The shifting perspective from a read-only-memory genome with copying errors to a read- and-write genome with competent change operators is fundamental: For decades it was assumed that driving force of evolution is mutation (error) and selection. Now it is recognized that errors cannot explain genetic novelty and complexity.
A variety of RNA based agents play essential roles in evolution and regulation in all DNA/Protein based life: basic non-coding RNA secondary structures built of (paired) stems and (not-paired) loops. RNA stem-loop swarms such as group I introns, group II introns, viroids, viral (RNA viruses, retrotransposons, LTRs, non-LTRs) and subviral networks (SINEs, LINEs, Alus) cooperate within cellular genomes as modular tools with its abundance of regulatory functions. Some noncoding RNAs built complementary consortia such as rRNAs, tRNAs, spliceosomes, editosomes, and other RNPs. Additionally counterbalancing modules such as toxin/antitoxin (TA) -, restriction/modification (RM) -, and insertion/deletion (INDEL) – modules assure identity (self/non-self) of cells, tissues, organs and even organisms.
Infectious RNAgents manipulate host genomes for (i) selfish replicative purposes or (ii) persistent co-evolutionary integration. The latter in most cases remain as defectives,
i.e. abundance of parts that now serve as co-opted modular tools for cellular needs or as full function elements that regulate complex developmental processes such as placentation in mammals. Also mixed consortia of RNA- and DNA virus-derived parts that integrate in host genomes have been found.
All fine-tuned steps and substeps of key cellular processes such as gene expression, transcription, translation, DNA recombination and repair, epigenetic imprinting (memory, learning), as well as various forms of innate and adaptive immunity are essentially constituted by such natural genetic content operators.
This symposium assembles approximately 50 experts (30 talks, 20 Posters) from different fields to discuss a fundamental new understanding of genetic novelty, code-generating, genome-formatting factors, multi-use nature for RNAgents and behavioral motifs of RNA-consortia. The small number of participants guarantees a relaxed and inspiring atmosphere for presentation and discussion. The Proceedings will be published.
Conference fee: € 300,00 USD 400,00 (Incl. full 3 day: conference, lunch, coffee breaks, gala-dinner on 4th of July with music performance)
Hotel room at conference site (incl. Breakfast): € 65,00 USD 85,00 (reduced special agreement single room)
Guenther Witzany, Telos – Philosophische Praxis, Buermoos, Austria email: email@example.com
Luis P. Villarreal, Center for Virus Research, University of California at Irvine, USA.
Head-Administrator: Hiltrud Oman, email: firstname.lastname@example.org
Visit our site: http://rna-agents.at/