Employment Opportunities

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Postdoctoral Fellow in Computational Biology at Boston University Medical Center

We are looking for a post-doctoral fellow in Computational Biology and Transcriptome Analysis to lead a joint project between laboratories of Dr. Ruslan Afasizhev at the Department of Molecular and Cell Biology and Dr. Stefano Monti in the Section of Computational Biomedicine at the BU School of Medicine. The candidate will have the opportunity to work in a unique computationally-oriented environment backed by an advanced molecular biology laboratory and substantial resources within the Boston University Medical Campus and collaborators at Harvard Medical School and the Broad Institute. The NIH-funded project involves de novo sequencing, assembly and functional studies of mitochondrial genomes from trypanosomatids, which are unicellular parasites causing a wide spectrum of human diseases. In this context, the candidate’s role will be to develop and apply methods to analyze High-Throughput Sequencing (Pac Bio and Illumina platforms, DNA and primarily coding and non-coding RNA-sequencing) data for the identification and characterization of the molecular pathways contributing to mitochondrial gene expression, and their perturbation in various loss-of-function genetic backgrounds. The ideal candidate will have: an interdisciplinary background in bioinformatics & computational biology; advanced expertise in the analysis and interpretation of sequencing data and its integration with other “omics” data sources; good programming skills; and advanced knowledge of statistical and machine learning methods. The position would be for a minimum of two years.

Requirements: Qualified candidates should have:
• A Ph.D. in computational biology, bioinformatics, computer science, engineering, mathematics, physics, or related field.
• Ability to program in Python and R, with knowledge of MATLAB and/or Java a plus.
• Familiarity with Unix systems.
• Demonstrated applied bioinformatics/computational proficiency as evidenced by relevant publications in peer-reviewed journals.

Cotnact: [email protected]

Post-doctoral position in the Lambowitz lab at the University of Texas at Austin

A post-doctoral position is available in the Lambowitz lab at the University of Texas at Austin to carry out biochemical and structural analysis of thermostable group II intron reverse transcriptases. Thermostable group II intron reverse transcriptases are novel enzymes with beneficial properties and novel activities that open new methods for next-generation RNA sequencing, RNA structure analysis, and analysis of non-coding RNAs. The focus will be on analyzing structure-function relationships in these enzymes by combining in vitro mutagenesis and directed evolution with biochemical analysis and X-ray crystallography. Experience in protein purification and X-ray crystallography is desirable. Applications now until position filled.

Mohr, S., Ghanem, E., Smith, W., Sheeter, D., Qin, Y., King, O., Polioudakis, D., Iyer, V.R., Hunicke-Smith, S. Swamy, S., Kuersten, S., and Lambowitz, A.M. Thermostable group II intron reverse transcriptase fusion proteins and their use in cDNA synthesis and next-generation RNA sequencing. RNA, 19, 958-970, 2013.

Collins, K. and Nilsen, T. Enzyme engineering through evolution: thermostable recombinant group II intron reverse transcriptases provide new tools for RNA research and biotechnology. RNA 19, 1017-1018, 2013.

Enyeart, P.J., Mohr, G., Ellington, A.D., and Lambowitz A.M. Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis. Mobile DNA 5:2, 2014.

Katibah, G.E., Qin, Y., Sidote, D.J., Yao, J., Lambowitz, A.M. and Collins, K. Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5. Proc. Natl. Acad. Sci., USA, doi/10.1073.1412842111, 2014.

Eamil: [email protected]

Seeking a highly motivated and independent individual interested in working in one of two areas

We are seeking a highly motivated and independent individual interested in working in one of two areas: 1) advanced single-molecule techniques to study RNA structure, or 2) programmable biosensors for RNA detection and purification. Successful candidate is to start this Fall and no later than December 2014 The single-molecule projects are more engineering based, and involve further development and testing of the recently invented Centrifuge Force Microscope (CFM) to probe the structure of individual RNA molecules with the application of force. The biosensor project is more biochemistry based, and involves adapting a recently developed DNA nanoswitch platform to RNA applications including detection and purification.

Minimum Qualifications: Ph.D. in Biomedical Engineering, Biophysics, Biochemistry or related field from a college or university accredited by USDOE or an internationally recognized accrediting organization

Preferred Qualifications (depending on area of interest): Experience in single-molecule biophysics (optical tweezers, AFM, etc.); Hands-on engineering and prototyping experience; Experience with optics, image analysis, or programming; Experience in DNA nanotechnology.

The RNA institute is a vibrant new establishment focused on the RNA sciences and interdisciplinary approaches. We have an extremely collaborative and friendly culture, facilitating scientific and social interactions. To apply, please send a cover letter, a CV, and contact info for 3 references to: [email protected].

Postdoctoral position in systems biology

Principal Investigator / Institute:
Christine Vogel, Center for Genomics and Systems Biology, NYU Department of Biology

We are looking for a postdoctoral researcher to join our lab at the earliest convenience. Our lab uses system-wide approaches to investigate protein expression regulation in response to environmental stress. Our primary model organisms are yeast and mammalian cell lines. We emphasize interdisciplinary work, combining wet- and dry-lab approaches, as well as large-scale and targeted small-scale experiments.

The position is tied to a specific project, but work on own ideas and new directions are always welcome and part of our every day research life. The proposed project involves work with mammalian cell lines, several large-scale techniques (e.g. mass spectrometry based proteomics, next-generation sequencing), computational data analysis, and close interaction with our statistics collaborators. Expertise in one or more of the above areas is desirable.

Our lab is positioned at the Center for Genomics and Systems Biology. We are the primary users of an LTQ Orbitrap Velos mass spectrometer and have access to state-of-the-art sequencing, robotics, and microscopy facilities. The Center for Genomics and Systems Biology is part of the NYU Department of Biology with close links to the NYU Medical School, the Courant Institute, and other well-known universities in the city – offering a rich and active scientific environment. The Center is located in the heart of Manhattan near Washington Square Park – one of the most historical, cultural and liveliest areas in the big city.

Benefits such as medical/dental/retirement/tuition remission are available to qualified applicants, see http://www.nyu.edu/employees/benefit/ (code 103). Funding is available for at least two years. NYU provides visa support and (limited) post-doctoral housing.

To apply for this position, please send your CV and contact details of your references via email. Please also include a letter of interest describing your background, your career, and research interests. We are looking for someone to enrich our lab with scientific creativity and new skills.

Requirements: PhD in a biological discipline, preferably experience with tissue culture and large-scale data analysis
Job location: New York, NY
Info: https://sites.google.com/a/nyu.edu/vogel-lab/home
Contact: [email protected]
Application: Now until position is filled

NIH-funded postdoc position addressing the roles of RNA helicases in human cells

We are currently looking for a postdoc with experience in NextGen sequencing/bioinformatics and basic molecular biology techniques to fill an NIH-funded position addressing the roles of RNA helicases in human cells.  Prior experience with mammalian tissue culture is a plus. Please apply directly to Dr. Elizabeth Tran via email, [email protected], and include a CV, list of peer reviewed publications and 3 references.  All applicants should have a minimum of two first author papers in a peer reviewed journal.

Post-Doctoral position open in the laboratory of Dr. Paul F. Agris

Post-Doctoral position open in the laboratory of Dr. Paul F. Agris within the RNA Institute (SUNY). Applicants are sought with expertise in the area of structural biology by RNA-NMR; RNA interactions with proteins, peptides, small molecules and other RNAs. Three modern high field NMR instruments with cryoprobes, one designed especially for RNA are available. The RNA Institute is known for its structural biology of RNA and RNA complexes using various biophysical techniques.

Applicants should submit:

1) complete resume’,

2) names and contacts of three references and

3) a brief description of RNA research experience that includes those approaches/technologies with which the applicant has extensive experience.

The RNA Institute provides a unique research resource environment for some 54 principal investigators and ~300 researchers conducting RNA science and its applications to human health problems, technology development and drug discovery in New York’s Capital District. Albany has the cultural activities of a large city but within the environment of a small city atmosphere, ready access to the Adirondacks, Berkshires, the NY lake district, Boston, and NYC.

Contact:[email protected]

RNA Biologist – The Chemical Biology of G-Quadruplexes in RNA

Following the award of an ERC Advanced Grant to Professor Shankar Balasubramanian (http://www.ch.cam.ac.uk/group/shankar), we seek to appoint a postdoctoral RNA biologist to explore the structure, function and biology of four-stranded RNA G-quadruplex structures. This interdisciplinary project builds on our experience in the understanding of non-canonical G-quadruplex nucleic acid structures. We recently demonstrated the existence of G-quadruplex structures in the DNA of human cells (Nature Chem. 5, 182, 2013), and are now extending our studies to RNA G-quadruplexes (Nature Chem. Biol. 3, 218, 2007; NAR 2012, 40, 4727, 2012; Nature Chem. 6, 75, 2014).

The candidate will have a sound practical and intellectual background in RNA biology and structure, excellent skills in molecular and cell biology and technical expertise in RNA manipulation and analysis. Candidates are expected to be excellent communicators, independent thinkers, demonstrate an intellectual capacity for innovation and be able to collaborate effectively to address the goals of this major initiative. The postholder will be primarily based at our Cambridge Institute Laboratory. Applicants should possess (or be about to receive) a PhD in a relevant discipline.

The post is available immediately, with funds available for 2 years in the first instance.

To apply online for this vacancy, visit http://www.jobs.cam.ac.uk/job/4525

Please ensure that you upload a 2-page Curriculum Vitae (CV), a covering letter and publications list in the Upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.

For queries regarding applying online for this post, please contact Leanne Moden, PA to Professor Shankar Balasubramanian, email: [email protected].

Please quote reference MA03899 on your application and in any correspondence about this vacancy.

The Department holds an Athena SWAN bronze award for women in science, technology, engineering, mathematics and medicine.

The University values diversity and is committed to equality of opportunity.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Postdoctoral Scholar Positions

Postdoctoral scholar positions are available at the Nanobiotechnology Center of the University of Kentucky and the NCI Cancer Nanotechnology Platform Partnerships (CNPP) program directed by Dr. Peixuan Guo (http://nanobio.uky.edu/Guo/peixuanguo.html). Strong background in RNA chemistry, RNA conjugation, Genetics, or Cell Biology is preferred.

To apply, please contact Dr. Hui Zhang at email: [email protected]. The University of Kentucky is an Equal Opportunity and Affirmative Action Employer.

H3 Biomedicine Postdoctoral Program

The H3 Biomedicine Postdoctoral Program provides an environment for scientists to undertake innovative academic-focused research projects in a biotech industry setting. H3 Biomedicine offers a framework for scientists to design and execute their research plans and provide appropriate training with a goal to present research at major scientific conferences and publication of results in leading peer-reviewed journals.

We seek highly motivated and enthusiastic individuals to join the H3 Biomedicine Postdoctoral Program based at our facility in Cambridge, Massachusetts. Individuals will interact with a team of scientists working towards understanding the role of RNA splicing in cancer and identifying novel therapeutic approaches for the treatment of targeted patient populations. H3 Biomedicine provides a state-of-the-art research facility and interactions with scientists from multiple disciplines including bioinformatics and genomics, target discovery, structural biology, enzymology, drug discovery and chemistry.

Research Areas

H3 Biomedicine has built a world-class research effort that applies cancer genomics and next generation chemistry geared towards the identification of novel cancer medicines. A major area of research at H3 Biomedicine is in RNA biology and RNA splicing in cancer. We have pioneered methods to drug the spliceosome and apply this knowledge to modulating deregulated cancer-specific splice events. Our ultimate goal is the discovery and development of novel therapies for the treatment of genomically-defined cancer patients.

We seek to attract postdoctoral candidates interested in pursuing research in the following three areas:

•        Exploring the disease mechanisms of spliceosome mutations in cancer (e.g. SF3B1, U2AF1, SRSF2) and nodes for therapeutic intervention with small molecule splicing modulators
•        The structural basis for splicing modulation approaches and aberrant splicing in SF3B1 mutant cancers.
•        Discovery and validation of driver RNA splicing alterations in cancer and identification of target modulation strategies to enable precision medicine.

Program Highlights

•        Regular interactions with mentor, and academic external advisor as appropriate, to formulate and execute research plans
•        Regular presentations at Scientific Founders Meeting to the H3 Biomedicine senior scientists and our academic founders Stuart Schreiber, PhD and Todd Golub, MD.
•        Presentation/publication of research at major scientific conferences/journals
•        Potential for transition into full-time employment should appropriate positions be available at the end of the postdoctoral position

Qualifications

The applicant must have completed, or is anticipated to complete within the next 3 months, a Ph.D. in Biology, Cancer Biology, Molecular Biology, Structural Biology, Biochemistry or a related field. Previous research experience in the area of RNA biology/splicing, cancer biology or structural biology/crystallography is desirable. Candidates should have displayed an ability to produce high quality research in peer-reviewed journals

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole mission is to become a prolific source of new drugs that treat more human cancers with greater success. H3 Biomedicine is applying the expertise of leading scientists to the integration of insights from cancer genomics with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs

Interested candidates may forward a CV to [email protected]

www.h3biomedicine.com

Postdoctoral Position Studying the Molecular Mechanisms of RNA Quality Control

A postdoctoral position studying the molecular mechanisms of RNA quality control is immediately available in Dr. J. Robert Hogg’s group at the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. The laboratory is an RNA biochemistry and molecular biology research group established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way). The research of the group and its members is supported by the collaborative and interdisciplinary NIH intramural program and state-of-the-art proteomics, high-throughput sequencing, microscopy, bioinformatics, flow cytometry, human iPS, mouse transgenic, and other core facilities.

The laboratory is focused on using biochemical methods to study the assembly and functions of viral and cellular messenger ribonucleoprotein complexes. A major tool in these efforts is a novel system for RNA hairpin tag-based affinity purification of messenger ribonucleoproteins from human cells followed by mass spectrometry. This approach led to the identification of a mechanism by which the key NMD factor Upf1 is able to directly sense 3′UTR length in the process of decay target discrimination (see Hogg and Goff, Cell, 143, 379-89 for more details). The lab is now pursuing several projects designed to understand the molecular mechanisms underlying 3’UTR length sensing by Upf1 and subversion of this process by retroviral RNA elements. These efforts require a combination of molecular, cell biological, biochemical, and proteomic techniques in mammalian cell culture and in vitro systems. More information is available at http://www.nhlbi.nih.gov/research/intramural/researchers/pi/hogg-robert/.

Requirements:

Interested candidates must have received a Ph.D. or M.D. within the past five years in molecular biology, cell biology, biochemistry, genetics or a related discipline and be highly motivated to participate in and design innovative research programs.  The candidate will be supported with an excellent intramural NIH fellowship in a stimulating and interactive research environment at NIH.

To apply:

Please email a cover letter indicating preferred start date and research area, CV, summary of research accomplishments, and names and contact information for at least three references to:

Dr. J. Robert Hogg
Email: [email protected]

The NIH is dedicated to building a diverse community in its training and employment programs.

DHHS/NIH is an Equal Opportunity Employer

Postdoctoral Fellow in Computational RNA Genomics

A Postdoctoral Fellow position in Computational RNA Genomics is available at the Genome Center and the Biomedical Engineering Department of the University of California, Davis. The postdoc will be working as part of a newly forming team in the Aviran lab (www.bme.ucdavis.edu/aviranlab) and will be developing probabilistic models and statistical inference algorithms for genomic big data analysis. Of particular interest is research relevant to our NIH-funded projects in RNA genomics and in structural RNA biology. The developed methods will be applied to problems in RNA systems and synthetic biology.

Required Qualifications

We are looking for a highly motivated, creative, and enthusiastic individual, with interest in RNA genomics, folding dynamics, or rational design. Candidates should have a PhD in bioinformatics, statistics, applied math, electrical engineering, computer science, biophysics, or a related field. Preference will be given to candidates with experience in probabilistic modeling and computational statistics or machine learning. Specific skills that are strongly preferred include proficiency in programming and scripting (using, e.g., Python, R, Matlab, or C/C++) and in hands-on genomic data analysis. Excellent writing and communication skills in English are required.

Interested candidates should submit a cover letter stating their interest in our research directions and why they are interested in joining, a CV with list of publications, and contact information for three references. Please combine all information into a single PDF and send to Dr. Aviran (saviran at ucdavis dot edu). Applications will be accepted immediately, with a proposed start date of Summer 2014. Duration: 3 years, depending on performance. NIH funding for this project has been recently granted through a K99-R00 award.

Review of applications will continue until an outstanding candidate has filled the position. The successful candidate will join a young, vibrant, and rapidly growing Biomedical Engineering department, a large and active Genome Center, and collaborative genomics and computational biology communities at UC Davis. For more information, please visit www.bme.ucdavis.edu/aviranlab/positions/.

Regulation of Cancer Genes by RNA Binding Proteins and Non-Coding RNAs

A post-doctoral research position is available in the laboratory of Dr. Aaron Goldstrohm in the Department of Biological Chemistry at the University of Michigan Medical School. The research project focuses on regulation of cancer genes by RNA binding proteins and non-coding RNAs. Candidates should hold a Ph.D. in biochemistry, genetics, cellular or molecular biology or related field. They should have strong interests in gene regulation and RNA biology and be skilled in molecular and cellular biology techniques.

The University of Michigan and the Goldstrohm Lab provide an outstanding training environment. In addition to abundant scientific and intellectual resources, the post-doctoral fellow well benefit from career and professional development opportunites.

To apply, candidates should submit curriculum vitae with publication record and contact information for three references. Please include a cover letter describing career goals, research experience and interests.

To learn more about our lab and research, please visit: http://www.biochem.med.umich.edu/?q=agoldstrohm

Study Protein-RNA Complexes Involved in HIV Alternative Splicing

A postdoctoral position is available to study protein-RNA complexes involved in HIV alternative splicing in the Department of Chemistry at Case Western Reserve University. The goal of this NIH funded project is to understand the structural and biophysical basis of how host proteins recognize HIV RNA elements to control the balance of viral splicing events. The position will require the elucidation of several high-resolution structures of isolated RNA elements and protein-RNA complexes as well as determining physicochemical parameters associated with these molecules.

The environment for RNA and protein structural biophysics at Case Western Reserve University is outstanding, with state-of-the art NMR spectrometers equipped with cryogenic probes (every field strength 500-900 MHz), instruments for X-ray crystallography, cryo-electron microscopy and other biophysical instrumentation. Major biophysical and biochemical instrumentation available in the PI’s personal lab include titration and scanning calorimeters (Microcal), two AKTA FPLC instruments, two Innova tissue culture incubators and several computer workstations for data analysis and structure calculations.

In addition to the strong instrumentation, the intellectual environment at CWRU is exceptional where barriers to collaborations are low. The PI maintains active collaborations with members of the Center for AIDS Research and interacts routinely with members of the Center for RNA Molecular Biology, Departments of Biochemistry, Pharmacology and Microbiology. Moreover, Cleveland offers a pleasant cultural setting for work and home life.

The ideal candidate will have a recent PhD in Biochemistry or Biophysics, a strong academic record, proven experience in biomolecular NMR spectroscopy or X-ray crystallography and fluent English language skills. Previous experience with RNA biochemistry is preferred.

To apply, please email a statement of research interests, CV and the names and contact information for three references to Dr. Blanton S. Tolbert ([email protected]). Informal inquiries are also welcome.

Diversity Statement:

In employment, as in education, Case Western Reserve University is committed to Equal Opportunity and Diversity. Women, veterans, members of underrepresented minority groups, and individuals with disabilities are encouraged to apply.

Reasonable Accommodations:

Case Western Reserve University provides reasonable accommodations to applicants with disabilities. Applicants requiring a reasonable accommodation for any part of the application and hiring process should contact the Office of Inclusion, Diversity and Equal Opportunity at 216-368-8877 to request a reasonable accommodation. Determinations as to granting reasonable accommodations for any applicant will be made on a case-by-case basis.

Postdoctoral Position to Investigate RNA-mediated Meiotic Regulation in Fission Yeast

Available immediately, term of appointment up to 3 years

The Wise lab in the Center for RNA Molecular Biology at Case Western Reserve University is inviting applications for a postdoctoral scientist to spearhead our efforts to understand the molecular basis of changes in RNA metabolism during the transition from proliferative growth and at successive stages of meiotic differentiation in fission yeast.  Previous work has elucidated two unusual regulatory strategies that come into play as this simple developmental pathway unfolds:

  • Increased accumulation of early meiotic mRNAs, driven by enhanced stability due to modulation of RNA binding by a protein that senses methylation of adenosine residues
  • Increased accumulation of middle meiotic mRNAs, driven by enhanced co-transcriptional RNA processing mediated by a meiosis-specific transcription factor

The project will utilize a combination of genome-wide and traditional molecular genetic approaches to dissect the cascade of events through which these sequential but interconnected regulatory mechanisms ensure proper temporal control of gene expression.  As counterparts of factors implicated in fission yeast meiotic regulation have recently been uncovered in budding yeast, flies and mammals, it may be illuminating to extend our studies through collaborations with RNA Center colleagues.  The Center for RNA Molecular Biology provides a stimulating and highly interactive research environment in which trainees benefit from the high concentration of faculty, students and postdocs with relevant expertise.

The ideal candidate will hold a recently (or soon to be) awarded Ph.D. in Molecular Biology, Biochemistry or a related discipline and have laboratory experience working with RNA.  A strong track record of self-directed research and excellent technical and communication skills are also essential.  Expertise in bioinformatics and/or genetic manipulation is highly desirable.  Salary support (NSF-funded) will be provided at a level commensurate with experience.

Interested individuals should send a cover letter including a description of research interests and career goals, as well as a detailed CV and the names of three references (with e-mail addresses and phone numbers) to Jo Ann Wise, preferably via e-mail ([email protected]).