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Postdoctoral Position Available to Study Structure and Mechanisms of Gene-regulatory Noncoding RNAs and Ribonucleoprotein Complexes.
A postdoctoral position is available starting in the Fall of 2015 in Dr. Jinwei Zhang’s group as part of the Laboratory of Molecular Biology (LMB) at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), in the National Institutes of Health (NIH)’s vibrant main campus in Bethesda, MD just outside of Washington DC. More details will become available at http://www-mslmb.niddk.nih.gov/
The laboratory aims to address a widening gap between the exponential growth of genome-wide discovery and functional description of the noncoding transcriptome, and a significant lack of three-dimensional structural information and mechanistic understanding of such complex noncoding RNAs. Initial projects include gene-regulatory riboswitches, stress-sensing Gcn2 kinase system, HIV and other viral RNA and RNPs.
The laboratory is established under the Earl Stadtman Investigator program, designed to facilitate high-risk, high-impact research (http://irp.nih.gov/careers/trans-nih-scientific-recruitments/stadtman-tenure-track-investigators). The research of the group is supported by the collaborative and interdisciplinary NIH intramural program consisting of more than 1100 labs and state-of-the-art equipment in structural biology (X-ray crystallography, Cryo-EM, SAXS, etc), biochemistry and biophysics core facilities with hands-on training provided by PhD-level support staff, genomics (RNA-seq), proteomics, and bioinformatics cores, flow cytometry and microscopy, etc. The NIH, NIDDK, and LMB are committed to the continued education and career development of trainees in many aspects such as numerous courses and workshops offered by NIH Office of Intramural Training & Education (OITE) and Foundation for Advanced Education in the Sciences (FAES), as well as intramural career transition funding (K grants) opportunities.
Requirements: Interested candidates must have received (or be expecting) a Ph.D. or M.D. within the past five years in molecular biology, structural biology, biochemistry, cell biology, or a related discipline, have excellent oral and written communication skills, and be strongly self-motivated to participate in and design innovative and rigorous research programs.
To apply: Please email a cover letter indicating preferred start date, CV, a brief summary of research interests, accomplishments, and career goals, and names and contact information for at least three references to: Dr. Jinwei Zhang, Email: [email protected]. The NIH is dedicated to building a diverse community in its training and employment programs. DHHS/NIH is an Equal Opportunity Employer.
Establish the Role of RNA Stability and Editing in Bone and Cartilage Tissue Homeostasis and Disease
A postdoctoral position is currently available in the laboratory of Drs. Michael Zuscik and Reyad Elbarbary in the Center for Musculoskeletal Research at the University of Rochester Medical Center (URMC). The primary focus of the research for this position is to establish the role of RNA stability and editing in bone and cartilage tissue homeostasis and disease. A second project will be related to our group’s ongoing study of the pathogenesis of osteoarthritis and the associated development of chondroregenerative therapeutic approaches. Candidates with expertise and/or interest in the musculoskeletal and RNA biology fields are encouraged to apply. Experience in mouse genetics, husbandry, genotyping and surgery, nucleic acid analysis, IP/ Western blotting, histologic methods and immunohistochemistry and cell culture is desired. Please send a current CV and a brief personal statement describing your career plans to Michael Zuscik ([email protected]) and Reyad Elbarbary ([email protected]).
A postdoctoral research fellow position is available at the University of California, San Francisco at the new Helen Diller Comprehensive Cancer Center (Mission Bay Campus) (http://pub.ucsf.edu/missionbay/tour/), to study the basic molecular mechanisms promoting quantitative and qualitative regulation in the translational control of gene expression and how deregulations in this process lead to distinct steps of cancer progression.
The potential candidate will utilize the first mouse models for components of the translation machinery in combination with novel proteomics, ribosome-profiling, and pharmacological strategies to study the dynamics of translation control in gene expression, in normal and cancer cells. Highly motivated individuals with a recent Ph.D., M.D. or M.D./Ph.D. and a background in mouse genetics, biochemistry, or cellular and molecular biology are encouraged to apply. Evidence of scientific accomplishment is required and bioinformatics skills are desirable. Requests should be addressed to: [email protected] and [email protected].
Please visit our webpage at ruggerolab.ucsf.edu.
The expansion of PTC Therapeutics, Inc. has created the need for a Research Scientist to support our Drug Discovery and Development programs focused on RNA biology. The selected candidates will be expected to work independently to guide a drug discovery program from understanding the biology and selection of a suitable target to the development and implementation of high throughput assays to identify small molecule modulators of the target gene expression. Additionally, the candidate will work closely with a cross functional team of scientists in support of research goals for multiple projects focused on the identification and advancement of small molecules that target novel processes of RNA biology with the ultimate goal of addressing unmet medical needs.
•Ph.D. degree in biosciences with 2+ years of experience as a postdoc or in pharmaceutical research/drug discovery.
•Strong molecular biology, mammalian tissue culture and assay development skills are required.
•Strong oral and written communication skills as evidenced by a strong publication/patent record are essential.
•Broad knowledge of multiple therapeutic areas ranging from genetic disorders to oncology is strongly preferred.
•RNA sequence analysis, alignment, secondary and tertiary structure prediction/RNA folding, RNA-DNA and RNA-RNA duplex and triplex formation/imperfect base-paring analysis
•Research on the function small RNA pathways (e.g. miRNAs, siRNAs and piRNAs) or mRNA processing pathways (e.g. alternative polyadenylation and circularization)
•RNA recognition by proteins and small molecule ligands
•Identification and analysis of RNA regulatory elements – control of splicing, transport, translation initiation/uORF, RNA editing, translational pausing and frameshifting, translation termination, UTR regulatory motifs – strength and utility as drug targets
•Experience in genome-wide analysis of gene expression: RNA-seq, CLIP-seq, ribosome profiling
Contact: [email protected]
A post-doctoral position is available for a qualified individual to carry out studies in the field of alternative splicing. A focus of the research will be on novel epithelial cell-type-specific splicing proteins (Esrp1 and Esrp2) that were identified in our lab in a cell-based genetic screen (Molecular Cell 33(5):591-601 (2009). We have use high throughput sequencing and other genome-wide technologies to identify global programs of alternative splicing in epithelial cells that are abolished upon Esrp depletion (Embo J. 29(19): 3286-3300; Mol. Cell. Biol. 32(8): 1468-1482). The research project will extend the use of genome-wide sequencing technologies to study programs of alternative splicing that are altered in newly developed Esrp1/Esrp2 KO mice, which display disease related phenotypes. Further details about the lab can be accessed at: http://www.med.upenn.edu/camb/faculty/ggr/carstens.html. The position requires an M.D. or Ph.D. degree. Previous experience in mouse genetics, RNA biology, and molecular or cell biology is preferred. Please send a CV including at least two references to: Dr. Russ P. Carstens, University of Pennsylvania School of Medicine, 575 Clinical Research Building, 415 Curie Blvd. Philadelphia, PA 19104, [email protected].
An exciting postdoctoral fellow position is available in the lab of Dr. Jacob Schwartz at the University of Arizona in Tucson, AZ, to study the role of RNA binding proteins in regulating transcription and DNA damage response. Specific projects include the role of RNA binding proteins in Lou Gehrig’s disease, Ewing sarcoma, and the role of noncoding RNAs in regulating transcription. Candidates with a strong background in molecular biology, biochemistry, or computational biology are encouraged to apply. The lab’s research focus ranges from protein purification, cell culture, primary neuronal cell culture, and whole mouse studies. Techniques include mass spectrometry, protein/RNA structure functional studies, immunofluorescence and microscopy, and next-generation sequencing. To apply please send a CV and letter of interest with the contact information for your references to [email protected].
1. Schwartz JC, Cech TR, Parker RR, “Biochemical properties and biological functions of FET proteins”, Annu. Rev. Biochem. 2015; 84 (Epub ahead of print)
2. Schwartz JC, Podell ER, Han SSW, Berry JD, Eggan KC, Cech TR, “FUS is sequestered in nuclear aggregates in ALS patient fibroblasts” Mol Biol Cell, 2014; 25(17):2571-8. (PMID: 25009283)
3. Schwartz JC, Wang X, Podell ER, Cech TR, “RNA seeds higher order assembly of FUS protein” Cell Reports, 2013; 5(4):918-25.
4. Schwartz JC, Ebmeier CC, Podell ER, Heimiller J, Taatjes DJ, Cech TR, “FUS binds the CTD of RNA polymerase II and regulates its phosphorylation at Ser2” Genes Dev, 2012; 26:2690-95.
5. Schwartz, JC, Younger, S, Nguyen,N, Hardy, D, Monia, BP, Corey, DR, Janowski, BA, “Antisense Transcripts are Targets for Small Activating RNAs”, Nat Struct Mol Biol. 2008 Aug;15(8):842-8.
A postdoctoral position to study the functional roles and regulation of localized RNAs is available immediately in Dr. Stavroula Mili’s lab at the National Cancer Institute, National Institutes of Health, Bethesda, MD. The lab is interested in understanding the regulation of RNA localization by cancer-associated proteins and the contribution of localized RNAs to tumor progression. The work relies on a variety of cell biological, microscopical and biochemical approaches in 2D and 3D cell culture systems. The research program is funded by the NIH Intramural program and is supported by state-of-the-art facilities on the NIH campus.
Interested candidates must have received a Ph.D. degree in cell biology, biochemistry or related discipline, and be highly motivated to design and pursue innovative research directions.
Applications should include a CV, description of research interests and prior accomplishments, contact information of at least 3 references and preferred start date. Please e-mail application materials to [email protected]
The NIH is dedicated to building a diverse community in its training and employment programs.
DHHS/NIH is an Equal Opportunity Employer.
Contribute to NIH-R01 Funded Projects Focused on mRNA Decay in Myotonic Dystrophy and Pluripotent Stem Cells
We are looking for an enthusiastic and hard-working post-doctoral fellow to contribute to NIH-R01 funded projects focused on mRNA decay in myotonic dystrophy and pluripotent stem cells. The projects aim to identify novel changes in mRNA metabolism that contribute to pathogenesis and pluripotency. State-of-the-art genome-wide approaches and other molecular techniques will be employed using primary and stem cells.
The successful candidate should hold a PhD and/or MD and have less than 5 years post-doctoral experience in the general area of cell and molecular biology. Preference will be given to those with experience in RNA biology, genome-wide approaches and/or stem cell biology. Bioinformatics expertise is highly desirable. The fellow will report to Jeff and Carol Wilusz, but will be expected to work somewhat independently. S/he will be encouraged to apply for fellowship funding and given the opportunity to train junior researchers. Excellent technical, oral and written communication skills are essential.
The Wilusz lab has extensive expertise in all aspects of RNA biology linked with disease and development.
We are located at Colorado State University, in Fort Collins, Colorado – frequently voted one of the “Best Places to Live in the US”.
Apply by 3/15/2015 for full consideration, but the position will remain open until filled. The start date could be as early as 4/15/2015; funding is available through 2019.
For complete job description and to apply go to http://jobs.colostate.edu/postings/8417.
CSU is an EO/EA/AA employer and conducts background checks on all final candidates.