pathways contributing to mitochondrial gene expression, and their perturbation in various loss-of-function genetic backgrounds. The ideal candidate will have: an interdisciplinary background in bioinformatics & computational biology; advanced expertise in the analysis and interpretation of sequencing data and its integration with other “omics” data sources; good programming skills; and advanced knowledge of statistical and machine learning methods. The position would be for a minimum of two years.

Requirements: Qualified candidates should have:
• A Ph.D. in computational biology, bioinformatics, computer science, engineering, mathematics, physics, or related field.
• Ability to program in Python and R, with knowledge of MATLAB and/or Java a plus.
• Familiarity with Unix systems.
• Demonstrated applied bioinformatics/computational proficiency as evidenced by relevant publications in peer-reviewed journals.

Cotnact: ruslana@nullbu.edu