Kevin V. Morris, Center for Gene Therapy, City of Hope, USA Archa Fox, University of Western Australia, Australia and
Paloma Hoban Giangrande, University of Iowa, USA
joint with the meeting on
Protein-RNA Interactions: Scale, Mechanisms, Structure and Function of Coding and Noncoding RNPs
Gene W. Yeo, University of California, San Diego, USA
Jernej Ule, UCL & The Francis Crick Institute, UK
Karla Neugebauer, Yale University, USA and
Melissa J. Moore, University of Massachusetts Medical School, USA
Submit an abstract and register for these Keystone Symposia conferences that will take place February 5–9, 2017 at Fairmont Banff Springs, Banff, Alberta, Canada.
Ribonucleic acid (RNA) binding proteins (RBPs) are rapidly being recognized as a major class of more than a thousand proteins that is widely conserved throughout eukaryotes and plays key roles in almost every aspect of RNA metabolism. RBPs interact with hundreds to thousands of coding and noncoding RNA substrates via cis-regulatory sequences or guided by associated small RNAs to form ribonucleoprotein (RNP) complexes. Increasingly, defects in the protein-RNA interactions by mutations within the regulatory proteins, RNA cis-elements or changes in protein availability or expression have led to numerous diseases. This meeting addresses critical gaps in our basic understanding of how, where and why these RNP complexes form using approaches that integrate high-throughput, massively parallel microarray, sequencing and proteomic technologies with structural biology, genomics, systems-level thinking and computational algorithms to probe RNPs at steps in the life cycle of processing both coding and noncoding RNAs. The specific aims are to: (1) Provide an opportunity and forum to gather interdisciplinary leaders in various fields to cross-fertilize a common, shared vision; (2) Introduce newcomers to the most cutting-edge methods that integrate mechanistic studies and high-throughput science; and (3) Consolidate the field moving forwards. As this unified field is relatively new, we will see shifts in current research paradigms and many opportunities should arise from interactions at this meeting.
- Scholarship & Discounted Abstract: October 5, 2016
- Late-Breaking Abstract: November 2, 2016
(for plenary short talk or workshop presentation consideration)
- Discounted Registration: December 6, 2016
(Through this date, you can still submit an abstract via our website for poster presentation and publication in our mobile app.)
Registered attendees of one meeting in a joint pair may participate in sessions of the other, pending space availability.