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A postdoctoral research fellow position is available at the University of California, San Francisco at the new Helen Diller Comprehensive Cancer Center (Mission Bay Campus) (http://pub.ucsf.edu/missionbay/tour/), to study the basic molecular mechanisms promoting quantitative and qualitative regulation in the translational control of gene expression and how deregulations in this process lead to distinct steps of cancer progression.
The potential candidate will utilize the first mouse models for components of the translation machinery in combination with novel proteomics, ribosome-profiling, and pharmacological strategies to study the dynamics of translation control in gene expression, in normal and cancer cells. Highly motivated individuals with a recent Ph.D., M.D. or M.D./Ph.D. and a background in mouse genetics, biochemistry, or cellular and molecular biology are encouraged to apply. Evidence of scientific accomplishment is required and bioinformatics skills are desirable. Requests should be addressed to: [email protected] and [email protected].
Please visit our webpage at ruggerolab.ucsf.edu.
The expansion of PTC Therapeutics, Inc. has created the need for a Research Scientist to support our Drug Discovery and Development programs focused on RNA biology. The selected candidates will be expected to work independently to guide a drug discovery program from understanding the biology and selection of a suitable target to the development and implementation of high throughput assays to identify small molecule modulators of the target gene expression. Additionally, the candidate will work closely with a cross functional team of scientists in support of research goals for multiple projects focused on the identification and advancement of small molecules that target novel processes of RNA biology with the ultimate goal of addressing unmet medical needs.
•Ph.D. degree in biosciences with 2+ years of experience as a postdoc or in pharmaceutical research/drug discovery.
•Strong molecular biology, mammalian tissue culture and assay development skills are required.
•Strong oral and written communication skills as evidenced by a strong publication/patent record are essential.
•Broad knowledge of multiple therapeutic areas ranging from genetic disorders to oncology is strongly preferred.
•RNA sequence analysis, alignment, secondary and tertiary structure prediction/RNA folding, RNA-DNA and RNA-RNA duplex and triplex formation/imperfect base-paring analysis
•Research on the function small RNA pathways (e.g. miRNAs, siRNAs and piRNAs) or mRNA processing pathways (e.g. alternative polyadenylation and circularization)
•RNA recognition by proteins and small molecule ligands
•Identification and analysis of RNA regulatory elements – control of splicing, transport, translation initiation/uORF, RNA editing, translational pausing and frameshifting, translation termination, UTR regulatory motifs – strength and utility as drug targets
•Experience in genome-wide analysis of gene expression: RNA-seq, CLIP-seq, ribosome profiling
Contact: [email protected]
A post-doctoral position is available for a qualified individual to carry out studies in the field of alternative splicing. A focus of the research will be on novel epithelial cell-type-specific splicing proteins (Esrp1 and Esrp2) that were identified in our lab in a cell-based genetic screen (Molecular Cell 33(5):591-601 (2009). We have use high throughput sequencing and other genome-wide technologies to identify global programs of alternative splicing in epithelial cells that are abolished upon Esrp depletion (Embo J. 29(19): 3286-3300; Mol. Cell. Biol. 32(8): 1468-1482). The research project will extend the use of genome-wide sequencing technologies to study programs of alternative splicing that are altered in newly developed Esrp1/Esrp2 KO mice, which display disease related phenotypes. Further details about the lab can be accessed at: http://www.med.upenn.edu/camb/faculty/ggr/carstens.html. The position requires an M.D. or Ph.D. degree. Previous experience in mouse genetics, RNA biology, and molecular or cell biology is preferred. Please send a CV including at least two references to: Dr. Russ P. Carstens, University of Pennsylvania School of Medicine, 575 Clinical Research Building, 415 Curie Blvd. Philadelphia, PA 19104, [email protected].
An exciting postdoctoral fellow position is available in the lab of Dr. Jacob Schwartz at the University of Arizona in Tucson, AZ, to study the role of RNA binding proteins in regulating transcription and DNA damage response. Specific projects include the role of RNA binding proteins in Lou Gehrig’s disease, Ewing sarcoma, and the role of noncoding RNAs in regulating transcription. Candidates with a strong background in molecular biology, biochemistry, or computational biology are encouraged to apply. The lab’s research focus ranges from protein purification, cell culture, primary neuronal cell culture, and whole mouse studies. Techniques include mass spectrometry, protein/RNA structure functional studies, immunofluorescence and microscopy, and next-generation sequencing. To apply please send a CV and letter of interest with the contact information for your references to [email protected].
1. Schwartz JC, Cech TR, Parker RR, “Biochemical properties and biological functions of FET proteins”, Annu. Rev. Biochem. 2015; 84 (Epub ahead of print)
2. Schwartz JC, Podell ER, Han SSW, Berry JD, Eggan KC, Cech TR, “FUS is sequestered in nuclear aggregates in ALS patient fibroblasts” Mol Biol Cell, 2014; 25(17):2571-8. (PMID: 25009283)
3. Schwartz JC, Wang X, Podell ER, Cech TR, “RNA seeds higher order assembly of FUS protein” Cell Reports, 2013; 5(4):918-25.
4. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR, “FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2” Genes Dev, 2012; 26:2690-95.
5. Schwartz, JC, Younger, S, Nguyen,N, Hardy, D, Monia, BP, Corey, DR, Janowski, BA, “Antisense Transcripts are Targets for Small Activating RNAs”, Nat Struct Mol Biol. 2008 Aug;15(8):842-8.
A postdoctoral position to study the functional roles and regulation of localized RNAs is available immediately in Dr. Stavroula Mili’s lab at the National Cancer Institute, National Institutes of Health, Bethesda, MD. The lab is interested in understanding the regulation of RNA localization by cancer-associated proteins and the contribution of localized RNAs to tumor progression. The work relies on a variety of cell biological, microscopical and biochemical approaches in 2D and 3D cell culture systems. The research program is funded by the NIH Intramural program and is supported by state-of-the-art facilities on the NIH campus.
Interested candidates must have received a Ph.D. degree in cell biology, biochemistry or related discipline, and be highly motivated to design and pursue innovative research directions.
Applications should include a CV, description of research interests and prior accomplishments, contact information of at least 3 references and preferred start date. Please e-mail application materials to [email protected]
The NIH is dedicated to building a diverse community in its training and employment programs.
DHHS/NIH is an Equal Opportunity Employer.
Contribute to NIH-R01 Funded Projects Focused on mRNA Decay in Myotonic Dystrophy and Pluripotent Stem Cells
We are looking for an enthusiastic and hard-working post-doctoral fellow to contribute to NIH-R01 funded projects focused on mRNA decay in myotonic dystrophy and pluripotent stem cells. The projects aim to identify novel changes in mRNA metabolism that contribute to pathogenesis and pluripotency. State-of-the-art genome-wide approaches and other molecular techniques will be employed using primary and stem cells.
The successful candidate should hold a PhD and/or MD and have less than 5 years post-doctoral experience in the general area of cell and molecular biology. Preference will be given to those with experience in RNA biology, genome-wide approaches and/or stem cell biology. Bioinformatics expertise is highly desirable. The fellow will report to Jeff and Carol Wilusz, but will be expected to work somewhat independently. S/he will be encouraged to apply for fellowship funding and given the opportunity to train junior researchers. Excellent technical, oral and written communication skills are essential.
The Wilusz lab has extensive expertise in all aspects of RNA biology linked with disease and development.
We are located at Colorado State University, in Fort Collins, Colorado – frequently voted one of the “Best Places to Live in the US”.
Apply by 3/15/2015 for full consideration, but the position will remain open until filled. The start date could be as early as 4/15/2015; funding is available through 2019.
For complete job description and to apply go to http://jobs.colostate.edu/postings/8417.
CSU is an EO/EA/AA employer and conducts background checks on all final candidates.
The Department of Cell and Molecular Physiology at Loyola University Chicago, Health Sciences Division seeks applicants for tenure-track positions at the ASSISTANT PROFESSOR, ASSOCIATE PROFESSOR and PROFESSOR level. We seek colleagues that will contribute to existing strengths in molecular neuroscience, cardiac physiology and biophysics. Our faculty are actively engaged in research in diverse areas including membrane transport mechanisms, molecular neuroendocrinology, neuronal excitability, neurobiological effects of alcohol abuse, and RNA/epigenetic regulation in health and disease. Applicants using proteomic and genomic tools to address fundamental questions in molecular neuroscience are strongly encouraged to apply. Departmental infrastructure includes resources in mass spectrometry, fluorescence microscopy, electrophysiology, animal facilities – including a small animal VIVO 2100 ultrasound, echocardiography instruments and surgical suites, viral vector core, molecular dynamics simulation, single molecule biophysics and biophysical spectroscopy. Other instrumentation and University core facilities are described here: (http://www.stritch.luc.edu/depts/physio). Laboratory space will be located in the new Center for Translational Research and Education. The faculty applicant will be expected to sustain an independent, externally funded research program. In addition, the applicant must have evidence of teaching experience and will be expected to contribute to graduate and medical education. Candidates must have a doctoral degree and postdoctoral experience; senior applicants should have a strong record of research productivity and extramural support. Review of applications will commence immediately and applications will be accepted until the position is filled. Apply directly at http://www.careers.luc.edu/applicants/Central?quickFind=57760
Equal Opportunity Employer: Minorities/Women/Veterans/Disabled
NIH-funded Postdoctoral Fellowship Position, to begin Oct 1, 2015 or later (duration: 2-5 yrs).
NIH-funded Postdoctoral Fellowship Position in Eukaryotic RNA Metabolism
National Institutes of Health (NIH), Bethesda, Maryland
The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to eukaryotic gene expression. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation. The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Richard J. Maraia, M.D.
Email: [email protected]
Maraia lab current interests
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation and disease.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.