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University of California, Santa Cruz (UCSC) Postdoctoral Position

The University of California, Santa Cruz (UCSC) invites applications for a postdoctoral position in the laboratory of Assistant Professor Angela Brooks in the Department of Biomolecular Engineering. The successful candidate will participate in research to further elucidate the role of somatic transcriptome alterations that contribute to cancer phenotypes, with a focus on altered RNA splicing. The successful candidate will be expected to develop and implement computational methods on high-throughput sequencing data, play key roles in international research collaborations, and lead collaborative projects consisting of other computational and “wet lab” biologists. Candidates with a strong cancer and/or RNA biology background with a strong interest in developing computational expertise are also encouraged to apply.

BASIC QUALIFICATIONS: Ph.D. or equivalent in computational biology, computer science, mathematics, statistics, bioengineering, genetics, biochemistry, molecular biology, cell biology, or other relevant field; demonstrated excellence in academic research as evidenced by one or more peer-reviewed, submitted, or in-preparation first-author publications.

PREFERRED QUALIFICATIONS: Experience with high-throughput sequencing data analysis; strong interpersonal skills; experience leading a team or project; good written and verbal communication skills; strong interest in RNA biology and cancer biology.

POSITION AVAILABLE: As soon as possible

TERM OF APPOINTMENT: The initial appointment is for one year, with likely extension, contingent upon availability of funding and positive performance evaluation.

TO APPLY:  Please send a cover letter, CV, and three references to anbrooks@nullucsc.edu.

Postdoctoral position in the field of RNA biology and metabolism

The German Cancer Research Center (DKFZ) invites applications for a highly motivated and creative postdoctoral researcher to explore the posttranscriptional regulation of metabolism. The DKFZ is located in the picturesque city of Heidelberg in the South of Germany and benefits from an exceptionally strong research environment, with Germany’s oldest university and several other leading life science research institutions in Europe. The successful candidate will join the lab of Dr. Bruno Galy in the „virus-associated carcinogenesis unit“ of the DKFZ.

Metabolic remodeling is emerging as a key process of physiology and disease. Although posttranscriptional regulations play a key role in shaping proteomes, genetic control of metabolism has so far been mostly investigated at the level of transcription. The interconnection between metabolism and the complex life of a mRNA, from its synthesis to its translation and decay, remains poorly understood. Iron metabolism is an ideal model system to study the posttranscriptional regulation of metabolism. Indeed, iron homeostasis is maintained by two RNA binding factors called Iron Regulatory Proteins (IRPs). The IRPs respond to changes in cellular iron levels and in turn modulate the translation or turnover of target mRNAs encoding iron management proteins. In this postdoctoral project, we will use high-throughput approaches developed recently to define the regulatory scope of the IRP network on a system wide scale. This integrative approach will be carried out in vivo, using state‐of-the‐art IRP mouse models. With this work we wish to unveil new facets of a central homeostatic circuit in the cell, and establish a basis for the study of other gene regulatory networks with similar properties.

The applicant holds a Ph.D. (or equivalent degree) in biology, biochemistry or related field and an excellent publication record. He/She is expected to have a strong background in RNA biology. A solid experience with cell and molecular biology techniques and in particular high throughput approaches (e.g. ribosome profiling) will be essential; familiarity with standard bioinformatical analysis of large data sets is also required. The candidate is rigorous, able to conduct independent research, but also enjoys interacting with colleagues of different disciplines and nations. Good presentation skills and experience on project management (importance of scheduling, deliverables, reporting) will be highly valued.

Funding for a total of 3 years is available and the position is open immediately. Your application (in English language) must include a CV, a summary of academic records, your research interests, and at least two letters of recommendation (or contact details of potential referees). For further question, please contact Dr. Bruno Galy (b.galy@nulldkfz.de).

Department of Cellular and Molecular Physiology at Yale School of Medicine

A postdoctoral position is currently available in the laboratory of Carson Thoreen in the Department of Cellular and Molecular Physiology at Yale School of Medicine. The laboratory is seeking to understand how the mTOR pathway, a master regulator of growth, controls the translation and stability of mRNAs under normal and disease contexts. We employ a wide range of approaches that include deep-sequencing (eg. ribosome profiling), bioinformatic and classical biochemical strategies. Creative individuals with a PhD or MD, and preferably a strong background in biochemistry and/or cell biology and a quantitative bent, are encouraged to apply. Applicants should send a current CV to carson.thoreen@nullyale.edu.

Diseases of mRNA metabolism

The MMPU aims at strengthening the link between molecular research and medicine and consists of 8 international teams of molecular research-oriented MDs, PhDs, PhD students and technicians. The research philosophy aims at the molecular understanding of the basis of common human diseases, its applications in diagnosis and therapy, and feedback from ‘bedside medicine’ into the research laboratory.

https://www.klinikum.uni-heidelberg.de/Molecular-Medicine-Partnership-Unit.114597.0.html

You will be integrated into the MMPU team “Diseases of mRNA metabolism” which focuses on basic and translational aspects of mRNA metabolism in common diseases such as the hemoglobin disorders, thrombosis and inflammation and childhood cancer. One position is required to pursue a project addressing the mechanism of nonsense-mediated decay (NMD), one of the cell’s key mRNA quality control pathways to limit the synthesis of faulty proteins. The other position will also be integrated into the SFB 1036 “Cellular Surveillance and Damage Response” addressing mechanisms of stress induced regulation of mRNA 3’ end processing.

The successful candidates (m/f) will be highly motivated and interactive scientists to join an international and collaborative team. You hold a degree in molecular biology, genetics, or biochemistry and ideally have a background in molecular and RNA biology. Experience in systems approaches such as ribosomal profiling and/or proteome-, mRNP-, or transcriptome analysis on a global level including bioinformatic skills will be an advantage.

The positions are available for three years with potential extension.

Please apply to:

MMPU
Andreas Kulozik, MD, PhD
kinderonkologie.hd@nullmed.uni-heidelberg.de

with a letter summarizing previous work experience and contact information of two referees.

www.klinikum.uni-heidelberg.de/Jobs-Karriere

We stand for equal opportunities for women and men. Severely handicapped with the same eligibility will be given priority.

GRK 1591-Posttranscriptional Control of Gene Expression: Mechanisms and Role in Pathogenesis

The Martin Luther University Halle-Wittenberg operates the research training group “GRK 1591-Posttranscriptional control of gene expression: mechanisms and role in pathogenesis” funded by the German Research Foundation (DFG).

For the working group of Prof. Großmann und Dr. Schreier the RTG is seeking a
PhD Student

Description:
MicroRNAs (miRNA) are small non-coding RNAs that influence cell physiology in health and disease. In the last years we investigated the role of miRNAs in heart hypertrophy. During the last years non-coding RNAs, have been shown to affect electrical properties of cardiomyocytes. The aim of our project is to analyze the impact of miR-221/222 and mirR-208b on electrical remodeling during heart hypertrophy and to identifie the underlying the molecular mechanisms of this influence.

We are an enthusiastic team and offer intensive training and mentoring. The successful candidate will have the opportunity to learn a wide spectrum of genetic, molecular biology, biochemical and cell biology techniques. She/he will be exposed to cutting-edge methods to study translational aspects of cardiovascular pathology (e.g. genetic knockout models, next-generation sequencing, in vivo methods, patch clamping). The willingness to participate in animal studies is mandatory. For further information can be obtained at www.medizin.uni-halle.de/index.php?id=786 or www.medizin.uni-halle.de/index.php?id=272.

Your profile:
We are looking for self-motivated individuals with a diploma or master’s degree in biochemistry, biology, veterinary medicine or related subjects. Previous exposure to and experience with basic biochemical and molecular biology techniques as well as interests in molecular aspects of cardiovascular research or RNA biology is essential.

Please send your application including a letter of motivation, CV, certificates, recommendation letters in one pdf file.
The position is limited to 3 years and the salary will be based on TV-L (65%).
The working Group of Prof. Großmann and Dr. Schreier is located at the Julius Bernstein Institute of physiology at the Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.

For further information please contact Dr. Barbara Schreier, phone 0049-3455574759 or barbara.schreier@nulluk-halle.de.

The Martin Luther University of Halle-Wittenberg is committed to increase the percentage of female scientists and encourages female applicants to apply. Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.

To apply for the position please send the application documents until the 15th of July 2016 either via e-mail to barbara.schreier@nulluk-halle.de or to the following address: Martin-Luther University Halle-Wittenberg, Julius Bernstein Institute of physiology, Magdeburger Str. 6, 06112 Halle/Saale, Germany. We ask for your understanding that we cannot return application documents that are sent to us by post. We apologize for any inconvenience this may cause.

Postdoctoral Researcher Positions at The Ohio State University

Two molecular biology Postdoctoral Researcher positions are available at The Ohio State University to work in a 20-member Nanobiotechnology and RNA nano technology  interdisciplinary lab directed by Peixuan Guo (http://rnanano.osu.edu/Guo/peixuanguo.htmlhttps://www.youtube.com/watch?v=rRGYHFulzkQhttps://www.youtube.com/watch?v=LpUGuEQos6Y). Please send CV to Nancy Wardle (wardle.5@nullosu.edu) and Dr. Hui Zhang (zhang.7173@nullosu.edu; phone number: 614-293-2188).

The Ohio State University is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation or identity, national origin, disability status, or protected veteran status.

Ribosome Biophysics Research

Area of research: ribosome biophysics
skill required: nucleic acid research experienence and basic molecular biology skills are desired but not required
starting date: immediately
duration: 4 years from NIH funding

The person will master a novel magnetic sensing-based force spectroscopy to study the chemical to mechanical energy transfer in the ribosome translation, and the mechanism/drug effects that control the viral frameshifting processes.
The projects are unique, cutting-edge, and challenging. The research environment is supportive, communicative, and open to individual innovation.
Candidates should have a Ph.D. in biophysics/biochemistry, physical chemistry, bioengineering, or a closely related field.

The University of Houston is an affirmative Action/Equal Opportunity employer. Minorities, women, veterans, and persons with disabilities are encouraged to apply. The compensation will be generous and competitive, including whole-family health insurance and appropriate retirement benefits. Personal/family needs will be considered

Postdoctoral position in Systems Biology of Bacterial ncRNA Regulation: Boston College, Chestnut Hill, MA

A postdoctoral position utilizing systems biology approaches to study the impacts of RNA regulators on bacterial fitness is available for a collaborative project between the Meyer and van Opijnen labs at the Biology Department at Boston College. The position will start between Jan. 1 and June 1, 2016 and is fully NIH funded for 3 years; yearly contracts will be issued.

The Meyer lab focuses on computational identification and experimental validation of novel ncRNA regulators, as well as understanding the evolutionary forces on ncRNA evolution in bacterial systems. The van Opijnen lab focuses on the application of genome-wide strategies to determine how microbial pathogens deal with and overcome stressors in their environment, and on the development of novel strategies to study bacterial pathogens. The labs are equipped with state-of-the-art technology including a robotics system, two massively parallel sequencers and a single cell analysis system, which are used in experiments that include high-throughput screens, full genome sequencing, RNA-seq, ChIP-seq and Tn-seq. For more information on each lab visit: bioinformatics.bc.edu/meyerlab/ and www.vanopijnenlab.com.

The candidate will preferentially perform both computational and experimental work (including mouse experiments) that focus on the systems biology of ncRNA regulation.

Requirements
• Ability to conduct collaborative research.
• Excellent English communication skills both in written and oral form.
• A PhD in molecular or micro- biology, computer science, bioinformatics, biochemistry, biophysics or related discipline. NB. A strong willingness and ability to learn is considered more important than experience in the topics studied by the labs.
• A track record of publications in peer-reviewed journals.
• Experience with mouse experiments, NGS-techniques, and or in statistical methods, programming languages (e.g. Python, Perl), mathematical modeling, and/or analysis of large-scale sequencing data, RNA biology of biochemistry, is a plus.

How to apply
Please send a cover letter, a letter describing your professional interests and ambitions, a curriculum vitae and contact information for at least two references to Dr. Meyer m.meyer@nullbc.edu. Applications will be considered until the position is filled.

The college and department
Boston College is situated on a beautiful campus dating back to the beginning of the twentieth century and is closely located to downtown Boston and Cambridge. The Biology Department and the lab have strong ongoing collaborative efforts with surrounding institutes including Harvard, MIT, and Tufts University. The core faculty in the Biology Department conducts research in areas including HIV, SIV, Toxoplasma, the immune system, and microbial community structures.

Postdoctoral Position in RNA Biology and Cancer Research

Postdoctoral positions are available in the lab of Dr. Olga Anczuków at The Jackson Laboratory for Genomic Medicine in Farmington, CT. Our lab investigates how changes in RNA splicing contribute to breast and ovarian cancer progression as well as drug resistance. We utilize 3D organotypic cell culture models, as well as mouse orthotopic transplantation and PDX models, to decipher the role of alternative-splicing alterations in cancer with the goal of developing novel therapeutic strategies for precision medicine.

Preferred skills and experience: We are looking for talented candidates with interests in RNA biology and cancer research. Successful candidates should have a PhD and/or MD degree with a strong background in molecular biology, cell biology, biochemistry and/or genomics. Research experience in computational biology is also desirable. The candidate should be highly self-motivated, able to work in a team environment, able to acquire new skills rapidly, and have strong written and communication skills.

About The Jackson Laboratory for Genomic Medicine: The successful candidate will join a stimulating and collaborative working environment with eight decades of distinguished research in mammalian genetics and a promising future in genomic medicine. The Jackson Laboratory is recognized internationally for its excellence in research and educational activities, unparalleled genomic resources, and outstanding research support services. It is voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine.

The Jackson Laboratory for Genomic Medicine is part of a $1.1 billion venture between The Jackson Laboratory and the state of Connecticut. The laboratory collaborates with leading medical institutions, including the University of Connecticut Health Center, the Yale University School of Medicine, and the BIDMC Cancer Center. The institute is located in a new, dedicated, state-of-the-art research building, a 183,000 ft2 space incorporating a broad range of the most advanced research laboratories and supporting facilities. It is within 2-hour drive of both New York City and Boston. Nearby recreational activities include hiking, biking, shopping and sampling the offerings of local restaurants in West Hartford. The area offers affordable living and great schools districts. The Jackson Laboratory offers a comprehensive medical plan and other benefits.

To apply: Applications should submitted via the career section of www.jax.org and include a Cover Letter and CV, as well as a list of references. When candidates are otherwise equally qualified, JAX will give preference to the Connecticut resident.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.

https://jax.silkroad.com/epostings/index.cfm?fuseaction=app.jobinfo&jobid=219962&company_id=15987&version=3&source=ONLINE&jobOwner=992398&aid=1

NIH-funded Postdoctoral Position in Structural Biology

A NIH-funded postdoctoral position in structural biology is open in Prof. Ailong Ke’s laboratory at Cornell University, Ithaca, NY, USA. Related research projects seek to understand the structure and function of RNA and RNA-protein complexes.The lab is interested in three main research areas: 1. Structure and function of RNA-protein complexes in CRISPR-Cas and other RNA-guided systems; 2. Structural enzymology of nuclease and helicase in DNA degradation and repair; 3. Structure and conformation dynamics of riboswitches and RNA-containing motors. For representative publications, please refer to Nature. 2016 Feb 25;530(7591):499-503.; Molecular Cell. 2015 Mar 19;57(6):1110-23; Nat Struct Mol Biol. 2014 Sep;21(9):771-7; Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3573-8; and Nat Struct Mol Biol. 2014 Jan;21(1):95-102.

Applicants are expected to hold (or expect) a Ph.D. or equivalent degree. Preferred prior experience in structural biology (crystallography or EM), nucleic acid biochemistry, single molecule biophysics, or molecular evolution. More additional information can be found at http://sites.google.com/site/kelaboratory/

To apply, please send CV and names of 3 references to: ak425@nullcornell.edu

Scientific programmer in Bioinformatics/Computational Biology

We are recruiting a Scientific programmer in Bioinformatics/Computational Biology
to join the Group Bioinformatics of RNA Structure and Transcriptome Regulation and  the BIMSB Bioinformatics Platform .

The Berlin Institute for Medical Systems Biology (BIMSB) is the most recently established institute at the Max-Delbruck Centre for Molecular Medicine (MDC) in Berlin, Germany, which is one of the national research centres of the Helmholtz Association. Research at BIMSB combines state-of-the-art high-throughput technologies with Bioinformatics, molecular biology, biochemistry and engineering to gain a comprehensive and fundamental understanding of different biological systems. The successful applicant will join an international team of interdisciplinary scientists on a vibrant research campus in Berlin, Germany.

The newly established Bioinformatics research group of RNA Structure and Transcriptome regulation (Prof. Meyer) seek an experienced scientific programmer to support the research of the Meyer group and to coordinate work with the BIMSB Bioinformatics Platform (Dr. Akalin).

Responsibilities – support the research program of the Meyer group and coordinate

sys admin work with the BIMSB Bioinformatics Platform
– develop, test, install and configure new scientific software (in

particular for analysing large scale data sets) as well as new

computational analysis pipelines integrating various data sources and

programs
– set up and maintain web-servers for Bioinformatics applications
– convert new and existing software and analysis pipelines into stable

software packages for Linux distributions, e.g. for official release and

for use on the high-performance multi-user compute cluster
– provide written and oral documentation of work and give, as required,

presentations on work

Requirements Essential skills:
– strong interest in Bioinformatics research and the scientific mission of

BIMSB
– excellent oral and written communication skills in English, including oral

presentations
– ability and flexibility to meet deadlines and to work independently as well

as effectively as part of a team

– excellent programming skills in C++, Java, R and basic knowledge of

statistics

– excellent programming skills of a scripting language (Perl and/or Python)
– experience establishing shared software profiles using reproducible builds

(e.g.Guix) and packaging software from source (.rpm, .deb)
– experience deploying software on different setting, in particular on

shared-user

high-performance cluster environment (Sun Grid Engine)
– experience working with, installing and managing linux machines (Ubuntu

and CentOS)
– experience setting up web-servers or proxy (e.g. Apache, Nginx) and in

automated system deployment and linux configuration management (e.g.

Puppet, Chef)

Desired skills:
– experience in Bioinformatics research, analysing and interpreting

high-throughput sequencing data
– experience in algorithm design
– working knowledge of network storage, hardware, file system management, backup/recovery
– experience working in an international environment and interdisciplinary

research setting
– oral and written communication skills in German (a plus, but not essential)

Certificates:
– essential: BSc or MSc in Computer Science or Bioinformatics/Computational
Biology or another science discipline with a strong focus on devising and

employing computational methods
– essential: a minimum of 2 (Msc) or 3 (BSc) years of experience as scientific
programmer
– desired: Red Hat Certified Engineer or Ref Hat Certified System Administrator

Salary Re-numeration according to German TVoeD (Bund/Ost) E13, depending on qualification and experience.
Application Deadline Friday, 3. June 2016
Start Date as soon as possible
Limitation The position is initially offered for 3 years, with the possibility for further extension beyond the initial 3-year contract.

For further information please contact:
Irmtraud Meyer (irmtraud.meyer@nullmdc-berlin.de) or Altuna Akalin (altuna.akalin@nullmdc-berlin.de).

URLs:

Meyer group (www.mdc-berlin.de/45451098)

Akalin group (www.mdc-berlin.de/20902467)

BIMSB (www.mdc-berlin.de/44055965)
How to apply:
Please submit your complete application as a single pdf-file by email to Ms. Sabine Froese (sabine.froese@nullmdc-berlin.de) including
•           letter of motivation (1 page max)
•           CV including relevant experience
•           university and other relevant certificates
•           contact details of 2 or more referees
•           N.B.: Please get 2 or more letters of recommendation to be sent directly to Ms. Sabine Froese (sabine.froese@nullmdc-berlin.de) by the application deadline.
The MDC is an equal opportunity employer and supports gender equality

Postdoctoral Position is Available in the Laboratory of Dr. Xin Li

A postdoctoral position is available in the laboratory of Dr. Xin Li, Assistant Professor at the University of Rochester Center for RNA Biology, Genome to Therapeutics, Department of Biochemistry and Biophysics. Research in the Li Lab (zhaohua.urmc.rochester.edu) is at the interface of reproductive and RNA biology. We thrive to understand how information is perpetuated and diversified through generations from an RNA perspective. The current known RNA-regulations in germ lines just represent the tip of the iceberg. We are looking for a highly motivated individual to uncover new mechanism together.

There are several ongoing projects in the lab: including the biogenesis and function of piRNAs, the translation regulation in germ-line development, the RNA structure and modification in testis, the cause and the consequence of germ-line aging. We are adopting an interdisciplinary approach including genetics, biochemistry, bioinformatics and cell biology, and testing our finding across different model organisms including humans, mice and chickens .

Being one of the founding members of the lab, the position will have the unique opportunity to work side by side with the PI. Ideas and data generated by the “dry” component of the lab will be tested rapidly and efficiently by “wet” bench members, and vice versa. You will attend our joint group meeting with Drs. Lynne Maquat and Yitao Yu and interact with other RNA biologists. We also have close interactions with the reproduction groups at Cornell University, including Drs. John Schimenti and Paula Cohen.

REQUIRED QUALIFICATIONS:

• A recent Ph.D. or equivalent experience
• One first-author publication
• Good communication and organization skills
• Awareness of details
• Preferred background on bioinformatics, reproduction, avian biology or RNA biology

Rochester Center for RNA Biology is a mecca for RNA researchers, with a long history of nurturing RNA biologists and discoveries. The University of Rochester was ranked one of the top 15 institutions in the nation for scientists to work according to The Scientist magazine’s annual survey of “Best Places to Work for Scientists in Academia”. It should be noted that the University of Rochester outranked every other research institution in New York State. The environment is very collaborative and congenial and has an infrastructure that allows me and others to recruit outstanding lab members. Moreover, the city of Rochester is safe, beautiful and affordable.

Please provide a cover letter describing your past projects and career goals. Please also describe what you hope to get out of this position and what you hope to bring to the Lab. Enclose your detailed CV with names and contacts of three referees to Xin_Li@nullURMC.Rochester.edu.

Postdoctoral position in Embryonic Reprogramming

A NIH funded postdoctoral position is available in the Cifuentes laboratory at Boston University School of Medicine for a talented and extremely motivated candidate willing to address fundamental questions of embryonic reprogramming using zebrafish as a model system.

The long-term goals of the laboratory and the available projects involve:
i) to uncover the RNA-protein interactions that occur during early embryogenesis using iCLIP and CRISPR mutagenesis, ii) to understand how do these interactions regulate RNA processing during developent and finally, iii) to integrate mRNA methylation and epitranscriptomics into this regulatory framework.

To address these goals, the lab combines zebrafish microinjection together with powerful genetic, genomic, and proteomic approaches. We are located in a renovated lab space at Boston University School of Medicine in the Department of Biochemistry, with close access to scientific core facilities and immersed in the lively city of Boston.

Candidates should have a PhD, MD, or equivalent degree and at least a first author publication. Strong experience in molecular biology is required and knowledge of computational biology will be a plus, but even more important is their motivation to learn and adapt to scientific challenges and become positive members of the lab. The position is funded for at least three years, contingent on performance. Additional information can be found at: http://www.bumc.bu.edu/biochemistry/people/faculty/daniel-cifuentes/

To apply please send to Dr. Cifuentes a cover letter stating research interests and accomplishments, CV, and contact information for three references in a single PDF

Postdoc in the Field of RNA–Protein Interactions

We are looking for a postdoc in the field of RNA –protein interactions.

The project will likely start early next year and should have a focus on the identification of drug targets. The candidate will have an important role in the final design of the project.
Applicants should have relevant experience in RNA biochemistry and ideally in “Omics” approaches.

The project is planned as a collaboration between Cellzome and the EMBL, and the position will be based at the EMBL campus in Heidelberg.

Informal enquiries can be made to me via phone or email. Please contact:
Dr. Paola Grandi
Group Leader Chemical Genomics
Cellzome GmbH, a GSK company
Meyerhofstr. 1
69117 Heidelberg, Germany
phone: +49 6221 137 57 323
mail: paola.x.grandi@nullgsk.com

Postdoc in Virology and RNA Interactions

The University of Copenhagen seeks to appoint a Postdoc to the Department of Immunology and Microbiology to work at Copenhagen Hepatitis C Program (CO-HEP) to commence as soon as possible.

During your postdoc, you will be working on RNA biology associated with different viral infections using and developing state-of-the-art methodology. Your studies will be part of establishing a platform in RNA and systems virology under the supervision of Associate Professor Troels Scheel. As part of CO-HEP, a highly active and competitive program headed by Professor Jens Bukh, you will be working in a dynamic, international environment with 25 other researchers including Senior Investigators, Postdoctoral Fellows, PhD and Master’s Students, Research Assistants, and Technicians. CO-HEP is affiliated with the University of Copenhagen and with Copenhagen University Hospital, Hvidovre.

RNA viruses are responsible for significant morbidity and mortality worldwide. Pathogens of our interest include hepatitis viruses, flaviviruses (e.g. dengue, yellow fever, zika), picornaviruses (e.g. polio, coxsackie) and alphaviruses (e.g. sindbis, chikungunya). RNA interactions and dynamics during viral infection are becoming increasingly important, and some, such as that of hepatitis C virus and miR-122, are emerging as therapeutic targets. Much, however, remains to be understood on RNA interactions during infection. During the project, you will apply high throughput methodology, such as RNA-seq, crosslinking immunoprecipitation (CLIP) and RNA antisense purification (RAP) as well as standard virology methods to study RNA interactions during infection. You will be expected to actively participate in method development and development of the project.

Required qualifications
The successful applicant should have:
•A PhD in virology, molecular biology, cellular biology, systems biology or related fields.
•Experience with virology, RNA biology, cell biology, systems biology or related fields.
•Interest in RNA viruses, molecular biology and novel deep sequencing methods.
•Research qualifications including experience with cell culture and molecular biology. Experience with virology, microbiology or immunology is an advantage but not a requirement.
•First author publications in high quality internationally recognized journals.

Copenhagen is a modern and international city with a high living standard.
For further information and to apply: http://employment.ku.dk/faculty/?show=817079
Further details can also be obtained by contacting Troels Scheel: tscheel@nullsund.ku.dk
The University of Copenhagen encourages all interested applicants to apply for this position. The closing date for applications is 23.59pm, Sunday 8 May 2016. Only online applications will be accepted.

Postdoctoral positions in RNA regulation at Sloan-Kettering, New York City

We seek motivated scientists with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to discover and functionally elucidate small RNA biogenesis, mRNA processing, and regulatory networks that govern neural specification and function.

Three major projects are available, each with substantial unpublished molecular and genetic data that the candidate can take advantage of. These projects include:
(1) Molecular genetic analysis of endo-siRNA systems across Drosophila species. This follows on recent work from the lab regarding hpRNA function in D. melanogaster (e.g. Wen et al, Molecular Cell 2015), and exploits our current annotation of rapidly evolving hpRNA systems across 12 fly species, and our ability to genetically manipulate other Drosophilid species yielding unexpected phenotypes. This work reveals adaptive function of the RNAi pathway in the testis and surprising biology of RNAi in other species.

(2) Elucidation of mechanism and biology of small RNA tailing and trimming pathways in Drosophila. This follows on recent work from the lab regarding the mirtron tailing enzyme Tailor (e.g. Bortolamiol-Becet, Molecular Cell 2015), and exploits our current generation of novel mutants and biochemical data on Tailor-associated factors and novel tailing enzymes. This work reveals new mechanistic insights into the regulation of small RNA modification, and its consequences on gonadal biology.

(3) Genetic analysis of neural miRNA mutants. Our laboratory has a rich background in elucidating miRNA biology, and our recent work explores neural development and behavior (e.g. Garaulet, Developmental Cell 2014; Sun, PLoS Genetics 2015; Garaulet Journal of Neuroscience 2016). Our current work reveals a panel of Drosophila neural miRNA mutants that exhibit profound defects, including in established and novel behavioral paradigms. This work reveals fundamental biology of miRNA regulation in vivo, and provides access into unexplored behavioral circuits.

We have openings for 2 highly motivated postdoctoral fellows with broad interest in integrative strategies to join our team. Relevant candidates for the first two projects will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods. Relevant candidates for the third project will have strong background in Drosophila genetics and neurobiological methods. Positions are available immediately and are funded for at least three years, contingent on performance. Please send letter of inquiry, CV and references to laie@nullmskcc.org.

POSTDOCTORAL POSITIONS IN BIOPHYSICS OF RNA-PROTEIN COMPLEXES

Post-doctoral positions are available in the Department of Biophysics at the Johns Hopkins University to study the dynamics of protein-RNA interactions during ribosome assembly and during regulation by small non-coding RNAs. Projects involve the integration of RNA biochemistry with intracellular X-ray footprinting, single molecule FRET, small angle X-ray scattering or mass spectrometry. Trainees benefit from extensive collaborations with laboratories at Johns Hopkins, the NIH, and the University of Maryland. The positions require self-motivated candidates comfortable with quantitative data analysis and methods development. Expertise in RNA biochemistry, single molecule biophysics, small angle scattering or high-throughput sequencing is helpful. Please send a CV and names of 3 references by e-mail to Professor Sarah Woodson swoodson@nulljhu.edu.