Employment Opportunities

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Postdoc in the Field of RNA–Protein Interactions

We are looking for a postdoc in the field of RNA –protein interactions.

The project will likely start early next year and should have a focus on the identification of drug targets. The candidate will have an important role in the final design of the project.
Applicants should have relevant experience in RNA biochemistry and ideally in “Omics” approaches.

The project is planned as a collaboration between Cellzome and the EMBL, and the position will be based at the EMBL campus in Heidelberg.

Informal enquiries can be made to me via phone or email. Please contact:
Dr. Paola Grandi
Group Leader Chemical Genomics
Cellzome GmbH, a GSK company
Meyerhofstr. 1
69117 Heidelberg, Germany
phone: +49 6221 137 57 323
mail: paola.x.grandi@nullgsk.com

Postdoc in Virology and RNA Interactions

The University of Copenhagen seeks to appoint a Postdoc to the Department of Immunology and Microbiology to work at Copenhagen Hepatitis C Program (CO-HEP) to commence as soon as possible.

During your postdoc, you will be working on RNA biology associated with different viral infections using and developing state-of-the-art methodology. Your studies will be part of establishing a platform in RNA and systems virology under the supervision of Associate Professor Troels Scheel. As part of CO-HEP, a highly active and competitive program headed by Professor Jens Bukh, you will be working in a dynamic, international environment with 25 other researchers including Senior Investigators, Postdoctoral Fellows, PhD and Master’s Students, Research Assistants, and Technicians. CO-HEP is affiliated with the University of Copenhagen and with Copenhagen University Hospital, Hvidovre.

RNA viruses are responsible for significant morbidity and mortality worldwide. Pathogens of our interest include hepatitis viruses, flaviviruses (e.g. dengue, yellow fever, zika), picornaviruses (e.g. polio, coxsackie) and alphaviruses (e.g. sindbis, chikungunya). RNA interactions and dynamics during viral infection are becoming increasingly important, and some, such as that of hepatitis C virus and miR-122, are emerging as therapeutic targets. Much, however, remains to be understood on RNA interactions during infection. During the project, you will apply high throughput methodology, such as RNA-seq, crosslinking immunoprecipitation (CLIP) and RNA antisense purification (RAP) as well as standard virology methods to study RNA interactions during infection. You will be expected to actively participate in method development and development of the project.

Required qualifications
The successful applicant should have:
•A PhD in virology, molecular biology, cellular biology, systems biology or related fields.
•Experience with virology, RNA biology, cell biology, systems biology or related fields.
•Interest in RNA viruses, molecular biology and novel deep sequencing methods.
•Research qualifications including experience with cell culture and molecular biology. Experience with virology, microbiology or immunology is an advantage but not a requirement.
•First author publications in high quality internationally recognized journals.

Copenhagen is a modern and international city with a high living standard.
For further information and to apply: http://employment.ku.dk/faculty/?show=817079
Further details can also be obtained by contacting Troels Scheel: tscheel@nullsund.ku.dk
The University of Copenhagen encourages all interested applicants to apply for this position. The closing date for applications is 23.59pm, Sunday 8 May 2016. Only online applications will be accepted.

Postdoctoral positions in RNA regulation at Sloan-Kettering, New York City

We seek motivated scientists with strong RNA background to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines experimental and computational approaches to discover and functionally elucidate small RNA biogenesis, mRNA processing, and regulatory networks that govern neural specification and function.

Three major projects are available, each with substantial unpublished molecular and genetic data that the candidate can take advantage of. These projects include:
(1) Molecular genetic analysis of endo-siRNA systems across Drosophila species. This follows on recent work from the lab regarding hpRNA function in D. melanogaster (e.g. Wen et al, Molecular Cell 2015), and exploits our current annotation of rapidly evolving hpRNA systems across 12 fly species, and our ability to genetically manipulate other Drosophilid species yielding unexpected phenotypes. This work reveals adaptive function of the RNAi pathway in the testis and surprising biology of RNAi in other species.

(2) Elucidation of mechanism and biology of small RNA tailing and trimming pathways in Drosophila. This follows on recent work from the lab regarding the mirtron tailing enzyme Tailor (e.g. Bortolamiol-Becet, Molecular Cell 2015), and exploits our current generation of novel mutants and biochemical data on Tailor-associated factors and novel tailing enzymes. This work reveals new mechanistic insights into the regulation of small RNA modification, and its consequences on gonadal biology.

(3) Genetic analysis of neural miRNA mutants. Our laboratory has a rich background in elucidating miRNA biology, and our recent work explores neural development and behavior (e.g. Garaulet, Developmental Cell 2014; Sun, PLoS Genetics 2015; Garaulet Journal of Neuroscience 2016). Our current work reveals a panel of Drosophila neural miRNA mutants that exhibit profound defects, including in established and novel behavioral paradigms. This work reveals fundamental biology of miRNA regulation in vivo, and provides access into unexplored behavioral circuits.

We have openings for 2 highly motivated postdoctoral fellows with broad interest in integrative strategies to join our team. Relevant candidates for the first two projects will have strong experience in studying RNA processing using cell culture, in vitro approaches, and genomewide methods. Relevant candidates for the third project will have strong background in Drosophila genetics and neurobiological methods. Positions are available immediately and are funded for at least three years, contingent on performance. Please send letter of inquiry, CV and references to laie@nullmskcc.org.

POSTDOCTORAL POSITIONS IN BIOPHYSICS OF RNA-PROTEIN COMPLEXES

Post-doctoral positions are available in the Department of Biophysics at the Johns Hopkins University to study the dynamics of protein-RNA interactions during ribosome assembly and during regulation by small non-coding RNAs. Projects involve the integration of RNA biochemistry with intracellular X-ray footprinting, single molecule FRET, small angle X-ray scattering or mass spectrometry. Trainees benefit from extensive collaborations with laboratories at Johns Hopkins, the NIH, and the University of Maryland. The positions require self-motivated candidates comfortable with quantitative data analysis and methods development. Expertise in RNA biochemistry, single molecule biophysics, small angle scattering or high-throughput sequencing is helpful. Please send a CV and names of 3 references by e-mail to Professor Sarah Woodson swoodson@nulljhu.edu.

NIH-Funded Postdoctoral Fellowship in RNA-Targeted Drug Discovery

Postdoctoral positions are available in the lab of Dr. Nathan Baird at the University of the Sciences in Philadelphia. The Baird lab combines emerging research in RNA biology with high-throughput chemical screening to advance RNA-targeted drug discovery. Additionally, research projects focus on structure-function analyses of novel RNA-ligand interactions.

Highly motivated candidates possessing skills in RNA biochemistry/biophysics or high-throughput screening are encouraged to apply. Additional skills in the analysis and management of large data sets, including a basic knowledge of computer scripting languages, are desirable though not required. Qualified candidates must have a Ph.D. in biochemistry, biophysics, or chemical biology related to RNA.

Research in the Baird lab is supported by a Career Transition Award (K22) from NIH. Extensive opportunities for collaborative and innovative science are a hallmark of the Baird lab, including existing collaborations with groups at NIH and Temple University. For more information, visit www.bairdlabusci.com. Candidates are requested to send a statement of interest, curriculum vitae, and contact information for 3 references to n.baird@nullusciences.edu

USciences is located in the University City District of Philadelphia in close proximity to a number of excellent neighboring universities, biotechnology companies, and large pharmaceutical companies.

The RNA Bioscience Initiative Faculty Positions

The RNA Bioscience Initiative is a major new interdepartmental effort to expand basic and clinical RNA biology research and education at the University of Colorado Anschutz Medical Campus. We anticipate hiring 5 new faculty members as well as additional personnel to develop RNA bioinformatics technology. In the first phase of recruitment, we invite applications for faculty positions in the areas of RNA technology and bioinformatics. Highly qualified applications at the Assistant Professor and more senior levels will be considered. The ideal candidates are developing novel experimental and computational technologies to investigate questions relevant to RNA biology in normal and diseased cells.

New recruits will join a highly interactive and interdisciplinary group of faculty (http://rnabio.CO), students, and postdoctoral fellows, and will enjoy access to state-of-the-art equipment and facilities on the new Anschutz Medical Campus. Candidates must hold a PhD (or equivalent) degree and have a strong record of research accomplishments.

Applicants should submit a cover letter, curriculum vitae, a brief description of research plans (2 pages), and the contact information for 3 people who will provide letters of reference.

Materials should be submitted at http://jobs.sciencecareers.org/job/401006/faculty-positions-university-of-colorado-anschutz-medical-campus-rna-bioscience-initiative/.

We will begin reviewing applications May 15, 2016 and the search will remain open until the positions are filled.

NIH-funded Postdoctoral Fellowship in Developmental Biology of Formation of RNA

NIH-funded Postdoctoral Fellowship in Developmental Biology of Formation of RNA: interaction with DNA
Postdoctoral Fellowship Position, to begin June 1, – August 15, 2016 (duration: 2-5 yrs).

NIH-funded Postdoctoral Fellowship Position in National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will examine how RNases H find their substrates and how, when these enzymes are defective, do the substrates cause severe neurological disorders using mouse models. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in mouse development, molecular biology, genetics and/or biochemistry is required. The successful candidate will confer regularly with the principal investigator on a mutually establish area of research. During the candidate’s tenure, creating new projects, development of technical skills, presentation, and communication skills will be strongly supported by the PI and other members of the laboratory.

Interested candidates should email a cover letter that details their specific interests in the research interests of the Crouch lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Robert J. Crouch
Email: crouchr@nullmail.nih.gov

Crouch lab current interests
• Role RNases H1and H2 in preventing genome instability
• Development of innate and adaptive immune responses
• Contribution of RNA/DNA hybrids and R-loops to genome integrity
•.Mitochondrial DNA replication and disorders
• Roles of ribonucleotides incorporated during DNA replication

Two Postdoctoral Fellow/Research Associate Positions in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine

Two Postdoctoral Fellow/Research Associate positions are immediately available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine.

The project is to elucidate molecular mechanisms of diseases caused by mutations in splicing factors. Its aim is to provide new, important insights into mechanisms that contribute to normal development and prevent carcinogenesis. All of the projects in the laboratory relate to aspects of mammalian pre-mRNA transcription and processing. The realization of these projects will involve state-of-the-art approaches in biochemistry, cell and molecular biology including genomics, genome engineering, and the development of cell culture models of disease.

The successful candidate will demonstrate dedication to pursue a research career in molecular genetics. The candidate will have a Ph.D. in biochemistry, molecular biology, genetics, developmental or cell biology, and will have first-author publications in top-tier, peer-reviewed journals. In addition, the candidate must have excellent skills in written and spoken English. Positions are supported by NIH grants for at least three years.

Please email your curriculum vitae, a brief description of research accomplishments and career objectives as well as contact information for 3 references to padgetr@nullccf.org.

Two Postdoc Positions Available to Study microRNAs and Translational Regulation in the Immune System

Postdoctoral positions are available in the Department of Immunology and Microbial Science at The Scripps Research Institute to study the functions and molecular mechanisms of microRNA and translational control in immune tolerance, immune responses, autoimmune disease, lymphoma, virus infection, and cancer immunotherapy. For more information, see Cell (2007) PMID: 17923094, Nature Immunology (2008) PMID: 18327259, Cell (2009) PMID: 19135886, Nature Immunology (2013) PMID: 23812097, EMBO J (2013) PMID: 23921550, Nature Immunology (2016) PMID: 26901150.

Position 1:
Highly motivated PhD, MD, or MD/PhD with a solid background in immunology. Working experience in the following areas is desired: the mouse immune system; immune tolerance; germinal center reaction; mouse models of autoimmune diseases or lymphoma; cancer immunotherapy, lentiviral or retroviral systems for gene expression; bone marrow reconstitution; Crispr/Cas9 gene editing, mouse genetics.

Position 2:
Highly motivated PhD, MD, or MD/PhD with a solid background in studying RNA, RNA-binding protein, and/or translational regulation in mammalian systems. The following expertise is desired: ribosome profiling, polysome profiling, CLIP, and bioinformatic skills.

Please e-mail application including cover letter indicating current and future research interests and expected availability date, CV, selected reprints of publications, names and contact information of three references to:
Changchun Xiao, Associate Professor, Department of Immunology and Microbial Science, The Scripps Research Institute, cxiao@nullscripps.edu.

Postdoctoral Scholar Position

Postdoctoral Scholar position is available in the laboratory of Dr. Ruslan Afasizhev at the Department of Molecular and Cell Biology, Boston University Medical Campus. Our NIH-funded program focuses on the mechanisms of RNA processing in trypanosomes. The areas of mitochondrial mRNA editing, mRNA stability, translation and small RNAs biogenesis are of particular interest. For more details, please see recent publications listed below. Our collaborations extend into structural biology, mass spectrometry, drug design and bioinformatics. Required qualifications include strong background in molecular biology and biochemistry, and a record of peer-reviewed publications. Experience in RNAi, bioinformatics, RNA-Seq, ribosome profiling, protein purification, mass spectrometry and parasite genetics is desirable, but not required. This position carries a starting salary of $42,000-45,000, commensurate with experience, plus health benefits. Funding will be provided for up to three years although fellowship applications are encouraged. Boston University Medical Campus is located in the vibrant South End area of Boston and offers a highly collaborative environment, unlimited networking possibilities, excellent core facilities and outstanding cultural and recreational opportunities. To apply, please send a letter of intent, CV and contact information for three references to ruslana@nullbu.edu.

Aphasizheva et al., Mol Cell Biol, 2014.
Aphasizheva and Aphasizhev, Trends in Parasitology, 2015.
Aphasizheva et al., Mol Microbiology, 2015.
Suematsu et al, Molecular Cell, 2016.

Computational RNA Biology & Systems Cardiology PhD / Postdoc positions

Successful candidates will join an enthusiastic and collaborative bioinformatics team in an excellent scientific environment. The Dieterich Lab is focused on post-transcriptional gene regulation and cardiovascular diseases. Especially, novel technologies in nucleic acids sequencing, mass spectrometry and imaging provide high-throughput data at an unprecedented depth and level of detail. The Dieterich Lab exploits these data source to leverage and deepen our understanding of post-transcriptional gene regulation on a systemic level.

Required Qualifications
Applicants should have a degree in computer science, bioinformatics, statistics or a comparable level of expertise with a background in the life sciences. Programming skills are essential.
Your technical expertise is complemented by essential soft skills, the ability to communicate and work in teams, flexibility and targeted action.

Tasks
Expanding our research activities in the field of computational RNA Biology with an emphasis on ncRNAs, RNA-binding proteins, post-transcriptional control and RNA modifications
Computational method development
Analysis, integration and modeling of data from different data sources and model systems (animal models and patient data)

Environment
The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 10,000 employees in more than 50 specialized clinical departments with roughly 1,900 beds, about 66,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
The campus on Neuenheimer Feld provides an international and vibrant research environment with highly interacting groups as well as state-of-the-art technologies and core facilities.

Postdoctoral Position on Genome Editing and iPSC Neurons

Postdoctoral Position on Genome Editing and iPSC Neurons
Johns Hopkins University
Jiou Wang Laboratory

Highly motivated postdoctoral candidates are invited to lead several new projects to address fundamental questions in RNA and protein homeostasis in relationship to neurodegenerative diseases. Candidates with background or experience in using genome editing tools such as CRISPR or stem cell models such as iPSC neurons are encouraged to apply.

The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research. Our lab is affiliated with the Department of Biochemistry and Molecular Biology of the Bloomberg School of Public Health and the Department of Neuroscience of the School of Medicine. The Baltimore/Washington D.C. area also offers rich professional and living opportunities.

Candidates should have a doctoral degree and strong research background. Please send a statement of research experience and career goals, a copy of Curriculum Vitae, and contact information of at least one reference to Dr. Jiou Wang at jiouw@nulljhmi.edu.

A complete listing of PubMed-accessible publications can be accessed at the following URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Jiou+Wang.

More information available at: http://neuroscience.jhu.edu/resources/directory/faculty/jiou-wang/. The Johns Hopkins University is an Equal Opportunity Employer.

Two-year NSF-funded Postdoctoral Position

Two-year NSF-funded Postdoctoral Position to investigate Meiotic Gene Regulation available in the Wise lab, Center for RNA Molecular Biology, Case Western Reserve University, Cleveland OH USA.

Highly motivated candidates are invited to apply for a postdoctoral position to spearhead the Wise lab’s efforts to understand the molecular basis of changes in RNA metabolism during meiotic progression in the fission yeast Schizosaccharomyces pombe. Previous work has uncovered two unusual regulatory strategies that come into play sequentially as this simple developmental program unfolds:

  • Increased accumulation of early meiotic mRNAs driven by enhanced stability due to sequestration of an RNA binding protein that mediates targeted turnover in mitotic cells
  • Increased accumulation of mid-meiotic mRNAs driven by enhanced co-transcriptional processing under the control of a transcription factor regulated by the early mechanism

The project will utilize a combination of genome-wide and traditional molecular genetic approaches to dissect the cascade of events through which these interconnected regulatory strategies ensure proper temporal control of gene expression. The Center for RNA Molecular Biology provides a stimulating and highly interactive research environment in which trainees benefit from the high concentration of faculty, students and postdocs with relevant expertise.

The ideal candidate will hold a recently awarded Ph.D. in Molecular Biology or a related discipline and have laboratory experience working with RNA and/or yeast. Expertise in bioinformatics is highly desirable. A strong track record of self-directed research and outstanding technical and communication skills are also essential.   The position is available immediately at a salary commensurate with experience.

To apply, please send a cover letter including a description of research interests and career goals, as well as a detailed CV and the names of three references (with e-mail addresses and phone numbers) to Jo Ann Wise via e-mail (jaw17@nullcase.edu).

Post-Doctoral Associate at the RNA Institute in Epitransciptomics, Mass Spectrometry and RNA Separation

As a post-doctoral associate here at The RNA Institute in epitransciptomics, mass spectrometry and RNA separation, you will work alongside and in collaboration with world class researchers who are developing cutting edge technology for the advancement of RNA therapeutics and diagnostics. We are looking for a bright and enthusiastic individual who seeks out answers and travels beyond known boundaries. A crucial part of your role will be the analytical development of high-throughput methods to characterize RNA modifications, Epitranscriptome, from a wide variety of biological systems using mass spectrometry-based technologies. In addition research will includes the development of high-throughput methods of RNA separation and purification and the use of chromatography to decipher RNA structure. Does this sound like you? If so, step into the future and prepare to make history.

As an integral part of the team you will play a significant role in impacting the development process, delivering critical data for go/no-go decisions. You will be an important opinion leader within project teams and at project team meetings. Working independently and conducting your own projects, progress reports and publications is all part of the position. Success is contingent on thinking on your feet and being adaptable to change and new possibilities. Most importantly, you will need to embrace collaboration and participate in projects with other members of the lab and external collaborators.

Minimum Education and Experience Requirements
• Applicants must have a Ph.D degree in biochemistry, molecular biology, chemistry or biology or related fields
• Demonstrated experience in one or more of the following areas would be preferable:
• molecular biology/biochemistry with experience in Nucleic Acids, in particular RNA;
• small-molecule mass spectrometry;
• chromatographic separation techniques;
• statistical analysis of large data sets.
• Ability to dissect problems and projects into manageable tasks
• Demonstrated organizational skills with the ability to handle multiple tasks with different priorities

Contact: mbasantasanchez@nullalbany.edu

NIH-funded Postdoctoral Fellowship Position in Eukaryotic RNA Metabolism

NIH-funded Postdoctoral Fellowship Position, to begin Oct 1, 2016 or later (duration: 2-5 yrs).
NIH-funded Postdoctoral Fellowship Position in Eukaryotic RNA Metabolism
National Institutes of Health (NIH), Bethesda, Maryland

The Fellow will investigate molecular mechanisms involved in RNA metabolism relevant to eukaryotic gene expression including tRNA profiling by tRNA-HydroSeq relevant to mRNA translation patterns and codon use during early development. Candidates must hold a Ph.D. or M.D. and have less than 5 years postdoctoral experience. Expertise in molecular biology, genetics and/or biochemistry is required, as are strong letters of recommendation. The successful candidate will confer regularly with the principal investigator but must develop self-directed research and have good technical, presentation, and communication skills as essential parts of the training experience.
Interested candidates should email a cover letter that details their specific interests in the research interests of the Maraia lab.
•Send a cover letter, C.V., and the names of three references with their email addresses and telephone numbers by Email to:
Richard J. Maraia, M.D.
Email: maraiar@nullmail.nih.gov

Maraia lab current interests
•mRNA biased codon use and effects of variable tRNA gene complement.
•Anticodon modification by tRNA isopentenylytransferase and its role in translation and disease.
•Molecular mechanisms of La-related protein -4 (LARP4) function in translation.
•Role of the La protein in tRNA production.
•Molecular mechanisms of transcription termination by RNA polymerase III.

NIH Funded Post-Doctoral Position in the Laboratory of Dr. Sam Butcher

An NIH funded post-doctoral position is immediately available in the laboratory of Dr. Sam Butcher (https://biochem.wisc.edu/faculty/butcher) in the Department of Biochemistry at the University of Wisconsin-Madison. The lab utilizes numerous biochemical and biophysical methods, including but not limited to NMR and X-ray crystallography. Lab members also operate in close contact with the NIH-supported National Magnetic Resonance Facility at Madison (NMRFAM), for which Dr. Butcher serves as co-PI. Active collaborations provide opportunities to acquire expertise in complimentary methods, spanning from yeast genetics to single molecule microscopy. The selected candidate will study the molecular biophysics of RNA-protein complexes that regulate gene expression, with an expected tenure between 2 – 4 years. Applicants must have a PhD degree in a related field and demonstrated ability to work both independently and interact well with an outstanding group of collaborative scientists. Madison, WI offers an outstanding intellectual environment with excellent public schools and a relatively low cost of living.

Postdoctoral Research Position in the Lab of Dr. Aaron Goldstrohm

A postdoctoral research position is available in the lab of Dr. Aaron Goldstrohm in the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota.

Dr. Goldstrohm seeks a highly motivated postdoctoral candidate to perform research on the role of post-transcriptional regulator mechanisms in cancer biology. Candidates should hold a Ph.D. in biochemistry, genetics, cellular and molecular biology or related field. They should have strong interests in cancer biology, gene regulation, RNA biology, and genetics. Individuals with experience in cancer research and molecular and cellular biology techniques are preferred. Candidates should have research skills including designing and executing experiments, interpreting data, and the ability to communicate results, as demonstrated by previous publications and presentations.

The University of Minnesota and the Goldstrohm Lab provide an outstanding training environment with state-of-the-art facilities and instrumentation including next generation sequencing, imaging, proteomics, and bioinformatics. Compensation will correspond with the NIH NRSA payscale, commensurate with experience, and will include health care benefits.

The University of Minnesota is located in metropolitan Minneapolis, a vibrant, affordable city with a strong economy and abundant cultural, intellectual, and recreational opportunities http://www.minneapolis.org/.

To apply, candidates should submit their curriculum vitae with publication record and contact information for three references to Dr. Aaron C. Goldstrohm at agoldstr@nullumn.edu.
Please include a cover letter describing career goals, research experience, accomplishments, and interests. To learn more about the Goldstrohm lab and research, visit: http://cbs.umn.edu/contacts/aaron-goldstrohm